According to the political judgment and orientation of the CPC Central Committee, "five in one" is the overall layout and "four comprehensive" is the strategic layout. Generally speaking, there is no essential difference between the overall layout and the strategic layout, because they are developed in the same dimension, so they can be expounded together, such as the overall strategic layout. Because the strategic height must be based on the overall situation, otherwise it will be promoted to strategy. Similarly, as long as it is an overall plan or measure, it must have strategic characteristics or be turned into a strategic plan. In that case, why should we separate two layouts? Just to distinguish words? Obviously not, there must be a deeper ideological connotation and logical relationship.

　　The basic relationship between the overall layout of "five in one" and the strategic layout of "four comprehensive"

　　China’s modernization road and construction goal and the Communist Party of China (CPC)’s self-construction and improvement of ruling ability are basically reflected in the overall layout of "five in one" and the strategic layout of "four comprehensive". And because both of them have rich connotations and extend to each other, which determines the intersection in some fields and contents. It is for this reason that we need to clarify the relationship between the two and clarify their respective boundaries. This is very important for better understanding the strategic deployment of the CPC Central Committee and the ruling ideology of the Supreme Leader General Secretary in theory, and it is equally important for the whole party and even the whole society to implement the major decision-making arrangements of the CPC Central Committee more consciously.

　　From the analysis, there is a fundamental or objective consistency between them, that is, to let the people enjoy a better life in economy, politics, culture, society and environment. On this premise, there are also some differences between the two, which determines the necessity and importance of distinguishing the overall layout from the strategic layout.

　　First of all, there are differences in the time, background and way of the two formulations. "Five in One" was put forward in the report of the 18th National Congress of the Communist Party of China. "The overall basis for building Socialism with Chinese characteristics is the primary stage of socialism, and the overall layout is five in one. The overall task is to realize socialist modernization and the great rejuvenation of the Chinese nation". Therefore, it is required that "comprehensive, coordinated and sustainable development must be more consciously regarded as the basic requirement for thoroughly implementing Scientific Outlook on Development, and the five-in-one overall layout of economic construction, political construction, cultural construction, social construction and ecological civilization construction should be fully implemented, so as to promote the coordination of all aspects of modernization, production relations and productivity, superstructure and economic base, and constantly explore the road of civilized development with production development, affluent life and good ecology". From this rigorous and comprehensive statement, we can see that the "five in one" is a political behavior that the party’s ideas are turned into the will of the country based on the country’s modernization process and goal.

　　The "Four Comprehensiveness" was put forward twice by the Supreme Leader General Secretary in the process of grassroots investigation at the end of 2014. Once, when he went to Fujian for investigation, he put forward that "coordinating and promoting the building of a well-off society in an all-round way, comprehensively deepening reforms, and comprehensively promoting the process of governing the country according to law" contained "three comprehensiveness". After that, he went to Jiangsu for investigation, and especially emphasized the extreme importance of strictly administering the party in an all-round way, and put it together with the construction of a well-off society, deepening reform and governing the country according to law, so he had the enrichment and development from "three comprehensive" to "four comprehensive". It is this rich development that has enhanced the height, width and strength of the strategic layout. Because, China’s political system or political design, the most fundamental feature is the leadership of the party. As the saying goes, "the party is the leader of everything in the study of the party, government, military and civilian affairs, east, west, north and south". Since the party leads everything, its mission responsibility is irreplaceable, its ruling ability must be unparalleled, it is not strict with the party, and it is "comprehensive and strict". It is absolutely impossible to reach such a level of ability.

　　If we probe into the formation process of "Four Comprehensiveness" more deeply, it will better help us to understand the formation, development and deepening of the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era. The 18th National Congress proposed "building a well-off society in an all-round way", the Third Plenary Session of the 18th Central Committee proposed "comprehensively deepening reform", the Fourth Plenary Session of the 18th Central Committee proposed "comprehensively promoting the rule of law", and the summary meeting of the party’s mass line education practice activities proposed "comprehensively promoting the strict administration of the party". From this, we can see that the ideological system originates from practice and has an endogenous and rigorous logical relationship. It is by no means a slap in the face and a point of view. More importantly, we can also understand the ideological course of the top leaders of the party and the country.

　　Secondly, the "two layouts" are developed in different dimensions. "Five in One" is the key aspect of China’s modernization, or the level of economic construction, political construction, cultural construction, social construction and ecological civilization. In other words, the construction level in all aspects is the development level of China’s modernization. It can also be said that only by realizing the "five in one" can we dare to say that Socialism with Chinese characteristics’s construction is on the right and broad road.

　　"Four Comprehensiveness" is the overall judgment and planning made by the top leaders of the Party and the country from a strategic perspective based on the current international and domestic political ecology and development status, focusing on the historical mission shouldered by the ruling party, and combining the main contradictions and problems faced. In a sense, it is standing at the intersection of history and times, looking for the general plan of governing the party and the country, and exploring the direction and breakthrough of the country and society. Therefore, as long as we make efforts in several aspects and achieve results, the development goals we have set can be achieved. What needs to be particularly emphasized here is that the "four comprehensiveness" is more personalized than the "five in one", with more vivid efforts and more obvious results.

　　Thirdly, the formation mode and process of "two layouts" are different. The overall layout is gradually formed and enriched by the Party in the process of promoting modernization, based on practical and ideological achievements, thus reflecting the process and height of the Party’s self-improvement. Including the "trinity" (economic construction, political construction and cultural construction) proposed in the report of the 16th National Congress, the "four-in-one" (economic construction, political construction, cultural construction and social construction) proposed in the report of the 17th National Congress, and the "five-in-one" (economic construction, political construction, cultural construction, social construction and ecological civilization construction) proposed in the 18th National Congress. Three party congresses have achieved three leaps.

　　The strategic layout has also gone through a process of gradual enrichment and development, which contains the ruling thoughts and ideas of the top leaders of the party and the country, and follows the law of exploration in practice, exploration in practice, or practice to theory and theory guiding practice, so it can achieve more results. This also enables us to further understand that the supreme leader’s thought of governing the country is rooted in practice, so it is more targeted and instructive.

　　The overall layout of "five in one" and the strategic layout of "four comprehensiveness" are both important categories of Socialism with Chinese characteristics Thought of the Supreme Leader in the new era.

　　Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era is the latest and important achievement of the third China of Marxism, which guides China’s road to great power, supports the "community of human destiny" under construction and inspires the development direction of human civilization. It is grand and systematic, which determines that the connotation is very rich and the ideological and theoretical significance is particularly significant.

　　Further analysis along this line of thought shows that Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era guides the Communist Party of China (CPC) to complete a new historical mission. So far, the Communist Party of China (CPC) has undertaken and is undertaking three historical missions, namely, "stand up, get rich and become strong" as clearly stated in the report of the 19th National Congress. The first two missions have been completed or basically completed, or the basic structure and main body construction have been completed. The latter is based on the first two, but it needs a bigger and more difficult breakthrough. Because it involves many fundamental propositions of the times that must be answered.

　　As the supreme leader of the party and the country, the supreme leader undertakes the historical mission of leading the whole party and the people of the whole country to pursue the century-old dream and realize the great rejuvenation of the Chinese nation. At the same time, as the leader of a big country and the highest decision-maker of the world’s second largest economy, he inevitably has to focus on and answer the question of where the world is going. What distinguishes a big country from a small country lies in its international responsibility or the responsibility of leading the world. In this sense, his ideological theory must coordinate the international and domestic situations.

　　We should answer the direction and path choice of human development in thought and theory. Where the world goes is not a natural or inevitable thing. It must be worked hard and won, and the key point is the choice of big countries and their leaders. The classic Marxist writers have long given an answer to what road mankind will take, that is, "Socialism will destroy capitalism and eventually realize communism." This ultimate goal has not changed so far, but the way and path to achieve it must change. Because, at that time, because the proletariat had not yet seized power, or after some countries seized power, the proletarian movement was generally in a weak position, and the political state of the whole world, various factors decided to take the road of violent revolution. This choice was in line with the world political ecology and its requirements at that time, but it had historical limitations. When history comes to the present, China has participated in the formulation of world rules. Since it is an important participant in the formulation of rules, the will can be realized in the game process, and there is no need to resort to violent means. Therefore, standing at the height of the times, General Secretary of the Supreme Leader clearly put forward "jumping out of the Cold War mentality and zero-sum game", emphasizing that "the Chinese dream and the American dream are interlinked", especially establishing the common mission of "building a community of human destiny" and proposing and actively promoting the construction of the Belt and Road. All these are different from "institutional confrontation to the death".It belongs to a new path of civilized development.

　　We should answer China’s current development path theoretically. It is a proposition of the times and a historical proposition that what shortcomings should be made up for the party’s governance or system construction in order to achieve the set goals faster and better. One of the measures to make up for the shortcomings is reform. Our reform has been clearly defined as "neither taking the old road of closed and rigid, nor taking the evil road of changing the flag." At the same time, it is also emphasized that "the great social change in contemporary China is not a master that simply continues our history and culture, a template that simply applies the ideas of classic Marxist writers, a reprint of socialist practice in other countries, or a replica of foreign modernization." This brings a major problem, how to theoretically answer what kind of road we are taking, which determines the system construction and renewal. There is no doubt that we are taking a pioneering road that has never been seen before. Lu Xun said: "There is no road on the ground. If there are more people walking, it will become a road." A truly pioneering road, as a pioneer, must theoretically explain the external performance and essential connotation of its own road, especially the endogenous logic and scientific laws. Only in this way can it provide new choices for countries and nations in the world who want to accelerate their development and maintain their independence. To answer this question well, we must learn from or include the overall layout of "five in one" and the strategic layout of "four comprehensive".

　　Only by deeply understanding and grasping the essential connotation of the theoretical system of the supreme leader’s thoughts on governing the country can we better promote and implement the "five in one" overall layout and the "four comprehensive" strategic layout.

　　Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era was born to meet the needs of the times, concentrating the wisdom of the whole Party. It is a grand ideological and theoretical system, including the overall layout of "five in one" and the strategic layout of "four comprehensive", but not limited to this. To be more accurate, both of them occupy an important position in the whole ideological and theoretical system, and they are indispensable, but not all of them. There are still many important ideas in them. Therefore, we need to master the whole ideological and theoretical system from a higher position, and only in this way can we dare to deepen the overall layout of the "five in one" and the "four comprehensive" strategic layout.

　　On the one hand, the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era was formed and developed at the height of the construction of Marxist political parties and the development direction of human civilization. Wang Huning put forward "four profound understandings" in his speech at the symposium on the publication of the second volume of The Supreme Leader’s Talks on Governing the Country, including "grasping the background of the emergence of the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era, grasping this important thought profoundly has made great original contributions to the development of Marxism, providing an action guide for realizing the great rejuvenation of the Chinese nation, and pointing out the direction for promoting the construction of a community of human destiny and opening up a better development prospect for mankind".

　　On the other hand, the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era was born out of the Communist Party of China (CPC)’s historical mission, and it was also built and deepened to fulfill the mission. Therefore, not only can we not understand a speech or a certain ideological point of view in isolation, but we can also not understand the "five in one" and "four comprehensive" in isolation. We must comprehensively and systematically understand and grasp the ideological connotation and logical relationship between them, otherwise we may generalize and even split.

　　This involves methodology. Generally speaking, the reason why a generation of leaders undertake the historical mission undertaken by a political party is because they are guided by systematic thought and theory with strict logic and rich endogeneity. Mao Zedong and Deng Xiaoping can undertake the historical mission of "standing up" and "getting rich" because they have formed a scientific ideological and theoretical system, which contains three major elements: political outlook, ideological line and ruling strategy. The party has a political line and leaders have a political view. Mao Zedong’s political view is class struggle, that is, people’s liberation is achieved through class struggle, the ideological line is seeking truth from facts, and the ruling strategy is to grasp revolution to promote production and lead production with revolution. Deng Xiaoping’s political view is peaceful development, that is, according to the development of the times, he jumped out of "taking class struggle as the key link", his ideological line is emancipating the mind, and his ruling strategy is to focus on economic construction and reform and opening up, that is, to stimulate productivity through reform and introduce productivity through opening up.

　　The historical mission undertaken by the supreme leader is to "strengthen", that is, to realize the great rejuvenation of the Chinese nation. What is national rejuvenation? That is, to surpass ourselves and go to the forefront of human civilization to play a leading role, which requires the ability to provide "public goods" to the world. The supreme leader is leading our party to improve this ability, and has provided such products to the world, for example, proposing to build a "community of human destiny"; Advocate "to discuss, build and share ‘ Belt and Road ’ The principle of construction is guided by the Silk Road spirit of peaceful cooperation, openness and tolerance, mutual learning and mutual benefit, and the goal of cooperation is to build a community of destiny and interests "; Established the development concept of "innovation, coordination, green, openness and sharing", and so on.

　　In short, only by comprehensively and profoundly understanding and grasping the thoughts of the Supreme Leader on governing the country, especially the essential connotation and basic characteristics of the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era, can we better clarify the basic relationship between the various elements or categories, and then effectively promote the "five in one" overall layout and the "four comprehensive" strategic layout.

　　(Author Gong Fangbin is a special researcher at the Beijing Supreme Leader New Era Socialism with Chinese characteristics Thought Research Center)

　　[References]

　　① Supreme Leader: "Decisive victory to build a well-off society in an all-round way and win the great victory of Socialism with Chinese characteristics in the new era — — Report in The 19th National Congress of the Communist Party of China, Xinhuanet, October 27, 2017.

　　[car home Car Handbook] Crown was also a household name at the beginning, but unfortunately it was badly managed in China and was in an embarrassing situation. However, in the near future, the launch of (|) may help the brand out of the haze. Lu Fang is a medium-sized SUV. In fact, it is the sister model of Guangzhou Automobile Toyota Highlander. Except for the appearance and logo, it is almost the same in other aspects. Of course, FAW Toyota will also launch several models according to Lu Fang’s own characteristics. Today, we will analyze which one is more cost-effective.

■　Model price

　　On August 27th, Lu Fang, the brand-new medium-sized SUV of FAW Toyota, was officially launched.The new car has launched six models, with the price range of 275.8-350.8 million yuan.Please see the following table for detailed selling price:

　　This price is very close to the price of the new generation Highlander. The difference is that Crown Lu Fang has two low-profile models as precursors, and the other four models are all four-wheel drive versions.

■　Appearance/interior color

　　FAW Toyota Crown Lu Fang is surrounded by the same sports appearance as the American Highlander XSE model. Compared with Highlander, the front enclosure of the new car adopts a larger grille design, and the large black horizontal grille makes the front face of the new car have a more exaggerated visual effect. The rear part is almost the same as Highlander. The main difference is that the new car adopts a double-layer design with different colors from the car body at the bumper below, which echoes the front of the car.

　　There are five choices of body colors. We have actually photographed two high-end models, Paris Red and Mo Yuan Black, besides streamer silver, carbon crystal brown and platinum white. In terms of interior, the suspended central control large screen, air conditioning control area integrated with the screen and three-spoke multi-function steering wheel of the new car are exactly the same as those of Highlander. The interior color provides two schemes of matching black and red and black. In contrast, the Paris red appearance+red and black interior highlights the sense of movement, but the color matching is exclusive to the top.

■　The whole power system is 2.5 hybrid.

　　In terms of power, Crown Lu Fang is equipped with a hybrid system (2.5HEV) based on a 2.5L four-cylinder engine. The maximum power of the 2.5L engine is 192 HP (141kW) and the peak torque is 238 Nm. The transmission system is matched with the E-CVT gearbox. In terms of motor, the two-wheel drive version is equipped with a 134kW motor, while the four-wheel drive version adds a 40kW rear motor. Overall, the comprehensive output power of this HEV power system is 249 HP (183kW).

■　Configuration analysis

●　Two-wheel drive enterprising version, the only five seats, not recommended.

　　Let’s take a look at the lowest progressive version of the whole department. This configuration is only one model, and it is a 5-seat version. I believe many people will not choose it. After all, people who buy Lu Fang or Highlander are going for 7 seats, so this 5-seat version is mainly for lowering the entry price.

●　Elite version, two-wheel drive is 11 thousand worse than four-wheel drive (general configuration, only recommended to consumers with tight budget)

　　Next, get on the right track, add 6,000 yuan to the 5-seat version, and you will get the 7-seat version, and then add 11,000 yuan to get a four-wheel drive system. To tell the truth, the price of this four-wheel drive system is not low, because this four-wheel drive system is based on electric drive, it has no central transmission shaft, and the rear axle has a 40kW motor, which is the rear axle motor and related electrical components that cost an extra 11,000 yuan. Simply put, the biggest competitiveness of entry-level models is the price. Since the map is cheap, just buy a two-wheel drive.

　　What configurations does the Elite Edition have? The standard LED headlights are not bad, but the 18-inch rim specifications are really a bit miserable. The interior is just so-so. The 7-inch color display and 8-inch central control panel of the instrument panel are relatively conventional. The multimedia system supports HiCar, CarPlay and CarLife, and the function is not bad. The basic safety and comfort configuration, the elite version of this car is also in place, as well as Fengyun Yuexiang Fengyun Zhixing interconnection configuration, which includes many practical functions, such as App remote control, theft tracking, concierge service, enjoyable parking/refueling and emergency rescue, which can be regarded as keeping up with the trend of the times.

　　However, the elite version doesn’t have reversing radar and reversing images. I didn’t expect Japanese cars to make a fuss about these things these days. I believe that consumers who buy this car basically have to spend extra money to install reversing images or radars. However, Toyota’s Zhixing safety system is the standard of all departments in Crown Lu Fang, which is kinder than Highlander, especially adaptive cruise and pre-collision system, and many people attach great importance to it. Generally speaking, the price of the elite version of the two-wheel drive is quite sincere, but because the configuration is still relatively low, it is only suitable for those consumers with tight budgets.

●　Deluxe edition, 21,000 more expensive than elite edition, recommended by four stars.

　　Compared with the elite version, the price gap is 21,000 yuan, and the configuration is slightly upgraded. The first thing is to change the 20-inch rim, which is worthy of Lu Fang’s size. Secondly, the reversing radar that spit in front finally came. In details, the Deluxe Edition has also been slightly improved. For example, the roof rack, the openable panoramic sunroof, the leather steering wheel, the leather seat (with front heating), the rear privacy glass and the doorsill pedal are all equipment that add extra points to the image. The most important thing is that Highlander doesn’t have this model. I think Crown Lu Fang is just right. I recommend it to four stars.

●　Distinguished edition, 19,000 scientific and technological sense improved obviously, recommended by four stars.

　　The price of the premium version is 19,000 yuan higher than that of the luxury four-wheel drive model of the previous gear. The 12.3-inch full LCD instrument panel and 12.3-inch central control screen have been upgraded to support voice recognition control, car networking and OTA upgrade, but the configurations such as HiCar, CarPlay and CarLife have been cancelled. In addition to the four Type-C interfaces of the whole car, there is also a USB interface in the front row. There is also a 360 panoramic image function, HUD head-up display, electric trunk, automatic anti-glare rearview mirror, and automatic folding of the exterior rearview mirror, which has obviously improved the sense of luxury and technology.

●　Ultimate edition, plus 18,000 to complete the configuration, recommended by four stars.

　　The flagship version of the top is mainly improved in comfort configuration, and the price has increased by another 18,000, such as an increase.The seat material has also been upgraded to perforated leather, and the interior also has more luxurious decorative strips and JBL audio. There are also front seat ventilation, lumbar support, main driver seat memory, steering wheel heating, streaming rearview mirror, car air purifier, second row seat heating and 220V power supply. Active safety has also been further upgraded, with the addition of parallel auxiliary and reversing vehicle side early warning system. Of course, the price of this car has also reached 350,800 yuan, which can be considered by consumers who pursue one step, and they can also choose red and black interiors.

■　Summary:

　　As we all know, this generation of Highlander has adopted a new structure, new power, and long-term excellent reputation, which has kept it in the treatment of raising the price and picking up the car. The appearance of sister car FAW Toyota Crown Lu Fang may be able to suppress the arrogance of Highlander. After all, the products are almost the same, and with the blessing of Crown brand, it is really unreasonable to sell them any more.Of course, domestic consumers are addicted to word of mouth. After all, not many people in Lu Fang have heard of it, so it is not so easy to catch up with Highlander in sales.

　　From the product point of view, the entry-level progressive version is 5 seats, which can be directly ignored. The elite version is a bit shabby, but fortunately, it is cheap, and there are two drives to choose from, which seems to be enough for those consumers who only value space and big size. The Deluxe Edition configuration can satisfy most people, while the Premium Edition and the Ultimate Edition configuration are gradually more comprehensive.Generally speaking, the price/performance ratio of middle and high-end models is not bad.(Text/Figure car home Zhang Ziyi)

US President Biden is going to shoot artificial intelligence again!

On the evening of March 7, local time, US President Biden delivered a high-profile State of the Union speech in the election year, which was also his third State of the Union address during his tenure. Biden called on Congress to take urgent action to regulate artificial intelligence through legislation. Biden warned that this technology will bring risks to Americans if it is not controlled.

It is noteworthy that it has been reported recently that the EU is ready to formulate comprehensive artificial intelligence rules or have a global impact.

Look at the detailed report!

Biden made an appeal.

According to CNN quoted by the Global Times, US President Biden delivered a State of the Union speech in the House of Representatives on the 7th local time. In his speech on domestic issues in the United States, Biden called on Congress to take urgent action to regulate artificial intelligence through legislation, including prohibiting "artificial intelligence voice imitation."

Just a few weeks ago, there was an incident of "AI imitating Biden’s phone call" in the United States. The "fake Biden" phone call generated by AI called on 5,000 voters who are most likely to support the Democratic Party not to vote in the New Hampshire primary. CNN subsequently reported that the US government traced and found that 71-year-old man Walter Monk and his Texas-based "Life" company were behind the scenes.

On the 7th, Biden urged legislators to "use the promise of artificial intelligence to protect us from its dangers" and warned that this technology will bring risks to Americans if it is not controlled. However, CNN said that for about a year, American legislators have been working hard to promote any meaningful artificial intelligence legislation. Although false information experts warn of the threat of artificial intelligence to opinion polls and public discourse, few people expect Congress to pass legislation to control the artificial intelligence industry in a divided election year.

At the end of October last year, US President Biden signed an executive order on artificial intelligence, and introduced the first set of White House regulations on generative artificial intelligence. According to the executive order, many government agencies in the United States need to formulate standards to prevent the use of artificial intelligence to design threats such as biological or nuclear weapons, and seek the best method for content verification such as "watermarking" and draw up advanced network security plans. Specifically, the order requires testing artificial intelligence products and reporting the test results to the federal government. It also proposes to attract global artificial intelligence talents to stay in the United States.

The White House said in a statement at the time that the executive order aims to ensure that the United States plays a leading role in fulfilling the promise of artificial intelligence and managing risks. As part of Biden’s comprehensive strategy of responsible innovation, it is based on the actions taken by the President before, including the voluntary commitment of 15 leading companies to promote the safe, reliable and trustworthy development of artificial intelligence.

In addition to artificial intelligence, Biden also mentioned a number of topics in his State of the Union address speech on March 7. In his speech, Biden reiterated that he would not send troops to Ukraine, but at the same time stepped up his appeal for assistance to Ukraine and targeted his Republican rival, former President Trump.

Biden vowed not to send American soldiers to Ukraine, saying that Ukraine wants military aid and weapons to fight back against Russia, not American personnel. "They don’t want American soldiers. In fact, there are no American soldiers fighting in Ukraine. I decided to keep this state. " Biden said. He stepped up his appeal to the United States to continue to provide assistance to Ukraine. Biden said that if the United States ignores Ukraine now, "Ukraine will face danger and Europe will face danger."

In his speech, Biden criticized Trump, who had previously encouraged Russia to "do whatever they want" to NATO countries that failed to fulfill their defense spending obligations. Biden said, "I think this kind of speech is outrageous, dangerous and unacceptable." CNN said that Biden did not directly mention Trump’s name, but called him "my predecessor, the former president of the Republican Party".

On the current Palestinian-Israeli conflict, Biden said that after the attack on October 7 last year, Israel has the right to attack Hamas, but it also has the "basic responsibility" to protect Gaza civilians. He said that he would instruct the US military to lead an urgent task to build a temporary dock on the coast of Gaza to receive a large amount of humanitarian supplies.

Biden also made comments on many issues such as education and economy.

The EU has also made big moves.

It is worth noting that in the field of artificial intelligence, the EU will also make big moves: comprehensive artificial intelligence regulations will be adopted soon.

Recently, foreign media reported that the EU is about to adopt comprehensive artificial intelligence regulations, which are very strict. The European Parliament is scheduled to vote on this legislation on March 13th, and a member of parliament said that he expected the legislation to be passed easily. According to the current timetable, the listing bill will basically take effect in 2026, and some provisions will take effect this year.

The bill will regulate different uses of artificial intelligence according to risks, including banning certain use cases, such as the "emotion recognition" system in the workplace, which will face the highest fine: 7% of global income or 35 million euros, whichever is higher.

The report pointed out that the EU will not be the first jurisdiction to regulate artificial intelligence, but the size of the European market means that the EU Artificial Intelligence Act will be affected globally, affecting the way multinational companies manage data and use artificial intelligence. The law will apply to enterprises operating in the markets of 27 countries and builders of artificial intelligence systems used by the European Union headquartered anywhere, including the United States.

In the United States, legislators also discussed artificial intelligence supervision, held industry hearings, and introduced bills. However, Congress has not yet passed legislation to widely regulate the use of this technology.

Frequent explosion models in the industry

At present, for artificial intelligence with great potential, regulatory legislation is one aspect, and development is also a very important aspect.

Recently, Sora detonated a new round of AI arms race, and the era of general artificial intelligence accelerated. In mid-February, Google released Gemini 1.5 Pro, which enhanced its ability to handle a large number of videos, texts and images. Developers can submit up to 1 million tokens to Gemini 1.5 Pro, which is equivalent to about 1 hour of video, 11 hours of audio or 700,000 words of text data.

Immediately, OpenAI released the Wensheng video model Sora, which can generate high-definition smooth video up to 60 seconds with text instructions, and has significant advantages in generating video length, coherence and multi-shot switching. Compared with the previous Wensheng video models Runway, ika and Stable Video, it has achieved cross-generation upgrade.

Galaxy Securities believes that the iterative speed of overseas technology giants to upgrade multimodal large models far exceeds expectations, Sora can simulate actions that affect the state of the world in a simple way, and the era of general artificial intelligence may come ahead of schedule. The broker further pointed out that multi-modal scenarios such as Sora and Gemini will broaden the downstream application scenarios, which will provide new production tools for movies, advertisements, games, short videos and other fields, and related industries are expected to reduce costs and increase efficiency and take the lead in application.

Sora’s powerful Wensheng video capability will rapidly promote the commercialization of the application end, stimulate the industrial scale, and then transmit it to the upstream computing infrastructure, and the demand for computing infrastructure will once again erupt. According to the calculation, Sora’s demand for computing power at the reasoning end will increase exponentially, which will drive the demand for infrastructure such as upstream chips, servers, optical modules and liquid cooling.

In addition, on March 5th, Anthropic released a new generation of AI big model series -Claude 3. There are three models in this series, which rank from weak to strong: Claude 3 Haiku, Claude 3Sonnet and Claude 3 Opus. Claude3 Opus has surpassed GPT-4 and Gemini 1.0 Ultra in many evaluation benchmarks, showing strong computing power in many fields, and further promoting the benchmark of artificial intelligence big model industry. Guolian Securities said that the Claude3 model was released, and the development of artificial intelligence continued to be interpreted, focusing on the three main lines of computing power, model and application.

Dongxing Securities said that the current artificial intelligence industry support policies and explosion models are frequent. As one of the engines of new productivity, artificial intelligence may promote the upgrading of traditional industries, and it will continue to make breakthroughs in the application side under the background of digital industrialization and industrial digital development. At the same time, it will benefit from the dimensions of data and landing in education, medical care, law and other fields. At the same time, the development of multi-modal and the release of new models will bring about the improvement of computing power demand and the pattern change on the model side. Model companies and application companies are expected to benefit from the development of the industry.

In the secondary market, artificial intelligence concept stocks continue to be active. On March 7th, in the US stock market, NVIDIA, the global leading AI computing enterprise, rose by more than 4%, reaching a new high for six consecutive trading days, with a market value close to 2.3 trillion US dollars, less than 300 billion US dollars from Apple’s closing market value. In the A-share market, on March 8, Industrial Fulian, Gaohong, Shengtong, and CLP Xingfa had daily limit.

Editor: Wang Lulu

Proofreading: Zhu Tianting

CCTV News:On the afternoon of January 18th, the Ministry of Commerce held a regular press conference. According to the spokesperson, the "2024 National Online New Year Festival" kicked off on January 18 and the event will last until February 17.

According to the Ministry of Commerce, digital, healthy and green are the new trends of consumption, and they are also the main new ideas of local activities. Around digital consumption, Beijing and other places held the first show of computer, communication and consumer electronic products, the "Science and Technology New Year Festival" and other activities. Around healthy consumption, Shanghai and other places hold "super holidays" and other activities in response to the seasonal demand in winter. Around green consumption, all localities have guided e-commerce enterprises to strengthen the supply of "small dishes", issued green packaging initiatives, and advocated a green and environmentally friendly lifestyle.

He Yadong, spokesman of the Ministry of Commerce:Closely following the needs of the New Year Festival, we will carry out three major "Spring Festival Rejuvenation" promotional activities. Around the rejuvenation of the home, Tianjin and other places carried out activities such as live broadcast of furniture and home appliances and special sales subsidies. Around the rejuvenation of the national tide, Zhejiang and other places carried out activities such as the "Non-legacy New Year Festival" and launched more domestic "tidal products". Around the scene rejuvenation, Shaanxi and other places carried out activities such as "Night Chang ‘an Chao Chang ‘an" to enhance the consumer experience in all aspects.

National Development and Reform Commission: Launching the "Consumer Help for the Spring Festival Action" in 2024

The National Development and Reform Commission (NDRC) recently launched the "Consumer Assistance for the New Year Action" in 2024, mobilizing and calling on organs at all levels, enterprises and institutions, social organizations and the general public to actively participate in holiday consumption assistance, and actively purchasing various products and cultural tourism services in underdeveloped areas such as poverty-stricken areas under the premise of fully respecting market rules.

In 2024, in the "Action of Consumption Helping the Spring Festival", all relevant regions and departments should increase the consumption and purchase of characteristic agricultural products in underdeveloped areas such as poverty-stricken areas, encourage them to go to poverty-stricken areas to carry out county-level cultural tourism consumption, and continue to strengthen the sales and assistance of products and services in poverty-stricken areas, especially in "three districts and three States", key counties for national rural revitalization, and relocation and resettlement areas.

Do a good job in organizing the supply of characteristic agricultural products in underdeveloped areas, smooth the passage from mountain to city, strengthen the control of product quality, and further increase the proportion of market-oriented help and sales.

In 2022 and 2023, in the "Consumer Help the Spring Festival Action", the total amount of sales assistance from various regions and departments reached 170 billion yuan, which effectively improved the income level of people out of poverty, promoted the development of characteristic industries and product upgrading in underdeveloped areas, and promoted the sustained recovery and expansion of domestic consumption.

Ministry of Culture and Tourism: Carry out the cultural tourism activities of "Happy New Year" throughout the country.

The reporter learned from the Ministry of Culture and Tourism on January 18th that during the Spring Festival, the Ministry of Culture and Tourism will organize the theme cultural and tourism activities of "Happy New Year" in 2024. The activities cover many fields such as Huimin’s cultural performances, intangible experience display, tourism and leisure consumption, and enrich people’s holiday life.

It is understood that the theme culture and tourism activities of the 2024 Spring Festival of "Happy New Year" were carried out from January 18 to March 11. This activity covers many fields such as public service activities, non-legacy experience display, tourism and leisure consumption, ice and snow research and tourism.

The theme activity of "Colorful Study Tour to China" is jointly participated by 11 provinces including Yunnan, Shandong, Zhejiang, Anhui and Jiangxi. Yunnan will launch a series of research activities such as "exploring biodiversity"; Jiangxi will launch the activity of "Traveling with Poetry in Jiangxi"; Protecting the beautiful Yangtze River theme research tourism activities, with the participation of provinces along the main stream of the Yangtze River; Shanghai will launch a "century-old civilization, butterfly changes into a new life — — Industrial research opens the next wonderful event; Hubei will launch a series of research theme activities such as "telling the epic of the red soul" and "welcoming the New Year without leaving behind"; The "ice and snow theme research tourism activities" are mainly concentrated in Heilongjiang and Jilin.

In addition, during the Spring Festival, the Ministry of Culture and Tourism will also launch the "100 Cities and 100 Districts" financial support consumption action plan, covering the whole chain of "eating, living, traveling, buying and entertaining", so that people can benefit and enterprises can really benefit.

　　BEIJING, Beijing, May 17 (Zhongqing) Following Beijing, hot cities such as Guangzhou, Shanghai and Shenzhen have successively introduced property market regulation measures for commercial projects. Although the intensity of control is different, it is clear that commercial projects should not be linked to residential properties, and some cities have also explored control methods in architecture and design, trying to reduce the possibility of commercial projects turning to residential uses from the product development end.

　　After Beijing, Shanghai, Shenzhen and other places followed up to regulate the commercial market.

　　On March 26th, Beijing Municipal Commission of Housing and Urban-Rural Development issued a document to regulate the commercial market, saying that "commercial and office projects (hereinafter referred to as commercial projects) should be developed, constructed, sold and used in strict accordance with the planned purposes, and may not be changed to residential purposes without approval", completely changing the rules of the commercial market.

　　The above-mentioned policies in Beijing not only block the channels for individuals to buy projects that have not been built, are under construction or are being sold, but also set strict thresholds for individuals to buy second-hand commercial houses.

　　Four days later, Guangzhou proposed to strengthen the management of commercial real estate projects. "Real estate development enterprise vendors do property, the sales target should be a legal entity; The commercial property purchased by a legal entity shall not be used as a residence, and when it is transferred again, it shall be transferred to the legal entity. "

　　On April 21st, many departments in Chengdu jointly issued the Notice on Further Strengthening the Management of Commercial and Office Construction Projects, requiring commercial and office construction projects to be developed, constructed, sold and used in strict accordance with the nature of planned land and planning permission, and it is strictly forbidden to change them into residential purposes without authorization.

　　On the same day, Shanghai required that the land transfer contract should specify that office land should not be used for apartment-style office projects, and commercial land should not be used for apartment-style hotels without agreement.

　　On May 12th, Shenzhen also issued a document to restrict the transformation of commercial offices. In the next five years, the transformation of commercial offices, R&D buildings into apartments, stealing areas and rebuilding will be strictly restricted. "After the introduction of the New Deal, such facilities will serve more office needs, that is, they are unlikely to serve the needs of housing." Yan Yuejin, research director of the think tank center of Yiju Research Institute, said that this has a negative effect on the subsequent Shenzhen commercial projects.

　　So far, Beijing, Shanghai, Guangzhou, Shenzhen, Chengdu and other cities have implemented control policies for commercial projects. From the perspective of urban types, they are basically concentrated in first-tier cities and some hot-spot second-tier cities.

　　Product design of multi-city document management and control returning to commercial attributes

　　No matter from the length of policy content, release time and follow-up supporting measures, Beijing has the strictest control over commercial projects.

　　"In the more than one month after March 26th, the actual transaction in the commercial market in Beijing fell sharply." Zhang Dawei, chief analyst of Zhongyuan Real Estate, bluntly said that it is the strictest commercial purchase restriction policy in history, which has dealt a significant blow to the overheated commercial market.

　　According to the policy of multi-site business regulation, it is a basic principle not to change it to residential use without authorization. For real estate development enterprises that change commercial real estate projects into residential purposes in violation of the plan, they all take a firm attitude of "once verified and dealt with seriously".

　　On the other hand, there are also differences in the intensity of regulation. Except for Beijing, other cities have not explicitly restricted individual commercial loan purchasers from running projects. Shenzhen, Chengdu and other places focus on product design control at the supply end.

　　For the development enterprises, the minimum division unit of newly-reported commercial projects is strictly regulated as not less than 500 square meters in Beijing, not less than 300 square meters in Guangzhou, and only part of the proportion is required in Shenzhen. In terms of transfer, Beijing and Guangzhou stipulate that purchased commercial properties can be transferred to legal entities and individuals, but Guangzhou has set "additional conditions" for the transfer, that is, individuals can not transfer again until they have obtained the immovable property certificate for two years.

　　Why is it limited? Crack down on speculation and limit the influx of people

　　"The activity of commercial projects is mainly due to the restriction on the purchase of houses and the high-end of houses, so a large number of public buildings are supported in the residential land." Speaking of the heat of the commercial market, Zhang Dawei believes that it has something to do with the increase in population.

　　Zhang Dawei said that in first-tier cities such as Beijing and Shanghai, the demand for permanent residents’ housing is huge. Some projects in the name of commerce, hotels and offices, by dividing property rights, change the use attributes of commercial projects, take "quasi-housing" as a selling point, and play a marginal role in electricity and water use to attract buyers.

　　However, due to the different nature of land use, there are obvious differences between commercial projects and commercial housing. First of all, the property right is 40 or 50 years, and there is no residential facilities (school district houses, etc.), with high residential density and small apartment type; The most important thing is that the house price will be lowered by 50-60% compared with the price of commercial housing in the same region.

　　"Low housing prices and no purchase restrictions are the main reasons for choosing commercial projects." Many interviewees who have purchased commercial projects told the reporter of Zhongxin. com.

　　Why should we regulate the commercial market? "The first is the planning problem. The business that is originally a residential facility has the property of residence, which is contrary to the planning and the related facilities cannot be followed up; The other is the population problem, such as the large population of commercial projects in Beijing and Shenzhen; In addition, due to the low land price of commercial land, developers take land with commercial land but sell it at residential prices, earning extra profits in disguise. " Zhang Dawei said.

　　Hua Zheng, an associate professor in the Department of Land Management, School of Public Administration, Renmin University of China, pointed out in an interview with the media that commercial regulation will ensure that residential houses and commercial offices belong to commercial offices, reduce the customer base of commercial properties, reduce the enthusiasm of developers and investors to run products, and then reduce the premium level of commercial land. "Cracking down on speculation in the commercial market will also limit the disorderly influx of population into big cities to a certain extent".

　　It’s not over! More cities may be planning to standardize the business market.

　　"There are cities that are brewing or starting to set off a new round of blockades ‘ Business changes to residence ’ 、‘ Do change and live ’ The policy tide. " Zhang Dawei predicted that before, the investment demand for buying commercial projects due to residential purchase restriction may face great risks.

　　Yan Yuejin, who predicted that Shenzhen and Shanghai would follow up the regulation of commercial projects, told reporters that in the future, some hot cities will actively follow up the purchase restriction of commercial projects. Although the intensity of control will not be equal to that of Beijing, one thing is certain: "Commercial projects are no longer linked to residential properties."

　　In Yan Yuejin’s view, in terms of policy strength, the measures to directly restrict or prohibit sales represented by Beijing are the most severe, and the control effect is the most obvious; However, the following mainstream model may be to standardize the supply side and actively control product design.

　　"Beijing and Guangzhou will not rule out the formulation of new policies for existing properties, for example, reasonable guidance for some buyers who sell and transfer houses." Some insiders analyzed to reporters. (End)

Original Wuyuan Li Na and other SIFIC infection horizons　

Author: Wu Yuan Li Na Jin Wenting Ma Yuyan

Review: Hu Bijie and Pan Jue

First, a brief introduction to medical history

Male, 63 years old, from Shanghai, was admitted to the Infectious Diseases Department of Zhongshan Hospital for the second time on November 23, 2022.

Chief complaint: indwelling catheterization with repeated urine color turbidity for 2 months and then 8 days.

Current medical history:

On September 19, 2022, I went to a hospital in Shanghai for fatigue, anorexia and dysuria. WBC 10.12×10 9/L, N 87.6%, Hb 53g/L, hsCRP 135.22mg/L, ESR 62mm/H, albumin 30.1g/L, Scr 589μmol/L, K 2 were examined. Urine routine: WBC 3892/ul, occult blood 3+/RBC 5579/ul, protein 2+; Chest CT: bilateral pleural effusion, partial atelectasis of lower lobe of both lungs; Abdominal pelvic CT: Bilateral middle and upper ureteral dilatation and renal pelvis and calyceal dilatation, the patch in the right part of calyceal is slightly high density, the bladder wall is thickened, there is a little flocculent blur around the left renal fat sac and ileocecal part, and there is a little effusion in the pelvic cavity. A large amount of turbid urine was drained by indwelling catheter. Urine culture showed that Klebsiella pneumoniae was positive. Considering urinary tract infection, acute kidney injury, hypokalemia and severe anemia, patients were given symptomatic support treatment such as anti-infection, bladder irrigation, antioxidation, potassium supplementation and blood transfusion. The symptoms of patients improved and the urine was slightly clarified. 10-18 Review urine routine: WBC3+, RBC3+, protein 1+, SCR 263 μ mol/L.

I was admitted to our department on October 19, 2022. Blood routine: WBC 5.08X10 9/L, N 66.1%, inflammatory markers: ESR 19mm/H, hsCRP 52.3mg/L, PCT 0.52ng/ml, Scr 257μmol/L, and urine routine: WBC 28493/μ. Urinary color Doppler ultrasound: hydronephrosis, bilateral ureteral dilatation, bladder wall thickening significantly; Abdominal pelvic CT: hydronephrosis of both renal pelvis and ureter, thickening of ureter wall (inflammatory change), inflammatory change of bladder and ureter may be large, the volume of both kidneys increases and the substance is thin. Meropenem 1g q12h is given for empirical anti-infection. Urology consultation considers the acute stage of infection, so it is not suitable to put double J tubes. If necessary, pyelostomy can be done, but it does not improve renal function much. Bladder irrigation is recommended. 10-20 middle-stage urine culture (sampling on October 19): Klebsiella pneumoniae was positive; 10-22 urine culture drug sensitivity: Carbapenem-resistant Klebsiella pneumoniae (CRKP), adjusted to ceftazidime and abamectin 2.5g q12h for anti-infection, and daily bladder irrigation. After treatment, the urine color of the patients gradually became clear, and the urine white blood cell and bacterial count gradually decreased during follow-up. The urine bacterial culture was negative on November 1 and November 4. Check the urine routine on November 09: WBC 28/uL, RBC 4/uL, urine protein+,bacterial count 29/UL;Blood WBC 7.64×10 9/L, N 76.5%, hs-CRP 0.4mg/L, ESR 25mm/H, PCT 0.18ng/mL, Scr 175μmol/L, which were significantly improved compared with those at admission. Stop ceftazidime and abamectin on November 11 and be discharged.

On November 15, 2022, the patient appeared turbid urine again, and there was no fever and other discomfort. On November 23, he was admitted to the hospital for a second diagnosis and treatment.

Past history: In September, 1991, T12-L1 comminuted fracture was treated with internal fixation. After operation, the catheter was retained for half a year due to urinary incontinence, and then the catheter was removed after urination. There was no urinary tract infection during this period. Diabetes for 16 years, insulin therapy, blood sugar control can be; Hypertension for 5 years, oral amlodipine to reduce blood pressure, blood pressure control can be.

Second, the admission examination (admitted on November 23, 2022)

[physical examination]

T: 36.2℃ P: 90 times/min R: 20 times/min BP: 176/105 mmHg.

Stay in bed, feel refreshed and calm, lose weight, and muscle atrophy of lower limbs; Breathing sounds in both lungs are thick, and dry and wet rales are not heard; The rhythm of the heart is regular, the abdomen is soft, without tenderness and rebound pain, without mass, without percussion pain in both kidneys, without tenderness at ureter point and rib and waist point, and the lower abdomen does not touch the enlarged bladder. During indwelling catheterization, the urine in the urine collection bag is turbid and more white flocs are deposited. Limbs are not swollen.

[Laboratory examination]

Blood routine: WBC 7.85×10 9/L, N 81.3%, HB 121g/L, PLT 170×10 9/L.

Urine routine: WBC 2775/μ l; RBC 2/μl, bacterial count: 39879/μl, nitrite positive, leukocyte esterase+++.

Inflammation markers: hs-CRP 17.9mg/L, ESR 68mm/H, PCT 0.12ng/mL.

Biochemistry: ALT/AST 23/21U/L, Alb 47g/L, Scr 199μmol/L, eGFR 30ml/min/1.73m2, na/k 140/5.5mmol/l.

Third, clinical analysis

Characteristics of medical history: middle-aged and elderly male, indwelling catheter, with repeated urinary turbidity and abnormal urine routine. Urine culture showed CRKP one month ago, and it improved after ceftazidime-ababactam treatment, but urine turbidity reappeared three days after drug withdrawal, blood inflammatory index increased, urinary leukocyte and bacterial count increased significantly, and the diagnosis of urinary tract infection was clear. The reasons for short-term recurrence after antibacterial drug treatment improved were considered:

Recurrence of CRKP infection: The patient has been indwelling catheter for 2 months, and there may be biofilm formation of catheter and abnormal urinary tract structure, which makes it difficult to completely eliminate the infection and relapse after stopping taking the drug. Therefore, urine culture and drug sensitivity test can be improved.

New infection: the patient has high risk factors of recurrent urinary tract infection, and the pathogen may be different each time. The patient’s previous CRKP infection treatment was effective, and the possibility of new pathogen infection should be considered in the short term, until the urine culture is perfect and clear.

Multiple infections: patients with abnormal urinary tract structure, indwelling catheter and other risk factors can not be removed, so it is necessary to be alert to the possibility of multiple pathogens including fungi combined with infection, repeat the cultivation of urine bacteria, mycoplasma, fungi and mycobacteria, and improve urine mNGS to help clarify the infected pathogens.

Four, further examination, diagnosis and treatment process and treatment response

On November 23, 2022, the middle urine smear was used to find bacteria: moderate amount of G- bacilli, and continued ceftazidime and abamectin 2.5g q12h ivgtt for anti-infection and bladder irrigation.

On November 26, 2022, the bacterial drug sensitivity of the middle-stage urine culture (sampling on November 23) was CRKP, ≥ 100,000 /ml, and urine mNGS: a large number of Klebsiella pneumoniae (species strict sequence number: 406,866) was detected.

On November 29, 2022, the abdominal and pelvic CT was reexamined: bilateral dilated hydronephrosis accompanied with inflammatory changes of ureter, and the parenchyma of both kidneys was thin, and the inflammatory changes of cystitis might be larger, similar to that of 22-10-20 slices.

November 30, 2022 (sampling on November 29): Enterococcus faecalis was positive. On December 2, according to the drug sensitivity, fosfomycin 3g qod was added orally, and ceftazidime and abamectin were suspended.

Repeated urine cultures on March, April and June, December, 2022: Enterococcus faecalis was positive and CRKP was negative.

On December 8, 2022, the urine WBC was 38738/μ L, and the bacterial count was 43285/μ L; Urine culture: CRKP positive, Enterococcus faecalis negative.

Phage therapy was carried out from the afternoon of December August, 2022: Phage cocktail (composed of 5 strains of Klebsiella pneumoniae phages A103KP172, A106KP176, A121KP192, A49KP106 and A58KP118, 5mL each), injected with 225mL physiological saline (according to the estimated bladder volume), and the total volume was 250mL, and then the catheter was clamped.

Urine routine on the third day of phage treatment on December 11, 2022: white blood cell count: 235/uL, bacterial count: 722/uL；; Urine bacterial culture was negative.

Urine routine on the 5th day of phage therapy on December 13th, 2022: white blood cell count: 279/uL, bacterial count: 92/ul; Urine bacterial culture was negative; Blood WBC 6.35X109/L, N 70%, hs-CRP 0.9mg/L, ESR 26mm/H, and inflammatory index decreased compared with before; Re-examination of urinary color ultrasound showed that bilateral renal pelvis separation and upper ureteral dilatation were better than before (10-20), and the thickness of bladder wall was reduced (12-25mm→13mm).

He was discharged from hospital on December 14, 2022 for follow-up.

V. Final diagnosis and diagnosis basis

Final diagnosis:

Complex urinary tract infection (CRKP, Enterococcus faecalis)

Neurogenic bladder, hydronephrosis and hydroureter (indwelling catheter)

Renal insufficiency

Diagnostic basis:

The patient is a middle-aged and elderly male with neurogenic bladder caused by paraplegia, indwelling catheter, turbid urine with flocs, increased CRP and PCT, significantly increased WBC and bacterial count in urine, repeated CRKP positive in urine culture, positive in enterococcus faecalis, abdominal basin CT: hydronephrosis of renal pelvis and ureter, anti-infection, normal inflammatory markers and urine routine after phage treatment, clear urine and negative urine culture, so complicated urinary tract infection.

The patient suffered from anorexia and dysuria, and the serum creatinine increased obviously. Abdominal CT showed that both kidneys were enlarged, the cortex was thin, and bilateral urinary tract was hydronephrosis. After active treatment such as controlling infection and improving renal function, the serum creatinine decreased, so the diagnosis of renal insufficiency was clear.

Six, experience and experience

Phage is a targeted sterilization virus in nature and a sterilization star in the "pre-antibiotic era". Phage therapy has a history of more than 100 years, but the discovery and application of broad-spectrum antibiotics have gradually marginalized it. With the increasingly serious problem of bacterial drug resistance, phages have once again received attention and become the most promising supplement and alternative therapy for treating superbugs. The clinical application of phage in China is relatively late, but it has developed rapidly in recent years. In 2017, the Shanghai Institute of Phage and Drug Resistance was established, with Professor Hu Bijie as an academic member. Since 2018, the institute has carried out the first clinical trial of phage therapy in China. At present, it has treated nearly 100 patients with drug-resistant bacterial infections from all over the country and accumulated rich clinical experience in phage therapy, which is a leading position in the field of clinical phage therapy in China.

Phage has many advantages, such as host bacteria dependence, targeted specific sterilization, no infection to eukaryotic cells (little influence on normal flora), no influence on bacterial drug resistance, synergy with antibacterial drugs, penetration of biofilm and so on. The cure rate of acute bacterial infection is high, and the therapeutic effect of chronic bacterial infection is no less than that of antibacterial drugs, and the safety of phage treatment is also extremely high. A systematic retrospective study showed that the vast majority of patients who received phage therapy had no or only slight adverse reactions, 86.7% patients’ clinical symptoms improved, and 78.8% patients achieved the eradication of pathogenic bacteria. Our clinical trials also show that more than 70% of patients have achieved good therapeutic effects, and there are no obvious cases of adverse reactions. This patient was repeatedly infected with Klebsiella pneumoniae due to long-term paraplegia, abnormal urinary tract structure, indwelling catheter and other factors. The diagnosis of complicated urinary tract infection was unquestionable, and the choice of antibacterial drugs was limited due to multi-drug resistance and renal insufficiency. Phage therapy is very suitable.

The disadvantages of phage therapy include narrow host spectrum, individualized plan (it is difficult to treat empirically), no unified standard for the best treatment decision, and rapid tolerance. Phage cocktails, combined antibacterial drugs and multiple treatments are usually used in clinic to improve the curative effect. At present, the targeted pathogens of phage therapy in our team mainly include: multi-drug resistant Gram-negative bacteria (Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecalis); Covering respiratory system, urinary system, abdominal cavity, bones and joints, skin and soft tissue and other infected sites; Treatment depends on the site of infection, and intravenous application of phage is still being explored. In this case, the patient didn’t have percutaneous nephrostomy because of the little clinical benefit, so he was treated by transurethral bladder perfusion, and the phage could not cover the whole urinary tract evenly. Although the pathogen turned negative in a short period of time and was well tolerated, its long-term curative effect may not be good, and it needs repeated phage treatment.

Phage therapy has huge clinical demand and broad market. In recent years, our team has focused on the clinical application (treatment and prevention and control of nosocomial infection) and basic research of phage therapy, with a view to becoming a powerful weapon to curb drug-resistant bacteria in the future.

references

[1] Uyttebroek S, Chen B, Onsea J, Ruythooren F, Debaveye Y, Devolder D, Spriet I, Depypere M, Wagemans J, Lavigne R, Pirnay JP, Merabishvili M, De Munter P, Peetermans WE, Dupont L, Van Gerven L, Metsemakers WJ. Safety and efficacy of phage therapy in difficult-to-treat infections: a systematic review. Lancet Infect Dis. 2022 Aug; 22(8):e208-e220.

[2] Chegini Z, Khoshbayan A, Taati Moghadam M, Farahani I, Jazireian P, Shariati A. Bacteriophage therapy against Pseudomonas aeruginosa biofilms: a review. Ann Clin Microbiol Antimicrob. 2020 Sep 30; 19(1):45.

[3] Lusiak-Szelachowska M, Weber-Dabrowska B, Gorski A. Bacteriophages and Lysins in Biofilm Control[J]. Virol Sin, 2020,35(2):125-133.

Every Monday night

The Department of Infectious Diseases of Zhongshan Hospital affiliated to Fudan University in Shanghai will be with you!

Photo: Xiaoxiao

Original title: "Detective Case: The Nemesis of Super Bacteria is Coming"

Read the original text

　　[car home Information] It’s the time of OTA summary every month again. This month (|) and Lightning Cat ushered in the first upgrade. At the same time, many cars owned by Changan, including Lantu FREE, Changan Lumin and Deep Blue SL03, have also been upgraded. The ideal L9/L8 is that OTA has upgraded as many as 35 new functions. Let’s look down at the specific upgrades.

　　OTA (full name: Over-The-Air technology) has become the most fashionable vocabulary at present, and it is also an important indicator to assess whether the products of car companies are intelligent enough. OTA is divided into FOTA and SOTA, in which SOTA refers to the software upgrade in the air, which is biased towards the software upgrade including the application of the vehicle system, just like the update of some application versions in smart phones; FOTA refers to the firmware upgrade in the air, which can upgrade and optimize the core modules such as vehicle three-electric system and control system, just like the operating system version update of smart phones.

● Euler automobile
OTA involves models: Euler ballet cat
OTA content: guard mode, sentry mode, etc.
OTA Push Time: February 14th

　　On February 14th, Euler Ballet Cat officially ushered in the first OTA upgrade. This OTA upgrade will add 11 functions, including guardian mode, sentry mode, intelligent driving birthday celebration, locking the car and automatically raising the window, etc., and there are also 21 functions. Optimization.

　　Specifically,Guardian mode:When in distress, automatically alarm and notify the emergency contact;Sentinel mode:Inform the owner of the abnormal situation at any time;Short-term resident mode (pet guarding function):The air conditioner works continuously when the car is locked;Cave time:Open the cave mode and take a short rest with white noise and dancing fire;Meditation mode:Create an exclusive "lounge";Egg mode:Festival birthday specific egg animation;Intelligent driving assistant:The menu interface [Intelligent Driving Assistant] can search/view the introduction of related functions to help novice drivers master the related functions of intelligent driving;Yunxi timbre:The voice assistant "Xiao Ou Xiao Ou" added male timbre;Auto-window-raising function of car locking:When locking the door can be set, all windows will close automatically;Maintenance mode:Provide security for the maintenance process; Privacy management upgrade: upgraded voice, fatigue detection (optional) and face recognition (optional) are turned off by default, and can be turned on by clicking again.

　　Instructions for upgrading: 1. Before upgrading, please read the OTA Upgrade Guidance Manual and precautions in detail; 2. All the functions have passed the internal verification and have been tried by the owner. If you encounter any problems during the use, you can contact them in time through the exclusive service group and the official customer service hotline: 400-666-5969. * This upgrade will be carried out in batches and is expected to be completed by the end of February. * Swan Lake and Nutcracker editions come standard with guard mode, sentry mode and cave mode. Meditation mode, Alice, Sleeping Beauty Edition can be equipped with a warm-hearted girlfriend optional bag to open the cave mode and meditation mode. Other new features are standard for all departments.

● Euler automobile
OTA involves models: Euler lightning cat
OTA content: new car function, optimization of remote parking, etc.
OTA Push Time: February 22nd

On February 22nd, Euler Lightning Cat officially pushed the first OTA upgrade. This upgrade has adopted the feedback from the first batch of users, which has brought about seven optimizations, including adding car functions, optimizing remote parking and unlocking near cars, etc., to enhance the car experience.

　　New car function: add video instructions of common functions to help new users get started quickly and understand and use the rich functions of Euler Lightning Cat through video.

　　Optimize the "remote parking" experience: optimize the radar and camera fusion algorithm of automatic parking, improve the ability to identify special objects during automatic parking, and provide more parking scene support. Optimize the control logic of remote parking, and improve the experience of mobile App controlling the automatic parking and parking of vehicles in the scene of leaving the car.

　　Optimize the "near-vehicle unlocking" function: optimize the logic of the near-vehicle unlocking function, increase the linkage mechanism between the back door and the four-door lock, and expand more usage scenarios.

　　Optimize the anti-interference ability of "electronic steering lock": optimize the software algorithm to improve the anti-interference ability of the vehicle to abnormal electromagnetic signals in special environment and improve the safety performance of the whole vehicle.

　　Improve the comfort of air conditioning in low temperature environment: according to the road test data of urban working conditions and extremely cold working conditions in winter of 2022, optimize the air conditioning parameters to improve the comfort of heating in low temperature environment.

　　Optimize charging performance: improve the compatibility of different brands of charging piles and support more charging pile brands. Optimize the software of power battery: optimize the algorithm of SOC quantity, and improve the accuracy of displaying SOC and remaining mileage.

　　Note: This upgrade is expected to take 45 minutes. It is recommended to make an appointment to upgrade. The upgrade process cannot be terminated and the vehicle cannot be used normally. OTA will be pushed in batches. Before upgrading, please switch the driving mode to economy mode or standard mode, and adjust the wiper switch to OFF position. In addition, it should be noted that the power is 20% or above, and the door glass lifting function cannot be used during the upgrade. Please do not open or close the door.

● Changan Automobile
OTA involves models: changan Lumin
OTA content: fast interconnection, rich voice commands, etc.
OTA Push Time: February 14th

　　On February 14th, Chang ‘an Lumin released the carefree charging package and ushered in the OTA upgrade of the car, making the charging more convenient and the car more intelligent.

　　It is reported that with the 3.3kW AC/DC integrated charger and the integrated fast and slow charging converter in the carefree charging package, it takes only 2.9 hours to charge the 210km battery life of Changan Lumin from 30% to 80%.

　　In terms of vehicles, Changan Lumin supports the following new functions after OTA:

　　1. Fast interconnection, which can realize music playing and phone call, only need one operation, and then automatically connect. (Only for Android phones)

　　2. Support the interconnection of mobile phones: After the interconnection of mobile phones, intelligent entertainment functions such as navigation, Internet music/radio, video projection and so on can be realized, and Bluetooth /USB music and navigation sound sources do not cover each other.

　　3. Enrich voice commands, covering all aspects of voice commands such as music playing/switching, making phone calls, navigation route selection and weather query.

● Changan Deep Blue
OTA models: deep blue SL03
OTA content: new Netease cloud music, 540-degree transparent chassis, etc.
OTA Push Time: February 6th

　　A few days ago, Changan Deep Blue officially announced the upgrade announcement of Deep Blue SL03 OTA. The new functions and optimization experience of this version of DEEPAL OS 1.1 include intelligent cockpit, intelligent driving, intelligent vehicle control and other fields. The main upgrade contents include the addition of Netease cloud music, support for "thousands of people" exclusive driving mode and 540 transparent chassis function. This OTA will upgrade the 515 pure electric version and 1200 extended range version of Changan Deep Blue SL03 first, and the 705 pure electric version will be upgraded later.

　　In terms of new applications, "Netease Cloud Music" was added; Applications such as "Deep Blue Experience Show", "Cloud Listening" and "Lazy Listening to Books" will be launched in the application mall, which can be downloaded by yourself.

　　In terms of interactive experience, the switch function of watching video and singing while driving is added; Add traffic query function; Optimize the rotation function experience of the central control panel, add a shortcut key to the center of the central control panel in the control center, and optimize the rotation function of the central control panel in voice control; Optimize the experience of the steering wheel custom button function. Press and short the custom button newly to set different shortcut functions separately. When the "light comity" and "low-speed pedestrian alarm sound" are turned on and off by the custom button, a text prompt is added to the central control screen.

　　In terms of assisted driving, a 540 transparent chassis function is added; Optimize the experience of vehicle cornering function in IACC state; Optimize the experience of vehicle close-range parking function in ACC and IACC States; Optimize the AEB trigger sensitivity experience in the case of low-speed car following; Optimize the problem that the false alarm of the vehicle forward-looking camera is blocked.

　　In terms of driving experience, the exclusive driving mode of "thousands of people and thousands of faces" has been added; The display and setting function of micronucleus high frequency pulse heating in the central control panel is added; Add "economic mode" driving mode; Optimize the experience of wiper adjustment function, and increase the 4-speed sensitivity adjustment option of wiper "automatic gear".

　　Official prompt, the above OTA upgrade content is partial, and the complete upgrade content is shown in the official announcement or subject to the actual push of the car. When upgrading, please park the vehicle in a safe area (gentle road section) and keep it still; During the upgrade, please do not charge for the time being; During the upgrade, it is normal that the screen may be turned off or restarted, and the instrument panel fault light will prompt briefly, so please do not intervene artificially. If you confirm the upgrade, you can click the upgrade now button or just use the reservation upgrade function, and the system will automatically update. The overall upgrade time is estimated to be 75 minutes, depending on the network environment.

● Lantu Automobile
OTA involves models: lantu FREE
OTA content: vehicle-machine interface, interaction, functions, etc.
OTA Push Time: February 10th

　　A few days ago, Lantu FREE ushered in the upgrade of OTA version 3.0. This OTA has carried out 71 optimization upgrades on the interface, interaction and functions of the car, including 13 new functions and 58 experience optimizations, and adopted more than 130 user requirements.

■ The interface is more vivid, and the car also has a "smart island"

　　Lantu Free OTA version 3.0 brings a smart island design like iPhone, and realizes rich interaction with simple design. As the fourth screen of the car, "Smart Island" function can pop up various important information such as navigation guidance, incoming call, enlarged map of intersection, location sent to the car and so on in an eye-catching way. At the same time, the interface can change flexibly according to different types of messages, and the driving distance and incoming call information can be grasped in real time, which not only ensures driving safety, but also avoids worrying about missing the intersection.

　　This OTA improves the value of the car interface, and the operation is convenient and intuitive. UI such as dashboard background, function icons and ADAS effect is fully optimized; The "Quick Control" interface has been redesigned, and the commonly used shortcut keys for vehicle control have been added to the negative screen, making it more convenient for users to use the functions. The added "weather forecast" mode and weather dynamic wallpaper directly display the weather on the central control screen, and cooperate with the weather animation to let users vividly feel the daily weather changes. The air conditioner, fragrance, seat and window in the car are integrated into a visual function plate, and the interface of each function setting is more convenient to control.

■ Navigation is more intimate, and the location of the mobile phone is sent by airdrop.

　　In response to the user’s demand, this OTA has added a binding page for handcart interconnection. Users can search for addresses through apps such as WeChat, Meituan and Public Comment, and then share them with the car machine with one click, thus realizing the synchronous sharing of mobile phones and car machines, saving the time of repeatedly searching for destinations on the car machine and making travel more efficient.

　　In addition, this update also enriches other functions of car navigation, making car navigation as convenient as mobile navigation. The navigation card on the home page newly displays the enlarged map of the intersection. When the vehicle drives to the intersection, the navigation interface will pop up the enlarged intersection image, making it more convenient for users to choose the lane. When there is no navigation, the car will display the road condition tips and estimated time-consuming for users to go home or go to the company, which is intuitive and convenient. This OTA also allows the co-pilot screen to view the navigation road conditions and panoramic map when navigating, and at the same time, it can search around, modify the destination and send the passing points to the central control navigation, so that the co-pilot can help the driver to go to every destination more effectively and conveniently, making driving safer.

■ More entertainment, creating a mobile leisure room.

　　This OTA has also expanded and optimized entertainment resources, making users’ in-car life richer. The co-pilot screen ushered in a comprehensive rejuvenation, and the homepage was updated to be recommended by iQiyi, directly selecting the hottest drama at present, so that the co-pilot can have more fun when taking a long-distance bus. The entertainment interface has also added the online radio resource "Cloud Listening" of Yangguang, which gives users who like to listen to radio broadcasts more choices. The multimedia page of the car machine is completely redesigned, and the operation logic is unified and optimized to turn pages vertically, completely duplicating the operation mode of mobile phones and smart TVs, which is easier to use and lowers the learning threshold for users. On the central control screen, music and radio stations are merged into a media card, and users can quickly switch media sources on the card.

　　In addition to the above updates, this OTA has also made a number of optimizations for intelligent voice, instrument display and system functions, such as adding voice skills, which can directly switch power modes; The quick account switching function is added, so that the same car can adapt to the driving habits of different people, so that the whole family can share the FREE； map; There is a new custom editing function of instrument card components on the lathe, which allows users to combine them according to their own usage habits, and the operation is as convenient as a mobile phone; The function of subtotal mileage has been added, so that users can accurately grasp the car data of each journey and so on.

● LI
OTA models: L9, L8
OTA content: intelligent driving, human-vehicle interaction, etc.
OTA Push Time: February 17th

　　LI announced today that the ideal L9 and L8 have welcomed OTA 4.3, and 35 new functions have been added to the 4.3 system to optimize 17 experiences. The OTA update is as follows:

　　First, intelligent driving

　　1. The high-speed NOA function standard on the ideal AD Pro is online, and vehicles can overtake independently, adjust the speed limit, enter and exit the ramp, etc.

　　2. Call in a straight line and start quickly in 5 seconds.

　　3. The first intelligent driving map construction early warning. Cooperate with Gaode Map to update the dynamic construction information and push it to the driver earlier.

　　4. Intelligent parking in inclined train spaces.

　　5. Lane departure auxiliary rectification.

　　Second, human-vehicle interaction:

　　1. There are many Bluetooth headsets in the back row.

　　2. New lyrics are displayed on the media card of the central control panel.

　　Third, the first three applications

　　1. The countdown function of traffic lights starts.

　　2. The intelligent cockpit "Task Master" is launched, and the cockpit function combination can be customized, including multi-field linkage such as seat, driving and lighting.

　　3. The video platform "Happy Premiere" landed in the car application center.

　　Fourth, the smart space upgrade

　　1. Add video aggregation search function. Say "I want to watch TV series" to my ideal classmates, and you can search across platforms without opening the application.

　　2. Locking the car outside the car will not turn off the power. The air-conditioned entertainment system can continue to be used in winter and summer, or when pets are used in the car.

　　3. Add the mobile phone key family sharing function. Multi-person car does not need the owner’s remote App to unlock.

● Feifan Automobile
OTA involves models: Feifan R7
OTA content: new cloud game function, enhanced voice generalization ability, etc.
OTA Push Time: February 24th

　　A few days ago, we learned from the official that Feifan R7 will carry out the first OTA upgrade, and the version of RISING OS 1.1.0 will be pushed to users from now on. It is reported that this upgrade will add 26 major functions and optimize 20 experiences. In addition, the official said that the OS software version equipped with RISING PILOT advanced intelligent driving system is expected to be pushed in late March.

"new6 3A themed games』

　　Specifically, version 1.1.0 of Rising OS is mainly aimed at upgrading the smart cockpit, including adding cloud game functions, supporting the connection of Bluetooth handles and mobile phone virtual handles, and built-in six 3A-themed games such as "the king of fighters 14", "Legend of the Sword and the Chivalrous Man 7" and "Leo’s Wealth". At the same time, the "Love Listening" application has been added to the central control screen, and music playback display has been added to the instrument screen. For models with non-streaming rearview mirrors, the function of viewing rearview images on a large screen in real time is added, which means that users have a "virtual streaming rearview mirror" that can be called at any time.

"Add the function of viewing rear-view images on large screen in real time"

　　In terms of interactive experience, the basic operation of Rising OS version 1.1.0 is smoother and smoother. The new version strengthens the ability of speech generalization and can achieve more efficient speech interaction recognition. At the same time, the cockpit voice control ability is further enhanced. The visual enhanced AR-HUD head-up system can realize the adjustment of switch, volume, brightness and height through voice, and the seat can also realize the all-round adjustment of position and angle through voice, eliminating the need for users to manually call complicated multi-level menus. In addition, the new version also improves the fluency of users’ main interactions such as drop-down menu, Widget Box and Dock bar.

　　The upgrade also added the functions of "automatic planning of energy-supplementing path" and "smart power finding". According to the remaining mileage and route environment, the vehicle can actively help the user plan the energy replenishment plan along the way and add the charging station to the navigation itinerary. The "Smart Power Search" function can automatically evaluate the distance, charging standard and busy/idle state of the surrounding charging/changing stations according to the vehicle location, and recommend the charging station with the best time and economic cost for users.

　　With the upgrade of RISING OS 1.1.0, the coverage of high-speed navigation has been continuously studied and iterated, and the coverage of high-speed navigation has been greatly increased in the cities that have been opened. In the new OS software version that Feifan Automobile plans to push in late March, it will optimize the intelligent driving scene and the coverage of urban road sections. In addition, we will be the first to experience the optimized high-speed navigation assistance function next week, which will bring you a detailed experience.

● Ford
OTA involves models: electric horse
OTA content: remote control of air conditioning, support for booking parking upgrades, etc.
OTA Push Time: February 15th

　　A few days ago, we learned from the official of Ford Electric Horse that from now on (February 15th), Ford Electric Horse will launch a new wave of OTA upgrade for China users this year. For a long time, Ford Electric Horse has continuously provided users with more functions, complete services and frequently-used car experience through OTA. This time, OTA upgraded the interconnection module for users, realized the ability of App to remotely control air conditioning and heating, and added related capabilities such as supporting reserved parking upgrades.

　　After the upgrade, users can remotely control air conditioning, seat heating and steering wheel heating through the Ford electric horse mobile App. The newly added functions of "heating and defogging" and "rapid cooling" can quickly remove the fog on the window and windshield, and reduce the cabin temperature in advance at the fastest speed.

　　OTA upgrade can be divided into parking upgrade and non-inductive upgrade. At present, the OTA upgrade of Ford electric horse belongs to non-inductive upgrade, and the upgrade process is completed in the background, without the user’s own control of the upgrade time, while the OTA parking upgrade can only be completed when the vehicle is not started. Therefore, in this OTA upgrade interconnection module, the function of supporting reservation parking upgrade is added, and the owner can freely choose the functions of "reservation upgrade" and "update now" to make an appointment update. In the future, the upgrade method will be decided according to the different OTA push modules to ensure the driving safety during the upgrade process. Thanks to Ford’s new generation of electronic and electrical architecture-FNV Intelligent Interconnection Network Architecture, a neural network and decision-making center for the whole vehicle was built, and Ford Electric Kyle realized the global cloud upgrade of software and firmware.

　　　Ford electric horse, which is positioned as a medium-sized SUV, currently has four models on sale, and the price range is 249,900-369,900 yuan. In terms of battery life, CLTC cruising range is 492 km, 513 km, 554 km and 619 km according to different vehicle configurations for consumers to choose from.

● Remote car
OTA involves models: remote star enjoys v.
OTA content: reduce vehicle energy consumption and optimize low-speed driving stability.
OTA Push Time: February 6th

　　On February 6th, Star V (including V5E and V6E) of Remote Automobile ushered in the first OTA upgrade in 2023. This OTA mainly involves the function upgrade of four modules, including: reducing vehicle energy consumption, optimizing low-speed driving stability, and increasing the use of air conditioning functions when charging. This OTA is a free push. You can follow the instructions or go to the remote car service station to upgrade after receiving the relevant SMS, phone call or notice from various platforms of the remote car. The specific operation process is as follows:

Operation instruction of Star Enjoy V5E/V6E OTA real vehicle:

　　When there is an upgrade task for the Star Enjoy V5E/V6E, there will be an OTA message on the dashboard 1-5 minutes after the vehicle starts, and the user can confirm or cancel the upgrade through the OTA button on the left side of the steering wheel.

OTA operation preparation

　　1. Before upgrading the vehicle, the following conditions shall be met:

　　1.1 The vehicle is in the ON state; 1.2 The vehicle is in a non-READY state; 1.3 The vehicle is not under high pressure; 1.4 The vehicle is at rest; 1.5 The vehicle is not charging; 1.6 Vehicle handbrake is pulled up; 1.7 the vehicle gear is in n (neutral); 1.8 vehicle trouble-free, instrument trouble-free lights; 1.9 The battery voltage of the vehicle shall be over 12V;

　　2. During the upgrade process, the following requirements shall be met:

　　2.1 Do not operate the vehicle; 2.2 The battery voltage of the vehicle shall be over 12V; 2.3 If the battery voltage is low, it is recommended to take power to upgrade;

　　3. After the upgrade is completed

　　3.1 The vehicle needs to be powered on and off again, and the vehicle should be READY. If the vehicle cannot be powered on, please record it in time and feed it back to the remote after-sales technicians.

Upgrade operation

　　1. Upgrade preparation

　　1.1 Operate the vehicle to power down, and the key is in the OFF position. 1.2 After the vehicle sleeps for 1-5 minutes, power it ON again (on gear) and wait for about 1 minute.

　　2. Confirm the upgrade

　　2.1 Observe the instrument information, and the instrument displays OTA. 2.2 click the OTA button to operate 2.2.1 to confirm the upgrade.

　　After confirming the upgrade, the word OTA on the instrument flashes slowly, indicating that the vehicle is undergoing OTA upgrade. Until the word OTA disappears, the buzzer will sound, indicating that the upgrade is complete. (During the upgrade, it is normal for the instrument to light the fault light and the OTA light to continuously flash).

　　Note: If the short press of the satellite enjoy V5E/V6E OTA button is still invalid (the word OTA of the instrument does not flash slowly), you can try to cancel the upgrade manually (press it for more than 3s), then power off the whole vehicle for 2 minutes, and then power on it again. After the word OTA appears, press it short to confirm the upgrade. According to experience, this operation has a high success rate of key pressing.

Cancel the upgrade

　　Press the OTA buttON for a long time (until the word OTA disappears on the dashboard), and after the next ON gear is turned on for 1-5 minutes, the OTA prompt light will continue to appear on the instrument. You can operate the above steps to upgrade.

　　This OTA upgrade has been strictly tested. If you fail to upgrade successfully, please contact us at 400-061-5566 as soon as possible, or go to the nearest remote car service station to enjoy the upgrade service.

● Baojun Automobile
OTA involves models: KiWi EV
OTA content: add smart driving such as memory parking and mobile App parking.
OTA Push Time: February 15th

　　On February 15th, the 2023 KiWi EV started the first system upgrade. This upgrade added intelligent driving functions such as memory parking and mobile App parking, and added eight new scenes of the "Scene Rubik’s Cube", and optimized a number of intelligent network connection functions of the vehicle.

　　　2023 KiWi EV adds memory parking function. This function relies on DJI vehicle-mounted stereo binocular camera, vehicle-gauge level controller and UAV homologous algorithm. Users can freely choose the starting point and ending point to learn and create routes in the parking lot, and support wired parking spaces such as outdoor ground parking lots and underground parking lots, vertical/horizontal/oblique trains, covering all kinds of scenes, and stopping immediately when they are visible.

　　　Users can intelligently avoid pedestrians/vehicles and passing cars when parking, and do not need to enter the parking space when learning the route. At the same time, the route creation limit is low, and it can be reversed for a short time when parking in memory, and it can be used at any time after the route creation is completed. In addition, the 2023 KiWi EV opened the car machine and the mobile phone Zhilian ecosystem, and the one-button parking function of the mobile App was launched. Users can park in and out by using the mobile App, covering more parking scenarios.

　　　Scene Rubik’s Cube uses intelligent driving recommendation algorithm, which can link navigation and binocular vision recognition system, and actively recommend driving assistance to users when the road is clear. At the same time, it can automatically identify the parking intention and parking space, and it is recommended to use the parking function. On the other hand, in the scene of getting on the bus, going home and going to the company, which is frequently used by users, it automatically triggers the greeting of getting on the bus, and actively recommends opening the route of going home/going to the company to realize "service to find someone". In addition, the system adds three quick scenes: the user can leave the car for a short time without turning off the power; Turn on the sleep mode to create a comfortable rest space; The camping mode supports the function of taking electricity from outside, which effectively solves the problem of "difficulty in using electricity" during camping. In addition to the above scenarios, the 2023 KiWi EV has added a custom scenario, which opens the full link of App, cloud and car. Users can freely set the opening conditions and combine custom voice, music, navigation, radio, air conditioning, etc., bringing a more fashionable and enjoyable intelligent interactive experience.

　　This upgrade has also carried out the optimization of the related functions of the intelligent network connection of locomotive and locomotive, the visual upgrade of the personality theme of "daytime mode", and the interface update of modules such as settings and air conditioning. Secondly, the car machine supports virtual image dressing, and various clothing accessories and makeup can be freely matched. The 2023 KiWi EV also supports five emotions to change freely and switch different timbres in different car scenes, bringing more intelligent human-computer interaction experience and meeting the individual needs of users. (Compile/car home Guo Chen)

? ? Huawei’s every move in the mobile phone industry has attracted widespread attention in the industry. Today, Huawei’s senior executive Yu Chengdong officially announced that the Huawei Mate 70 series will be officially released in mid-November. I believe this news will definitely arouse the expectations of countless technology enthusiasts. Yu Chengdong also said on social media: "The most powerful Mate in history! See you in November!" This not only indicates the imminent arrival of the Mate 70 series, but also shows that this new machine may bring disruptive innovation.

? ? It is reported that the Mate 70 series will include four models: Mate 70, Mate 70 Pro, Mate 70 Pro + and Mate 70 RS Extraordinary Master. According to early revelations, these models will continue the classic style of the Mate 60 series in appearance design, with a three-hole screen design on the front and support for 3D facial recognition. In addition, the new series will also introduce side fingerprint recognition to further enhance the user’s unlocking experience.

? ? There are even netizens who have produced corresponding Mate 70 product rendering graphs and some promotional materials.

? ? Another highlight of Huawei’s Mate 70 series is the new native Hongmeng system. This system is Huawei’s self-developed operating system, which aims to achieve a higher degree of autonomy and control. Yu Chengdong has said that after a decade of hard work, Huawei has achieved a breakthrough in the core technology of the operating system, and the launch of Hongmeng system marks another milestone in Huawei’s software ecosystem construction.

? ? According to the revelation, the Mate 70 series will no longer be compatible with Android-developed applications and will only support Hongmeng native applications. This strategy will undoubtedly promote the development of Hongmeng’s ecosystem, but also raise users’ expectations for the new system.

? ? In terms of appearance design, the Mate 70 series will cancel the previous dual-screen color scheme and use the rear camera area of the large round module, which will return to the consistency with the Mate 50 series. It is worth mentioning that the rear main camera will be equipped with the domestic outsole sensor customized by Howell, with a large variable aperture to ensure high-quality photos under different lighting conditions. The screen of the Mate 70 series will use 1.5K OLED technology, with the screen shape of equal depth and four curves, making the whole machine more delicate and elegant in visual effect. Its four-sided and equal-width design also makes the overall look and feel more harmonious.

? ? In terms of hardware, the Mate 70 series will be equipped with the latest Kirin processor, which will significantly improve performance. In terms of battery life, the series of mobile phones will be equipped with a new silicon anode battery with a capacity between 5000 and 6000mAh, further extending the service life and meeting the high demand of users.

? ? At the same time, Huawei’s Mate 70 series has begun to distribute equipment to offline dealers, but Huawei’s confidentiality measures for new products are still very strict. The relevant warning sign clearly states: "Before the conference, unauthorized opening is prohibited, and the fine for unpacking in advance is 500,000 yuan." This move shows the importance Huawei attaches to the release of new products, and also reflects the common practice of mobile phone manufacturers before the release of new products.

? ? According to various sources, the release of Huawei’s Mate 70 series has attracted great attention. As Huawei’s new flagship product, the Mate 70 series has not only been fully upgraded in appearance design and performance configuration, but also reflects Huawei’s determination and strength in independent research and development and innovation. Whether it is the launch of the new system or breakthroughs in photography and battery life, this series of products is full of expectations.

? ? So this is the most powerful Mate phone in history. Are you ready to buy it?

The TV series "legend of bruce lee" landed on a set of prime files of CCTV on October 12, and immediately became a popular topic on the national screen. Bruce Lee’s worldwide China Kung Fu craze is a cultural wonder of the 20th century. He is known as the first celebrity in China Kung Fu. With the popularity of Kung Fu movies starring him at home and abroad, China Kung Fu is also famous in the world. Bruce Lee’s 32-year life, full of vitality, is like a comet streaking over the international martial arts and film circles. Although it is short, it is extremely dazzling! The so-called Bruce Lee is actually a miracle and a legend, and Bruce Lee’s life is far more exciting than a play …　 Long archives 　Original name:bruce lee　　　　　　English name:Bruce Lee　　　　Milk name:Xifeng 　Nickname:Ma Wei? God-made Lan Zi Niu Wang Tou? Solve the dragon and the scarlet king at a certain time 　Native place:Guangdong Shunde　　 　　 Ethnic group:Han (HA)　　　　　　　　　　　　　Nationality:United States of America 　Born in:November 27, 1940　　Died in:Friday, July 20th, 1973, 11:30pm (at the age of 32). 　Zodiac:dragon　　　　　　　　birthplace: USA-San Francisco (Jason Dixon Street Hospital, San Francisco) 　delbert mann173CM　　　　 　　100-meter performance:11.8 seconds　　　　　　　　　　　Weight:64 kg 　Blood type:O type 　　　　　　　Hobbies:Martial arts, meditation, cha-cha, reading, philosophy 　Education:He studied at La Salle College in Hong Kong and went to Seattle-Washington University to study philosophy and psychology in 1961. 　Beginner kung fu:Wing Chun　　　　　　　　　　　　Master:Ip Man (Wing Chun Master) 　Father:Li Haiquan (Li Manchuan) (Famous and Ugly Cantonese Opera)　　　　　　Mother:He Jintang (Eurasian) 　Sister:Grace, Fife 　　　Brother:Peter (loyal detective)　　　　　　　　　Brother:Robert　　　　　 　Madam:Linda Emily (Linda)　Son:Brandon Lee (accidentally killed while filming) Daughter:Li Xiangning (from the film)

Mortal hero 　　When Bruce Lee was a child, his physique was weaker than that of ordinary people, and he still had physical defects-long and short legs (one inch apart), big myopia (1,000 degrees) and short stature (1.73 meters). However, under such congenital conditions, Bruce Lee not only practiced a shocking martial arts, but also created his own Jeet Kune Do, and eventually became a generation of martial arts masters. Whether hard-working or intelligent, Bruce Lee’s life is a legend, from an ordinary person to an "altar". 　　Bruce Lee has become a spiritual idol of modern people, not only because of his superb martial arts, but also because of his "self-esteem". In the commercial world with a strong smell of Hollywood powder, he conquered the world by his own flying, kicking and punching. In his short acting career, he never used body double once. People can still remember his famous saying: "I am a martial artist first, then an actor." Dragon power one Hit a heavy fist of 159 kilograms with a weight of 62 kilograms 2 Hit 726 kilograms with nunchakus. three Kick a strong man in armor 20 meters away. four Extend and retract the straight arm of the 34 kg barbell horizontally, and hold it for 20 seconds after extending. five Easily insert your finger into an unopened can of Coca Cola. six Kick a 45 kg sandbag with a side kick. seven Kick about 135 kilograms of sacks to the ceiling height.

Dragon lore Jeet Kune Do 　　Jeet Kune Do is an all-round free fighting technique created by Bruce Lee, which combines the essence of various martial arts in the world. "Jeet Kune Do" means the way to stop an opponent from punching, or the way to intercept an opponent to punch. It is the program and essence of Jeet Kune Do that "taking the impossible as the law and infinity as the limit". 　　Comments on Jeet Kune Do by World Masters 　　American karate champion Lewis Deere told the American Black Belt magazine: "I can’t meet another person who is as crazy about martial arts as Bruce Lee. He can succeed because he is willing to work hard except for half of his talent. He really works very hard. The origin is fast, accurate and energetic enough to make him look at the martial arts arena. In addition, his knowledge and proficiency in various martial arts instruments can be called an expert, but no one can match him. "　 　　Purpose of Jeet Kune Do training:　 　　1. Destroy the enemy facing you-remove the obstacles to freedom, justice and humanity; 　　2. Destroy anything that bothers your mind, without hurting people, but you can overcome your greed, anger and ignorance. Dragon Juesha nunchaku 　　During Bruce Lee’s stay in the United States, he learned nunchakus and Filipino nunchakus from Dan Enosando, a famous American Filipino nunchakus and nunchakus, who was also a teacher, friend and apprentice. Under his guidance, he learned nunchakus and nunchakus and became an expert in using sticks. 　　Bruce Lee used nunchakus for the first time in the Hollywood drama The Green Hornet. Nunchakus are two round hardwood sections, which are connected by chains or pimps. They can be slammed and strangled, combining the rigidity of the stick with the femininity of the whip. An American martial arts monograph once introduced: "One end of a waving nunchakus can produce a force of 1,600 pounds, while a human bone can be crushed with only eight and a half pounds of force. Bruce Lee nunchakus performs, and once the chain or pimp connecting nunchakus is wrapped around each other’s neck, it is enough to hang people with a gentle pull. " Bruce Lee often carries nunchakus for self-defense. 　　Now, many states in the United States prohibit the use and possession of nunchakus by law. The reason is that some young Americans have seen Bruce Lee’s Kung Fu movies, or heard about the power of nunchakus, and they have also played with nunchakus, resulting in human lives and being condemned by public opinion. Dragon Juesha Cunquan 　　Bruce Lee Invincible Inch Boxing evolved from Wing Chun’s Inch Strength Boxing, which is a particularly advanced killer skill in Jeet Kune Do. Bruce Lee’s "inch fist" can hit a person who weighs more than 75 kilograms several meters away. 　　Wing Chun Boxing has a special way of exerting strength, which is called inch strength. The so-called inch strength refers to the short, brittle explosive force that suddenly accelerates the contraction of muscles when it is very close to the target or when the action is about to be completed. In the wing wing gate, the wing wing master can launch a continuous and compact attack without gaining momentum, and knock down the opponent at a distance of 1 to 3 inches or even in a close-fitting state. According to the principle of mechanics, the force produced by an object after acceleration is the greatest. Therefore, if the strength of a fist is large, it must also be slammed after bending the arm to ensure that there is enough distance to accelerate. The inch strength is the opposite, requiring a large force in the shortest distance. 　　After the founding of the People’s Republic of China, the state advocated "martial arts fitness", and many sects further promoted "martial arts to get rid of diseases", which attracted a large number of patients to join the ranks of martial arts. However, they passed on martial arts to the younger generation, which made a lot of self-defense techniques lost. This historical lesson is worth reflecting on …

Dragon journey 　　Bruce Lee was born in San Francisco, USA, and spent his childhood and adolescence in Hongkong. Bruce Lee was very thin when he was young. His father taught his son to practice Tai Ji Chuan when he was 7 years old for his strong physique. At the age of 13, Bruce Lee systematically studied Wing Chun Boxing with the famous teacher Ye Wen, and set up a wooden stake at home, practicing against it every day. In addition, he also practiced Hongquan, Baihe Boxing, Tan Leg, Shaolin Boxing, Poke Foot and other boxing styles, which laid a solid foundation for later creating Jeet Kune Do. 　　In order to improve the level of martial arts, Bruce Lee not only studied China’s boxing, but also studied western boxing. While attending western boxing training classes, he saved his pocket money to buy a documentary about the boxing match of Louis, the world champion, from which he learned the footwork, posture, boxing and training methods of the champion. He also often participates in boxing competitions inside and outside the school, constantly enriching his actual combat experience. 　　Go to the United States for further study and create Jeet Kune Do. 　　Fearing that Bruce Lee would fail in school, at the age of 18, Bruce Lee’s parents decided to send Bruce Lee to study in the United States. Bruce Lee’s life in Seattle is quite hard. After he entered the university, he devoted all his energy to studying martial arts besides studying. He organized a "China Kung Fu Team" at school, and often conducted training and performances on campus, which won the praise of teachers and students. 　　Bruce Lee gradually became proficient in Kung Fu and even reached a higher level through continuous improvement. Among them, "Li Sanjiao", "Inch Fist" and "Hooking Hands" are his unique skills. Bruce Lee is a generalist. Besides mastering all kinds of boxing, he is also good at various instruments such as long sticks, short sticks and nunchakus, and he also studies Qigong and hard work. 　　In order to promote Chinese martial arts, Bruce Lee rented a corner of a parking lot on campus during his sophomore year, and put up the brand of "Zhenfan National Art Museum". He practiced while teaching and worked hard, and his skills improved greatly, especially his leg skills. In the Zhenfan National Art Museum, he met Linda, a female medical student who came to study martial arts. After more than a year of communication, they gradually developed feelings. In August 1964, they officially got married. After their marriage, Bruce Lee and his wife both dropped out of school and joined forces to run a martial arts school. 　　Since the news that Bruce Lee subdued four knife-wielding gangsters in Chinatown, Florida, and bravely saved Chinese girls was published in the newspaper, Bruce Lee’s name has spread all over the United States, and TV stations such as Florida have also asked him to perform leg skills, and China Kung Fu has attracted people’s attention. And the museum of Zhen Fan Guo Shu, which he founded, has gradually flourished. In order to expand his influence, Bruce Lee often participated in martial arts competitions everywhere, and successively opened martial arts branches and apprentices in Seattle, Oakland and Los Angeles. The scale and equipment of the martial arts museum are constantly improving, and many prominent martial arts stars in the world, such as American karate champion Rolex, are vying to worship him as a teacher, and famous Hollywood movie stars such as James Hempin and Steve are his disciples. Ali, the world champion, also paid a visit to exchange experiences with him. Boxers of various schools in the United States often gather in the martial arts school in Bruce Lee to discuss martial arts, and his aim of "making friends with martial arts" has achieved the expected results. 　　Set foot in the film industry, kung fu shocked the world. 　　In the early 1970s, a wave of China Kung Fu movies swept the world. The resounding name of Bruce Lee shocked the whole world. 　　In the summer of 1971, Bruce Lee accepted the invitation of Hong Kong Golden Harvest Film Company, and signed two films for 15,000 US dollars. The first film was "Tangshan Big Brother" with the theme of China martial arts. The film’s budget is only $100,000, and the script was written while filming. In this case, it has set a record for the highest box office since the opening of Hong Kong, reaching HK$ 3 million. After Big Brother in Tangshan, Bruce Lee filmed Jingwumen, which doubled the budget compared with Big Brother in Tangshan and caused a greater sensation. Bruce Lee’s fearless spirit and amazing fighting skills in the film, especially his performances of "Li Sanjiao", "Lying Boxing" and "nunchakus", are full of praise. Since then, Bruce Lee has organized the Concord Film Company, edited, directed and acted in the films "The Raptors Crossing the River" and "The Game of Death", and also co-filmed "enter the dragon" with Warner Film Company of the United States, and personally played the leading role. Just as Bruce Lee was ambitious and ready to finish filming The Game of Death, he died suddenly in Hong Kong on July 20th, 1973 at the age of 32 due to drug allergy. 　　The cause of death is a mystery 　　Bruce Lee died more than 30 years ago, and the cause of death is still a mystery. After studying Bruce Lee’s autopsy report, an American expert on the cause of death thought that Bruce Lee died of a rare sudden epileptic death, rather than brain edema caused by drug allergy, because drug allergy only made the patient’s neck swell. 　　Phil Jenkins, an expert at Cook County Death Cause Research Office in Chicago, USA, pointed out that Sudden Epilepsy can cause epileptic symptoms, leading to the failure of the heart or lungs. This disease causes nearly 500 deaths in the UK every year, and the main victims are men aged 20 to 40. Lack of sleep and stress will increase the chances of getting sick. Bruce Lee’s case is in line with the relevant conditions. He was in his prime at the time of the incident and was under great physical and mental stress. 　　Bruce Lee’s autopsy report after death indicated that the cause of death was cerebral edema, and it was suspected that he was allergic to the painkillers he took. However, Phil Jenkins said that drug allergy often leads to swelling of the neck rather than brain, so he didn’t believe that Bruce Lee died of drug allergy.

Bruce Lee (third from left)’ s family photo at the age of 5. Long family 　　Dragon parents 　　Bruce Lee’s father is named Li Haiquan. Li Haiquan is a well-known comedian in Guangdong, one of the four famous and ugly Cantonese operas, and often takes his family to tour all over the world, which is why Bruce Lee was born in the United States. Bruce Lee’s mother, He Jintang, is half German and handsome. 　　As a child, Bruce Lee was very naughty, didn’t like studying, had a strange personality and liked being alone. However, he was very dedicated in making movies, and with his talent, he became a famous child star, which was very popular with girls. Bruce Lee was also a man of temperament since childhood, and making friends with girls was also his hobby. At the age of 13, he entered Ye Wen’s door to learn martial arts, looking for people to fight everywhere, and won the Hong Kong Inter-school Boxing Championship in 1957 and the Hong Kong Cha-cha Open Championship in 58. Bruce Lee and his wife Linda. 　　Mrs. Long　 　　Bruce Lee’s wife, Linda Emily, was his classmate at the University of Washington, and their love experience was quite bumpy. When Linda met Bruce Lee, Bruce Lee was dating Amy, a Japanese girl. Later, Linda joined the "Zhen Fan Guo Shu Guan" founded by Bruce Lee, and learned Kung Fu from Bruce Lee. It can be said that Bruce Lee and Linda had a mentoring relationship at first. Later, Bruce Lee and Amy broke up, and Linda gradually entered Bruce Lee’s life. In 1963, they officially started to associate, and in 1964, they entered the wedding hall. Linda became the lover of Bruce Lee’s life. 　　Linda, Bruce Lee’s wife, gave up her studies for the sake of her family. She always followed Bruce Lee. She didn’t expect Bruce Lee to become an international superstar in the future. She just wished Bruce Lee to achieve her ideal. Bruce Lee’s happiness and success are the greatest happiness in her life. She is a woman who deeply loves Bruce Lee. She has been under a lot of pressure, but her love for Bruce Lee has never changed. Perhaps this is what we call true love for life. After Bruce Lee’s death, Linda remarried and later divorced her husband. Linda also established the Jeet Kune Do Association with Bruce Lee’s disciples in the United States, so as to carry forward and inherit Bruce Lee’s martial arts. Linda, who is nearly seventy years old, now lives in Seattle, USA. Bruce Lee’s son Brandon Lee. 　　Son of the Dragon 　　When Bruce Lee died, Brandon Lee was only 8 years old. Brandon Lee was born a stubborn child, and with a tall and strong body, he has always been king of the children. When he was in middle school, he became famous for being "unreasonable, outrageous and nonsense" and was expelled from three schools successively. When Brandon Lee was 9 years old, his mother, Lianda, began to let him take martial arts classes. Since then, Brandon Lee has embarked on the road of martial arts. Brandon Lee, who is nearly 20 years old, easily stepped into the Hollywood film and television circle with her perfect body shape. As soon as she entered the film industry, she became famous for her exquisite martial arts. 　　In the American film Rapsa Fire (1992), Brandon Lee became first hero, which established his star status in Hollywood. In 1993, Brandon Lee took on an action film with a grotesque style-The Crow. Late at night on March 31st, the filming has come to an end. Brandon Lee will perform a scene in which the hero is shot by a "drug dealer", but after the gunshot, the prop gun in the hand of the "drug dealer" shoots a real bullet and hits Brandon Lee. On the afternoon of April 1st, Brandon Lee died in a nearby hospital, and the death of Brandon Lee became an unsolved mystery. Bruce Lee’s daughter Li Xiangning 　　Little Dragon Maiden 　　In April 1969, Bruce Lee’s daughter Li Xiangning was born. She was five years younger than her brother Brandon Lee. After growing up, Li Xiangning tried to be a martial arts star in addition to co-managing the Bruce Lee Fund with her mother. However, she has always been interested in joining the music industry and hopes to become a singer. Li Xiangning met Brad Laner, a musician of the five-member band Medicine, and reorganized Medicine to make a new album, The Mechanical Forcesof Love. Now Li Xiangning is still active in the art world. She recently participated in the production of the TV series legend of bruce lee, and she is one of the producers of the drama.

Editor: Liu Yinglai

What I want to introduce to you today is. Next, let’s take a look with Xiaobian.

First of all, from the appearance, the front face of Haoyue L looks very domineering and looks sporty. Coupled with the cold headlights, the design looks very simple. The car is equipped with LED daytime running lights, automatic opening and closing, delayed closing and so on. Coming to the side of the car, the body size of the car is 4900 mm * 1910 mm * 1770 mm. The car adopts unique lines, and the side wall gives people a very fashionable feeling. With large-sized thick-walled tires, smooth lines run through the whole side of the car. Looking back, the rear of the car looks cleaner and fresher, the taillights look simple, and with the unique exhaust pipe, it is still relatively hard on the whole.

When I came to the car, the interior design was avant-garde and rich in functions. The steering wheel of the car is very simple and fashionable, and it is made of leather, showing a sense of atmosphere. Take a look at the central control. The car is equipped with a simple and fashionable touch-sensitive LCD central control screen, which makes the interior style impressive and looks very cute. Let’s take a look at the dashboard and seats again. The car is equipped with a tough dashboard, which is very eye-catching. The car uses a leather/suede mix seat, which is wide and thick, improving the riding experience of the driver and passenger.

Haoyue L is matched with a wet dual clutch (DCT) gearbox, with a maximum power of 160KW and a maximum torque of 325N.m, with good power performance.

The car is equipped with car networking, driving mode selection, remote control key, Bluetooth key, rear wiper, traction control (ASR/TCS, etc.), which fully ensures the convenience and comfort of the car experience.

OK！ Next, let’s sum up. Such a car with the right price is enough to meet the daily practical needs, and it doesn’t take much thought to maintain it at ordinary times, and the cost performance is good.