Just after the summer vacation, dozens of parents in a kindergarten in Jiangyin, Jiangsu Province are worried about one thing about their children. According to several parents told The Paper, a teacher in the park was diagnosed with tuberculosis during the summer vacation, and then 28 children and 4 faculty members in the park were found to be infected with tuberculosis, and 5 of them were diagnosed with tuberculosis.

　　Jiangyin City Center for Disease Control and Prevention (hereinafter referred to as CDC) confirmed the above statement to The Paper. Five children diagnosed with tuberculosis are currently out of school and taking therapeutic medication, and 23 children infected with mycobacterium tuberculosis are taking preventive medication.

　　According to Jiangyin’s official introduction, after the relevant epidemic situation was monitored in early July, the functional departments and territories did a lot of work, and experts from provincial and municipal CDC participated in the whole process of support, and repeatedly made face-to-face explanations to parents, accompanying parents to invite the most famous experts in China to consult in Shanghai, and the epidemic situation was handled as quickly, legally and effectively as possible.

　　At present, the kindergarten has screened more than 270 teachers and students in the whole kindergarten. At present, there are no new cases of tuberculosis and the disease has not spread further.

　　28 children were infected, the first mass incident of tuberculosis in kindergarten in Jiangyin.

　　The incident kindergarten is the experimental kindergarten in Zhouzhuang Town, Jiangyin City (Nijiaxiang Branch).

　　According to the director of the park named Sun, The Paper was told that in May and June this year, a teacher in the park, Li Qing (a pseudonym), suffered from throat discomfort and other symptoms. After that, the teacher went to Jiangyin People’s Hospital and Jiangyin Chinese Medicine Hospital for examination on May 26th and June 2nd respectively.

　　"The results of the examination at that time were allergic rhinitis and allergic cough, and no tuberculosis was detected." Sun Yuanchang said.

　　However, the condition is still not good. After the summer vacation this year, the teacher went to Wuxi Second People’s Hospital for examination on July 8 and learned that he had tuberculosis. "The symptoms at that time were serious and hemoptysis." Sun said.

　　Parents know that the above happened on July 15th (Sunday). On the morning of the same day, the class news informed more than 30 teachers and students in the teacher’s class to conduct T-SPOT screening for tuberculosis on July 17th (Tuesday)..

　　Chen Xianwen, director of Jiangyin CDC, told The Paper that in this round of screening, among more than 30 teachers and students in this class, 17 (including 13 students and 4 faculty members) had strong positive results, that is, they had obvious tuberculosis infection, which made them more likely to get sick.

　　On July 20, the CDC organized the 17 people to go to Jiangyin People’s Hospital for further chest X-ray examination. Chen Xianwen said that one child’s chest X-ray was abnormal, that is to say, there was a suspected tuberculosis patient.

　　But parents are not at ease with Jiangyin’s test results. Finally, under the coordination of many parties, on July 26, Jiangyin CDC, Health Planning Commission, Education Bureau and other departments organized the students to go to the Public Health Clinical Center affiliated to Fudan University in Shanghai for inspection. The final conclusion is that among the 17 people, 5 children were diagnosed with tuberculosis.

　　"As soon as we found many cases, we expanded the scope of screening in mid-August and screened more than 270 teachers and students in the kindergarten." Chen Xianwen said that in the end, 15 strong positive cases were found, and there were no new cases of tuberculosis.

　　Now,The 28 infected students are all taking medication. Among them, five students diagnosed with tuberculosis have dropped out of school at home.. Yan Haidong, deputy director of Jiangyin Health Planning Commission, told The Paper,One of the five children is the child of the sick teacher Li Qing..

　　Chen Xianwen said that after investigation, there was an epidemiological correlation between 32 infected people and the initial illness of the sick teacher, that is, the former was infected and the latter spread after the illness.

　　"This is the first tuberculosis group incident in Jiangyin that I have learned about in the past ten years." Chen Xianwen said that no new cases have been found.

　　According to Yan Haidong, the kindergartens involved organize teachers to have a physical examination every year. After passing the physical examination, they will issue a health certificate to the teachers. They checked Li Qing’s medical examination record in August 2017, and "the chest radiograph is normal".

　　Two major questions of parents

　　Although the child has been treated at present, parents still have two big questions.

　　First, they hope that the garden and the Education Bureau will explain why the teacher was not found to be suffering from tuberculosis in time and stop his class in time to prevent the disease from spreading further. Parents believe that the garden and the education department have dereliction of duty in supervision.

　　It is understood that teacher Li Qing is a nursing teacher in the kindergarten, and she usually takes care of the children’s lives most of the time.

　　"Our child coughed one day and the teacher told him to go home and rest, saying that he was afraid of affecting (infecting) other children. Why did the sick teacher cough for several months and wear a mask to attend class, and the garden still let her continue to attend class?" A student’s parents said to The Paper.

　　Xu Qianfeng, director of Jiangyin Education Bureau, told The Paper, "The key is that the teacher’s first two visits were not tuberculosis. Since it is not an infectious disease, there is no reason not to let her attend class. It is normal for a teacher to cough and have an uncomfortable voice in class. "

　　The sick teacher Li Qing (pseudonym) told The Paper that before the diagnosis, she didn’t know that she was suffering from tuberculosis. "What a great experience it is to know that I have an infectious disease and go to work. I also have children." Li Qing said that after the diagnosis in July, she told the kindergarten leaders that she was tuberculosis. Before that, kindergarten leaders sometimes asked her why "cough has been bad" and whether she had seen a doctor.

　　"Teachers and schools don’t know in advance that it is tuberculosis. How can they be held responsible? Punish teachers? Teachers are also victims. " Wang Jian, deputy director of Jiangyin Education Bureau, told The Paper.

　　Parents’ second question is why before going to Shanghai for examination, the screening result organized by Jiangyin CDC was "only one suspected tuberculosis patient", while the result in Shanghai was five cases.

　　After screening in Jiangyin, Jiangyin CDC suggested that students infected with germs can start preventive medication for patients with strong positive, which is different from therapeutic medication for patients diagnosed with tuberculosis. "If you didn’t go to Shanghai for diagnosis, didn’t the five confirmed patients delay the treatment opportunity?" Student’s parents B said to The Paper.

　　In this regard, Chen Xianwen said that the difference in diagnosis results between the two places may come from two reasons. First, "Shanghai is a CT diagnosis, and we take a chest film. There is a difference in the clarity between chest film and CT"; On the other hand, "the two diagnoses are six days apart, and the development of tuberculosis is dynamic, which may also affect the diagnosis results."

　　"We handled it according to the" Code for Prevention and Control of Tuberculosis in Schools (2017 Edition) ",and the above requirement is to take a chest X-ray. However, Shanghai’s medical technology and concept are more advanced. They use more accurate and advanced CT. We have reported the inconsistent diagnosis results caused by the two diagnostic methods to the (Jiangsu) Provincial Health Planning Commission. " Yan Haidong, deputy director of Jiangyin Health Planning Commission, told The Paper.

　　CDC: Tuberculosis is treatable.

　　Parents reported that at present, the children’s medical expenses are paid in advance by parents and later reimbursed by the government.

　　In addition to asking kindergartens to take responsibility, another issue that parents are concerned about is whether children can be cured and whether it will affect their future study and work.

　　Chen Xianwen said that after years of medical development, tuberculosis is currently preventable, controllable and treatable. For patients with strong positive, the incubation period of bacteria is generally six months. As long as they are properly treated and recuperated during this period, they can recover slowly. For patients diagnosed with tuberculosis, the general treatment period also takes half a year. "From the tuberculosis cases we have contacted before, the recovery rate is over 90%." Chen Xianwen said.He also said that cure does not mean never recurrence, and not paying attention to physical maintenance will increase the chance of tuberculosis recurrence.

　　Chen Xianwen also said that the impact of tuberculosis on studies and work is limited to the period of illness. "If you just had tuberculosis, the employer won’t refuse to hire you. If you are suffering from tuberculosis at the time of applying, it will not work. " Chen Xianwen said that people are afraid of tuberculosis because they are afraid of infection, but if it is cured, it will not have an impact.

　　What’s more, "statistics show that at present, 40% of Chinese people are infected with mycobacterium tuberculosis, but some of them are hidden and have not yet developed." Chen Xianwen said to The Paper.

　　However, parents’ concerns remain. It is reported that after the tuberculosis group incident, the enrollment rate of the kindergarten in the new semester was greatly affected. Wang Jian, deputy director of Jiangyin Education Bureau, saw from the data on September 5 that,At present, there are only more than 100 students enrolled in the park, which is nearly half of the number compared with last semester. Many parents transfer their children to other kindergartens..

　　Even, "a teacher transferred to another school and was boycotted by the parents of that school." Parents of students said to The Paper.

　　At the same time, some parents reported that Li Qing’s illness may have been infected by previous tuberculosis cases in her village and town. "It seems that (the patient) lives opposite Li Qing’s house."

　　In this regard, Li Qing told The Paper that she was unclear. "The doctor just told me that I didn’t know where I was infected before, and then my body’s resistance dropped, and I often got sick after staying up late and not resting enough."

　　Yan Haidong, deputy director of Jiangyin Health Planning Commission, said that the tuberculosis patient from Li Qing’s hometown was diagnosed with tuberculosis in January this year, but there is not enough evidence to verify whether there is a correlation between the two diseases. "It is understood that this person is not a close contact of Li Qing". "Because tuberculosis is mostly transmitted through the respiratory tract, Li Qing has a wide range of activities and many contacts, so it is temporarily impossible to verify where she was infected."

　　Cao, deputy director of Jiangyin CDC, told The Paper that at present, there is a unified online monitoring system for tuberculosis in China, and the CDC has special personnel to check the detection system every day. As long as a case of tuberculosis is found, it will begin to follow up its medical treatment.

　　The system especially focuses on monitoring key places such as schools. "If there are cases in schools, the system will automatically send relevant messages to the mobile phones of disease control personnel." Cao said.

　　Take Li Qing’s illness as an example."After she was treated in Wuxi on July 8, the doctor entered this case into the monitoring system. However, she did not indicate that she was a teacher at that time, so she was treated as an ordinary tuberculosis case." Yan Haidong said.

　　succedentOn July 12, Li Qing went to Jiangyin People’s Hospital to get medicine. "When the hospital medical staff asked about the illness, they asked about their occupation. After knowing that she was a teacher, they updated this information to the monitoring system and reported it to the competent department., our CDC staff also found in the monitoring system, and then organized school screening. "Cao said to The Paper.

　　"Now the country is very strict in the prevention and control of infectious diseases. If there are cases that are missed, the punishment is very severe." Cao said. (The Paper reporter Chen Ke intern Wan Xiaotian)

1905 movie network news September 2, byMarielle HellerDirecting,Tom Hanks、Matthew RhysThe starring healing masterpiece A Beautiful Day in the Neighborhood has released a special feature of "Tom Hanks" actors, which shows in detail the process of Tom Hanks’s successful interpretation of the legendary TV presenter "Mr. Rogers" who has grown up with generations with his profound understanding and superb acting skills.

Matthew Rhys, who plays the hero Lloyd in the film, commented: "Tom’s version of Mr Rogers can’t be duplicated, because it’s too perfect.". The film Rotten Tomatoes is as fresh as 95%, and it has been rated as one of the top ten films of the year by Time Magazine and praised as "the film needed by the times", which will be released nationwide on September 18th.

No prosthesis, no special effects. Tom Hanks turned into a legendary host by acting.

With silver hair and a gentle smile, Tom Hanks sang the theme song of "Mr. Rogers’s Neighbors" slowly and calmly in front of the camera, as if the TV presenter who accompanied generations of growth was still with us. Seeing this reduction, even Joanna Rogers, the widow of Mr. Fred Rogers, couldn’t help sighing: "He looks as cute as Fred."

However, director marielle heller revealed that when fixing makeup for Tom Hanks, she avoided complicated special makeup and facial prosthesis, only customized a wig for him, and added Mr. Rogers’ unique eyebrow shape to him. She said that these are enough, "the rest depends on his eyes to show."

The winner of the two-time Oscar for Best Actor restored the "Mr. Rogers" in everyone’s memory with his profound understanding of the role and superb acting skills, and added his own unique interpretation. He dedicated the classic "One Minute Gaze" in the film to the audience, broke the "fourth wall" and had a soul dialogue with you and me off the screen.

Do your homework, deeply interpret the incarnation of "chatter" and the legendary host of "silence"

In order to get to know Mr. Rogers better, Tom Hanks spent a lot of time watching Mr. Rogers’ program "Mr. Rogers’ Neighbors" repeatedly, and even read the script written by Mr. Rogers himself for the program. For Tom Hanks, the biggest challenge in playing Mr. Rogers is to "slow down". Tom Hanks himself is warm and cheerful, full of gas in his speech, while Mr. Rogers is quiet, deep and slow.

In order to restore Mr. Rogers’ unique temperament, Tom Hanks deliberately "slowed down" himself during the performance and restrained his instinctive gestures and tone when he spoke. The magic thing is that when you do this, you will naturally enter the state. Not only that, Tom Hanks also learned the skills of controlling the puppets because he had to operate the puppets such as Daniel Tiger and King Friday himself in the film.

The perfect match between the real film emperor and the legendary actor and the prototype.

For the audience, Mr. Rogers is the most trusted and lovely elder, while Tom Hanks is an excellent actor who is widely loved and approachable. Many people may not know that Tom Hanks was also Mr. Rogers’ favorite actor. And Mr. Rogers let Tom Hanks break his rule of "no longer playing the real person", and the charm of this legendary figure is self-evident.

One is the Hollywood Evergreen drama bone that left many classic images in the audience’s mind, and the other is the legendary program host who enriched the spiritual world of several generations. Tom Hanks plays Mr. Rogers, and the "film emperor" interprets the "legend". Uncle Tang is definitely the perfect person to play Mr. Rogers.

　　● In the buyer’s show of a store, many netizens showed photos of children wearing lipstick and eye shadow. Some of the main characters in the photos looked like preschool children of four or five years old. The child’s tender face was too rosy because of blush, his eyes were swollen because of pink eye shadow, and his mouth was painted with big red lipstick.

　　● Search for "children’s makeup" and "children’s cosmetics" shows that some cosmetics sold to children and used by children are actually adult cosmetics, which are "fake" children’s cosmetics. In the vicinity of some schools, students can buy eye shadow with sequins, lipstick and other products in the canteen for only a dozen yuan, and these products are not marked with children’s cosmetics.

　　● According to the provisions of the Law on the Protection of Minors and the Regulations on the Supervision and Administration of Children’s Cosmetics, children’s cosmetics must be marked with "precautions" and "special signs", otherwise they may not be sold. It is illegal for a merchant to sell non-children’s cosmetics to children. Obviously, it is impossible to indicate the "children’s cosmetics mark".

　　● In the sales process, it is necessary to strengthen the review of the sales and operation qualifications of e-commerce platforms and retailers. Those who use children’s toys to sell children’s cosmetics without cosmetics business qualifications should be considered as "beyond the business scope" and punished; If ordinary cosmetics are passed off as children’s cosmetics, they will be punished in accordance with the provisions of the Consumer Protection Law.

　　□ Our trainee reporter Ding Yi

　　□ Our reporter Wen Lijuan

　　"How to sell children’s eye shadow in the toy store? Cosmetics have become something that children can buy and use at will ‘ Toys ’ ？” This is the doubt of Li Qing (pseudonym), a resident of Chaoyang District, Beijing, during the Spring Festival this year.

　　According to a recent investigation by the reporter, many children are using children’s cosmetics, but some children’s cosmetics are sold in toy stores, and even appear in the canteen around the school. Some of the cosmetics claimed to be used for children do not have children’s cosmetics signs, and they are not written and reminded. Minors need to use them under the supervision of adults.

　　In fact, in order to regulate the production and operation of children’s cosmetics, National Medical Products Administration organized and issued the Regulations on the Supervision and Administration of Children’s Cosmetics. The reporter of Rule of Law Daily conducted an investigation.

　　Toy shops sell children’s cosmetics.

　　No children’s cosmetics logo

　　Li Qing brought some cosmetics such as facial mask, lipstick, eye shadow and liquid foundation for her own use when she returned to her hometown for the Spring Festival this year. As a result, her 11-year-old sister saw it and clamored for "makeup" every day. After careful inquiry, I learned that some girls in my sister’s class in the fifth grade of primary school had biochemical makeup, at least took good-looking art photos, and some even brought pale pink lip balm to school.

　　"Sister envy classmates ‘ Exquisite ’ I must teach her how to make light makeup. " Li Qing said.

　　Considering her younger sister’s age is too small and her skin is delicate, Li Qing is worried that her stealing her own cosmetics will cause skin allergy, so she decides to take the initiative to buy children’s cosmetics for her younger sister to use. However, when Li Qing entered "children’s cosmetics", "children’s eye shadow" and "children’s lipstick" in the search box of the shopping platform, he found that many children’s cosmetics sellers were toy stores.

　　After hesitation, Li Qing still placed an order for her sister to buy some children’s cosmetics with good quality, but after receiving the goods, she found that some sequined eye shadows didn’t bear the logo of children’s cosmetics.

　　Zong Jing (pseudonym), a citizen of Jinan, Shandong Province, also bought some children’s cosmetics for her little daughter who went to kindergarten in the toy store on the shopping platform.

　　Zong Jing told reporters that her daughter especially likes to apply makeup such as eye shadow and lipstick to her face.

　　The little girl can’t speak fluently. When asked by a reporter why she likes makeup, she smiled and nodded timidly and said, "Yes, makeup can make me happy."

　　Zong Jing admits that she doesn’t know the ingredients of the children’s cosmetics she bought, but she only sees that the shops claim that it is a cosmetic that children can use. "But these shops don’t specialize in children’s cosmetics."

　　After opening the shopping link of children’s cosmetics given by Zong Jing, the reporter found that this is a toy franchise store, and the name of the link is marked "Toys for little girls aged 3 to 6".

　　The reporter’s investigation found that on the e-commerce platform, there are indeed many children’s cosmetics sets with high sales volume sold in toy stores, such as "XX Baby High-end Toys", with the toy type of "playing house" and the trade name of "XX Children’s Cosmetic Toy Set".

　　In the buyer’s show of a store, many netizens showed photos of children wearing lipstick and eye shadow. Some of the main characters in the photos looked like preschool children of four or five years old. The child’s tender face was too rosy because of blush, and his eyes looked swollen because of pink eye shadow. His mouth was painted with big red lipstick.

　　The cosmetics sold in this shop did not remind children to use them under adult supervision. In the comment area, some netizens asked "Is there a small golden shield (a sign of children’s cosmetics)", and some buyers replied "No". More buyers answered "What is a small golden shield", and some buyers said that there was a little side effect after using it, "The child is a little itchy after wearing eye shadow or blush".

　　According to the Regulations on the Supervision and Administration of Children’s Cosmetics, which came into effect on January 1, 2022, children’s cosmetics refer to cosmetics that are suitable for children under the age of 12 (including 12 years old) and have the functions of cleaning, moisturizing, refreshing and sun protection. Labeling words such as "applicable to the whole population and the whole family" or using trademarks, patterns, homophones, letters, Chinese Pinyin, numbers, symbols, packaging forms, etc. to imply that the product users include children’s products, it shall be managed according to children’s cosmetics.

　　At the same time, China encourages cosmetics operators to display children’s cosmetics in different areas and publicize children’s cosmetics signs in the sales areas. For children’s cosmetics operators in the e-commerce platform and those who operate children’s cosmetics through self-built websites and other online services, information such as cosmetics labels consistent with cosmetics registration or filing materials should be fully, truly and accurately disclosed, and children’s cosmetics signs should be continuously publicized in a prominent position on the product display page.

　　The children’s cosmetics logo "Xiaojindun" was issued by National Medical Products Administration. Since May 1, 2022, children’s cosmetics applying for registration or filing must be marked with the children’s cosmetics logo.

　　In other words, "Little Golden Shield" is a distinctive sign that children’s cosmetics are different from adult cosmetics, disinfection products, toys and other easily confused products. Non-children’s cosmetics may not be marked with this sign.

　　According to Yao Jinju, a professor at the School of Law of Beijing Foreign Studies University and director of the Research Center for Chinese and Foreign Education Law, whether selling children’s cosmetics in physical stores or on e-commerce platforms, the "Little Golden Shield" logo must be marked and publicized, and selling children’s cosmetics that are not marked and publicized on the packaging display surface/page is suspected of violating the law.

　　Adult cosmetics are sold to children

　　It is easy to buy around the school.

　　During the investigation, the reporter found that the results of searching for "children’s makeup" and "children’s cosmetics" showed that some cosmetics sold to children and used by children were actually adult cosmetics, which were "fake" children’s cosmetics.

　　For example, a store on a certain platform sells a "Children’s Day Cosmetic Set", which includes products such as cream, liquid foundation, blush, loose makeup powder, lipstick, 30-color eye shadow tray, eyeliner and mascara. The product is known as "one set!" Multi-scene application. After authoritative testing, you can buy with peace of mind. Plant makeup, my mother is more at ease. "

　　The reporter asked the seller: "Is this children’s cosmetics?" The customer service replied: "The main products are ‘ cream, liquid foundation, blush, makeup remover, face cream, lipstick and loose makeup powder; Xiaojindun ’ Logo, others have not been applied for yet. The products are safe and gentle, so you can buy them with confidence. "

　　Because no eye shadow, eyeliner, mascara and other products were mentioned, the reporter confirmed to the customer service whether these products belonged to children’s cosmetics, and the customer service said, "No ‘ Xiaojindun ’ Sign ",but" children can use it, which is quite gentle and easy to use, and the customer feedback is good. "

　　A chain big-name online skin care and beauty shop sells a "children’s stage makeup performance makeup kit, eye shadow blush powder cake integrated non-toxic makeup". The reporter asked the customer service: "Does this belong to children’s cosmetics?" The customer service replied, "It’s not children’s cosmetics, no ‘ Xiaojindun ’ Sign. " The reporter asked whether the children’s dance class performance program can be used. Customer service said: "It can be used, the makeup will not be light, and the effect is very good."

　　The reporter saw that more than 200 people bought this cosmetic in a week, and more than 900 people bought it. There are more than 290 comments in the comment area, most of which are favorable comments: "I bought it for children to perform, and everything is complete." "I have a full set of makeup tools, including eye shadow, foundation, blush, loose powder, makeup brush and powder puff." "My girl likes it very much."

　　The reporter also visited a number of large supermarkets and skin care cosmetics shops in Chaoyang District and Xicheng District of Beijing, and found that most businesses did not distinguish between children’s makeup and adult makeup.

　　In an adult makeup chain, the reporter said that he would buy children’s makeup for his cousin in elementary school. The clerk said that there is no special children’s makeup, but "it can help to match a box". The reporter asked if there were any side effects, and the clerk said, "Choose something mild that can be used for sensitive skin. Many children buy our makeup for performances, and it makes no difference."

　　The reporter bought a color eye shadow named "sequined eye makeup for children’s performance" in a convenience store, and repeatedly asked the merchant whether the product was specially used for children’s makeup. The other party said "yes". After the reporter paid, he unpacked the goods and found that the goods did not belong to children’s cosmetics, and even the production license number was not written. The business scope of the manufacturer did not include children’s cosmetics.

　　The reporter also found that there are also businesses selling cosmetics near primary and secondary schools in some areas, and businesses sell adult cosmetics to children.

　　In a canteen near a primary school in Shandong province, students can buy eye shadow with sequins for only a dozen yuan, lipstick and other products for dozens of yuan. These products are not marked with children’s cosmetics, and the merchant said that the sales volume is quite good. "Light lipstick sells well, and there is lip balm with color, which will not be discovered by the teacher in class."

　　On a short video platform, a blogger conducted a "cosmetic evaluation of stationery store at the entrance of primary school". At the entrance of a primary school, the blogger bought Floral Liquid Foundation, Makeup Pencil, Cosmetic Household Bucket (Eyebrow Pencil, Eyeshadow, Blush, etc.). After trying Floral Liquid Foundation, she sighed, "God, it’s so silky, even acne marks can be covered, and this is only 19.9 yuan."

　　Can you sell lipstick and eye shadow that are not children’s cosmetics around the school?

　　In Yao Jinju’s view, businesses are not allowed to sell non-children cosmetics to children. According to the Law on the Protection of Minors and the Regulations on the Supervision and Administration of Children’s Cosmetics, children’s cosmetics need to be marked with "precautions" and "special signs", otherwise they may not be sold. It is illegal for a merchant to sell non-children cosmetics to children, and it is obviously impossible to indicate the "children’s cosmetics mark".

　　Zhang Bufeng, a professor at the Law School of Minzu University of China, believes that if such products are children’s toys, that is, products such as "lipstick toys" and "blush toys" produced according to toy standards are not managed as cosmetics, the relevant departments should test the relevant element content of toy materials according to the relevant provisions of the Product Quality Law and relevant standards. At the same time, it should be found out whether the operator has the qualification to deal in cosmetics. If he has not obtained the qualification to sell cosmetics, he is engaged in business activities in violation of regulations.

　　"Operators shall, in accordance with the provisions of the Law on the Protection of Minors, mark the precautions in a prominent position for toys that may endanger the physical and mental health of minors. If they are not marked, they shall not be sold. Those who sell in violation of regulations infringe upon the legitimate rights and interests of minors and cause personal, property or other damage shall bear corresponding responsibilities according to law. " Zhang Bufeng said.

　　Regulatory provisions should be fully implemented.

　　Set up a safe area around the school.

　　In view of the chaos of children’s cosmetics sales, the interviewed experts gave suggestions on governance.

　　"Children include kindergarten children and primary school students. Merchants will use children’s unique psychology to integrate popular cartoons, online games, fashionable toys and other elements into cosmetics packaging, which will arouse children’s curiosity about cosmetics and children’s groups will also influence each other. " Yao Jinju said that the supervision of children’s cosmetics sales should be strengthened.

　　"China’s supervision of children’s cosmetics is very strict, and the" Regulations on the Supervision and Management of Children’s Cosmetics "has been specially issued, with a view to supervising the whole process of children’s cosmetics from production to sales to ensure the safety of children’s use of cosmetics." Zhang Bufeng said.

　　Zhang Bufeng explained that in the production process, we must strictly control the formula design and use of raw materials of children’s cosmetics in accordance with the Guidelines for the Declaration and Evaluation of Children’s Cosmetics and the Quality Management Standards for Cosmetic Production, so as to meet the scientific and necessary production requirements. In the packaging process, urge the responsible person to strictly implement the legal requirements such as "Little Golden Shield", "Attention" or "Warning" in China’s Regulations on the Supervision and Administration of Children’s Cosmetics, and not to label words such as "food grade" and "edible" or food-related patterns.

　　Zhang Bufeng believes that in the sales process, it is necessary to strengthen the review of e-commerce platforms and the sales and operation qualifications of retailers. Those who use children’s toy packaging to sell children’s cosmetics without cosmetics business qualifications should be considered as "beyond the business scope" and punished; If ordinary cosmetics are passed off as children’s cosmetics, they will be punished in accordance with the provisions of the Consumer Protection Law. We should also advocate that sellers have business qualifications, and actively fulfill the legal responsibility of establishing and implementing the inspection and record system of incoming goods and displaying children’s cosmetics in different regions as stipulated in the Regulations on the Supervision and Administration of Children’s Cosmetics.

　　"In the supervision link, the department responsible for drug supervision and management should list cosmetics operators with concentrated sales behavior as key supervision targets in accordance with the principle of risk management, combined with local conditions and according to the sales situation of different businesses, and increase the frequency of supervision and inspection to ensure the safety of children’s cosmetics." Zhang Bufeng said.

　　The interviewed experts believe that the "Regulations on the Supervision and Administration of Children’s Cosmetics" should be fully implemented at present, and the relevant competent departments need to strengthen supervision and inspection and supervise the frequency of sampling inspection, and timely investigate and deal with the illegal sales of children’s cosmetics; Smooth complaint channels, protect consumers’ rights and interests, and attach great importance to the complaints and reports that occur during the process of parents buying and children using children’s cosmetics, and dispose of them in time.

　　In Yao Jinju’s view, in view of the phenomenon of selling non-children cosmetics around schools, businesses should be given the obligation to pay attention or warn them according to law. At the same time, from the perspective of market supervision, we can rely on the "student safety regional system" to carry out supervision.

　　For example, the Regulations on the Safety Management of Kindergartens in Beijing Primary and Secondary Schools (Trial) stipulates that within 200 meters around the school, relevant departments should focus on rectifying the environmental order around the school according to their duties, and strengthen the supervision of business service places and business service activities around the school, as well as the public security situation and traffic order.

　　"In addition to strengthening supervision, citizens should also be encouraged to report illegal sales of non-children cosmetics or children’s cosmetics with unqualified quality around schools." Yao Jinju said.

　　What should parents pay attention to when choosing cosmetics for their children?

　　Zhang Bufeng believes that we should not blindly buy products marked with "food grade" and "edible", which are explicitly prohibited in the Regulations on the Supervision and Administration of Children’s Cosmetics. If consumers can’t identify whether cosmetics are children’s cosmetics, they should take the initiative to ask the operators, and can check the product registration or filing information through the "Cosmetics Supervision" App. Do not use beauty toys as children’s cosmetics.

　　Zhang Bufeng reminded that it is necessary to choose suitable cosmetics for children of different ages. According to the Classification Rules and Catalogue of Cosmetics issued by National Medical Products Administration, cosmetic efficacy claims used by infants aged 0-3 years do not include "make-up" categories such as beauty modification and makeup removal. To this end, parents should not buy "make-up" for infants under 3 years old. It is illegal to claim that the cosmetics label can be used by infants under 3 years old.

　　Yao Jinju said that "Xiaojindun" is not a product quality certification mark, and the label "Xiaojindun" on the cosmetics package only shows that this product belongs to children’s cosmetics, and its purpose is to "improve the recognition of children’s cosmetics and protect consumers’ right to know", which does not mean that the quality and safety of this product are certified. Therefore, in addition to paying attention to the "golden shield", parents should carefully check the business license of the operator, the national compulsory product certification certificate and other documents when purchasing, and choose a formal merchant with complete licenses to conduct transactions. At the same time, as consumers, we should pay attention to business information, product reputation, evidence retention and other matters.

15-21 April

It is the 30th National Cancer Prevention Publicity Week.

The risk factors for the development of different cancer species are different, and the high-risk groups are different for different malignant tumors.

However, high-risk risk does not mean cancer, and high-risk people do not mean cancer patients. It is very important to understand the knowledge of cancer prevention, improve bad habits, and insist on regular physical examination of cancer prevention, so as to achieve "early detection, early diagnosis and early treatment" in the process of cancer prevention.

Today we invited two experts.

Help us popularize science.

How to find cancer early

And what are the cutting-edge screening technologies?

Li Hua

Director of Jiahui International Cancer Center and Director of Oncology Department

Peng Chen

Director, Medical Imaging Department, Jiahui

What is the probability of "cancer"?

According to the current clinical data, about 15%~20% of cancers are caused by genetic mutations. About 25% of cancers are caused by gene mutation and environmental factors.

The above ten cancers are all related to gene mutation. For example, colorectal cancer, about 10% of colorectal cancer is a hereditary disease, mainly related to MMRp gene mutation.

However, we are familiar with thyroid cancer, which usually has three types, namely papillary cancer, follicular cancer and medullary cancer. Among them, 20~30% of medullary thyroid cancer is a genetic disease, mainly related to RET gene mutation.

How do you know yourself?

Is there any risk of being inherited?

Then how do we know if our genes are at risk of mutation? This requires a relatively novel but very popular detection technology, that is, genetic testing.

Genetic testing is especially recommended for five groups of people in the following situations.

In fact, genetic testing is believed to have many problems, such as

1. How old is it to do genetic testing?

2. Is it enough to do genetic testing once?

3. How to detect it? Do you need to draw blood or extract other tissues?

4. Where should genetic testing be done? How to prevent cancer after getting the results?

Click on the link below to reserve a live broadcast at three o’clock.

Let’s go live to get to know each other.

In addition, you can also click on the following applet.

Learn more about cancer genetic risk assessment

Timely detection and early screening

Turn "serious illness" into "minor illness"

Only when you pay attention to the "clues" of your body can you find the disease as early as possible and turn many "serious diseases" that may occur in the future into minor illnesses.

01

Self-examination of breast tumor

For example, if you feel a lump in your breast or abnormal nipple discharge, you may need to go to breast surgery to carry out corresponding examinations to rule out breast tumors. Therefore, the annual physical examination is very important.

02

Self-examination of gastric tumor

Discovering epigastric discomfort and black stool may indicate upper gastrointestinal bleeding, and it is necessary to carry out gastroscopy to eliminate the possibility of gastric tumor; It is necessary to use colonoscopy to rule out the possibility of intestinal tumor when stool bleeding or abnormal stool characteristics are found.

03

Self-examination of other tumors

If you find abnormal vaginal bleeding, hematuria, a lump in the head and neck, swollen lymph nodes all over the body, long-term low fever, and a sharp drop in weight for unknown reasons in the short term, these may also be signs of tumors, so you should see a doctor in time.

Common cancer screening suggestions

Learn more about screening recommendations

Understand cutting-edge screening technology

Be the first person responsible for your health.

Have you ever heard of the amazing cutting-edge technology like PET-CT, which can screen out tumors all over the body, so that the hidden health risks in the body can be hidden?

To this end, our anchor Cao Cao deliberately tried it once.

Want to know how she will experience? Who, including this kind, is suitable for this examination?

What are the precautions before inspection?

Will there be radiation in this test? Are there any people who are not suitable for this kind of examination?

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Original title: "Teach you how to screen for early cancer! Make you healthy and cancer-free! 》

Read the original text

People’s Daily Online, Chengdu, December 13 (Reporter Guo Ying) On December 12, the 7th World Sichuan Cuisine Conference opened in Deyang Wende International Convention and Exhibition Center. Zuo Yongxiang, Vice Governor of Sichuan Provincial People’s Government, Jiang Ming, President of China Business Federation, Emily Scott, Director of Agricultural Trade Department of US Embassy in China, Dangmin, Vice President of Public Affairs of Unilever North Asia, and Xing Ying, President of World Chinese Food Federation attended the conference. Liu Guangqiang, secretary of Deyang Municipal Party Committee, gave a welcome speech.

Zuo Yongxiang said in his speech that Sichuan cuisine, as a treasure of China cooking art, has gradually formed a unique style of "taste-oriented" and "good spicy flavor" after precipitation and development, and is famous all over the world. Sichuan has always been committed to the inheritance and innovation of Sichuan cuisine culture, and has further polished the "golden signboard" of Sichuan cuisine by accelerating the construction of the pioneering area for innovative development of Sichuan cuisine, implementing the "three-name" brand cultivation project of Tianfu famous dishes, famous chefs and famous shops, implementing the three-year action of promoting Sichuan cuisine to go abroad, and local legislation of Sichuan cuisine. The World Sichuan Cuisine Conference has set up an international platform for cooperation and exchange of Sichuan cuisine. We sincerely invite all the guests to take a look around Sichuan. While tasting fresh, mellow, spicy and delicious food, we can further feel the natural and humanistic charm and innovative development vitality of Sichuan. I look forward to working with you to protect and inherit this precious cultural heritage, adhere to the tradition of inheritance and innovation, so that the story of Sichuan cuisine will shine new glory on the world stage and create a bright future for Sichuan cuisine; We warmly welcome entrepreneurs to invest in Sichuan and share development opportunities. Sichuan will wholeheartedly create the best investment environment and provide the best service for everyone.

Jiang Ming said that catering is an important livelihood industry to meet people’s needs for a better life. In the past two years, Sichuan cuisine, as the cuisine with the largest number of stores in Chinese dinner, has witnessed a vigorous industrial development and the number of stores has continued to grow. At present, Sichuan cuisine is entering a new development cycle. With the trend of brand and chain strengthening and the acceleration of globalization, Sichuan cuisine industry will usher in more development opportunities and broader market space. China Business Federation will always be committed to promoting the reform and development of the business service industry, building a bridge between the government and enterprises, and serving the majority of members and industry enterprises.

Sichuan cuisine, as one of the eight major cuisines in China, is not only the best in the catering market in China, but also a shining business card of China culture on the world stage. In recent years, the Sichuan Provincial Party Committee and the provincial government have attached great importance to the development of Sichuan cuisine industry, formulated policies to support the development of Sichuan cuisine industry, and created a good business environment. The Sichuan cuisine industry has developed rapidly, the industrial scale has been expanding, the industrial chain is being improved, the formats and industries are rich and diverse, and its international influence is increasing day by day.

The precipitation of history and culture has created a unique Deyang cuisine. As early as thousands of years ago, Sanxingdui people had many food-related utensils, using "hot pot", "hip flask" and "wine glass". During the Qing Dynasty, Li Diaoyuan, the father of Sichuan cuisine and Sichuan opera, was born here, and his compilation of Letter to the Sea was hailed as an encyclopedia of ancient Bashu culture, and the written Record of Awakening Garden was the first Sichuan cuisine menu. In modern times, many famous chefs and famous teachers have gathered in Deyang, giving birth to a number of Sichuan cuisine masters such as Wang Jiyun, Guo Yuanguang and Li Changchun. In Deyang, the Deyang griddle, the tender striped mandarin fish, the fat but not greasy Lianshan Sichuan style pork, the yellow dumb rabbit with fresh and tender pepper flavor, the delicious dried salted duck in Shifang, and the fine dried noodles in Zhongjiang are full of praise.

Liu Guangqiang introduced "Deyang Taste" in his welcome speech. He expects everyone to take this conference as an opportunity to pay more attention to Deyang, bring more business opportunities to Deyang, and carry out in-depth cooperation in the fields of agricultural special products, meat processing and prefabricated ingredients.

At the opening ceremony, Big Data Analysis of Sichuan Cuisine Consumption Trends in 2024, Report on Internationalization Development of Sichuan Cuisine Industry (2024), Management and Management Standards for Overseas Sichuan Cuisine Restaurant and Deyang Initiative for High-quality Development of Sichuan Cuisine Industry were released. The signing ceremony of the cooperation between the World Federation of Chinese Cuisine Industry and Deyang Municipal People’s Government was held.

It is understood that this conference has carefully created four exhibition areas of Deyang characteristics, Sichuan cuisine industry, hot pot culture and Sichuan cuisine literature, and will hold more than 20 activities such as Sichuan cuisine skill competition and hot pot banquet competition.

Recently, a group of renderings of M8, which were drawn by a car blogger according to the patent drawings, have a high similarity with the final vehicle products. The front face design of Wenjie M8 adopts a zigzag daytime running light, and the middle decorative plate can be lit at the edge, and the logo stands in it, so the overall shape is simple and atmospheric. The Xinghe design of vehicles is an important symbol to distinguish different levels of vehicles. The higher the level, the brighter the Xinghe. There is no "Xinghe" area in the M7, while the M8 has a full side shape, and the tail design is a reduced version of M9. The size of the light group is reduced, and the license plate frame is moved down. The first model chose the color scheme of "Purple Gas from the East", which added a sense of fantasy.

The front face design of the M8 is different, which is considered as a design strategy to prevent "one loss and one loss" and spread risks. Bloggers predict that the M8 in the world may be positioned at the level of 300,000 yuan, and the price is between M7 and M9. The design and positioning of this model have attracted the attention and discussion of the market.

Original Wuyuan Li Na and other SIFIC infection horizons　

Author: Wu Yuan Li Na Jin Wenting Ma Yuyan

Review: Hu Bijie and Pan Jue

First, a brief introduction to medical history

Male, 63 years old, from Shanghai, was admitted to the Infectious Diseases Department of Zhongshan Hospital for the second time on November 23, 2022.

Chief complaint: indwelling catheterization with repeated urine color turbidity for 2 months and then 8 days.

Current medical history:

On September 19, 2022, I went to a hospital in Shanghai for fatigue, anorexia and dysuria. WBC 10.12×10 9/L, N 87.6%, Hb 53g/L, hsCRP 135.22mg/L, ESR 62mm/H, albumin 30.1g/L, Scr 589μmol/L, K 2 were examined. Urine routine: WBC 3892/ul, occult blood 3+/RBC 5579/ul, protein 2+; Chest CT: bilateral pleural effusion, partial atelectasis of lower lobe of both lungs; Abdominal pelvic CT: Bilateral middle and upper ureteral dilatation and renal pelvis and calyceal dilatation, the patch in the right part of calyceal is slightly high density, the bladder wall is thickened, there is a little flocculent blur around the left renal fat sac and ileocecal part, and there is a little effusion in the pelvic cavity. A large amount of turbid urine was drained by indwelling catheter. Urine culture showed that Klebsiella pneumoniae was positive. Considering urinary tract infection, acute kidney injury, hypokalemia and severe anemia, patients were given symptomatic support treatment such as anti-infection, bladder irrigation, antioxidation, potassium supplementation and blood transfusion. The symptoms of patients improved and the urine was slightly clarified. 10-18 Review urine routine: WBC3+, RBC3+, protein 1+, SCR 263 μ mol/L.

I was admitted to our department on October 19, 2022. Blood routine: WBC 5.08X10 9/L, N 66.1%, inflammatory markers: ESR 19mm/H, hsCRP 52.3mg/L, PCT 0.52ng/ml, Scr 257μmol/L, and urine routine: WBC 28493/μ. Urinary color Doppler ultrasound: hydronephrosis, bilateral ureteral dilatation, bladder wall thickening significantly; Abdominal pelvic CT: hydronephrosis of both renal pelvis and ureter, thickening of ureter wall (inflammatory change), inflammatory change of bladder and ureter may be large, the volume of both kidneys increases and the substance is thin. Meropenem 1g q12h is given for empirical anti-infection. Urology consultation considers the acute stage of infection, so it is not suitable to put double J tubes. If necessary, pyelostomy can be done, but it does not improve renal function much. Bladder irrigation is recommended. 10-20 middle-stage urine culture (sampling on October 19): Klebsiella pneumoniae was positive; 10-22 urine culture drug sensitivity: Carbapenem-resistant Klebsiella pneumoniae (CRKP), adjusted to ceftazidime and abamectin 2.5g q12h for anti-infection, and daily bladder irrigation. After treatment, the urine color of the patients gradually became clear, and the urine white blood cell and bacterial count gradually decreased during follow-up. The urine bacterial culture was negative on November 1 and November 4. Check the urine routine on November 09: WBC 28/uL, RBC 4/uL, urine protein+,bacterial count 29/UL;Blood WBC 7.64×10 9/L, N 76.5%, hs-CRP 0.4mg/L, ESR 25mm/H, PCT 0.18ng/mL, Scr 175μmol/L, which were significantly improved compared with those at admission. Stop ceftazidime and abamectin on November 11 and be discharged.

On November 15, 2022, the patient appeared turbid urine again, and there was no fever and other discomfort. On November 23, he was admitted to the hospital for a second diagnosis and treatment.

Past history: In September, 1991, T12-L1 comminuted fracture was treated with internal fixation. After operation, the catheter was retained for half a year due to urinary incontinence, and then the catheter was removed after urination. There was no urinary tract infection during this period. Diabetes for 16 years, insulin therapy, blood sugar control can be; Hypertension for 5 years, oral amlodipine to reduce blood pressure, blood pressure control can be.

Second, the admission examination (admitted on November 23, 2022)

[physical examination]

T: 36.2℃ P: 90 times/min R: 20 times/min BP: 176/105 mmHg.

Stay in bed, feel refreshed and calm, lose weight, and muscle atrophy of lower limbs; Breathing sounds in both lungs are thick, and dry and wet rales are not heard; The rhythm of the heart is regular, the abdomen is soft, without tenderness and rebound pain, without mass, without percussion pain in both kidneys, without tenderness at ureter point and rib and waist point, and the lower abdomen does not touch the enlarged bladder. During indwelling catheterization, the urine in the urine collection bag is turbid and more white flocs are deposited. Limbs are not swollen.

[Laboratory examination]

Blood routine: WBC 7.85×10 9/L, N 81.3%, HB 121g/L, PLT 170×10 9/L.

Urine routine: WBC 2775/μ l; RBC 2/μl, bacterial count: 39879/μl, nitrite positive, leukocyte esterase+++.

Inflammation markers: hs-CRP 17.9mg/L, ESR 68mm/H, PCT 0.12ng/mL.

Biochemistry: ALT/AST 23/21U/L, Alb 47g/L, Scr 199μmol/L, eGFR 30ml/min/1.73m2, na/k 140/5.5mmol/l.

Third, clinical analysis

Characteristics of medical history: middle-aged and elderly male, indwelling catheter, with repeated urinary turbidity and abnormal urine routine. Urine culture showed CRKP one month ago, and it improved after ceftazidime-ababactam treatment, but urine turbidity reappeared three days after drug withdrawal, blood inflammatory index increased, urinary leukocyte and bacterial count increased significantly, and the diagnosis of urinary tract infection was clear. The reasons for short-term recurrence after antibacterial drug treatment improved were considered:

Recurrence of CRKP infection: The patient has been indwelling catheter for 2 months, and there may be biofilm formation of catheter and abnormal urinary tract structure, which makes it difficult to completely eliminate the infection and relapse after stopping taking the drug. Therefore, urine culture and drug sensitivity test can be improved.

New infection: the patient has high risk factors of recurrent urinary tract infection, and the pathogen may be different each time. The patient’s previous CRKP infection treatment was effective, and the possibility of new pathogen infection should be considered in the short term, until the urine culture is perfect and clear.

Multiple infections: patients with abnormal urinary tract structure, indwelling catheter and other risk factors can not be removed, so it is necessary to be alert to the possibility of multiple pathogens including fungi combined with infection, repeat the cultivation of urine bacteria, mycoplasma, fungi and mycobacteria, and improve urine mNGS to help clarify the infected pathogens.

Four, further examination, diagnosis and treatment process and treatment response

On November 23, 2022, the middle urine smear was used to find bacteria: moderate amount of G- bacilli, and continued ceftazidime and abamectin 2.5g q12h ivgtt for anti-infection and bladder irrigation.

On November 26, 2022, the bacterial drug sensitivity of the middle-stage urine culture (sampling on November 23) was CRKP, ≥ 100,000 /ml, and urine mNGS: a large number of Klebsiella pneumoniae (species strict sequence number: 406,866) was detected.

On November 29, 2022, the abdominal and pelvic CT was reexamined: bilateral dilated hydronephrosis accompanied with inflammatory changes of ureter, and the parenchyma of both kidneys was thin, and the inflammatory changes of cystitis might be larger, similar to that of 22-10-20 slices.

November 30, 2022 (sampling on November 29): Enterococcus faecalis was positive. On December 2, according to the drug sensitivity, fosfomycin 3g qod was added orally, and ceftazidime and abamectin were suspended.

Repeated urine cultures on March, April and June, December, 2022: Enterococcus faecalis was positive and CRKP was negative.

On December 8, 2022, the urine WBC was 38738/μ L, and the bacterial count was 43285/μ L; Urine culture: CRKP positive, Enterococcus faecalis negative.

Phage therapy was carried out from the afternoon of December August, 2022: Phage cocktail (composed of 5 strains of Klebsiella pneumoniae phages A103KP172, A106KP176, A121KP192, A49KP106 and A58KP118, 5mL each), injected with 225mL physiological saline (according to the estimated bladder volume), and the total volume was 250mL, and then the catheter was clamped.

Urine routine on the third day of phage treatment on December 11, 2022: white blood cell count: 235/uL, bacterial count: 722/uL；; Urine bacterial culture was negative.

Urine routine on the 5th day of phage therapy on December 13th, 2022: white blood cell count: 279/uL, bacterial count: 92/ul; Urine bacterial culture was negative; Blood WBC 6.35X109/L, N 70%, hs-CRP 0.9mg/L, ESR 26mm/H, and inflammatory index decreased compared with before; Re-examination of urinary color ultrasound showed that bilateral renal pelvis separation and upper ureteral dilatation were better than before (10-20), and the thickness of bladder wall was reduced (12-25mm→13mm).

He was discharged from hospital on December 14, 2022 for follow-up.

V. Final diagnosis and diagnosis basis

Final diagnosis:

Complex urinary tract infection (CRKP, Enterococcus faecalis)

Neurogenic bladder, hydronephrosis and hydroureter (indwelling catheter)

Renal insufficiency

Diagnostic basis:

The patient is a middle-aged and elderly male with neurogenic bladder caused by paraplegia, indwelling catheter, turbid urine with flocs, increased CRP and PCT, significantly increased WBC and bacterial count in urine, repeated CRKP positive in urine culture, positive in enterococcus faecalis, abdominal basin CT: hydronephrosis of renal pelvis and ureter, anti-infection, normal inflammatory markers and urine routine after phage treatment, clear urine and negative urine culture, so complicated urinary tract infection.

The patient suffered from anorexia and dysuria, and the serum creatinine increased obviously. Abdominal CT showed that both kidneys were enlarged, the cortex was thin, and bilateral urinary tract was hydronephrosis. After active treatment such as controlling infection and improving renal function, the serum creatinine decreased, so the diagnosis of renal insufficiency was clear.

Six, experience and experience

Phage is a targeted sterilization virus in nature and a sterilization star in the "pre-antibiotic era". Phage therapy has a history of more than 100 years, but the discovery and application of broad-spectrum antibiotics have gradually marginalized it. With the increasingly serious problem of bacterial drug resistance, phages have once again received attention and become the most promising supplement and alternative therapy for treating superbugs. The clinical application of phage in China is relatively late, but it has developed rapidly in recent years. In 2017, the Shanghai Institute of Phage and Drug Resistance was established, with Professor Hu Bijie as an academic member. Since 2018, the institute has carried out the first clinical trial of phage therapy in China. At present, it has treated nearly 100 patients with drug-resistant bacterial infections from all over the country and accumulated rich clinical experience in phage therapy, which is a leading position in the field of clinical phage therapy in China.

Phage has many advantages, such as host bacteria dependence, targeted specific sterilization, no infection to eukaryotic cells (little influence on normal flora), no influence on bacterial drug resistance, synergy with antibacterial drugs, penetration of biofilm and so on. The cure rate of acute bacterial infection is high, and the therapeutic effect of chronic bacterial infection is no less than that of antibacterial drugs, and the safety of phage treatment is also extremely high. A systematic retrospective study showed that the vast majority of patients who received phage therapy had no or only slight adverse reactions, 86.7% patients’ clinical symptoms improved, and 78.8% patients achieved the eradication of pathogenic bacteria. Our clinical trials also show that more than 70% of patients have achieved good therapeutic effects, and there are no obvious cases of adverse reactions. This patient was repeatedly infected with Klebsiella pneumoniae due to long-term paraplegia, abnormal urinary tract structure, indwelling catheter and other factors. The diagnosis of complicated urinary tract infection was unquestionable, and the choice of antibacterial drugs was limited due to multi-drug resistance and renal insufficiency. Phage therapy is very suitable.

The disadvantages of phage therapy include narrow host spectrum, individualized plan (it is difficult to treat empirically), no unified standard for the best treatment decision, and rapid tolerance. Phage cocktails, combined antibacterial drugs and multiple treatments are usually used in clinic to improve the curative effect. At present, the targeted pathogens of phage therapy in our team mainly include: multi-drug resistant Gram-negative bacteria (Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecalis); Covering respiratory system, urinary system, abdominal cavity, bones and joints, skin and soft tissue and other infected sites; Treatment depends on the site of infection, and intravenous application of phage is still being explored. In this case, the patient didn’t have percutaneous nephrostomy because of the little clinical benefit, so he was treated by transurethral bladder perfusion, and the phage could not cover the whole urinary tract evenly. Although the pathogen turned negative in a short period of time and was well tolerated, its long-term curative effect may not be good, and it needs repeated phage treatment.

Phage therapy has huge clinical demand and broad market. In recent years, our team has focused on the clinical application (treatment and prevention and control of nosocomial infection) and basic research of phage therapy, with a view to becoming a powerful weapon to curb drug-resistant bacteria in the future.

references

[1] Uyttebroek S, Chen B, Onsea J, Ruythooren F, Debaveye Y, Devolder D, Spriet I, Depypere M, Wagemans J, Lavigne R, Pirnay JP, Merabishvili M, De Munter P, Peetermans WE, Dupont L, Van Gerven L, Metsemakers WJ. Safety and efficacy of phage therapy in difficult-to-treat infections: a systematic review. Lancet Infect Dis. 2022 Aug; 22(8):e208-e220.

[2] Chegini Z, Khoshbayan A, Taati Moghadam M, Farahani I, Jazireian P, Shariati A. Bacteriophage therapy against Pseudomonas aeruginosa biofilms: a review. Ann Clin Microbiol Antimicrob. 2020 Sep 30; 19(1):45.

[3] Lusiak-Szelachowska M, Weber-Dabrowska B, Gorski A. Bacteriophages and Lysins in Biofilm Control[J]. Virol Sin, 2020,35(2):125-133.

Every Monday night

The Department of Infectious Diseases of Zhongshan Hospital affiliated to Fudan University in Shanghai will be with you!

Photo: Xiaoxiao

Original title: "Detective Case: The Nemesis of Super Bacteria is Coming"

Read the original text

CCTV News:On July 12th, "News Network" reported a number of economic data of China in the first half of the year. The data showed that China’s economic operation continued to improve, with strong resilience, great potential and sufficient vitality.

China’s summer grain harvest

According to the data released by the National Bureau of Statistics on July 12th, in 2024, the total output of summer grain in China was 149.78 million tons, or 299.6 billion Jin, an increase of 7.25 billion Jin or 2.5% over 2023. The national summer grain harvest was good.

The sown area of summer grain remained stable. In 2024, the sown area of summer grain was 399.2 million mu, of which the sown area of wheat was 346.361 million mu, an increase of 475,000 mu compared with 2023.

The yield of summer grain has increased. The national summer grain yield reached 375.2 kilograms per mu, an increase of 9 kilograms or 2.5% over the previous year, of which the wheat yield reached 399.1 kilograms per mu, an increase of 2.6%. Regionally, among the 25 summer grain producing areas, 21 have increased their output.

In the first half of the year, China’s trade in goods exceeded 21 trillion yuan, a record high in the same period.

The General Administration of Customs announced on July 12th that in the first half of this year, the total import and export value of China’s goods trade increased by 6.1% year-on-year, the trade scale reached a new high, and the quarterly trend continued to improve.

According to customs statistics, in the first half of the year, the total import and export value of China’s goods trade was 21.17 trillion yuan, a year-on-year increase of 6.1%. Among them, the export was 12.13 trillion yuan, up 6.9%; Imports reached 9.04 trillion yuan, up 5.2%.

In terms of trade scale, in the first half of the year, the import and export scale of China’s goods trade exceeded 21 trillion yuan for the first time in the same period. The growth rate of import and export accelerated quarter by quarter, with an increase of 7.4% in the second quarter, which was 2.5 and 5.7 percentage points higher than that in the first quarter and the fourth quarter of last year respectively. The quality of import and export of goods continued to improve and the scale grew rapidly.

In terms of trade patterns, in the first half of the year, China’s general trade import and export was 13.76 trillion yuan, up 5.2%, accounting for 65% of China’s total foreign trade. In the same period, the import and export of processing trade was 3.66 trillion yuan, an increase of 2.1%, accounting for 17.3%. In addition, China’s import and export by bonded logistics was 2.96 trillion yuan, an increase of 16.6%.

From the perspective of trading partners, in the first half of the year, China and its largest trading partner — — The total trade value of ASEAN was 3.36 trillion yuan, up by 10.5%, accounting for 15.9% of China’s total foreign trade value. In the same period, China’s total import and export to countries that jointly built the "Belt and Road" was 10.03 trillion yuan, an increase of 7.2%.

From the perspective of business entities, in the first half of the year, the import and export of private enterprises was 11.64 trillion yuan, up 11.2%, accounting for 55% of China’s total foreign trade, up 2.5 percentage points over the same period last year. In the same period, the import and export of foreign-invested enterprises and state-owned enterprises both increased.

Financial support for the real economy remained stable in the first half of the year.

According to the data released by the People’s Bank of China on July 12th, the stock of social financing scale at the end of June was 395.11 trillion yuan, up 8.1% year-on-year. Among them, the balance of RMB loans to the real economy was 247.93 trillion yuan, up 8.3% year-on-year. Financial support for the real economy remained stable.

China’s civil aviation economy continued to improve in the first half of the year.

The reporter learned from the Civil Aviation Administration of China on July 12 that in the first half of the year, China’s civil aviation economy operated steadily and steadily. By the end of June, the investment in fixed assets in the whole industry was 61.52 billion yuan, up 33.2% year-on-year, and the total transportation turnover was 70.3 billion tons kilometers, up 32.2% year-on-year. The domestic and international markets of air transportation both exceeded the same period in 2019. The scale of international passenger transport recovered to 81.7% in the same period of 2019.

In the first half of the year, the number of passengers sent by national railways exceeded 2 billion.

The reporter learned from China State Railway Group Co.,Ltd. on July 12th that in the first half of the year, the national railways sent a total of 2.096 billion passengers, up by 18.4% year-on-year, and the railway passenger volume, passenger turnover and other indicators ranked first in the world. The daily average number of passenger trains was 10,256, a year-on-year increase of 9.4%.

In 2024, the Beijing-Hangzhou Grand Canal was successfully completed.

The reporter learned from the Ministry of Water Resources that recently, in 2024, the water replenishment task of the Beijing-Hangzhou Grand Canal was successfully completed. Since the full-line flow was realized on March 20, the full-line water state has been maintained at present, and the full-line water duration has exceeded 100 days for the first time. As of July 1st, the water supply sources have accumulated 1.536 billion cubic meters of water to the north section of the Yellow River of the Beijing-Hangzhou Grand Canal, completing 181.8% of the planned water supply.

In the 100,000-class independent car market, Geely Xingrui stands out with its excellent sales and reputation. For a high-profile car, the quality and performance of the three parts are the key to measure its quality. Below, let’s have a deep understanding of the three pieces of Geely Xingrui and explore whether they are worth buying.

First, a solid chassis

Geely Xingrui adopts front McPherson independent suspension and rear multi-link independent suspension, in which the addition of E-shaped multi-link structure and lateral stabilizer bar gives Xingrui a compact and comfortable driving experience. The front and rear suspension strokes reach 185MM and 203MM, respectively. This super-long design not only improves the comfort, but also provides strong support for the handling and stability of the vehicle.

Second, a strong dynamic heart

Xingrui is equipped with Volvo Drive-E series 2.0TD in-cylinder direct injection turbocharged engine, which has won the honor of "Ward Top Ten Engines" for many times. It provides Xingrui with a maximum horsepower of 190 horses and a peak torque of 300 Nm. Compared with joint venture models such as sagitar and Civic, its power performance is undoubtedly better, showing Geely’s sincerity.

Third, intelligent transmission partners

Xingrui, which matches the 7-speed wet powershift, not only performs well in shifting speed and efficiency, but also gives consideration to dynamic response and fuel economy. Although there may be a little pulling feeling at low speed, the overall performance can still meet the daily driving needs, showing a good adjustment.

On the whole, Geely Xingrui’s outstanding performance in the three major parts, coupled with its cost-effective interior design, spacious space and rich configuration, makes it a trustworthy and purchased model. In the rise of domestic automobile brands, Geely Xingrui is undoubtedly a strong competitor in the field of independent cars, which proves the strength and progress of independent brands.

[Autohome Ningbo Discount Promotion Channel] Currently, there are promotions underway, and you can enjoy a discount of up to 28,000 yuan, and the minimum starting price is 188,600 yuan. As a much-watched model, the price reduction of eπ 008 undoubtedly provides more car buying options for Ningbo consumers. If you are interested in this model, you can click "Check Car Price" in the quotation form to get a higher discount.

eπ008采用了前卫动感的设计语言，前脸部分采用了封闭式进气格栅，搭配锐利的前大灯组，整体造型简洁而富有科技感。车身线条流畅，彰显出强烈的运动气息。整体风格时尚大气，充分展示了eπ008的独特魅力。

eπ008的车身尺寸为5002*1972*1732毫米，轴距达到了3025毫米，宽大的车身与充裕的轴距为驾乘者提供了宽敞舒适的内部空间。该车的车侧线条流畅，呈现出一种动感和优雅的美感。此外，前轮距和后轮距均为1650毫米，确保了车辆在行驶过程中的稳定性和操控性。轮胎规格为265/45 R21，搭配精致的轮圈设计，进一步提升了车辆的整体质感和运动感。

eπ008的内饰风格以简约而优雅为主，为驾乘者提供了一个舒适的驾驶环境。方向盘采用皮质材质，手感柔软，支持手动上下和前后调节，能够满足不同驾驶者的需求。15.6英寸的中控屏采用悬浮式设计，集成了多媒体系统、导航和电话等功能，同时配备的语音识别控制系统让用户可以通过语音指令轻松控制车内的多媒体、导航和空调等功能。中控台下方配备的USB和Type-C接口满足了充电和数据传输的需求。主副驾驶座椅采用仿皮材质，主驾驶座椅具备加热、通风和头枕扬声器功能，副驾驶座椅则具备加热和通风功能，同时前后排座椅均支持电动调节，提供多角度的支撑和舒适感。此外，第二排座椅还支持靠背调节和腿托调节，后排座椅则具备比例放倒功能，进一步提升了乘坐的便利性。

eπ008搭载了一款强劲的发动机，最大功率达到了200kW，最大扭矩为340N·m，为车辆提供了卓越的动力性能。

汽车之家车主 表示，eπ008的外形设计中庸大气，但在一些细节处理上还需提升。这一评价反映了产品在外观设计上的成熟度和细节打磨上的潜力，为后续的改进提供了明确的方向。