? ? ? ? ? ? Many car owners are buying Xpeng Motors for the first time, some are pure novice users, and they are not familiar with all kinds of buttons on the car. In addition, the minimalist design of Tucki similar to Tesla, many users say that they can’t use it, so it’s hard to remember, and their heads are so big! ! !

? ? ? ? ? ?Today’s most detailed graphic tutorial, here he comes! Hand in hand to teach you the usage of MONA M03 buttons. It is recommended to save them and look at them often to ensure that you can use them quickly without making mistakes! ! !

? ? ? ? ? 1. The first scene, the buttons on the steering wheel, the intelligent adjustment and the use of lighting, are used the most and must be mastered!

? ? ? ? 2. Second, double flashing lights and reading lights, put down in the back row, in case of emergency, such as high-speed breakdown, be sure to know where it is and turn it on at the first time! ! !

? ? ? ? ?3. Adjust the seat button and the glass lifting switch!

? ? ? ?4. Air conditioning adjustment in the back row, as well as charging port and small storage box under the trunk!

? ? ? ?5. It is our biggest feature, how to open and close the electric hatchback door, and how to set your own default opening height to avoid rubbing on it!

? ? ? ? That’s all for today’s sharing. Have you all learned? Novices must remember the meaning and usage of each key to travel safely on the road! ! !

? ? ? Finally, I wish all new friends a happy Mid-Autumn Festival! ! !

　　The number of fans is 5 million. Brother Donkey is under great pressure after getting rich overnight.

　　Claiming to have no face value and no culture, understanding the real circle of friends through the network.

　　In the webcast room, fans called him "Brother Donkey". At 9 o’clock every night, tens of thousands of fans have been "in place" on time, waiting for his appearance. In the online world, no one cares about his real name.

　　"Brother Donkey" is actually only 28 years old this year, and looks a little vicissitudes. In his own words, "people in their twenties look like they are almost forty years old". However, it doesn’t matter. Anyway, he didn’t take the common route of sucking powder by facial value at all. A year ago, he began to put some self-made hilarious ultra-short films on a video App, usually for more than ten seconds. Unexpectedly, it became popular overnight, and the number of fans soared from tens of thousands to more than five million now, making it the top three fans in this video App, online celebrity.

　　A year ago, he was only the owner of a small tobacco hotel in Shijiazhuang. A year later, when he came to Guangzhou, his life was undergoing earth-shaking changes.

　　Text, map/Guangzhou Daily reporter Du Anna

　　In a large building on the edge of Guangzhou, the reporter found such a super online celebrity who would get lost in his own community.

　　I have just moved to the community for almost two months, and Brother Donkey usually just stays at home. At the appointed time of the interview, he was driving around the community in his own sports car with more than one million yuan, and he still couldn’t find the appointed place.

　　Brother Donkey is 1.85 meters tall, with a white T-shirt and a pair of blue shorts. He dresses casually. Brother Donkey’s signature dress is a gold chain thicker than his fingers. He said that he didn’t buy it after online celebrity developed. "We’ll just show how much money we have at home.".

　　A year ago: urban "Jianghu" youth

　　No one saw that Brother Donkey would be where he is today, including himself.

　　Brother Donkey used to be a small owner of a tobacco hotel in Shijiazhuang, and the actual investor of this store was his father. In Brother Donkey’s eyes, Dad is a thoughtful businessman, from greenhouse cultivation in the countryside of Mudanjiang in Northeast China to vegetable trade, and then to running a restaurant in Shijiazhuang, step by step, making him a "rich second generation" — — Brother donkey

　　Speaking of his past life, he described himself as a playboy who was born in the countryside and had a primary school education, and became a city youth and wandered on the edge of mainstream culture.

　　Xiao Pang, his friend for many years and now his partner, thinks that Brother Donkey was famous in the local area before he became a super online celebrity, and his status in the Jianghu should not be underestimated. Xiao Pang used to be a waiter in the restaurant of Brother Donkey’s father. He was attracted by Brother Donkey’s personal charm and stopped working as a waiter. Every day, he was inseparable from him.

　　Three-person "donkey family class"

　　Brother Donkey’s current creative team also has a core member named Jia Erchang. The trio formed the present "Donkey Family Class". Jia Er is often a wise man in the eyes of Brother Donkey. He is thoughtful and far-sighted. "When he saw that I was going to be popular, he quickly went to my restaurant and invited me to dinner. Finally, the three of them stuck together."

　　Brother donkey, it’s purely fun to go online and become popular. Two years ago, someone told him that there was a fun video software that was especially suitable for him. Brother donkey’s eyes shine, and he is like a duck to water for a person who usually takes "amusing" as his hobby.

　　In the original Caotai team, Brother Donkey’s wife was a photographer, Brother Donkey was the protagonist, and almost all the chefs, waiters and logistics staff in his father’s restaurant made guest appearances in his hilarious jokes.

　　In order to attract attention, Brother Donkey has taken great pains. He scoured the Internet for props, bought a giant deck of playing cards, recorded several jokes, simulated several "landlords" games, and satirized how the "two-short" players turned their excellent cards into bad cards in the poker field.

　　The video broadcast effect was somewhat unexpected. One of the videos reached several million hits, and the fans of Brother Donkey rose by 30,000 to 40,000.

　　A year later: a fire broke out.

　　Brother donkey was very excited after a good game. Brother donkey said that the original works now seem to be the most satisfactory. He said that even if he looked back now, he would still laugh.

　　In the more than 200 works of "Donkey Family Class", most of the contents are from their original works, and some of them are remakes. Brother Donkey mainly creates hilarious short videos of more than ten seconds, while Jia Erchang writes "feature films" of about two minutes. Over the past two years, they have formed a tacit understanding.

　　The soaring number of fans

　　My brother remembers the excitement of tens of thousands of fans for the first time. At that time, he answered questions from fans. Every time the powder rises, he is even too happy to sleep.

　　Now, "a little numb", rising powder has become a burden. During the interview, he took out his mobile phone and took a look. In just one hour, on the video playback platform, it has already increased by 1,263. According to the statistics of Brother Donkey, the speed of his powder increase is almost 10,000 people a day.

　　The comments and private messages on the video playback platform are basically too busy for Brother Donkey.

　　In addition, hundreds of people request to add his WeChat friends every day. My brother didn’t look at his mobile phone for a few minutes, and the invitation to add WeChat friends has already been arranged in a "long queue". And most of the requests, the final result is ignored. Only some fans who brush their screens and "give gifts" frequently during his live broadcast may be added as WeChat friends by him.

　　Seeing that Brother Donkey is on fire, there are also many platforms to ask him to "move". He found that his "charm" is not infinite, the number of fans can’t come up, and the number of viewers during live broadcast is not as good as that of the existing platform.

　　I once thought about giving up.

　　In a year, Brother Donkey has gone from a small owner of a tobacco hotel to a super online celebrity now. The income has gone from 1.2 million yuan a year to 700,000 yuan a month now. He himself said that it was almost a rich man overnight.

　　"However, everyone only sees the scenery of success, but can’t see our sadness and suffering." Brother Donkey has refused to place advertisements when recording hilarious short films since he became online celebrity. Because of this, fans will look down on us.

　　But this principle has also been broken. That difficult time almost ruined Brother Donkey’s road to super online celebrity. Brother Donkey said that in fact, the monthly income of 700,000 to 800,000 yuan is only this year. For a long time, they not only earned nothing, but also posted it upside down.

　　However, what hit them hard was not the investment. "After all, the cost is not high, just a few people eat and some props", but the people around them don’t understand. "Jia Erchang’s parents saw their son with me, making jokes in the Woods all day. They are almost thirty, and they can’t earn a penny. Like a fool, they are anxious."

　　Brother donkey said, "My wife is also anxious. Is it silly to say that you pat all day?"

　　Dialogue with Brother Donkey: "I am a very wonderful online celebrity"

　　Guangzhou Daily: Did you ever think that you would become online celebrity?

　　Donkey: I didn’t expect that. I thought about 110 thousand ways to get rich, but I didn’t expect this one.

　　Guangzhou Daily: What’s your income now?

　　Brother Donkey: The monthly income is about 700,000 to 800,000 yuan. Most of the money was sent by fans in the webcast room. A live broadcast usually earns about 50 thousand yuan.

　　Guangzhou Daily: How many "zombie fans" do you think are among your fans?

　　Brother Donkey: There must be, because some people don’t interact with each other, and it won’t be long before they go offline. But each paragraph is played more than 2 million times a day. There should be no moisture in this.

　　"I don’t want to go too high, I don’t have great ability."

　　Guangzhou Daily: Are you satisfied with your work?

　　Brother donkey: I think the early works are better. I found the previous jokes interesting myself, but the current ones are just so-so. Jiang Lang is at his wit’s end.

　　Guangzhou Daily: What is your dream?

　　Brother donkey: I hope that one day a famous director will take a fancy to us and be able to make a movie. So we don’t play junk advertisements, but also for this dream.

　　Guangzhou Daily: Is there a great director looking for you now?

　　Donkey: No. But there are too many people looking for us to make micro-movies. We need to watch the script.

　　Guangzhou Daily: Do you still want to make a film by a famous director?

　　Donkey: I don’t want to. Now we know that the entertainment circle is not what we think. People like us can just make a big online movie. It’s better to be a chicken head than a phoenix tail. I don’t want to go too high, I feel that I don’t have that great ability, and I feel that I have reached the bottleneck.

　　Guangzhou Daily: Will you be anxious now?

　　Brother Donkey: Actually, I’m a little depressed after a long time. Since I came to Guangzhou, I only slept a few hours a day. I often shut myself in my room, watch WeChat, Weibo’s public platforms, find some meaningful jokes, and some popular content on the platforms. I feel too tired, just look at the car, and I can’t stop thinking for a moment. At present, the whole operation team has nearly 20 people, including shooting, editing, chef, logistics and bodyguards. The salary of each person is 10 thousand yuan a month, which is not a small expense.

　　"Second-and third-tier stars are no match for me."

　　Guangzhou Daily: Why did you come to Guangzhou?

　　Brother Donkey: In the past, during the live broadcast, it was a clothing factory in Guangzhou that provided me with clothes for free. Later, I came to this boss and felt that Guangzhou was very developed, and I picked up money casually. I cooperate with this clothing factory and act as their agent. I only say it once a day in the live broadcast room, and my micro-signal is filled up. Hundreds of people are designated customers. I sell clothes for a clothing factory and often run out of stock as soon as I sell them. I have used several micro-signals. Before, someone put my WeChat on the homepage of the video playback platform, and it was added to 5000 people at once. The WeChat card could not be opened and had to be invalidated. I have five or six micro-signals now, each of which is thousands of people.

　　Guangzhou Daily: Are you satisfied with the current situation?

　　Brother Donkey: oh, let a man of spirit venture where he pleases. If it doesn’t work right now, I’m happy, too. I’ve already enjoyed this process, which is quite exciting. I have reached such a "stage". Now that my fame has spread, people will not forget me for at least two or three years. For example, I can make movies. I still have some brand shares, and I will definitely not return to my original position.

　　Guangzhou Daily: Everything has a life cycle. How do you plan your future?

　　Brother Donkey: I can accept my disciples now and throw my popularity at them. Besides, I can invest in making movies.

　　Guangzhou Daily: Are you a little different from ordinary online celebrity?

　　Brother Donkey: Yes, I am a very wonderful one. To face value without face value, to culture without culture, to talent without talent, primary school culture.

　　Guangzhou Daily: Where are your fans mainly concentrated? Who are they?

　　Brother Donkey: It’s all over the country. If you travel all over the country, you just need to fill up your car and get fans everywhere. Just let me know when you broadcast live. There are fans in all fields, including business owners, social workers and public officials.

　　Guangzhou Daily: You look like a movie star now?

　　Brother Donkey: Second-and third-tier stars can’t compete with me. I think it’s almost 1.5 lines now.

　　"The Internet has made me see the reality clearly"

　　Guangzhou Daily: What’s your daily routine?

　　Brother Donkey: I sleep at dawn, get up in the afternoon and work at night almost every day.

　　Guangzhou Daily: What is the content of the live broadcast?

　　Brother Donkey: When fans ask me questions, I say what I think, which is very straightforward. I don’t hide, I don’t lie. Because telling a lie requires hundreds of lies to make up for it.

　　Guangzhou Daily: How will you relieve stress?

　　Brother Donkey: I’m going to open a martial arts school. You can vent when you have time.

　　Guangzhou Daily: What’s your biggest feeling after you became online celebrity?

　　Brother donkey: the internet is a magnifying glass in reality, which makes me see many people clearly. For example, the brothers who used to play together, when they saw that I was popular, came to me and said that they would kick my current partner out. I certainly wouldn’t. They called names behind their backs and said everything.

　　When I first started filming, I asked some friends for help. They not only didn’t help but also laughed at me. Now that I am popular, they all come back to me.

　　Reporter’s notes

　　He lives in a "parallel world"

　　After listening to Brother Donkey’s story, many people expressed their sighs. Is the Internet a world parallel to reality? Why is he popular?

　　During the interview, the performance of this super online celebrity made people feel extremely fickle. In the early communication, half of the people were "missing", and the interview site was temporarily changed. It was extremely unpunctual when the interview time came.

　　After a great test of patience, a guy who is 1.85 meters tall, with a thick gold finger chain and driving an Audi R8 sports car appeared in front of the reporter.

　　This has 5 million fans, and the super internet celebrity is full of apologies. It turns out that he just moved here not long ago, and his long-term day-and-night work and rest, coupled with the living habits of the super house, have never wandered around the community. So I drove around the community for several times and still couldn’t find the agreed place.

　　Brother donkey’s characteristic is to constantly subvert your inherent idea of online celebrities.

　　Finally, the interview had to be conducted on the side street of a stuffy and humbled shop. He parked his luxury car on the side of the road and walked into the roadside shop without hesitation. While not forgetting to joke, he said that he was originally a peasant, and he felt very adapted to this environment.

　　In the whole interview, he did not shy away from talking about the dilemma he faced, and reached a bottleneck in his creation. Although his income has reached a new peak, the higher he stands, the more lonely he feels, even if he has millions of fans.

　　He has no pushers or advisers, so he can only think for himself. He looks heroic, but in the face of his future, he looks conservative and worried. He doesn’t like some online celebrity, keen to expand the scale. He is satisfied with the flexible and free creative team at present.

　　After the tornado in Jiangsu, he took 30,000 yuan and drove from Guangzhou at 2 o’clock in the middle of the night, driving for more than 20 hours, and went to the hospital in the disaster area to give money to the victims. He didn’t record any video because he was afraid of being said to be a show, and he didn’t mention anything on the webcast platform. That’s what he wants.

　　In the end, he said frankly that it was not that he didn’t care about the media interviews, but that he felt as if he had nothing to talk about and was very unconfident, so he had to keep running away.

　　It is such a contradictory but true young man who becomes a super red man in another parallel world.

　　The transformation of cell fate is determined by precise and complex signal regulation and epigenetic regulation, and the study of its molecular mechanism is one of the core problems that need to be solved urgently in the development of cell biology. Studies have shown that mouse pluripotent stem cells have two different states in signal maintenance and function, namely, primitive Epiblast stem cells, EpiSCs) and naive Embryonic stem cells, ESCs). In vitro, these two kinds of pluripotent stem cells can transform each other. Under the stimulation of ActivinA and bFGF signals, naive ESCs can differentiate into primed EpiSCs. On the contrary, by overexpressing a single naive pluripotent gene, such as Esrrb, Klf2, Nr5a2, etc., the initial to naive transition (PNT) can also be realized. Studying the mechanism of cell fate change in mouse PNT process can provide reference for isolating or inducing naive pluripotent stem cells from different species, but the main molecular mechanism of cell fate change in mouse PNT is still unclear.
　　On May 11th, Pei Duanqing’s research group and Liu Jing’s research group of Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences published a research paper entitled BMP4 resets mouse epi blast stem cells to naive proliferation through zbtb7a/b-mediated chromatin remolding online in the journal Nature Cell Biology. In this study, we first found that BMP4 can induce PNT in mice, and established an efficient PNT induction system with clear components. Subsequently, high-throughput sequencing techniques such as ATAC-seq were used to reveal the specific molecular mechanism of mouse PNT process.
　　At first, researchers found that growth factor BMP4 can induce PNT in mice. With the help of visual reporting system and screening of compound library, it was found that EZH2 inhibitor EPZ6438 and DOT1L inhibitor EPZ5676 can significantly improve the induction efficiency, and then a mouse PNT induction system with a clear chemical composition with an induction efficiency of 80% within 8 days was established.
　　On the basis of this platform, researchers combined bioinformatics analysis based on chromatin transposase accessibility sequencing (ATAC-Seq). The dynamic changes of chromatin accessibility in the process of PNT induced by small chemical molecules in mice were described, and it was found that the most critical factor in this system, BMP4, mediated the progress of PNT by regulating chromatin accessibility, on the one hand, inhibiting the opening of differentiation-related sites, on the other hand, promoting the opening of naive pluripotent gene sites. By analyzing the gene sites where BMP4 opens and activates expression, the researchers found that the new downstream targets of BMP4, Zbtb7a and Zbtb7b, regulate the function of PNT by influencing chromatin remodeling. Furthermore, chromatin immunoprecipitation (Chip) proved that Zbtb7a directly binds to and activates the expression of naive pluripotent genes such as Esrrb, Klf2, Nr5a2, thus regulating the occurrence of PNT.
　　To sum up, this study established an efficient technical platform for chemical induction of mouse PNT, revealed the molecular mechanism and found new targets from the perspective of chromatin accessibility, and made new discoveries in the study of cell fate transformation mechanism, which provided a new understanding and breakthrough point for the study of chemical regulation of cell fate transformation, and also provided a very meaningful reference direction for other research systems, such as the acquisition of naive pluripotent stem cells in human system.
　　Researchers Pei Duanqing and Liu Jing are the corresponding authors of this paper. Doctoral students Yu Shengyong and Zhou Chunhua, Ph.D. students Cao Shangtao and He Jiangping are the co-first authors of this paper.
　　Paper link
　　Cell fate transition process, chromatin changes and intervening regulatory proteins

　　Beijing, January 30th, 2007 (Reporter Chang Yafei of the Central Television Station) Recently, there was a picture circulating on the Internet: the central government required "returning home from a low-risk area with a green code", but in the province, it became "negative proof of nucleic acid test", in the city, it became "home isolation", in the town, it became "nucleic acid proof+centralized isolation+home isolation", and in the village, it became "please leave gracefully". The reporter’s interview and investigation found that although this picture on the Internet has deductive elements, it is also a reflection of the facts at the grassroots level. Especially in some places, the epidemic prevention policy is "overweight" or even "one size fits all".

　　On January 27th, at the press conference of the joint prevention and control mechanism in the State Council, Zhao Chenxin, secretary-general and spokesman of the National Development and Reform Commission, and Zeng Yixin, deputy director of National Health Commission, proposed that all localities should not be allowed and do not want to make "one size fits all" treatment when implementing the relevant policies formulated by the state for returning home for the New Year, and should not block people from traveling and returning home, but should give more protection and convenience to the people. What problems did the "Spring Festival returnees" encounter? Why is the "return home policy" being "overweight" in implementation?

　　National Health Commission recently issued the Notice on Printing and Distributing the Work Plan of COVID-19 Epidemic Prevention and Control in Rural Areas in Winter and Spring (hereinafter referred to as the Notice). The "Notice" clarifies that returnees need to return home with a negative result of effective nucleic acid test within 7 days, and implement home health monitoring for 14 days after returning home, during which they will not gather or flow, and carry out nucleic acid testing every 7 days. On January 14th, Xiao Li returned to a low-risk area in Benxi City, Liaoning Province from nangang district, a low-risk area in Harbin, with a negative report of nucleic acid test. When he returned to the village, he was asked to stay at home for 7 days.

　　Xiao Li told reporters: "Normally, those who return home from low-risk areas and have negative reports of nucleic acid testing can move at home normally without isolation. However, our village said that according to the superior’s opinion, I was still quarantined at home for 7 days. However, after the expiration of 7 days of isolation, no one gave me a nucleic acid test, and there were no measures and guarantees during the isolation process. In fact, it was a mere formality. "

　　Xiao Li said that because of the recurrence of the epidemic in Heilongjiang Province, his colleague Xiao Zhang returned to a low-risk area in his hometown of Hubei for 10 days and was isolated in his hometown. He said: "He had already returned home for about 10 days, and there were sporadic cases in Heilongjiang, so the local government asked them to concentrate on isolation again. From the day he came home, he was not released until 14 days after the quarantine expired. Not all of Hubei is like this, but only some parts of Hubei, such as a certain district or a certain township. This is actually the grassroots blindly pursuing prevention and control effects in the process of prevention and control without considering the actual situation. "

　　Mr. Wang from Shanghai recently returned his high-speed train ticket to his hometown in Jiaozuo, Henan. He said that in mid-January, he paid attention to his hometown’s policy of returning home. He learned from the neighborhood Committee that people returning from low-risk areas only need to provide proof of nucleic acid testing within 7 days and then monitor their health at home. He also took the initiative to declare his trip to the neighborhood Committee. But I didn’t expect that the feedback policy of the neighborhood Committee changed two days later: when he returned from Shanghai, he needed to be isolated at his own expense.

　　Mr. Wang said: "My mother called me and said that people in the community came to tell me that if I went back, I would go to the designated hotel for 14 days at my own expense. There is no point in going back like this, because the annual leave is only seven days. This is a soft way to let you not come back. "

　　Ms. Zhou from Anqing City, Anhui Province told the Voice of China reporter that she had planned to go back from Shanghai to visit her grandmother with a cerebral infarction during the Spring Festival, but because the community where her hometown is located requires that she be isolated at home for 14 days and have a nucleic acid test every seven days. Ms. Zhou calculated that the second nucleic acid test after returning home coincided with the date of the doctoral examination, and the neighborhood Committee stressed that the date of nucleic acid could not be revised, so she had to stay in Shanghai.

　　"Even if the nucleic acid testing, why can’t we reschedule? Wouldn’t it be nice to advance or postpone one day? But the people in the neighborhood Committee kept saying ‘ No ’ . In the process of talking to the staff of the (neighborhood) Committee, I found it hard to accept what she said. She said, ‘ I don’t care if you are low-risk or what kind of risk, as long as you come to us, that’s it. ’” Ms. Zhou said.

　　Requirements of returning home for epidemic prevention and control in Anqing City, Anhui Province

　　The "overweight" epidemic prevention policy has also been corrected in some places.

　　On January 24th, a village in Linxi County, Xingtai, Hebei Province issued a notice forbidding villagers working outside to go home for the New Year. After being reported by the media, the village secretary said that there was something wrong with the statement of the notice, but he just hoped that the villagers outside would try not to go home and had corrected the notice. Some netizens also reported that in Taocheng District, Hengshui City, Hebei Province, residents’ committees or property requirements, if they have to return to Hengshui under special circumstances, need to report to the community residents’ committees for registration in advance. After the personnel arrive, they will be isolated for 14 days at their own expense. After media reports, residents’ committee staff said that they had received orders from their superiors to cancel the notice. At present, the requirement is to carry out nucleic acid testing twice within 3 days after returning home, and to monitor the physical condition at home during this period, and not to go out unless necessary.

　　Regarding the deformation of the policy of returning home during the Spring Festival in some areas, Yang Hongshan, a professor at the School of Public Administration of Renmin University of China, told the Voice of China reporter that this is a manifestation of insufficient refined management in some places. He said: "The relationship between epidemic prevention and control, local resumption of production and normal production and living order is actually a parallel relationship, not a one-way choice relationship. Therefore, we can see that in today’s local epidemic situation, maybe our place needs to take care of all aspects. Simply considering only one factor and pursuing absolute safety or absolute self-exemption may also be a manifestation of insufficient initiative and meticulous management in some places. In the process of operation, the basic top-down epidemic prevention and control policies and related laws and regulations are sometimes ignored by grassroots governments. "

　　Yang Hongshan believes that it is necessary to attract the attention of local governments through media publicity and reports, so as to urge them to take corresponding measures in time to stop the "overweight" epidemic prevention and control behavior. Local governments should adopt differentiated management by regions and levels, and pay more attention to "embroidery" and human feelings.

　　"Today, in the face of big data, there is also a collaborative management mechanism between different regions. It is necessary to take the clues of the epidemic itself as the guide, and adopt refined prevention and control measures for local and sporadic epidemics. In the case of complete control, just for the convenience of one’s own work, regardless of the convenience of the other party, and completely ignoring the interests and rights of the other party, it is actually a bit simple and rude, and it is also a manifestation of not taking measures according to people’s policies in local governance. The more you are in the grass-roots governance, the more you face the vivid reality, and the more you know all kinds of differentiated situations. In fact, in the process of grassroots governance, it is more necessary to consider the human touch. " Yang Hongshan said.

This is the 2329th article of Da Yi Xiao Hu.

Up to now, there have been three epidemic outbreaks caused by coronavirus in this century, namely, Severe Acute Respiratory Syndrome (SARS) in 2002-2003, Middle East Respiratory Syndrome (MERS) that began to spread in 2012, and novel coronavirus (COVID-19) that appeared at the end of 2019. China is a country with severe disasters in SARS and this time in novel coronavirus.

First, what is coronavirus?

Coronavirus exists widely in nature. Coronavirus was first isolated from chickens in 1930s, and it was isolated from human nasal wash more than 20 years later by scholars and named B814 virus. Later, scholars made an in-depth study of the virus from its morphology, and found that the envelope of the virus had a spinous process like a corona and a king’s crown, so the coronavirus was named from this. Its natural hosts are mainly vertebrates, and people, cows, pigs, cats and bats are all its natural hosts.

Coronavirus is slightly spherical in shape, with a diameter of 80-160nm. The "crown" on its surface is a fiber process of 12-24nm, and the end of the fiber process is also spherical. The envelope of the virus consists of two layers of lipids, with membrane protein M and fibrillary protein S interspersed between them, and some coronaviruses also have hemagglutinin glycoprotein HE. The interior of the virus is composed of RNA and nucleocapsid protein N, showing a spiral structure.

S protein is the key protein of coronavirus-infected cells, which contains host cell receptor recognition sites and is the main determinant of virus virulence. M protein is the main protein responsible for virus particle assembly. N protein is closely combined with viral RNA, which can protect viral genomic RNA through spiral stacking and encapsulation. At the same time, it can delay the growth of infected cells and make them stay in the division period for a longer time, so that viral RNA can be translated to the greatest extent. HE protein plays a key role in the formation of virus particles.

As far as virus classification is concerned, coronavirus belongs to single-strand positive-strand RNA virus, which indicates that the genetic information of coronavirus is carried by RNA, and the cloned progeny virus has a high mutation rate. After entering the host cell, it directly uses ribosomes in the host cell to produce protein needed for virus replication without transcription. Coronavirus can kill cells, thus damaging various organs, and persistent infection occurs simultaneously with acute infection, mainly attacking gastrointestinal tract, respiratory tract and nervous system.

Second, the coronavirus that humans have fought.

Before SARS, it was thought that only two kinds of coronaviruses could cause human infection. At present, there are seven kinds of coronaviruses that can infect humans, including highly lethal coronaviruses, severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) and novel coronavirus virus (COVID-19).

The common feature of coronavirus is that it is generally sensitive to heat, and it is moderately stable in a suitable maintenance solution at 4℃, and can be stored for several years at -60℃. With the increase of temperature, the virus resistance decreases. Coronavirus is acid-resistant and alkali-resistant, and sensitive to organic solvents and disinfectants such as alcohol and ether.

The symptoms of coronavirus infection are mostly similar, mainly fever, chills, cough and so on. The main routes of transmission are droplet transmission and contact transmission.

1. SARS coronavirus (SARS-CoV)

Severe acute respiratory syndrome (SARS) was caused by SARS-CoV. By July 2003, it had spread to 24 provinces, autonomous regions, municipalities directly under the Central Government and 28 other countries in China. A total of 8096 clinically diagnosed cases were reported worldwide, and 774 cases died. Nearly 20%~30% of the patients needed mechanical ventilation due to respiratory failure, and the mortality rate was 9.6%. Epidemiology in many provinces and cities showed that the mortality rate increased with age, mostly over 60 years old. Its incubation period is within 2 weeks, usually 2~10 days. The population is generally susceptible and has a strong epidemic degree. The main onset age is 20-30 years old. The source hosts may be bats and civets. The transmission routes are mainly from person to person: droplet transmission in close respiratory tract, aerosol transmission and hand-to-hand contact transmission; Animals and people: civets/bats ~ people (possible). SARS-CoV has the general characteristics of coronavirus, but it is not a mutant of other known coronaviruses, nor is it a recombinant of known coronaviruses. SARS-CoV infects lung epithelial cells, and its S protein binds to angiotensin converting enzyme 2(hACE2) receptor, which invades and replicates in vivo. Because hACE2 is mainly in the lower respiratory tract, the symptoms of the upper respiratory tract are lacking, and the virus often peaks when hospitalized, which is easy to cause nosocomial infection of the lower respiratory tract.

2. MERS coronavirus (MERS-CoV)

Middle East Respiratory Syndrome (MERS) was caused by MERS-CoV, which was first confirmed in Saudi Arabia in 2012, affecting 27 countries and regions around the world, with a mortality rate of about 35%. According to statistics of a case, the mortality rate increases with age. The mortality rate is 39% in people younger than 50 years old and 75% in people over 60 years old. The longest incubation period is 14 days, and the population is generally susceptible. The median age of onset is 49 years old. Source host: it may be camel or bat. Transmission route: animal and human: dromedary ~ human (possible); People: Close contact. The infection site is epithelial cells in the lung, which causes explosive nosocomial transmission, and has obvious gastrointestinal symptoms and renal failure. It mainly binds to dipeptidyl peptidase 4(DPP4) in the lower respiratory tract, gastrointestinal tract and kidney, and there is no mutation that enhances human infection.

3. 2019 novel coronavirus (2019-nCOV)

Novel coronavirus was caused by 2019-nCOV. From mid-December 2019 to the beginning of 2020, 59 cases of unexplained pneumonia were reported in Wuhan, and similar cases were found in other regions and countries. On January 7, 2020, it was initially identified as "novel coronavirus", and on January 12, the WHO named the virus 2019-nCoV. Up to now, more than 70,000 cases have been diagnosed, and more than 2,400 cases have died, with a mortality rate of about 3.1%. It has spread to most provinces and cities in China and nearly 30 countries. The transmission routes may be droplet transmission, contact transmission and aerosol transmission. The incubation period is 1~14 days. At present, the source host may be a bat. Shi Zhengli’s team from Wuhan Institute of Virology has found that its genome is 79.5% identical to SARS-CoV and 40% similar to MERS-CoV. 2019-nCOV, like SARS-CoV, invaded by combining with human angiotensin converting enzyme 2(hACE2), infecting respiratory system, gastrointestinal tract and testis, affecting heart function and liver function. According to the current data, compared with SARS and MERS, it is more contagious and the mortality rate is not as high as the first two.

Third, actively protect against novel coronavirus

Personal protection requires frequent hand washing and hand hygiene. Cover your mouth and nose with paper towels when coughing or sneezing, which can effectively prevent the spread of droplets. Wear masks in public places, avoid contact with animals with unknown health conditions, and reduce the trading of live birds and wild animals.

At present, various industries have started to return to work. For the office, everyone should actively declare their health. If there are suspicious symptoms such as fever, fatigue and cough, it is recommended to seek medical advice in time, avoid going to work sick, strengthen ventilation and ventilation in public areas, clean and disinfect public areas and public goods regularly, keep the environment clean and hygienic, keep a proper distance when there are many people in the unified office area, and reduce centralized meetings by video and teleconference.

Authors: Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine

Written by Zhang Yijie

Xiong xudong revises

Some pictures are taken from the network. If there is any infringement, please inform and delete them.

　　International Online Report: According to the website of the National Bureau of Statistics, the gross domestic product in the first half of the year was 41,896.1 billion yuan, up 6.8% year-on-year at comparable prices. Quarterly, it increased by 6.8% in the first quarter and 6.7% in the second quarter, and remained in the range of 6.7%-6.9% for 12 consecutive quarters. In terms of industries, the added value of the primary industry was 2,208.7 billion yuan, a year-on-year increase of 3.2%; The added value of the secondary industry was 16,929.9 billion yuan, an increase of 6.1%; The added value of the tertiary industry was 22,757.6 billion yuan, an increase of 7.6%.

　　First, the agricultural planting structure is optimized and the production situation is better.

　　With the adjustment of grain planting structure, the national summer grain harvest is expected to be good. The structural reform of agricultural supply side deepened, and the planting area of cotton and soybean increased. Animal husbandry production is stable. In the first half of the year, the output of pig, cattle, sheep and poultry meat was 39.95 million tons, up 0.9% year-on-year; Among them, the output of pork was 26.14 million tons, an increase of 1.4%. The number of live pigs was 409.04 million, a year-on-year decrease of 1.8%; 334.22 million pigs were slaughtered, an increase of 1.2%.

　　II. Industrial growth was generally stable and the structure continued to be optimized.

　　In the first half of the year, the added value of industrial enterprises above designated size actually increased by 6.7% year-on-year, and the growth rate dropped by 0.1 percentage point compared with the first quarter. In terms of economic types, the added value of state-owned holding enterprises increased by 7.6% year-on-year, collective enterprises decreased by 1.9%, joint-stock enterprises increased by 6.7%, and foreign-invested enterprises from Hong Kong, Macao and Taiwan increased by 6.2%. In terms of three categories, the added value of the mining industry increased by 1.6% year-on-year, the manufacturing industry increased by 6.9%, and the electricity, heat, gas and water production and supply industries increased by 10.5%. The added value of high-tech industries and equipment manufacturing increased by 11.6% and 9.2% respectively, which was 4.9 and 2.5 percentage points faster than that of industries above designated size. In June, the added value of industrial enterprises above designated size increased by 6.0% year on year. From January to May, the total profits of industrial enterprises above designated size nationwide reached 2,729.8 billion yuan, a year-on-year increase of 16.5%; The profit rate of main business income of industrial enterprises above designated size was 6.36%, an increase of 0.35 percentage points over the same period of last year.

　　Third, the service industry grew rapidly, and emerging service industries flourished.

　　In the first half of the year, the national service industry production index increased by 8.0% year-on-year, and the growth rate dropped by 0.1 percentage point compared with the first quarter, maintaining a relatively fast growth rate. Among them, information transmission, software and information technology services, leasing and business services maintained rapid growth. In June, the national service industry production index increased by 8.0% year-on-year. From January to May, the operating income of service enterprises above designated size increased by 13.3% year-on-year, 0.2 percentage points faster than the same period of last year; Among them, the operating income of strategic emerging service industry, science and technology service industry and high-tech service industry increased by 18.1%, 17.5% and 15.4% respectively, which were 2.4, 5.0 and 4.5 percentage points higher than the same period of last year.

　　Four, residents’ consumption and market sales increased steadily, and consumption upgraded goods grew rapidly.

　　In the first half of the year, the per capita consumption expenditure of the national residents was 9,609 yuan, a nominal increase of 8.8% year-on-year, 1.2 percentage points faster than that in the first quarter, and a real increase of 6.7% after deducting the price factor, 1.3 percentage points faster. Among them, the per capita consumption expenditure of urban residents increased by 6.8% in nominal terms, accelerating by 1.1 percentage points; The per capita consumption expenditure of rural residents increased by 12.2% in nominal terms, accelerating by 1.2 percentage points. In the first half of the year, the total retail sales of social consumer goods was 180018 billion yuan, up 9.4% year-on-year, and the growth rate dropped by 0.4 percentage points compared with the first quarter. According to the location of business units, the retail sales of urban consumer goods reached 15,409.1 billion yuan, an increase of 9.2%; The retail sales of rural consumer goods reached 2,592.7 billion yuan, up by 10.5%. According to consumption types, catering revenue was 1,945.7 billion yuan, an increase of 9.9%; Retail sales of commodities reached 16,056.1 billion yuan, an increase of 9.3%. The sales of consumption-upgrading commodities grew rapidly, with household appliances and audio-visual equipment, communication equipment and cosmetics of units above designated size increasing by 10.6%, 10.6% and 14.2% respectively, 0.2, 0.5 and 2.9 percentage points higher than the same period of last year. In June, the total retail sales of social consumer goods increased by 9.0% year-on-year, 0.5 percentage points faster than last month.

　　5. Investment in fixed assets grew steadily, while private investment and manufacturing investment rebounded.

　　In the first half of the year, China’s investment in fixed assets (excluding farmers) was 29,731.6 billion yuan, up 6.0% year-on-year, and the growth rate was 1.5 percentage points lower than that in the first quarter. Among them, private investment was 18,453.9 billion yuan, up 8.4% year-on-year, 1.2 percentage points faster than the same period of last year. In terms of industries, investment in the primary industry increased by 13.5%; Investment in the secondary industry increased by 3.8%, of which manufacturing investment increased by 6.8%, and the growth rate rebounded for three consecutive months, 3.0 percentage points faster than that in the first quarter and 1.3 percentage points faster than that in the same period of last year; Investment in the tertiary industry increased by 6.8%, of which investment in infrastructure increased by 7.3%. Investment in high-tech manufacturing increased by 13.1% year-on-year, and the growth rate was 7.1 percentage points faster than the total investment. In the first half of the year, the national investment in real estate development was 5,553.1 billion yuan, a year-on-year increase of 9.7%. The national commercial housing sales area was 771.43 million square meters, up by 3.3%. The national sales of commercial housing reached 6,694.5 billion yuan, up by 13.2%.

　　6. The surplus of import and export of goods narrowed and the trade structure continued to improve.

　　In the first half of the year, the total import and export volume of goods was 14,122.7 billion yuan, a year-on-year increase of 7.9%. Among them, exports reached 7,512 billion yuan, up 4.9%; Imports reached 6,610.7 billion yuan, an increase of 11.5%. Imports and exports offset each other, with a surplus of 901.3 billion yuan, a decrease of 26.7% over the same period of last year. The trade structure was further optimized, and the import and export of general trade increased by 12.2%, accounting for 59% of the total import and export, an increase of 2.3 percentage points over the same period of last year. The export of mechanical and electrical products increased by 7%, accounting for 58.6% of the total export. Imports and exports to the top three trading partners maintained growth. China’s imports and exports to the European Union, the United States and ASEAN increased by 5.3%, 5.2% and 11% respectively, accounting for 41% of China’s total imports and exports. In the same period, China’s import and export to 16 countries in Central and Eastern Europe increased by 14.7%, which was 6.8 percentage points higher than the growth rate of total import and export of goods. In June, the total import and export volume was 2,493.6 billion yuan, a year-on-year increase of 4.3%. Among them, exports were 1,377.7 billion yuan, an increase of 3.1%; Imports reached 1,115.8 billion yuan, up 6.0%. In the first half of the year, industrial enterprises above designated size achieved a export delivery value of 5,716.2 billion yuan, a year-on-year increase of 5.7%. In June, industrial enterprises above designated size realized export delivery value of 1,054.7 billion yuan, an increase of 2.8%.

　　Seven, residents’ income grew steadily, and the employment situation was stable and positive.

　　In the first half of the year, the per capita disposable income of the national residents was 14,063 yuan, a nominal increase of 8.7% year-on-year, and a real increase of 6.6% after deducting the price factor. According to the place of permanent residence, the per capita disposable income of urban residents was 19,770 yuan, a nominal increase of 7.9% year-on-year, and a real increase of 5.8% after deducting the price factor; The per capita disposable income of rural residents was 7142 yuan, a nominal increase of 8.8% year-on-year, and a real increase of 6.8% after deducting the price factor. The per capita income difference between urban and rural residents was 2.77, 0.02 less than the same period of last year. The median per capita disposable income of the national residents was 12,186 yuan, a nominal increase of 8.4% year-on-year. In June, the national urban survey unemployment rate was 4.8%, which was the same as last month and decreased by 0.1 percentage point over the same month of last year. The survey unemployment rate in 31 big cities and towns was 4.7%, which was the same as last month and decreased by 0.2 percentage points over the same month of last year. At the end of the second quarter, the total number of rural laborers who went out to work was 180.22 million, an increase of 1.49 million or 0.8% over the same period of last year. The average monthly income of migrant workers was 3,661 yuan, a year-on-year increase of 7.5%.

　　Eight, consumer prices rose moderately, and industrial prices rose steadily.

　　In the first half of the year, the national consumer price rose by 2.0% year-on-year, which was 0.1 percentage point lower than that in the first quarter. By category, the prices of food, tobacco and alcohol rose by 1.4%, clothing by 1.1%, housing by 2.3%, daily necessities and services by 1.6%, transportation and communication by 1.2%, education, culture and entertainment by 2.1%, medical care by 5.5% and other goods and services by 1.1%. In June, the national consumer price rose by 1.9% year-on-year, an increase of 0.1 percentage point over the previous month and a decrease of 0.1% from the previous month. In the first half of the year, the ex-factory price of industrial producers nationwide rose by 3.9% year-on-year, an increase of 0.2 percentage points over the first quarter; The purchase price of industrial producers nationwide rose by 4.4% year-on-year. In June, the ex-factory price of industrial producers nationwide rose by 4.7% year-on-year, with an increase of 0.6 percentage points from the previous month and 0.3% from the previous month. The purchase price of industrial producers nationwide rose by 5.1% year-on-year and 0.4% quarter-on-quarter.

　　Nine, the transformation and upgrading have achieved remarkable results, and new kinetic energy has accelerated growth.

　　The economic structure continued to be optimized. From the perspective of industrial structure, the growth rate of added value of the tertiary industry in the first half of the year was 1.5 percentage points faster than that of the secondary industry; The proportion of GDP was 54.3%, 0.3 percentage points higher than that of the same period of last year and 13.9 percentage points higher than that of the secondary industry. From the perspective of demand structure, the contribution rate of final consumption expenditure to economic growth is 78.5%, which is 47.1 percentage points higher than the total capital formation. New industries and new products are growing rapidly. From the perspective of industrial structure, the added value of strategic emerging industries in the first half of the year increased by 8.7% year-on-year, 2.0 percentage points faster than that of industries above designated size. The output of new energy vehicles increased by 88.1%, industrial robots by 23.9% and integrated circuits by 15.0%. New consumption is booming. From the perspective of trade structure, the national online retail sales in the first half of the year was 4,081 billion yuan, a year-on-year increase of 30.1%. Among them, the online retail sales of physical goods was 3,127.7 billion yuan, up by 29.8%, accounting for 17.4% of the total retail sales of social consumer goods, up by 3.6 percentage points year-on-year; The online retail sales of non-physical goods reached 953.3 billion yuan, an increase of 30.9%. Green development has progressed steadily. From the perspective of energy conservation and emission reduction, the energy consumption per unit of GDP decreased by 3.2% in the first half of the year.

　　X. The structural reform of the supply side has been further promoted, and the market expectation is generally good.

　　Structural de-capacity continued to deepen. In the first half of the year, the utilization rate of industrial capacity in China was 76.7%, 0.2 percentage points higher than that in the first quarter and 0.3 percentage points higher than that in the same period of last year. The effect of destocking is outstanding. At the end of June, the area of commercial housing for sale nationwide decreased by 14.7% year-on-year. The leverage ratio and cost of enterprises continue to decline. At the end of May, the asset-liability ratio of industrial enterprises above designated size was 56.6%, down 0.6 percentage points year-on-year. From January to May, the cost per 100 yuan of main business income of industrial enterprises above designated size was 84.49 yuan, a year-on-year decrease of 0.31 yuan. Investment in the short-board sector has grown rapidly. In the first half of the year, the investment in ecological protection and environmental management and agriculture increased by 35.4% and 15.4% respectively, which was 29.4 and 9.4 percentage points faster than the total investment. The market is expected to remain prosperous. In June, the comprehensive PMI output index was 54.4%, the manufacturing purchasing manager index was 51.5%, and the non-manufacturing business activity index was 55.0%, which continued to run in the expansion range.

　　Generally speaking, in the first half of the year, the national economy continued to develop steadily and steadily, and the favorable conditions for supporting the economy to move towards high-quality development increased, laying a good foundation for achieving the main economic and social development goals for the whole year. However, we should also see that the uncertainty of the external environment has increased, and the domestic structural adjustment is in the critical period. We must adhere to the general tone of striving for progress while maintaining stability, maintain strategic strength, adhere to the supply-side structural reform as the main line, continue to expand effective demand, focus on revitalizing the real economy, actively respond to external challenges, prevent and resolve potential risks, guide and stabilize social expectations, and scientifically and comprehensively promote steady growth, promote reform, adjust structure, benefit people’s livelihood, and prevent risks to ensure stable and healthy economic operation.

Wu Zhenyu, the two film emperors’ rival in love, spoiled Sun Honglei on the spot.

　　"The Warring States" is based on the unprecedented tragic hegemony of the Seven Heroes of the Warring States in history, and describes the epic legend that two legendary militarists, Sun Bin and Pang Juan, evolved from close brothers to enemies and finally fought a decisive battle on the battlefield. Sun Honglei plays Sun Bin, who is kind-hearted, and Wu Zhenyu plays Pang Juan, who is fierce. The fate of the Warring States troubled times makes the two film emperors struggle in the play and become rivals in love. When it comes to the conflict between love and friendship, Sun Honglei faltered and finally reluctantly said, "Brothers come first, love comes second." Wu Zhenyu said helplessly, "I choose beauty, but beauty doesn’t choose me. When I chose my brother, my brother left me. "

　　"I think Sun Bin is wandering between a genius and an idiot. He has great talent in military affairs, but he doesn’t even have the basic ability to live in life. This time it’s more risky, and I hope it won’t thunder everyone." In order to experience the role, Sun Honglei also came to Sun Bin’s hometown and made a trip. "Bitter risks, cross the rubicon, deviance, etc. are all strategies used by Sun Bin in the movie." Sun Honglei said that the film shows the interlocking military strategies in a suspenseful way.

　　Although Wu Zhenyu has always been famous for playing a role with strange personality, he gently spoiled Sun Honglei at the scene that day. At that time, the host asked Wu Zhenyu to call Sun Honglei in three identities: brother, rival in love and enemy. Wu Zhenyu was shy and shouted, "Mmm!" Make a scene.
　

The Xingtu brand, which debuted at the 2017 Frankfurt Motor Show, can be regarded as a new force in the autonomous high-end field. It has three models: LX, TX and TXL, covering the mainstream compact SUV and medium-sized SUV segments. In order to achieve further upward breakthroughs in the brand and cater to its own high-end positioning, Xingtu planned a medium and large SUV model VX very early, but due to various reasons, the release time has been repeatedly delayed, which has whetted consumers’ appetite. Finally, the new car is determined to be officially launched on March 18, 2021, and the Chinese name Lanyue has been announced.

As the fourth SUV model launched by the Xingtu brand, Lanyue is no longer named with simple English letters, indicating that the new car will have a unique positioning. Due to the largest size in the Xingtu brand, and the use of exclusive M3X architecture and a large number of advanced technologies, Lanyue undoubtedly plays the role of family flagship. The listing of Xingtu Lanyue launched a total of 6 models, respectively equipped with the group’s latest 1.6T and 2.0T turbocharged engines, priced at 16.89-22 9,900 yuan. For a high-end mid-to-large SUV, consumers will definitely value its comprehensive configuration performance when purchasing, so which of the 6 models is more cost-effective?

Brief description of the model

Lanyue is based on the latest M3X Mars architecture of the Xingtu brand. Compared with previous products, Lanyue has a comprehensive improvement in safety and technology. Of course, as a family flagship model, Lanyue also shows a good temperament.

The appearance of Lanyue restores the design of the Xingtu VX concept car to the greatest extent, and the overall shape is slightly tough and full of futuristic atmosphere. The front face is more square, and the inside of the polygonal air intake grille is decorated with banner chrome, with large-sized headlights on both sides, which is full of momentum. The trapezoidal lower grille is wrapped in silver chrome decoration, and the fog lamp area on both sides also adds vent decoration, which looks more youthful and fashionable.

The side has the stable temperament of a medium and large SUV, and the straight waist line and wide eyebrows show a certain sense of strength. The tail shape is relatively heavy, and the through-type LED taillights play a finishing touch to the overall design. The reflector design on both sides echoes the fog lights on the front of the car. The bottom silver lower guard and chrome-plated double tail row add a sporty atmosphere.

The Lanyue series offers two sizes of rims, among which the entry-level Star Enjoy Edition and the three Star Yao Edition models are all in the 19-inch double five-spoke Y shape, and they are painted in black, which is full of sports. The tires are made of Magis Victra Sport 5 series products, which focus on sports and handling. The tire specifications are 235/55 R19; while the high-end Star Rui version and Star Zun version are equipped with 20-inch two-tone multi-spoke rims, which has a stronger design sense. The tires are made of Continental MaxContact MC6 series products, which have excellent safety and comfort. The tire specifications are 245/45 R20.

In terms of appearance color, Lanyue offers 5 body colors to choose from, namely meteorite gray, star track blue, Haoyue white, nebula purple, and phantom night black. The main color is star track blue, which shows a stable temperament without losing a sense of fashion. Haoyue white and phantom night black two colors are biased towards the style, while meteorite gray and nebula purple are obviously more personalized.

The interior design of Lanyue generally continues the family design style. The regular layout and a large number of horizontal lines effectively stretch the visual width. The full LCD instrument and central control screen use the mainstream dual-screen floating design, which has a strong sense of technology. In addition, as a high-end brand, Lanyue is also more particular about the materials used. The center console, front and rear door panels and other parts have added dark wood grain decoration, and the seats are also made of Meridian punched leather with diamond-shaped pattern design, creating a more luxurious atmosphere.

In terms of configuration, all Lanyue models come standard with full LED headlights, headlight height adjustment, keyless entry/start and other functions. In terms of multimedia, it is equipped with Lion4.0 Lion Zhiyun system, which supports FOTA cloud upgrade, remote start, GPS real-time car navigation, smart home interconnection, mobile phone interconnection/mapping Apple CarPlay and other functions. The high-end models are also equipped with L2.5-level automatic driving assistance system, including ACC adaptive cruise, FCW front collision warning, LKA lane keeping, TJA traffic congestion assistance and other functions.

In terms of power, Lanyue is equipped with the latest third-generation ACTECO engine, providing 1.6TGDI and 2.0TGDI engines, with maximum power of 197 horsepower and 254 horsepower respectively, and peak torque of 290 Nm and 390 Nm respectively. The transmission system is matched with a 7-speed wet dual-clutch gearbox and is equipped with a timely four-wheel drive system.

II. Vehicle configuration highlights and recommendations

The 290T two-wheel drive Star Enjoy Edition is an entry-level model for the whole series of Lanyue, priced at 168,900 yuan. Although the price is advantageous for a mid-to-large SUV positioned at the high end, a closer look at the configuration sheet shows that there are not many bright spots, which only meet the basic needs. First, the entry-level model is equipped with a 1.6TGDI engine. Although the maximum power is not much different from the 2.0TGDI version, the maximum torque is still 100 Nm apart. Secondly, in terms of frequently used lights and auxiliary driving functions, the entry-level model is only equipped with LED near and far lights, and does not provide the two practical functions of automatic headlights and adaptive near and far lights, which are currently more popular. In addition, the entry-level model only provides the rear radar and ordinary reversing image functions, and the lack of front radar and 360-degree panoramic images may affect driving or parking at narrow intersections. In terms of active and passive safety, the configuration performance of the entry-level model is not comprehensive enough. Not only is it not equipped with the L2.5 level automatic driving assistance system promoted by the manufacturer, but even the airbag only provides the front and side four configurations, and lacks the protection of the head airbag. In addition, in terms of seat configuration, the performance of the entry-level model is also quite decent. The seat is made of ordinary leather material, only the main driver’s seat is electrically adjusted, and it is not equipped with a practical waist support adjustment function, which greatly reduces the ride comfort. Of course, the entry-level model’s configuration performance in multimedia and air conditioning is still worthy of recognition. The whole system is equipped with a 12.3-inch central control display, and the commonly used navigation, automatic speech recognition, mobile phone interconnection, vehicle to everything and OTA upgrades are also readily available. Air conditioners are equipped with three-zone automatic air conditioners as standard in the whole system, and the rear row also provides a separate trend and control area. Considering the low power and configuration of the entry-level model, combined with its relatively affordable price, it is only suitable for consumers who have a small budget and do not have high requirements for power and configuration.

III. Difference analysis of recommended vehicle configurations

As a low-end model, the 290T two-wheel drive Xingyao version priced at 179,900 yuan is 10,000 yuan more expensive than the entry-level model. The added configuration mainly focuses on convenience and comfort, including front radar and 360-degree panoramic images, electric trunk with induction function, leather seats, lumbar support adjustment, front seat heating, driver’s seat memory, etc., which greatly improves the car experience. At the same time, the model has also been slightly upgraded for lighting multimedia, adding functions such as automatic headlights, facial recognition and the original driving recorder. But from the configuration and price point of view, the cost performance of this model is still OK. If you don’t care about the lack of 1.6TGDI engine power, then the 290T two-wheel drive Xingyao version is a good choice.

Compared with the two 290T models, the four 390T models not only have better power performance, but also have a higher overall configuration level. Especially in terms of active safety and lighting, the 390T models are equipped with L2.5-level automatic driving assistance systems, including ACC adaptive cruise, FCW front collision warning, LKA lane keeping, TJA traffic congestion assistance and other functions. In addition, the 390T models are also equipped with adaptive far and near light to improve night driving safety.

Among the four 390T models, the editor’s key recommendation is the 390T two-wheel drive Xingyao version priced at 188,900 yuan. On the basis of the configuration of the 290T two-wheel drive Xingyao version, in addition to adding the L2.5 level automatic driving assistance system, the HUD head-up display and adaptive far and near light functions are also added to further improve safety. Although some configurations are also reduced accordingly, such as front radar, front mobile phone wireless charging, waist support adjustment, etc., it has little impact on daily car use, and the value of the increased configuration is much higher than the reduced configuration, and the comprehensive cost performance is higher.

The overall configuration of the 390T four-wheel drive version is very close to the recommended model, the difference is only that it is equipped with a timely four-wheel drive system, and the price has also increased by 12,000 yuan. Considering that the timely four-wheel drive system has limited improvement in the actual performance of the vehicle, and the fuel consumption of the four-wheel drive model is relatively higher, if the car environment is mainly urban roads, then the 390T four-wheel drive version is also not recommended. As for the two high-end models, on the one hand, the price is relatively high, and on the other hand, the added configuration plays a more icing on the cake role. Including parallel assist, reversing car side warning, seat ventilation, 8-speaker SONY audio, steering assist light, exterior rearview mirror memory, exterior rearview mirror reversing automatic down, automatic anti-glare interior rearview mirror, negative ion generator, etc. These configurations can certainly enhance the luxury temperament of the vehicle, but they are not very helpful for daily use. Therefore, from the perspective of comprehensive price and various configurations, the 390T two-wheel drive Xingyao version has a more obvious cost-effective advantage among all models of Xingtu Lanyue, and it is recommended to give priority when purchasing.

As a top actress in the entertainment industry, Yang Ying’s every move has attracted much attention. However, as her popularity continues to rise, so does her responsibility. As a public figure, her words and deeds are magnified, as if she is enjoying the benefits of starlight, but also forgetting the self-discipline and norms that a top star should have.

The recent Crazy Horse episode has put Yang Ying’s image at an unprecedented risk. What was originally a niche entertainment experience has entered the public eye because of Yang Ying’s visit. The incident has raised questions not only about Yang Ying’s personal character, but also about her sense of responsibility as a public figure. Unfortunately, this time she does not seem to have delivered satisfactory answers.

In the turmoil caused by the Crazy Horse show incident, Yang Ying’s social account was banned for up to three months. This is undoubtedly a heavy blow for Yang Ying. In the digital world, this is almost equivalent to disappearing from the public eye. Fans are thrown into confusion and unease for a while. After all, in this era of face-seeing, no exposure means being forgotten. However, this may be an opportunity to reflect and replan their own star path.

Despite the ban, Yang Ying has not completely faded from the public eye. Within a week, it was revealed that she was involved in the shooting of a magazine. Although this time her photo did not appear on the cover, it became the inside page, a low-key approach that was both cautious and revealed her determination not to give up. After the halo faded, Yang Ying chose a more restrained and low-key way to show the world that she is still trying to move forward.

Once upon a time, Yang Ying’s acting skills were widely criticized, but her performance in variety shows undoubtedly gave her a lot of credit. Now, although the Crazy Horse show incident has caused her reputation to drop to the bottom, she has not given up. Amid the public ridicule, Yang Ying seems to be answering the question of "soft ban" with action. She is no longer the actress who only shines under the spotlight, but quietly works behind the scenes to prepare for her next appearance.

During this time, she learned how to grow in the trough and how to find a way out in the controversy. Her transformation has shown us a more mature and confident Yang Ying. Although the road ahead is not smooth, she is ready to face new challenges.

Today’s Yang Ying has stepped down from the position of a top star, but she is not far away from the entertainment industry. She began to try more roles and constantly push her comfort zone. Her performances also began to become more realistic and natural, no longer just superficial forms. Her efforts and persistence have allowed us to see a more comprehensive and in-depth Yang Ying.

Looking back at Yang Ying’s ups and downs in life, we see a growing and improving her. Although she has encountered setbacks, she did not give up but honed herself in the face of difficulties and continuously improved herself. Her story tells us not to give up easily even when facing difficulties. Only by persevering in hard work can we achieve success.

Let’s look forward to Yang Ying’s next role together as she continues to create her own brilliance in the entertainment industry!

Responsible editor:

[Text | Interface, Yuan Yingqi]

Nongfu Spring, which has repeatedly said that there is no need to list, finally decided to list on the Hong Kong Stock Exchange. The company that mainly produces "a little sweet" mineral water has a financing scale of no more than 1 billion US dollars, but it is a high probability event that it will enter the 100 billion market value club after listing.

We carefully read the prospectus submitted by Nongfu Spring to the Hong Kong Stock Exchange and found that the company had mixed feelings.

Nongfu Spring "not bad money"

Nongfu Spring was established in 1996, and its founder Zhong Liangyi holds 87.4% of the shares. The company’s main business contributes about 95% of the total operating income. The main products include drinking water, tea beverages, functional beverages and fruit juice beverages, accounting for 60%, 13%, 16% and 10% of the revenue respectively. Among them, drinking water and fruit juice beverages have grown rapidly.

Image source: Prospectus, Interface News Research Department

According to the prospectus, Nongfu Spring has maintained steady growth in the past three years. From 2017 to 2019, the income was 17.491 billion yuan, 20.475 billion yuan and 24.021 billion yuan respectively, with a compound annual growth rate of 17.2%. Nongfu Spring achieved net profit of 3.385 billion yuan, 3.612 billion yuan and 4.954 billion yuan in the past three years, with a compound annual growth rate of 21.0%.

Image source: Prospectus, Interface News Research Department

In 2019, the comprehensive gross profit margin of Nongfu Spring was as high as 55.4%. Mainly due to the gross profit margin of 60.2% of the largest drinking water product. The gross profit margins of other categories such as tea beverages, functional beverages and fruit juice beverages were 59.7%, 50.9% and 34.7% respectively.

In terms of net profit, the net profit rate of Nongfu Spring rose to 22.8% in 2019, of which sales expenses accounted for the largest proportion of the three fees. Specifically, sales expenses accounted for 24.2% of operating income, and the most important ones were transportation expenses and advertising expenses, which were 2.53 billion and 1.22 billion yuan respectively, accounting for 10.5% and 5.1% of operating income, respectively.

In terms of cash, Nongfu Spring adopts the first payment and then the goods transaction method, and the book receivables are very small. From 2017 to 2019, the company’s net operating cash inflow was greater than the net profit of the year, especially in 2019, the net operating cash inflow was as high as 8.73 billion yuan. From 2017 to 2019, the book structured deposits were 2.04 billion, 3.60 billion and 200 million yuan respectively. The average interest rate earned was between 4.0% and 4.9%.

The sharp decrease in cash in 2019 was due to the concentrated dividend of Nongfu Spring up to 9.50 billion yuan before listing. Among them, the major shareholders received 8.20 billion yuan. Previously, although Nongfu Spring also had annual dividends, the amount was 2-300 million yuan. And the total financing of Nongfu Spring is only 1 billion US dollars.It is certain that Nongfu Spring did not choose to go public because of a lack of funds.

What is the valuation after going public?

Master Kong Holdings, the equivalent producer of mineral water in Nongfu Spring, has been listed on the Hong Kong stock market. In 2019, Master Kong Holdings’ beverage business contributed HK $39.70 billion to operating income, which was greater than Nongfu Spring’s operating income. But net profit was only HK $3.72 billion, far less than Nongfu Spring’s 4.95 billion yuan.

At present, the market value of Tingyi Holdings is 77.20 billion Hong Kong dollars, corresponding to the price-to-earnings ratio of about 20.8 times in 2019. It is estimated that the total market value of Nongfu Spring after listing is at least about 130 billion Hong Kong dollars. In fact, Nongfu Spring is better than Tingyi Holdings in terms of profitability and growth, and the market may give a higher valuation.

According to the prospectus, the drinking water market is still in a stage of rapid development. According to Nielsen’s forecast, it is still expected to maintain a growth rate of about 10% in the next five years. Compared with the beer and condiment market, the drinking water market has more room. Based on the high concentration of the drinking water market, it is also possible to produce a leader with a larger market value than Budweiser Asia Pacific (1876.HK) and Haitian Flavor (603288.SH) in the long run. The average price-to-earnings ratio valuation of beer in the Hong Kong stock market is 30-40 times. The average valuation of soy sauce and vinegar in the class A share market is more than 40 times. Based on this, we have predicted the market value of Nongfu Spring.

Image source: Interface News Research Department

The troubles of Nongfu Spring

Although the situation is good, Nongfu Spring is not a smooth road.

First of all, the drinking water business depends on the source of water, and the bottleneck facing the long-term growth of Nongfu Spring is the limited source of water. According to relevant laws and regulations, units and individuals who directly extract water from natural resources (such as rivers, lakes and groundwater) need to obtain a water extraction license and pay a water resource fee. Enterprises need to extract water according to the approved annual water extraction plan. Moreover, mineral water has the dual attributes of water resources and mineral resources. The production of mineral water should also apply for a mining license according to law. In other words, the scarcity of water sources on the one hand helps enterprises to establish high industry barriers, and on the other hand restricts enterprises to expand production capacity. It is conceivable that with the development of the industry, there are fewer and fewer untapped water sources.

The situation of Nongfu Spring’s newly obtained water sources in recent years is not optimistic. At present, Nongfu Spring has a total of 10 water sources. The main production bases are still Qiandao Lake in Zhejiang, Changbai Mountain in Jilin, Danjiangkou in Hubei and Wanlv Lake in Guangdong, which were obtained before 2005. With the increase in environmental awareness, the water withdrawal from water sources obtained by Nongfu Spring in recent years has become smaller and smaller. In 2019, the newly obtained water withdrawal from water sources was only 504 thousand cubic meters per year. Although the approved water withdrawal from water sources currently owned by Nongfu Spring is much larger than the actual production capacity of the company, the company does not have the problem of insufficient water withdrawal in the short term. However, products concentrated in water sources in Zhejiang, Guangdong, Jilin and Hubei are also limited by the transportation radius.

Nongfu Spring has less water sources that can produce mineral water, which is not conducive to product upgrades in the future. In addition, the average ton price of Nongfu Spring drinking water has declined for two consecutive years, the company explained, because of the increase in sales of large-packaged drinking water with lower unit prices. In the short term, Nongfu Spring may face the risk of lower gross margins.

Due to the scarcity of domestic water sources, Nongfu Spring has begun to go overseas. Nongfu Spring has acquired Otakiri Springs, a New Zealand bottled water company. The prospectus revealed that Nongfu Spring will look for suitable acquisition targets in the future. However, the overseas market is more mature than the Chinese market, and the growth space is limited. The risk of "going out" is really not small.

Image source: Prospectus, Interface News Research Department

Secondly, Nongfu Spring also faces the problem of "succession". The company has five executive directors. Among them, the founder Zhong Shuzi currently serves as the chairperson and general manager of the company, with a shareholding of 87%. Appropriately reducing the founder’s shareholding ratio through listing can achieve the effect of optimizing the shareholding structure and reducing decision-making risks. At present, Zhong Shuzi is 66 years old and has been deeply involved in the operation of Nongfu Spring. Another executive director, Guo Zhen, deputy general manager in charge of the overall operation and production of Nongfu Spring, is also 62 years old. Zhong Shuzi, the son of Zhong Shuzi, is currently a non-executive director of the company and does not participate in daily operations. Zhong Shuzi joined the group in 2014 and is currently the general manager of Yangshengtang (Nongfu Spring Holding Company) Brand Center.

It is worth mentioning that at the same time as the listing of Nongfu Spring, another company controlled by founder Zhong Shanyuan, 603392.SH, landed on the class A share main board on April 29. The current market value is 6 billion yuan, and the daily limit has not been opened. In the Hurun wealth list in 2020, Zhong Shanyuan was listed with 14.10 billion yuan. With the listing of the above two companies, his worth is expected to rank among the top five on the rich list.