爱上海419论坛-阿拉上海后花园419-夜上海最新论坛社区-上海品茶工作室

　　10moon17sunThe 6th China Academy of Sciences and 14th Beijing Workers’ Track and Field Games were held in the National Olympic Sports Center. Li Chi Ngai, secretary of the Party Committee of the Institute of Zoology and head of the delegation, led the athletes and the audience about.80People took part in the sports meeting.

　　morninghalf past eight,The sports meeting held a grand opening ceremony. The phalanx of athletes of the animal team entered the stadium with neat steps. In front of the phalanx was a giant panda representing the characteristics of animals. The athletes launched the slogan "Keep fit, devote themselves to science and serve the country" to convey the concept of service dedication. Subsequently, the ninth set of broadcast gymnastics exhibition competition kicked off the sports meeting, and the team represented by animals.twentyA total of 100 athletes participated in the competition.

　　In the one-day competition, the athletes of the animal representative team participate in the following events.Broadcast gymnastics,60riceRun with the ball、100rice、1500rice、four×100riceShot put, long jump, double shuttlecock kicking, football shooting, etc. The athletes fought bravely on the field, showing the sportsmanship of never giving up. Among them, Li Chi Ngai took the initiative and participated.60riceRunning with the ball lifted the athletes’ morale. Li Mei in the pest room won the fourth place in the women’s shot put in Group C, and Ge Ming in the stem cell room won the men’s shot put in Group A.1500riceFourth place, broadcast gymnastics won the Excellence Award.

　　　 The sports meeting was highly valued by the leaders of the Institute, supported by various offices and research groups, carefully organized by trade unions, and actively coordinated by graduate students’ associations and trade unions.After complicated organizational preparations such as athletes’ registration, practice, preliminaries and audience collection, as well as the support and enthusiastic participation of employees and graduate students, the athletes and audience of the Animal Institute of this Games fully demonstrated the spirit of unity and forge ahead with practical actions.For this reason, the sports delegation of the Institute of Zoology won the "Excellent Organization Award".

The team of athletes from the Institute of Zoology entered the venue.　

Secretary Li Chi Ngai runs fast.　

Researcher Sun Yue Hua shot vigorously.

Li Mei threw a hard throw.

Wang Jiangning flies across the sky

Ge Ming sprints with all his strength.

Wang Chengmin is ready to go.

　　CCTV News (Focus Interview): Taking the expressway has become one of the main ways for everyone to travel. 307.07 million vehicles, this figure is the cumulative traffic volume of the national expressway network in the past May Day holiday, with an average of more than 61 million vehicles driving on the expressway every day. This figure is nearly 20% higher than the May Day holiday in 2019 before the epidemic. At present, in view of the huge demand and road pressure, there are about 5,000 kilometers of expressway sections in the national expressway network, including the Hubei section of Beijing-Hong Kong-Macao Expressway, which has been in operation for more than 20 years.

　　The upgrading and reconstruction project of Hanjiang Bridge was completed five months ahead of schedule. Before the May Day holiday, the Hubei section of Beijing-Hong Kong-Macao Expressway resumed truck traffic. In just a few days, the traffic volume rose rapidly. Throughout the May Day holiday, Beijing, Hong Kong and Macao — — The daily traffic volume of this busiest expressway in Hubei exceeds 260,000 vehicles, and nearly 70% of them are logistics freight vehicles from south to north.

　　Wang Bo, instructor of the 2nd Squadron of Caidian Brigade, No.1 Team of Hubei High Police Corps: Dongxihu District of Wuhan City is equivalent to a transit point of national logistics. It is distributed from Dongxihu Lake of Wuhan City first, and then radiated to the periphery of the country, and began to deliver goods. We understand that the majority of freight car drivers are willing to take the old Beijing-Zhuhai Expressway. The so-called Beijing-Zhuhai Expressway is now called Beijing-Hong Kong-Macao Expressway, and they are willing to take this expressway.

　　It starts in Beijing, with a total length of 2,285 kilometers, and passes through the North China Plain, Jianghan Plain, Central Hunan Plain, Nanling Plain and Pearl River Delta Plain, and finally reaches the ports of Hong Kong and Macao through eight provinces and cities such as Beijing, Hebei, Henan, Hubei, Hunan and Guangdong. The Beijing-Hong Kong-Macao Expressway, which was built in the 1980s, is one of the earliest traffic arteries running through the north and south in China, and it is also the "national comprehensive three-dimensional traffic network in 2035".

　　Bin Fan, Deputy Director of Engineering Management Department of Highway Bureau of Ministry of Transport: The most impressive figure of the national comprehensive three-dimensional traffic network is a diamond-shaped map, which has four poles, namely, the northernmost part of Beijing-Tianjin-Hebei, the southernmost part of Guangdong-Hong Kong-Macao Greater Bay Area, the Yangtze River Delta in the east and Chengdu-Chongqing in the west. In the middle of these four poles, a diamond-shaped six-axis is constructed, and Beijing-Hong Kong-Macao is just within the main axis in the north-south direction. The Beijing-Hong Kong-Macao Expressway is the most important north-south passage in China.

　　After more than 20 years of operation, the Beijing-Hong Kong-Macao Expressway has been extended all the way, supporting the coordinated development of Beijing-Tianjin-Hebei, the implementation of the Yangtze River Economic Belt and Guangdong-Hong Kong-Macao Greater Bay Area’s national strategy, and also driving and witnessing the rapid development of the areas along the route. Wuhan is the epitome of it. The thoroughfare of nine provinces and the Beijing-Hong Kong-Macao Expressway have made it one of the most developed cities in Central China in 20 years. Wuhan Dongxihu District, which is close to Beijing-Hong Kong-Macao Expressway, has become the most extensive logistics transit and distribution center in Central China.

　　The Hubei section of Beijing-Hong Kong-Macao Expressway has a total length of more than 290 kilometers. When construction started in 1998, it was the first expressway with a design speed of 120 kilometers per hour in Hubei Province. The rapid economic growth has brought about a rapid increase in passenger and freight traffic, and the Hubei section of the Beijing-Hong Kong-Macao Expressway has long been unable to meet the demand. In China’s 177,000-kilometer expressway network, some expressways built earlier are facing similar problems more or less.

　　Bin Fan: Especially in the central and eastern regions, some economically developed areas, the capacity of highways can no longer fully meet the travel needs of local people and the corresponding needs of passenger and freight transport. After the aorta is opened, the microcirculation is unblocked, and the aorta is opened, the vitality of the whole economy will be instantly driven.

　　After the reconstruction and expansion projects of Hebei and Henan sections of Beijing-Hong Kong-Macao Expressway were completed successively, the reconstruction and expansion project of the northern section of Hubei Province was officially launched. Hubei’s plan is to upgrade and expand the original two-way four-lane old road into a two-way eight-lane new road by widening subgrade and bridge.　

　　It doesn’t sound complicated. For Hubei, there are problems they must face. One of the challenges is that the whole reconstruction and expansion project must be carried out under the condition of ensuring the normal and safe passage of the whole road. Because the Beijing-Hong Kong-Macao Expressway is the north-south aorta, it cannot be cut off. This is the first time for Hubei.

　　Shen Diandong, commander of the reconstruction and expansion headquarters of Jiaotou Beijing-Hong Kong-Macao Expressway in Hubei Province: Our first multi-party meeting involved 42 units, and it was difficult to coordinate. The 42 units coordinated and acted in unison. This difficulty can be imagined.

　　The Hubei section of Beijing-Hong Kong Expressway is connected with many highways and railways, and dozens of related units need coordination. This is a test of the coordination of local departments. Two months ago, the reinforcement and upgrading of the Hanjiang Bridge on the Beijing-Hong Kong-Macao Expressway needed to be completed under the condition that half of the bridge deck was kept open. With the cooperation of traffic police, road administration, operating units and construction parties, the task of traffic guidance and reform was successfully and safely completed.

　　Sean, Captain of the 3rd Brigade of Beijing-Zhuhai Detachment of Hubei Traffic Expressway: This reconstruction and expansion is the first time in Hubei Province to try to construct while opening to traffic, including management experience and pressure from the construction unit, which we have never seen before. When we first started construction, we said that we would go all out to support and unconditionally choose to complete the task with good quality and quantity.

　　On the Hanjiang Bridge, half of the vehicles on the bridge deck pass normally in both directions, and the other half are under construction, which is rare in previous expressway construction. On the one hand, construction, on the other hand, freight and passenger vehicles whizzed past, which became a unique landscape in the reconstruction and expansion project of the northern section of Hubei Province of Beijing-Hong Kong-Macao Expressway.

　　Hubei, where great rivers flow, is a province of thousands of lakes. The Beijing-Hong Kong-Macao Expressway passes through rivers, lakes and many wetlands here. These areas have soft soil and high water content. The existing highway subgrade has been stable since it was opened to traffic for more than 20 years. However, the settlement of the widened new subgrade needs to be controlled to avoid potential safety hazards, which is another difficult problem in the reconstruction and expansion of Hubei section of Beijing-Hong Kong-Macao Expressway. They need to find local solutions. In the reconstruction and expansion section of East and West Lake of Beijing-Hong Kong-Macao Expressway, precast piles with an average length of 40 meters are being hammered into soft soil one by one.

　　Liu Baiping, Director of Wuhan Branch of the Beijing-Hong Kong-Macao Expressway Reconstruction and Expansion Headquarters in Jiaotou, Hubei Province: The technology of pre-cast piles is widely used in the building system, because the scope of building is relatively limited, but the highway is linear and occupies a wide range. The reason why we consider piling in this place is that the soft soil below is very thick, ranging from 10 to 20 meters thick to 40 to 50 meters thick.

　　Under the 9-kilometer-long pavement, precast piles will be densely covered, and the new road will be built on the subgrade reinforced by precast piles. This is also the first attempt in Hubei.

　　Liu Baiping: There is also a hat on the pile, which is equivalent to a stool. There are legs below, and a hat is worn on one leg. Most of the area is mainly stressed on the pile, forming a composite subgrade.

　　In addition to the treatment of soft soil subgrade, there are many attempts to adapt to local conditions in the process of reconstruction and expansion. In the choice of bridge width, Hanjiang Bridge is a newly built twin-tower cable-stayed bridge in parallel with it, while Fulunhe Bridge is a newly built pile-column assembled bridge like building blocks in parallel with the old bridge.

　　It is precisely because one needs to meet the navigation requirements of the Han River, and the other can save more time and construction cost, including the new use of construction waste, such as the waste asphalt mixture generated when milling and planing the road surface, which will be collected and reused. These practices are accumulating experience for more highway reconstruction and expansion in the future.

　　Bin Fan: As far as we know, the total mileage of the expressway reconstruction and expansion project under implementation has exceeded 5,000 kilometers. The reconstruction and expansion will be carried out immediately, including the Leiyang-Yizhang section of Hunan Province, including the northern section of Beijing-Zhuhai, which is the northern section of Guangdong Province, including the Beijing-Hong Kong-Macao Expressway. The national expressway aorta has been gradually opened, especially in promoting regional coordination and high-quality development, which has played a more obvious role.

　　In Hubei, the builders of the reconstruction and expansion of the Beijing-Hong Kong-Macao Expressway are still making a brand-new attempt. In the precast beam yard of Fulun River Bridge, the birth of each beam, from steel processing, concrete mixing, pouring and demoulding to steam curing of this beam before leaving the factory, has achieved digital control of the whole process. Before the appearance, each beam will be affixed with a QR code that belongs only to it. Like an ID card, it records all the information about this beam. And these information will also enter the building information model of Hubei section of Beijing-Hong Kong-Macao Expressway in the background. In reality, at the same time of reconstruction and expansion, a digital expressway is also being built simultaneously. This represents one of the most advanced management methods of expressway construction today.

　　After driving the rapid development of the areas along the route for more than 20 years, it is a new vision of the old expressway of Beijing, Hong Kong and Macao to help China’s economy develop with high quality in the new era. Before the May Day holiday, Shen Diandong, commander of the reconstruction and expansion of the Beijing-Hong Kong-Macao Expressway in Jiaotou, Hubei Province, specially invited the commander and engineers who built the old Beijing-Zhuhai Expressway more than 20 years ago to the scene of the reconstruction and expansion. A Beijing-Hong Kong-Macao Expressway, known as the "First Road" at that time, was a monument in the hearts of a whole generation. Now, it will glow with new vitality under the feet of a new generation of road builders. In the evening, the logistics park started the busiest time of the day again. These goods, which are related to our food, clothing, housing and transportation, will run in our direction on the expressway and in Beijing, Hong Kong and Macao in the trucks of drivers.

　　By the end of 2022, the total expressway scale in China has reached 177,000 kilometers, ranking first in the world. At the same time, the number of motor vehicles in China has also exceeded 400 million. In order to further open the highway aorta, it is estimated that 25 thousand kilometers of newly rebuilt expressway will be completed during the 14 th Five-Year Plan period. This will play an important role in supporting the national major strategy, improving the national comprehensive three-dimensional transportation network and promoting the high-quality development of transportation infrastructure. Smooth the aorta and help the great circulation. With the gradual progress of the project, everyone’s travel will be more convenient and smooth in the future.

　　Sohu Entertainment News Compared with movies, the scale of TV dramas that are watched by horrible people will naturally converge a lot. Among many TV stations in the United States, except Showtime, which is paid for, and HBO, which is quite deep, most TV dramas broadcast by other TV stations are secretive and dare not show more than half an inch of skin. I am used to seeing the characters wrapped tightly on the screen every day. Occasionally, a fragrant lens will make my pupils dilate. I want to press the pause button immediately and remember this unforgettable sexy moment.

　　Double-faced female spy Alias

　The female spy played by Jennifer Garner is absolutely generous. She often takes off her blouse and makes a sexy appearance. This has also become one of the successful elements for the drama to win a large number of fans. In Jenny Buddhism, you know that "good things should be shared with everyone".

　　Lost

　Sawyer always exudes a wild smell when he wears clothes on weekdays. When he walks out of the sea naked, which woman will not scream?

　　Grey’s Anatomy

　Although the pictures of the three female doctors taking a bath together received all kinds of bad comments, it did become a major attraction at that time, not to mention that after reading it, you can’t forget it. In contrast, Dr. "McSteamy"’ s bathing picture is a hundred times better, and how can the looming thigh lines not be reverie?

　　Beach guard Baywatch

　This TV series has a long history, but it is safe to say that the audience may not remember what was played in it at all, but you will never forget Pamela Anderson running on the beach in a high-heeled bathing suit.

　　Friday Night Lights

　As long as there is a picture of Tim Riggins, we can see those eight abdominal muscles waving to us, which makes people want to tip him.

Editor: Li Ming

Original Guo Lin Ji Lianmei Ji Lianmei Pharmacist

Everyone should have seen the hot search this morning about the death of 28 people in South Korea after being vaccinated with influenza vaccine, which made many friends worry about the safety of influenza vaccine.

I probably followed the news. At present, I suspect that two cases are related to anaphylactic shock. The relationship between other deaths and influenza vaccine has not been established and is still under investigation.

It is said that the death toll rose to 36 in the afternoon, but South Korea did not stop the flu vaccination. It is likely that the death has nothing to do with the vaccine. This incident is unusual, and I will continue to pay attention to the progress of this incident.

With regard to these two deaths suspected of anaphylactic shock, let me popularize the knowledge of adverse reactions related to influenza vaccine.

Vaccines are medicines, and adverse reactions may occur when any medicine is used. Anaphylactic shock is a rare adverse reaction that may occur when any vaccine is inoculated.

Moreover, whether to treat diseases or prevent diseases, whether to use drugs or not is a choice after repeatedly weighing risks and benefits.

As far as influenza vaccine is concerned, it is a relatively mature drug. If its adverse reactions are weighed against the risk of serious complications after getting the flu, the advantages of influenza vaccination must outweigh the disadvantages. Therefore, mainstream medical views have always recommended that everyone get the flu vaccine, and I personally recommend it, and I have always adhered to the relevant knowledge of popular science influenza vaccine.

There are three types of influenza vaccines this year, namely inactivated trivalent influenza vaccine and tetravalent influenza vaccine by intramuscular injection, and attenuated trivalent influenza vaccine by nasal spray.

Below, we will talk about their common adverse reactions respectively.

First, inactivated influenza vaccine (including trivalent and tetravalent)

The common side effects of inactivated influenza vaccine by intramuscular injection are mainly manifested in two types:

Local reaction, that is, swelling, induration, pain, burning sensation at the inoculation site, etc.

Systemic reactions, namely fever, headache, dizziness, lethargy, fatigue, myalgia, general malaise, nausea, vomiting, abdominal pain, diarrhea, allergies, etc.

These side effects have two characteristics:

First, it is usually mild, with few severe reactions.

Second, it can fade by itself within a few days.

In order to look more intuitive, we summarize these common side effects and their countermeasures as follows:

Two, freeze-dried nasal spray influenza attenuated trivalent vaccine

In this year (2020), freeze-dried live attenuated nasal spray influenza vaccine was newly launched in China. During the phase III clinical trial of the vaccine, 4,500 subjects aged 3-17 were vaccinated once, and the safety was observed for more than 6 months after vaccination. The results are as follows:

From the data point of view, the overall safety of this vaccine is good. The safety data of similar products abroad are similar, with mild adverse reactions and self-healing. Serious adverse reactions are rare.

However, because the vaccine has just been applied in China this year, the biggest challenge for vaccinators and recipients is unfamiliarity, so both sides need to strictly grasp the contraindications of attenuated nasal spray vaccine, so as to avoid predictable adverse reactions.

For example, although there is a needle in the vaccine box, this needle is used to prepare lyophilized powder for dissolving the vaccine, and the final vaccine is inoculated by "nasal spray". If the vaccinator is negligent and takes it for granted that he can inject with an injection needle, it will bring harm to the vaccinator.

For example, if the vaccinator has rhinitis or asthma, he can’t use the nasal spray live vaccine, because the nasal mucosa congestion and swelling caused by rhinitis may weaken the effect of the vaccine, and the rhinitis that may occur after vaccination may also be confused with the original rhinitis. It is also not suitable for children who are regularly receiving nasal spray treatment.

Another example is that the vaccine is a live vaccine, which is not suitable for children with impaired immune function, because it may theoretically cause children with impaired immune function to contract the flu. However, children with impaired immune function can be safely vaccinated with inactivated influenza vaccine.

After vaccination, you need to observe in the immune unit for 30 minutes to ensure that there is no serious allergic reaction before leaving.

Finally, I would like to reiterate my view on influenza vaccine: it is a relatively mature drug. If we weigh its adverse reactions with the risk of serious complications after getting the flu, the advantages of influenza vaccine must outweigh the disadvantages.

I hope everyone will not give up eating because of choking.

I also recorded a short video of related knowledge, which will be posted on the video number tomorrow. Welcome to identify the QR code below and pay attention to my video number.

If the dry goods explained in the video are helpful to you, please help me share them with more parents. Every praise, forwarding and comment from you is the motivation for me to keep updating the video number. Thank you for your support!

People who like this content also like it.

Original title: Common Adverse Reactions of Influenza Vaccine and Countermeasures

Read the original text

According to Jiading News, on October 18th, the Standing Committee of the Fifth National People’s Congress in Jiading District of Shanghai held its 47th meeting. The meeting voted to adopt the Decision of the Standing Committee of Shanghai Jiading District People’s Congress on Accepting Yuan Lee’s Request to Resign as Deputy Head of Shanghai Jiading District and the Decision of the Standing Committee of Shanghai Jiading District People’s Congress on Accepting Zhou Wenjie’s Request to Resign as Deputy Head of Shanghai Jiading District. The meeting decided to appoint Dong Yiwen, Wang Hao and Xia Weidong as deputy heads of Jiading District.

Among the three newly appointed deputy district heads, one "post-70s" is Dong Yiwen, former member of the Standing Committee of Jiading District Committee and organization minister. A non-party cadre is Wang Hao, chairman of the Jiading District Committee of the Democratic Progressive Party. There is also a long-term work in the public security system, and once served as a member of the Party Committee and deputy head of the Economic Investigation Corps of the Shanghai Public Security Bureau.

Dong Yiwen, female, born in February 1973, Han nationality, from Yinxian County, Zhejiang Province, joined the work in July 1995 and joined the Communist Party of China (CPC) in December 1994. She holds a university degree, holds a master’s degree in public administration and is an economist. He is currently a member of the Standing Committee of Jiading District Committee and the Party Group of the District Government.

He has served as secretary of Yangpu District Real Estate Management Bureau, assistant to the section chief of Propaganda Department of District Housing and Land Management Bureau and Weibaixin (Group) Co., Ltd., department-level cadre of District Housing and Land Management Bureau, deputy secretary of Party branch of Shanghai Siping Property Management Company, director of the office of District Housing and Land Management Bureau and Weibaixin (Group) Co., Ltd. (who also serves as the section chief of Legal Affairs Department of District Housing and Land Management Bureau), deputy secretary of Yangpu District Committee of Communist Youth League, secretary of Yangpu District Committee of Communist Youth League and party secretary. Deputy Secretary of the Party Working Committee of Kongjiang Road Community (Street), Director of the Office, Deputy Director of the Organization Department of the District Committee, Secretary of the District Social Work Party Committee, Deputy Director of the Organization Department of the District Committee (director level), Standing Committee of Jiading District Committee and Minister of the Organization Department of the District Committee.

Wang Hao, male, born in April, 1968, Han nationality, Shanghainese, joined the work in July, 1990, graduated from the Democratic Progressive Party, with a bachelor’s degree in science, and is a first-class middle school teacher. Former director of Minhang District Education Bureau and chairman of Democratic Progressive Party Committee.

He has served as a teacher, head of teaching and research group and director of Shanghai Shanghong Middle School, deputy section chief and chief of Chinese Education Department of Minhang District Education Bureau, chief of general education department of Minhang District Education Bureau, chief of general education department of Minhang District Education Bureau, deputy director of District Education Bureau, deputy secretary-general of District Political Consultative Conference, deputy director of Special Committee Office, deputy secretary-general of District Political Consultative Conference, director of Special Committee Office, chairman of Minhang District Committee of China Democratic Progressive Party, deputy secretary-general of District Political Consultative Conference, director of Special Committee Office and director of District Education Bureau.

Xia Weidong, male, born in December 1968, Han nationality, Shanghainese, joined the work in July 1988, and joined the Communist Party of China (CPC) in June 1993, with an in-service university degree. He is currently a member of the party group of Jiading District Government.

He has successively served as police officer of Jianghai Police Station and Nanqiao Police Station of Fengxian County Public Security Bureau, member of Nanqiao Police Station of County Public Security Bureau, deputy director of Nanqiao Police Station of County Public Security Bureau, deputy commander of Criminal Investigation Brigade of County Public Security Bureau, deputy commander of Criminal Investigation Detachment of Fengxian Branch of Public Security Bureau, director of Jianghai Police Station of Fengxian Branch of Public Security Bureau, member and director of Party Committee of Fengxian Branch of Public Security Bureau, assistant director and director of Command Division, member and deputy director of Party Committee of Qingpu Branch of Public Security Bureau.

(The original title is "Personnel | Three Newly Appointed Deputy District Heads in Jiading District, Shanghai")

1905 movie network news The brand-new drag racing action blockbuster (Baby Driver), produced by British WorkingTitle and directed by British genius director edgar wright, has been continuously praised since it landed in mainland cinemas. The word-of-mouth rating of the film on authoritative rating websites such as Time and Douban ranked first in the same period, and it was also praised by domestic authoritative media, film critics, KOL and other parties. Peach trees, poisonous Sir, independent fish, etc. are even more rare "three consecutive pushes", constantly giving Amway this film to the audience: "Cool! What a leg shake! Entertainment commercial films can also be made with personality and good looks. ""The anti-routine is full of creativity, and it is difficult to find the same kind when looking around the film history! "

　

As a typical British director, edgar wright is well-known for his wild imagination and personal interest in smuggling illicit goods. This new work "The God of Car Theft", which has been prepared for many years, has brought his dual attributes of "fans" and "fans" to the extreme. Under his carefully selected 30 leg-shaking BGM, he not only filmed the action scenes such as racing, parkour and gun battles, but also "hidden".

　

Let’s take a deep look at what "stalks" in the film are worth remembering:

　

[Salute/Line Stud]

　

1. Long-shot tribute to the previous work

　

Shortly after the opening of the film, the long shot of "Baby" buying coffee for gang members just pays tribute to director edgar wright’s own film "Shaun the Zombie". In "Shaun the Zombie", there is also a similar long opening shot, which shows the walking corpse of Shaun, the protagonist played by simon pegg, who goes to the supermarket to buy drinks.

　

2&3. My ears don’t work, so I bought the wrong mask.

　

In the second gang robbery in the movie, Brother Dao said at the meeting that he wanted to buy the mask of Michael Myers, the killer in the Moonlight Panic series. As a result, the pronunciation of "Michael" and "Mike" was confusing, and finally he bought the mask of Mike Myers, the main actor, which became a funny stalk and appeared in the scene where gangs spit on each other before the robbery.

　

4&5, and "Aunt Mei" are all supporting roles … …

　

In the movie, "Baby" and his adoptive father sat on the sofa and watched TV at night. When they changed channels, Meryl Streep, Brad Pitt and Disney’s Monster Company 2 appeared on TV. Moreover, these movie lines that flashed on TV also appeared in the following plot.

　

In other words, the "baby" is learning and using the movie lines that have appeared on TV. For example, in Monster Company 2, "We are a team, and nothing is more important than our friendship." This is what "Baby" said when she was threatened by Doug on a date with Deborah and had to compromise. Besides, the sentence "These children grow up so fast!" in "Love is Complicated" "Baby" took Brother Dao’s son to seek information at the post office, and the counter staff asked him how old his child was.

　

6. Fight Club — — Don’t let Buddy see blood.

When changing channels, Pete’s Fight Club appeared twice before and after, and Buddy also recited the lines of Fight Club when he first saw JD’s hat tattoo: "Will this work?" In fact, it indicates that Buddy’s ending will be blackened by love, suggesting that the baby and Buddy will finally fight to death.

　

Director edgar wright talked about the egg in an interview: "I heard that the matador had to stand on the ground to end the battle, so the’ baby’ had to get off at last." At the restaurant, Darlene also said to the bat, "Don’t let Buddy see red, or he will get out of hand." It also implies the egg of bullfighting. Director Edgar also pointed out that "when he finally tried to kill the baby, he was immersed in the red light."

　

7. Pay tribute to "Desperate Mandarin Duck"

　

The images of "Baby" and Deborah, Buddy and Darlene in the film all pay tribute to the classic "Bonnie and Clyde": Buddy and Darlene kill each other with heavy machine guns in the film; "Baby" and Deborah are trying to escape from the world. But at the end, "Baby" didn’t run away with Deborah, but chose the right path, creating a sunny and positive ending, instead of ending in tragedy like Buddy and Darlene’s "Bonnie and Clyde".

　

8. "Suspects don’t need to" pay tribute to Quentin

　

The film also pays tribute to the plot of Quentin’s "Reservoir Dogs", and the combination of people involved in the task changes every time. In "Auto Thief", director Edgar made three robberies in order to reflect this point, each time it was a brand-new combination of people, and the third time was definitely the most wonderful super combination.

　

9. Pay tribute to the release day

　

The director has mentioned many times that the movie The Driver, which was released on July 28th, 1978, was one of the sources of inspiration for Auto Thief. The release date of "Tiger’s Mouth Pulling Teeth" appeared twice in the film: once in the long shot of "baby" buying coffee, the release date was graffiti on the street wall; The other time was the number on the clothes of "Baby" after he went to prison (2871978). Because the director was British, he put the date before the month, not the American 7281978.

10. Pay tribute to the expression of sunglasses

In the film, the "baby" bowed his head to hold sunglasses and looked up to pay tribute to Kubrick’s clockwork orange. "Head down, eyes up, I call it Kubrick lens. Every time I want to shoot, I always say to Ansel: "clockwork orange" expression! " Director Edgar revealed in an interview.　

　

11. "The car is heavy enough to overturn the police car!"

　

At the gang meeting before the second robbery, "Bat" once questioned that the "baby" wearing headphones was not listening to Brother Dao at all, and then "baby" told the whole process without breathing. One of them said, "The car must be heavy enough in case the police car needs to be overturned." This is reflected in the final life-and-death confrontation with Buddy. The "baby" directly knocked over the police car stolen by Buddy.

　

[Musical Feelings Terrier]

　

12. Why is the hero called "baby"? Why is the movie called "Baby Driver"?

　

Director edgar wright has explained on many occasions that generally in criminal gangs, in order to hide their identity, everyone is commensurate with the code name, and "baby" is the youngest one in the gang, so this code name is more appropriate.

　

The selection of the classic lyric B-A-B-Y from the hit record Carla released by "Memphis Soul Queen" in 1966 as the chat material for "Baby" and "Deborah" also echoes this setting. Interested viewers will also find that "Baby" really picked up the vinyl record of this album. The real name "Miles" of "baby" is in harmony with his identity as an escape driver. As for the title "baby driver", it is a classic single of the same name from the famous folk group Simon&Garfunkel.

　

13. The 15-year origin of "shaking your legs for six minutes"

　

The most talked about in "Car Thief" is "shaking your legs for six minutes" at the beginning of the film. But in fact, as early as 15 years ago, director edgar wright tried this creative trick to direct MV for MintRoyale, an electronic band from Manchester, England. This song is called "Blue Song" and included in the band’s 2007 album "Pop is… "in. This MV, like Auto Thief, tells the story of robbing a bank. In this MV, Noel Fielding, a British comedian, plays a No.2 driver who loves music as much as "Baby".

　

14. "The King of Soul Songs" Jamie Foxx teased his friend Barbara.

　

Bartz, the crazy shit-stirring stick in the gang, is played by Jamie Foxx, the Oscar winner and musician. In the film of 2004, he perfectly restored ray charles, the father of American soul music, with a fake performance and called him the Oscar in one fell swoop. As an outstanding musician, he has been nominated for Grammy Awards many times.

　

Interestingly, although "Bartz" played by Jamie in "Car Thief" is dressed as a hip-hop musician, he pretends not to know who Barbra Streisand is — — And this "award-winning professional" who has many authoritative awards such as Oscar, Tony Award, Grammy Award, Emmy Award and Golden Globe Award is actually a good friend with Jamie in private.

　

15. It’s unlucky to listen to Knocking on the Door of Heaven before robbery … …

　

"Bartz" said of his former teammate: "We were safe, but he hung up because he was listening to Knockin’On Heaven. "Make the audience laugh. This song comes from Bob Dylan, a famous American folk singer. Yes, it is the one who won the Nobel Prize last year and almost didn’t receive it.

　

And the phrase "Bartz" is not groundless — — Edgar wright, the director, specially interviewed real robbers for filming this film and asked them what songs they would listen to before the "action". Besides this song, there are The End of the Road and Hotel California that can’t be listened to. Interestingly, one of the robbers named Joe Loya also made a guest appearance as a robbed bodyguard in the film.

　

[Friendship Guest Stud]

　

16. Jon Spencer started and finished.

　

At the beginning of the film, the music of the "shake your legs for six minutes" racing scene comes from Jon Spencer Blues Disclosure’s "Bellbuttoms". The last line (not narration) before the end of the whole film is also from the lead singer Jon Spencer.

　

Yes, he is the one who said to the "baby", "Here’s a letter for you, boy!" The prison guard. The director said that he hoped to finish what he started, so he chose this song and wanted to end it with his voice.

　

17. red hot chili peppers legendary bassist "Brother Flea" has been addicted to drama again.

　

Eddie in the second wave of robbery gangs in the film doesn’t have much time to play, but he actually plays a lot. He is the legendary bass player "Flea" in red hot chili peppers. In addition to being a musician, he also likes to guest play some small roles in movies, such as Needles in the series and Jake, the thinking worker in the series. Coincidentally, there is also a character named "Doc" in the first part of Back to the Future, and "Griff" in the second part, which just corresponds to the code names of Kevin Spacey and jon bernthal in Auto Thief.

　

18. Baby’s mother is really a singer.

　

The most sensational of "Auto Thief" OST is "Easy". Besides the original version of Lionel Richie (yes, the one who sang "Say You, Say Me"), the film also included a cover version of American female singer Sky Ferreira. In the film, her version of the tape is not only regarded as a relic of the "baby" mother, but also played the "baby" mother herself.

　

19&20, these guys shouted Banana! The "underworld" is actually a musician.

　

The leader of the short white arms dealer (black policeman) who was killed by Bartz was played by the famous film musician paul williams. He has been nominated for the best original song at the Academy Awards for many times, and in 1977, he won both an Oscar and a Grammy for the theme song of his lyrics "Evergreen". Coincidentally, the singer and composer of this award-winning work is barbra streisand, whom Jamie Foxx "teased" in "Car Thief".

　

Besides, when Brother Dao met Baby in a fancy restaurant, the two gangsters around him were also famous hip-hop musicians, namely Big Boi and Killer Mike. The two have released a single together, and the former is a member of Outkast, a famous Atlanta hip-hop group, and one of the creators of Chase Me, the theme song of Auto Thief.

　

21, "adoptive father" seiyuu turned out to be the director’s idol.

　

The actor named "Baby" adoptive father is C.J. Jones. He is the first African-American deaf-mute comedian to play a movie on the big screen in Hollywood. He is really deaf-mute, and he also uses real sign language when playing. Many viewers were moved by their father and son’s previous affection.

　

As mentioned above, The Driver is one of the sources of inspiration for this film. In addition to paying tribute to the release date of the film, Edgar even wanted to let the film director walter hill play a role directly, but unfortunately it was not done because of the schedule. However, in the final trial scene of the film, the legendary director gave his voice by translating for the "baby" adoptive father and acted as the "seiyuu" of the second adoptive father.

　

22. The "Haier Brothers" in Atlanta came out again.

　

When the "baby" shot and wounded Buddy in the restaurant, he escaped with Deborah and hijacked a red sports car. The two young people in the sports car who were hip-hop in America were online celebrity twins, who were famous in the United States. The "yellow and violent" brothers often appeared in movies, magazine covers and the most popular MV of traprapper.

　

[There is no one who controls obsessive-compulsive disorder in this detail … … 】

　

23. The lyrics go over a wall, and spades turn into hearts in seconds.

On the way of "Baby" buying coffee and dancing, every lyric of BGM’s Harlem Shuffle appeared in various forms where he passed by. The graffiti on the background wall was originally a spade, but after the "baby" saw his favorite sister, the spade immediately turned into a heart. According to foreign media reports, this graffiti was specially drawn by the director who hired local artist Peter Ferrari.

　

24, listening to songs must be put from the beginning, sunglasses just can’t be taken off.

　

The image of "baby" sunglasses and headphones is not only cool, but also many people want to isolate themselves from the outside world.The shadow of the world’s urban civilization. For example, be sure to put the songs in the iPod from the beginning, and step on it well before driving; For example, if sunglasses are knocked out, they should be replaced immediately. The setting of sunglasses and headphones just reveals his obsessive-compulsive paranoia in his heart, and sometimes shows a little black humor, which is probably one of the reasons why the director can be sought after by fans all over the world.

　

25. There is a story behind the robbers’ tattoos.

If you look closely, you will find that the tattoos on the necks of several criminals in the gang and their character characteristics can always form interesting ones.Correspondence. For example, "her" and "his" tattooed by "Bonnie and Clyde" Buddy and Darlene respectively imply their inseparable love relationship; For example, Bartz really has several "bats" tattooed on his neck; For example, Lanny Joon, a Korean-born actor, initially tattooed a grandiose "HATE" (hatred). In order to expand business, the letter "E" was forcibly erased and changed to "HAT" (hat), but in fact "JD" (John Doe) means "Anonymous" in English, and this role soon got a lunch.

　

[which cars have the protagonist aura? 】

　

In the whole film, at least 34 different models of cars can be seen. The most interesting thing is that because the director specially interviewed the real robbers before, he knew that the cars they used to commit crimes would never be luxury cars like those in "Speed and Passion", but family cars with low visibility and superior performance, such as Subaru Xiaohong, the favorite car of "Baby", and Escalade, Yukon and Chevrolet Avalanche. The luxury car in the heroine Deborah’s heart is a retro classic car.

　

26. Subaru second-generation impreza WRX

　

The highlight of the film is the coquettish and domineering red Subaru in the opening six minutes. But before shooting, thisThe Subaru was changed from a full-time four-wheel drive to a rear-wheel drive, and the extremely difficult U-Turn and the continuous drift of more than 180 degrees in the film were completed. The basin friends who love cars should not blindly imitate it!

　

27, the second generation Chevrolet K5 Blazer

At the end of the film, "Crash Wars", "Baby" drives a second-generation K5 Blazer and Buddy produced in 1980s.Dodge Charger police cars fought each other, and finally Buddy’s car was pushed off the patio.

　

28, 1959 Chevrolet ImpalaConvertible.

　

Deborah’s ideal "luxury car" is such an old guy from the 1950s, which shows that this girl is still very tasteful. At the end of the film, as soon as the "baby" released on bail walked out of the prison gate, it was a good ending to see a beautiful woman and a beautiful car greeted him.

　

29. User-made GTA5 video God restores "shake your legs for six minutes"

　

The opening "Shake Your Legs for Six Minutes" of "Car Thief" attracted the attention of many grand theft auto v players. A foreign player named Domestic Mango on Youtube also used this game to make another 4-minute and 37-second short film, which accurately restored the most important scene of diversion, drift and sudden braking in the six-minute paragraph, and made a sincere tribute to this brand-new blockbuster that paid tribute to many classic blockbusters.

　

[Atlanta Real Landmark Test]

　

The whole film was filmed in Atlanta in the eastern United States. In order to show more realism, the director added many local landmarks and brands, and the details were embarrassing.

　

30. "Criminal Records"

　

When "Baby" first heard Deborah humming "B-A-B-Y" in the restaurant, she immediately bought the record and went home to sing and dance happily. The place where the "baby" in the film buys records is this old-school vinyl record store named Criminal Records in Atlanta, USA.

　

31. Bacchanalia Restaurant.

　

Opened in 1993, it is one of the most acclaimed high-end restaurants in Atlanta. In the film, Darlene and Buddy mentioned this restaurant when they kissed in the elevator, and then in the laundry room, "Baby" also invited Deborah to this restaurant for a date, calling it "the best place to drink and eat in the city."

　

32. Sweet Auburn apartment of "Baby"

　

The apartment where the fictional "baby" lives in the movie is actually located in the historic district of Sweet Auburn, which is near the historical site of Martin Luther King, and was once an important political, economic and cultural center for African Americans in the first half of the 20th century. We can imagine what the "baby" who lives here does every day. Maybe he will visit the town market here, where there are the best meat products in Atlanta, bakeries, bookstores, pharmacies and the most popular restaurants in 11 cities.

　

33. Octane Coffee

　

Before every important meeting of the robbery gang, "Baby" always goes to this store to buy coffee. The name "Octane" is perfect for a fast-paced car chase movie.

　

34. Goodfellas Pizza

　

When "Baby" tried to get rid of his life as a runaway driver who robbed a bank, he began to work as a delivery boy at Goodfellas Pizza, hoping to bring joy to others with his own fast driving skills.

　

35. Romantic road trip to the extreme: ROUTE 66 (Route 66)

　

Deborah described this passage when she first met Baby: "I want to drive a vintage luxury car that I can’t afford, and there is no destination all the way west, only music and roads." What a romantic thought (mood). My little sister should be an old driver, too.
　

On the wall of the restaurant where Deborah works, the most famous brand of route 66 in the United States hangs. This most famous "Mother Road" has witnessed American history since the first half of the 20th century, from Chicago across the land of the United States to Los Angeles, and it is also the location for movies such as movies and movies.
　

In fact, before the British director wrote the script, he gave himself a trip to road trip across the United States. He drove from new york to L.A. by himself, and I believe he also incorporated many special feelings in his journey at that time. Therefore, at the end of the "anti-climax" of the movie, the pair of desperate mandarin ducks staged a romantic elopement. They may really want to drive this scenic avenue from Highway 20, but unfortunately it still backfired. After Baby was arrested, Deborah mailed him a postcard, including a mural from Bo’s Diner in route 66. In the end, on the day when Baby was released from prison, Deborah was driving a vintage car. Perhaps this road trip symbolizing freedom and dreams will finally begin.

　

Isn’t it romantic? There are too many connotations to see? Edgar wright, the director, ingeniously combined music with racing and the anti-type and anti-routine of action elements. How can you enjoy it with two brushes and three brushes? "Auto Thief" is being shown in China. If you miss it, your summer will be incomplete!

CCTV News:On July 12th, "News Network" reported a number of economic data of China in the first half of the year. The data showed that China’s economic operation continued to improve, with strong resilience, great potential and sufficient vitality.

China’s summer grain harvest

According to the data released by the National Bureau of Statistics on July 12th, in 2024, the total output of summer grain in China was 149.78 million tons, or 299.6 billion Jin, an increase of 7.25 billion Jin or 2.5% over 2023. The national summer grain harvest was good.

The sown area of summer grain remained stable. In 2024, the sown area of summer grain was 399.2 million mu, of which the sown area of wheat was 346.361 million mu, an increase of 475,000 mu compared with 2023.

The yield of summer grain has increased. The national summer grain yield reached 375.2 kilograms per mu, an increase of 9 kilograms or 2.5% over the previous year, of which the wheat yield reached 399.1 kilograms per mu, an increase of 2.6%. Regionally, among the 25 summer grain producing areas, 21 have increased their output.

In the first half of the year, China’s trade in goods exceeded 21 trillion yuan, a record high in the same period.

The General Administration of Customs announced on July 12th that in the first half of this year, the total import and export value of China’s goods trade increased by 6.1% year-on-year, the trade scale reached a new high, and the quarterly trend continued to improve.

According to customs statistics, in the first half of the year, the total import and export value of China’s goods trade was 21.17 trillion yuan, a year-on-year increase of 6.1%. Among them, the export was 12.13 trillion yuan, up 6.9%; Imports reached 9.04 trillion yuan, up 5.2%.

In terms of trade scale, in the first half of the year, the import and export scale of China’s goods trade exceeded 21 trillion yuan for the first time in the same period. The growth rate of import and export accelerated quarter by quarter, with an increase of 7.4% in the second quarter, which was 2.5 and 5.7 percentage points higher than that in the first quarter and the fourth quarter of last year respectively. The quality of import and export of goods continued to improve and the scale grew rapidly.

In terms of trade patterns, in the first half of the year, China’s general trade import and export was 13.76 trillion yuan, up 5.2%, accounting for 65% of China’s total foreign trade. In the same period, the import and export of processing trade was 3.66 trillion yuan, an increase of 2.1%, accounting for 17.3%. In addition, China’s import and export by bonded logistics was 2.96 trillion yuan, an increase of 16.6%.

From the perspective of trading partners, in the first half of the year, China and its largest trading partner — — The total trade value of ASEAN was 3.36 trillion yuan, up by 10.5%, accounting for 15.9% of China’s total foreign trade value. In the same period, China’s total import and export to countries that jointly built the "Belt and Road" was 10.03 trillion yuan, an increase of 7.2%.

From the perspective of business entities, in the first half of the year, the import and export of private enterprises was 11.64 trillion yuan, up 11.2%, accounting for 55% of China’s total foreign trade, up 2.5 percentage points over the same period last year. In the same period, the import and export of foreign-invested enterprises and state-owned enterprises both increased.

Financial support for the real economy remained stable in the first half of the year.

According to the data released by the People’s Bank of China on July 12th, the stock of social financing scale at the end of June was 395.11 trillion yuan, up 8.1% year-on-year. Among them, the balance of RMB loans to the real economy was 247.93 trillion yuan, up 8.3% year-on-year. Financial support for the real economy remained stable.

China’s civil aviation economy continued to improve in the first half of the year.

The reporter learned from the Civil Aviation Administration of China on July 12 that in the first half of the year, China’s civil aviation economy operated steadily and steadily. By the end of June, the investment in fixed assets in the whole industry was 61.52 billion yuan, up 33.2% year-on-year, and the total transportation turnover was 70.3 billion tons kilometers, up 32.2% year-on-year. The domestic and international markets of air transportation both exceeded the same period in 2019. The scale of international passenger transport recovered to 81.7% in the same period of 2019.

In the first half of the year, the number of passengers sent by national railways exceeded 2 billion.

The reporter learned from China State Railway Group Co.,Ltd. on July 12th that in the first half of the year, the national railways sent a total of 2.096 billion passengers, up by 18.4% year-on-year, and the railway passenger volume, passenger turnover and other indicators ranked first in the world. The daily average number of passenger trains was 10,256, a year-on-year increase of 9.4%.

In 2024, the Beijing-Hangzhou Grand Canal was successfully completed.

The reporter learned from the Ministry of Water Resources that recently, in 2024, the water replenishment task of the Beijing-Hangzhou Grand Canal was successfully completed. Since the full-line flow was realized on March 20, the full-line water state has been maintained at present, and the full-line water duration has exceeded 100 days for the first time. As of July 1st, the water supply sources have accumulated 1.536 billion cubic meters of water to the north section of the Yellow River of the Beijing-Hangzhou Grand Canal, completing 181.8% of the planned water supply.

　　China news agency, Beijing, November 1 (Reporter Zhang Su) On November 1, the reporter confirmed from China Aerospace Science and Industry Corporation that they plan to set up a satellite company to build a satellite-borne narrowband global mobile Internet of Things according to the commercialization model.

Data Map: At 12: 11 on January 9, China’s "Kuaizhou No.1 A" general-purpose solid launch vehicle was successfully launched in Jiuquan, Gansu. China News Agency issued Wei Zhang photo

　　China Aerospace Science and Industry Corporation is the largest missile manufacturer in China. In recent years, they have repeatedly made "heavy punches" in the field of commercial aerospace. Fast boat series solid launch vehicles are its "fist products". Since the research and development began in 2009, three fast boat rockets have been successfully launched, and it is planned to achieve "four rounds a week" in 2018. If successful, this will set a new world record for the launch frequency of a single type of launch vehicle.

　　The latest news is in satellite development. Tan Qianhong, secretary of the Party Committee of the Fourth Research Institute of China Aerospace Science and Industry Corporation, revealed during the interview that the plan for establishing a satellite company has been submitted to the group and is awaiting approval.

　　Tan Qianhong said that the satellite company will mainly develop and launch small satellites operating in low orbit and form constellations by networking to provide narrowband communication services, thus improving the communication level in remote areas and at sea.

　　The reporter noted that this description is consistent with the "Cloud Project" proposed by China Aerospace Science and Industry Corporation. "Xingyun Project" is a low-orbit small satellite communication constellation system, including 100 low-orbit satellites, which can realize the seamless acquisition, transmission and sharing of Internet of Things information around the world, and build an information ecosystem including cloud computing, big data and other services.

　　"Xingyun Project" was independently developed by the Fourth Research Institute of China Aerospace Science and Industry Corporation. According to Guo Yong, president of the Institute, the first technical verification satellite of the project, Xingyun Experiment No.1, was successfully launched into orbit on the Kuaizhou No.1 carrier rocket in January this year, and two more experimental satellites are planned to be launched in 2018.

　　Guo Yong also said that the Institute successfully developed the first rapid control mirror device for satellites in China. He told the China News Service reporter that by adjusting the mirror, the laser beam can be changed to point to another satellite without changing the attitude of the satellite to realize space optical communication. After testing, the comprehensive performance of this product has reached the international advanced level. (End)

Special feature of 1905 film network It’s another Mid-Autumn Festival. With several new Chinese films joining the station circle, the market that has been depressed for many days is about to revive.

As the first film, directed by Qian Jiale and starring Ekin Cheng, Jordan chan, Xie Tianhua, Lin Xiaofeng and Qian Jiale, it is undoubtedly the most anticipated film by the audience at present.

No matter the number of people who want to see it, the market arrangement or the first day box office, it is currently at the top of the films of the same period, which can be described as "threatening".

Although we have a large number of die-hard fans for 22 years, and although we are still friends in need, will we really get used to seeing the hot-blooded teenagers who used to fight from Causeway Bay to Tsim Sha Tsui with knives become middle-aged uncles who are now fighting overseas with guns?

Fortunately, after watching the whole film, all the worries and doubts are "superfluous": the background has moved to Inner Mongolia, Budapest, Hungary and Fukuoka and Montenegro, which has made the film break away from the traditional routine and become an international large-scale action movie.

In other words,In terms of scale and effect, The Golden Brothers has surpassed the traditional Jianghu movies.

In the plot, there was a hot scene from the beginning, and then there was no sloppiness all the way, and all kinds of blood were boiling, but they didn’t fight blindly, especially in Budapest, where everyone "outsmarted" first, then got involved in the plot, and then set off a gun battle, which made people scream and enjoy themselves in one go, and the reversal and conflict among them made people sweat.

But don’t think that this is all. Later, such as the villain plan, the Japanese flying car, and even the final battle of "siege" are quite enjoyable, and one wave after another makes people applaud.

At the same time, we did not forget to continue the brotherly feelings of the past films, especially a few literary dramas, which also earned a lot of tears from the audience. It can be seen that as a director, Qian Jiale can be described as "both civil and military", which has not only produced the usual lively rhythm of Hong Kong films, but also sublimated them to the international level of action, and even preserved the classic feelings. It is really not simple.

In a word, The Golden Brothers is a transnational action film with special feelings and characteristics.Regardless of the audience or fans of genre films, it is enough to say that they are satisfied!

In fact, the "Golden Brothers" group began in the film in 1998 and has been formally formed for exactly 20 years.

But for many viewers who like them, when did this feeling begin?

It is said that ten or twenty years ago, the mainland was still the era of video halls. From videos to VCDs, there were always a group of young fans watching various Hong Kong movies around a 20-inch TV.

Among them, the most clamoring for the boss to show it must be as many as dozens of this series of movies.

After seeing blood boiling or tears, "Causeway Bay" has become the most vivid landmark memory of that generation of young people for Hong Kong, and "I am a bearer in Causeway Bay" has also become one of their most common catchphrases. Even the organizational composition, location distribution and membership power of "Hong Xing" and "East Star" have been well analyzed by them, as if they were really "Jianghu people".

Film stills

Even the audience who have seen this series of movies, no matter from the north or the south, will basically hum two sentences: "Jiandong always basks in the sun, I play in the sun", "To forget the wrong and to miss the past" and "I will rush in at will and look forward to it".

Not to mention that at that time, young people all over the street were imitating Chen Haonan’s hairstyle or pheasant’s expression, and even putting a watermark "tattoo" on their bodies, as if people could become characters in movies if they saw a pattern. …

All the details are destined to evoke the classic feelings of the audience from all aspects after more than 20 years. For example, in 2015, the five brothers came to four:

"friendship days Concert" has traveled all over the country. Whenever the melody of "friendship days" rings, there is always a chorus:

In 2017, the online drama "Anti-Black" with a good reputation in the mainland, in addition to "Pheasant Brother" Jordan chan, there are also "Big Brother B" Wu Zhixiong and "East Star Camel" Wai-Man Chan, etc.

Of course, the variety show "Where is Dad Going 5" is indispensable. Only Jordan chan "loses his temper" with his son Jasper, and netizens will feel that "Pheasant Brother is possessed!" ：

The film directed by Wu Junru for the first time also has one of the indispensable elements:

Including those that haven’t been released, and with the participation of Ekin Cheng, Xie Tianhua and Lin Xiaofeng, it was called a reunion by the audience.

In short, even if time flies and youth is gone, the audience will always accept this "feeling card" that has lasted for more than 20 years. But many people may not know that the birth of this IP is also a secret history of Hong Kong movies.

It is said that before the filming of the first film, director Liu Weiqiang and screenwriter Wen Juan were still "enemies", which was related to Wen Juan’s various ridicules and curses on the film directed by Liu Weiqiang on the radio. Liu Weiqiang, who was furious, planned to beat him. He didn’t want Jing Wong to pull them together, but he proposed a three-person company to film, which was as dramatic as "becoming sworn brothers" in reality.

To this end, the three also set up a film company that was very representative of Hong Kong film industry in the late 1990s: BOB.

However, compared with today’s classic status, many people were not optimistic about bringing the prototype comics to the screen. Even Jing Wong, as a producer, thought that this piece was difficult to sell, but Wen Juan was full of confidence: "I don’t think this film is a Jianghu film, but when it is a youth growth film, I want to make those who don’t know Jianghu feel very good."

Stills of "People in Jianghu"

However, the performance of "People in the Jianghu" is still beyond everyone’s imagination: all the performances in Hong Kong were full, with a total of more than 900,000 in half an hour. By 1: 30 midnight, it had received 1.08 million, and finally the midnight box office alone reached more than 1.3 million!

In the end, relying on the "dead schedule" one week before Christmas, the cumulative box office grossed 21.12 million Hong Kong dollars, which officially opened the box office myth of this series of movies.

Stills of "People in Jianghu"

　

More miraculously, after Man in the Jianghu, the three masters actually finished two sequels in half a year: and.

The former started in mid-February, and it took only 14 days to shoot with the framing tape. On March 28, it went to the midnight show. On the premise that there was no time to prepare at all, even in Ekin Cheng, there was only a four-day schedule, and the scene was started by "flying paper boy" every day; The latter received a deposit in mid-April, flew to the Netherlands for filming at the end of the month, filmed the whole film in May and released it at the end of June, just to catch up with the summer file … …

Even so, the two sequels still earned HK$ 22.49 million and HK$ 19.5 million respectively. In other words, in the past six months, the cumulative revenue of the trilogy has reached 63 million Hong Kong dollars, which is one of the most representative Hong Kong IP films in the late 1990s.

　

According to statistics, as of 2000, the cumulative box office of the six-part series (People in Jianghu, Raptors Crossing the River, absolute monarch, Invincible, enter the dragon, Winner is King) has exceeded 99 million Hong Kong dollars, which can be described as earning a lot of money compared with the low-cost production of each episode.

Of course, this is not to mention all kinds of "foreign articles" such as Thirteen Sisters in Hongxing, The Story of Pheasant, Hong Xing Large Allen, etc. If all the statistics are true, then this IP has accumulated a box office of at least over HK$ 100 million at the low tide of Hong Kong movies in the middle and late 1990s, which, to some extent, is a "rescue" series!

In addition to the box office success, the trilogy has also spawned a large number of classic lines that still make the audience memorize.

Jing Kun’s cruelty:

Pheasant’s vagrancy;

Raven’s unruly madness:

There is also the same touching love, such as the trouble of Chen Haonan and Xiao stammer:

Pheasant’s confession to Ding Yao;

Even more indispensable is the brotherhood of "there is no afterlife in this life":

And prevent young people from going astray, and summarize and reflect on the rivers and lakes:

Looking back at the whole series, it is actually not to teach young people to enter the underworld, nor to show the secret history of various underworld, but to make people understand what "love and righteousness are worth a thousand dollars", to promote the sharing of troubles between brothers, and to reveal the values that all gangsters have no good end.

Therefore, from Hong Kong in those days to the mainland today, it always resonates with the younger generation.

　

It is worth mentioning that the play emphasizes punishing evil and promoting good, and crouching tiger, hidden dragon is the same outside the play.

In this series, several big brothers and sisters are film emperors, and their acting strength is overwhelming.

Among them, Wu Junru is the first actor who won the best actress with this series of films:

Wu Junru won the Golden Award for "Thirteen Sisters of Hongxing".

In contrast, the "younger generation" has made great achievements in acting. For example, Jordan chan, the pheasant, won the Academy Award for Best Supporting Actor, and Karen Mok, who plays the priest’s daughter, also won the Academy Award for Best Supporting Actress. No wonder there is a tacit understanding in the film:

Even the behind-the-scenes creation, together with the Infernal Affairs series, has become two labels of Liu Weiqiang’s directorial career:

Qian Jiale, who plays "Big Head", not only won the Golden Bauhinia Award for Best Supporting Actor, but also won the Golden Horse Award for Best Action Design several years ago.

Today, he is not only a well-known director and action director, but also the president of the Hong Kong Action Acrobatics Association, which can be described as fame and fortune:

Interestingly, in addition to showing the scenery of rivers and lakes, it has also brought joy to Hong Kong people (even viewers watching TVB in South China) for ten years.

Since 1995, the variety show "Super Invincible Winner", starring Ceng Zhiwei, has been ranked first in Hong Kong’s ratings for a long time. Various game links have made the audience smile. As "awards for the elderly", Lin Xiaofeng, Jordan chan and Qian Jiale have also contributed, which is enough to prove that these "teenagers" have many talents:

Now "Golden Brothers" is produced by Ceng Zhiwei, which can be said to reproduce these two classic signs at the same time, thus bringing more classic feelings.

So, with these unique cards, will you go to the cinema to support the "sentimental" work "Golden Brothers"?

　　Photo courtesy of vision china

　　Gene therapy can "correct" the mutant genes that cause diseases, thus bringing hope for the patients suffering from congenital genetic diseases. But recently, in a clinical trial of gene therapy conducted by a biotechnology company in the United States, two children who participated in the trial died unfortunately.

　　After decades of twists and turns, gene therapy has brought new hope for the treatment of major human diseases, especially many genetic defects. However, gene therapy has recently suffered setbacks.

　　Recently, an American biotechnology company (Audentes Therapeutics) issued a letter saying that among the 17 children with neuromuscular rare diseases who participated in the company’s "AT132" gene therapy, two children died after receiving high-dose gene therapy.

　　The key research of this gene therapy began in 2017, aiming at treating a fatal disease caused by a single gene mutation — — X chromosome linked myotubular myopathy. The treatment was originally intended to be submitted this year and expected to be approved by the US Food and Drug Administration by the end of the year, but the plan has now been shelved.

　　Some children died while receiving gene therapy 20 years ago. What are the differences between the gene therapy at that time and this gene therapy? After decades of development, what improvements have been made in gene therapy and what problems are still facing? In this regard, the Science and Technology Daily reporter interviewed relevant experts.

　　"What is missing makes up for what is missing" and "corrects" mutated genes.

　　In human body, there is a gene named "MTM1", which is used for the development and maintenance of muscle cells by expressing a protein called "Myocardin". X chromosome linked myotubular myopathy is caused by the mutation of "MTM1" gene.

　　X chromosome linked myotubular myopathy mainly affects skeletal muscle, and its symptoms are muscle weakness and hypotonia. Muscle lesions will damage the patient’s ability to sit, stand and walk, even cause difficulty in eating and breathing, and may also lead to ophthalmoplegia, facial muscle weakness and muscle reflex disappearance.

　　At present, the main treatments for the disease include physical therapy and the use of support equipment such as ventilators. Studies have shown that the chemical drug "pyridostigmine" may be beneficial to improve clinical symptoms, but no formal clinical trial has been carried out. Generally speaking, there is no effective treatment for this disease at present.

　　To this end, researchers began to explore the use of gene therapy to "correct" mutated genes. "Based on ‘ What is missing is what is needed ’ The gene therapy uses adeno-associated virus (AAV) as a vector to transfer normal ‘ MTM1’ Genes are introduced into muscle cells to produce myotubes with normal function, thus repairing the function of damaged muscle cells. " Qiu Zilong, a researcher at the Center for Excellence and Innovation in Brain Intelligence of China Academy of Sciences, said that this is a "permanent cure" treatment method, and under ideal conditions, it can even achieve "one treatment and lifelong benefit".

　　How to realize this "correction" process? "The whole process and ‘ Drip ’ Very similar. " Qiu Zilong pointed out that the researchers injected the adeno-associated virus loaded with normal "MTM1" gene into the patient’s blood, delivered the adeno-associated virus vector to muscle cells through blood circulation, and produced "myosin protein" with normal function in it.

　　Before these children participated in clinical trials, the gene therapy had been pre-clinical studied, including verifying the safety and effectiveness of the therapy in cell and mouse disease models cultured in vitro, and the therapy was generally safe.

　　But in order to improve the therapeutic effect, the researchers tested a higher dose of gene therapy. "High doses are particularly important for neuromuscular diseases, because more copies of genes are needed to reach the targeted tissues through blood circulation." Dr. Cheng Cheng, from the School of Bioengineering, East China University of Science and Technology, said that the dose used in this gene research is the highest dose in gene therapy: 300 trillion copies of genome per kilogram of body weight.

　　The upgraded transmission carrier is safer.

　　In recent years, gene therapy has developed rapidly. The event that the "brake button" was also pressed occurred in 1999. An 18-year-old American patient named Jesse Kissinger died in a clinical trial of gene therapy with adenovirus as the carrier.

　　At that time, researchers used adenovirus as a vector to insert genes into patients’ cells to replace those parts that were lost or dysfunctional and caused diseases. A few days later, Jesse died of multiple organ failure due to severe immune response, which poured cold water on those who were initially optimistic about gene therapy.

　　After the tragedy of Jesse Kissinger’s death due to gene therapy, the researchers reduced the size of the laboratory and focused on finding safer virus vectors. Finally, they discovered and promoted the use of adeno-associated viruses.

　　Adeno-associated virus (AAV) is a kind of single-stranded DNA deficient virus with the simplest structure found at present. Adeno-associated virus gene therapy uses adeno-associated virus as a carrier to deliver therapeutic genes to specific tissues and organs, and these therapeutic genes stably exist and express in the form of free bodies in these non-splinter cell, thus effectively treating monogenic genetic diseases.

　　At present, adeno-associated virus (AAV) is the mainstream carrier platform for gene therapy, and there are also adenovirus and lentivirus gene therapy. Qiu Zilong pointed out that compared with adenovirus, adeno-associated virus vector has the advantages of high safety, low immunogenicity, longer curative effect and easy modification, and the newly discovered adeno-associated viruses such as AAV8 and AAV9 are 10-mdash stronger than adenovirus in transferring genes into cells. A hundred times. Lentiviruses, on the other hand, have the characteristics of randomly integrating genomes, and there is a potential risk of destroying normal gene functions.

　　In addition to the rare diseases caused by single gene mutation reported in this report, gene therapy is also used to treat Parkinson’s disease, Alzheimer’s disease, cancer and other complex diseases at home and abroad. At present, about 42 companies and nearly 100 drug research and development projects use adeno-associated virus vectors for gene therapy. In this fatal accident, the carrier used by researchers for gene therapy was AAV8.

　　Too high dose is easy to produce toxic and side effects.

　　Regarding the insecurity of gene therapy, Cheng Cheng believes that in the case of "AT132" gene therapy, the cause of children’s death may be that they received an excessive dose of adeno-associated virus intravenous injection, which produced a large number of antibodies against adeno-associated virus. The combination of virus and antibody can further activate complement pathway or innate immune response, thus causing strong toxic and side effects.

　　"Another kind of insecurity is the dislocation expression of normal genes." Cheng Cheng took the gene therapy of spinal muscular atrophy "Zolgensma" as an example, saying that intravenous injection would lead to excessive accumulation of normal genes carried by "Zolgensma" in the liver, but this gene did not play a role in the liver, which triggered a common hepatotoxicity after treatment, which was manifested by the increase of transaminase.

　　As early as a few years ago, james wilson, an American scientist who was a pioneer in gene therapy and one of the developers of adeno-associated virus, expressed concern about the high-dose vector used in gene therapy. In February 2018, the Wilson team published a paper saying that after high-dose injection of adeno-associated virus, it caused serious toxic reactions in rhesus monkeys and piglets, and one rhesus monkey had to be euthanized due to liver failure. To this end, Wilson called on researchers to carefully monitor similar toxic effects during gene therapy.

　　Wilson’s collaborator, Professor Gao Guangping of the Massachusetts Institute of Technology, once expressed similar views. In an interview in 2019, he expressed concern that the rapid development of this field would make people less cautious and might make Jesse Kissinger happen again.

　　"Scientific and technological progress will experience setbacks." Qiu Zilong said that although this high-dose gene therapy caused the death of the patient, the effectiveness of gene therapy cannot be denied. In the face of the lack of effective treatment for rare diseases with single gene, gene therapy has indeed brought hope to many patients and their families. At present, there are still many shortcomings in gene therapy, which needs continuous improvement and perfection by experts and scholars in the field to make it safer and more effective, and should not be abandoned because of choking.

　　In promoting the development of gene therapy, Qiu Zilong suggested that it is necessary to constantly transform to obtain new types of adeno-associated viruses with special tissue affinity, reduce the immune response of the human body after injection, achieve more accurate delivery of normal genes, and further reduce toxic and side effects; At the same time, research and develop better gene regulatory elements, so that normal genes delivered to patients can produce functional proteins in a timely and appropriate way.

　　Cheng Cheng also suggested that the production and purification process of adeno-associated virus can be further optimized to reduce impurities in the virus and improve its purity. Choose a better carrier delivery mode, such as intrathecal injection or intraventricular injection for diseases of nervous system.