Author: Ni Wan, vice president, professor and doctoral supervisor, School of Journalism and Communication, Shandong University

　　Since the party’s symposium on news and public opinion work was held in 2016, marked by a series of important speeches by the Supreme Leader General Secretary, our understanding of news and public opinion work has entered a new stage. At present, the ecology of public opinion, the pattern of media and the mode of communication have undergone profound changes, and the work of news public opinion is facing new challenges. In 2020, the epidemic in COVID-19 made us deeply realize the importance of the news and public opinion front. At the deployment meeting of coordinating the prevention and control of epidemic situation and economic and social development in COVID-19, the General Secretary of the Supreme Leader particularly emphasized that it is necessary to "improve the effectiveness of news and public opinion work", which is also the inevitable path for China to realize the modernization of national governance capacity in the field of public opinion. In the all-media era, the whole process of news gathering, production, distribution, reception and feedback has undergone tremendous changes. Generally speaking, improving the effectiveness of news public opinion work should meet ten basic requirements.

　　One of the requirements: effectively judge the information environment.

　　In the era of all-media, new features have emerged in China’s information environment. First, in terms of international information environment, western media, represented by the United States, still have a monopoly position in the international public opinion field, and they do everything they can to strengthen the leading position of information technology and stabilize the monopoly of information field. Second, in terms of social and ideological environment, it is facing a great change that has never happened in a hundred years. The ecology of public opinion and the ideological situation of the public in China are more complicated and changeable, and the collision of ideas is more intense. There are different social ideological trends behind it, and capital forces representing different positions are involved in different degrees. At the same time, with the in-depth application of emerging media, the opinions of netizens show a typical trend of group polarization. Thirdly, in the aspect of media application environment, media application shows the core characteristics of socialization, mobility, intelligence and data, media content presents the mainstream expression of audio-visual, and media forms converge into a platform operation mode.

　　To effectively judge the international information environment, we must fully understand the ideological struggle behind the information environment and the long-term and difficult struggle for international discourse power; To effectively judge the social ideological environment, we must fully understand the characteristics and influence of the changes in China’s social ideological trend in the new era, and lay an ideological and cognitive foundation for the modernization of the national governance system and governance capacity; To effectively judge the media application environment, it is necessary to have a deep understanding and control of the ecology of information content production and dissemination under the background of high-speed iteration of media technology.

　　Requirement 2: Grasp the communication opportunity effectively.

　　Time effect is the yardstick to test the work level of news public opinion. Whether it is theme propaganda, typical propaganda, achievement propaganda, or emergency reporting, hot spot guidance, and public opinion supervision, we must focus on time and efficiency and reflect the requirements of time and efficiency.

　　First, effectively grasp the opportunity from the law of news and public opinion communication. Grasping the opportunity is an inevitable requirement to follow the law of news public opinion dissemination, which depends on the different attributes of different events: some need to speak out immediately and be tit for tat; Some need to release public opinion and gradually guide; Some need to plan as a whole and move at the right time.

　　The second is to effectively use the opportunity from the operation law of the communication platform. From a global perspective, a diversified head platform matrix with obvious advantages has been formed, and the operating characteristics of each head platform are different, forming different communication characteristics and laws. The systematic use of cross-platform communication chain is an important guarantee for effectively grasping the communication opportunity.

　　The third is to effectively grasp the opportunity from the time law of user behavior. As far as the media resources used by all kinds of users are concerned, there are significant differences in the distribution of usage time, duration and type among different user groups, and at the same time, it also shows obvious regularity. Grasping the law of users’ use time is the practical basis for effectively grasping the communication opportunity.

　　The third requirement: effectively plan communication strategies.

　　How to plan the communication strategy effectively? We should seize the opportunity, grasp the rhythm, pay attention to strategies, be good at setting topics, and let the hot heat up and the cold cool down through the continuous supply of high-quality content.

　　First, the timing is accurate and the information is true. In the era of all-media, the network information from major media platforms is complex and has strong communication, but the content is inevitably biased and difficult to trace and verify. On the one hand, news media workers are required to pay more attention to the timeliness, authenticity and accuracy of information dissemination; on the other hand, higher requirements are put forward for the construction of the guiding force of new mainstream media: we should not only grasp the communication opportunity, but also always uphold the principle that authenticity is the life of news.

　　The second is to reflect the overall situation and grasp the rhythm. "What to report, what not to report, what to publicize more and what to publicize less must proceed from the overall situation and reflect the requirements of the overall situation." In the dialectical relationship between quantitative change and qualitative change, we should set topics, grasp the rhythm, and stress the systematic and effective balance between national reports and local reports, first reports and follow-up reports, news reports and in-depth reports.

　　The third is to enrich the content and respond to concerns. For the principles and policies of the party and the government and the issues that the people are concerned about, we should not stop at the simple presentation of information, but fully consider the people’s understanding ability and concern when formulating communication strategies, and fully interpret the major policies and specific policies of the party and the government.

　　Requirement 4: Effectively construct internal and external relations.

　　From the perspective of organizational communication, building a new mainstream media and shaping an all-media communication system requires the effective construction of a coordinated internal relationship among all components within the organization and a benign interaction with the external environment, which is the organizational guarantee for improving the effectiveness of news and public opinion work.

　　In terms of internal relations construction, the new mainstream media, as a special social organization, adheres to the party’s leadership over news and public opinion work, which is the premise for the operation of this news and public opinion organization. In specific work links, it is necessary to have an effective internal work coordination operation mechanism, an effective upper and lower communication management control mechanism, and an effective emergency management decision-making mechanism.

　　In terms of the construction of external relations, the media, as an integral part of the social system, is bound to face the problem of dealing with the external environment. Specifically, it is necessary to effectively coordinate the relationship with party and government organs, enterprises and institutions, social organizations, the general public and other media.

　　As General Secretary of the Supreme Leader requested, "We should establish the concept of propaganda, mobilize all fronts and departments to do it together, and more closely integrate propaganda and ideological work with administrative management, industry management and social management in various fields." The coordination of internal and external relations is the basis for completing this requirement.

　　Requirement 5: Effective production of media content

　　Under the background of all media, we should adhere to the advanced technology as the support and content construction as the foundation, and implement the requirements of the Supreme Leader General Secretary "to build a socialist ideology with strong cohesion and leading force, so that all the people can be closely United in ideals, beliefs, values and moral concepts".

　　Facing the new development situation at home and abroad, the effective production of media content should be presented strategically on the basis of implementing the "four self-confidences". For content production, we should be especially good at expressing, and the profound truth should impress and convince people by telling stories.

　　In terms of domestic communication, keeping integrity and innovation is the core of telling a good story. Keeping the right is to consolidate the foundation and cultivate the yuan, and always keep the direction, position, root vein and bottom line; Innovation means pioneering and innovating, and solving new problems with new ideas, ideas, methods and means. This requires news media workers to change their style of writing, bend down, calm down, examine the truth, tell the truth, move the truth, and strive to create works with thought, temperature and quality.

　　In terms of international communication, storytelling is the best way of international communication. We should make great efforts to strengthen the construction of international communication ability, including building a foreign discourse system and consolidating the semantic foundation of telling China’s story; Integrate new concepts, new categories and new expressions at home and abroad to lay a pragmatic foundation for telling China’s story well; Promote media integration, create key media for external publicity, and build a channel foundation for telling the story of China, so as to accelerate the promotion of the international influence of China’s discourse, so that the whole world can hear and hear China’s voice clearly.

　　Requirement 6: Effective use of communication skills.

　　In order to make the policy of giving priority to positive publicity achieve good results, we must effectively improve communication skills. A condescending, empty and tasteless news report with blunt language and rigid form can’t really touch people’s hearts, even if the content is no matter how good. Good ideas, concepts and contents should be expressed through vivid forms and various means in order to achieve the best publicity effect. It is necessary to adopt more popular forms, constantly enhance the vividness and visibility of news propaganda, and strive to improve the quality and level of news propaganda.

　　First, under the requirements of the in-depth development of media integration, with the help of the opportunity of all-media development, we should give full play to the advantages and characteristics of emerging media such as "two micro and one shake", various news clients, websites and forums.

　　Second, news, summary, sidelights, editorials, comments, charts, diagrams, short videos, H5, cartoons and other forms should be comprehensively used to enrich news language and creative skills.

　　The third is to improve interactivity, especially to innovate discourse forms and enhance the user stickiness of new mainstream media while ensuring positive publicity, so as to enhance the publicity effect.

　　The fourth is to be good at creating and exploring hot spots, while not blindly chasing hot spots. We should not only pay attention to the hot spots that netizens pay attention to, but also keep the seriousness, accuracy and politics of mainstream media.

　　Requirement 7: Effectively analyze user data.

　　With the continuous development of media technologies such as 5G, big data, cloud computing, Internet of Things, artificial intelligence, etc., mobile media with socialization, intelligence and data as the main line has entered an accelerated development stage. From audience to netizens to users, every individual on the Internet can be accurately digitally portrayed.

　　Effective user data analysis is of great practical significance to the development of news public opinion work. By analyzing the data, we can not only know user attributes, user preferences and user influence, but also modify the communication strategies of media organizations according to the analysis results, and predict user behavior and guard against a series of ideological risks.

　　In recent years, domestic journalism has paid more and more attention to the measurement and use of user data. The data analysis function of byte system platform can capture real-time hot spots and predict possible hot spots in the future based on massive behavior data and article data of user groups, and provide data analysis of hot events for media organizations. It does not collect news in the real sense, but through the capture and analysis of data such as user attributes and reading behaviors, it re-integrates and finds users’ concerns in the massive content published on the platform, so as to reproduce news.

　　Requirement 8: Effectively distribute accurate information.

　　At present, cross-platform and intelligent information distribution mechanism is gradually taking the lead. First, multi-platform linkage communication: under the trend of platformization, the same news event and the same content material are distributed on different media platforms after processing, resulting in linkage resonance effect. Second, intelligent distribution: personalized content push led by algorithms has become the mainstream of news distribution, especially artificial intelligence technology including robot writing is changing all aspects of news topic planning, information collection, content generation and product distribution, leading to increasingly blurred boundaries between news production, distribution and consumption.

　　Accurate distribution of information is not only a problem of technology and market, but also a guidance and control problem that needs to be effectively solved in news and public opinion work. Therefore, the General Secretary of the Supreme Leader specifically pointed out that "it is necessary to explore the application of artificial intelligence in news gathering, production, distribution, reception and feedback, and comprehensively improve the ability of public opinion guidance" and control the "algorithm" with mainstream value orientation.

　　Requirement 9: Effectively evaluate the communication effect.

　　For news opinion workers, the pursuit of effect and actual effect should be the starting point and the end result of public opinion guidance, so as to effectively enhance the ability of public opinion guidance.

　　The evaluation of communication effect plays an important role in improving the effectiveness of news public opinion work. Its premise is to judge from the ideological level whether the news and public opinion work has adhered to guiding people with correct public opinion, and that all work is conducive to upholding the Communist Party of China (CPC)’s leadership and China’s socialist system, promoting reform and development, enhancing the unity of people of all ethnic groups throughout the country, and maintaining social harmony and stability. From a practical point of view, on the one hand, an effective evaluation of communication effect should be able to directly reflect the concrete results of news public opinion work at home and abroad, society and individuals, organizations and groups from three overlapping dimensions of cognition, attitude and behavior; On the other hand, through the evaluation of communication effect, we can effectively sum up the experience and lessons of news public opinion work and better guide future work.

　　Requirement 10: effectively shape the ecology of public opinion

　　To effectively improve the communication, guidance, influence and credibility of news public opinion is to effectively shape a good public opinion ecology.

　　First, there must be a scientific top-level design. It is necessary to adapt to the trend of differentiated communication and accelerate the construction of a new pattern of public opinion guidance. Since the 18th National Congress of the Communist Party of China, the central government has rearranged the ecological pattern of public opinion in China from a strategic perspective, and now it has achieved remarkable results.

　　Second, we must grasp the relationship between online and offline. Nowadays, more and more people are used to expressing their demands and opinions through the Internet. The General Secretary of the Supreme Leader stressed that it is necessary to "respond to social concerns, especially the concentrated demands of the masses in a timely manner, not avoid contradictions, and actively promote problem solving", and listen carefully to well-intentioned criticisms, opinions and suggestions. To do a good job in online public opinion monitoring, we should accurately grasp and effectively respond to people’s concerns and demands expressed through the Internet, properly solve the problems reflected as soon as possible, and realize the benign interaction between online and offline.

　　Third, we must run on the track of the rule of law. Effective news public opinion work should not only stimulate positive energy and promote truth, goodness and beauty in the whole society, but also resolutely crack down on malicious spreading of false information and creating panic, so as to ensure that a good public opinion ecology runs on the track of the rule of law.

Visualization of Original Ugly Sister’s Patent Analysis

Dogs are our friends and family members. As dogs get older, many dogs will develop tumors like people. At present, domestic pet hospitals can provide very few treatment schemes for pet tumors, only surgery and chemotherapy, and radiotherapy for small animals is still prohibited in our country.

In recent years, there have been many breakthroughs in the treatment of human tumors, such as PD-1, CAR-T cell immunotherapy, etc. These methods have shown good therapeutic effects on tumors, and some can even be completely cured.

Therefore, when the dog who has been with us for more than ten years is old and has a tumor, and it can’t be operated and the chemotherapy effect is not good, of course we can’t just give up. Try to find out whether there is a tumor immunotherapy program suitable for dogs, inhibit tumors, let them live with cancer, and be happy and healthy to accompany us for a few more years.

Today, this article introduces the current scheme that can be used for pet tumor treatment by analyzing related patents.

PART 1 retrieval strategy

Technical scope of patent search: This search is mainly aimed at the technology of tumor immunotherapy involving pets. Therefore, the key words include: dog, cat, pet, cancer and tumor, and the IPC classification numbers involved are C12N (bio-related) and A61K or A61P (drug-related).

Geographical scope of patent search: the current search is to provide domestic pet owners with a treatment plan in China, and the technical feasibility in places too far away like the United States and Europe is not high. Therefore, the applicant’s address is limited to Chinese mainland and Japan (considering that Japan’s medical technology is developed and close to us, many Chinese patients go to Japan for treatment of cancer).

Manual reading and screening: after the number of patent documents is limited to the range that can be read manually through the above retrieval, manual reading is started to screen useful information. The basic requirement of the standard of artificial screening is to make it clear that it can be used for tumor treatment in dogs, and more preferably, it can give experimental data in the examples to confirm that it does have anti-tumor effect in dogs.

PART 2 analysis results

Through analysis, the treatment schemes that can be tried in domestic tumor immunotherapy for pets are sorted out as follows:

1. Beijing Weijiexin Biotechnology Co., Ltd

CN110590959A, recombinant canine PD-1 fusion protein, its preparation method and application, filed on September 19, 2019.

This patent application provides a recombinant canine PD-1 fusion protein, and in its example, it shows that this treatment scheme has been used in pet cats and dogs. It should be the second half of 2019 in a pet hospital in Beijing for clinical trials.

Therapeutic effect: The overall objective remission rate is 20%-30%.

The inventor of this patent application, Dr. Luo Haoshu, is an associate professor and master/doctoral supervisor of the School of Biology, China Agricultural University.

2. Beijing Conoco Fu Biotechnology Co., Ltd.

WO2019149039A1, an anti-tumor protein composition and its application, filed on January 9, 2019.

The patent application relates to an anti-tumor method using cytokine fusion protein, which comprises an anti-tumor composition, including proteins IL12, GMCSF and IL2, and achieves the technical effect of good inhibition on tumors at all stages and slight adverse reactions.

This cytokine fusion protein is a broad-spectrum anti-tumor drug. The protein anti-tumor drug is directly injected into the tumor to adjust the immune environment inside the tumor and realize the inhibition of the tumor. Experiments on sarcoma, oral melanoma and breast cancer in dogs and cats have been done in the examples, and the data show that most tumors have been suppressed, even shrunk and subsided.

Further search found that Conoco Clothing Company and the inventor of this patent, Zhang Jinyu, also applied for two other patents and published a paper in The Lancet’s sub-journal EBioMedicine. Although these two patents and journals did not explicitly say that they were used to treat Wang Wang tumor, their technical contents were very relevant to this application:

WO2018184484A1, cytokine combination, with the earliest priority date of April 6, 2017, relates to a cytokine combination, which comprises at least three cytokines, and the cytokines are selected from the following groups: IL12, GMCSF, FLT3L, IL2, IL15 and IL21；;

WO2020024922A1, protein heterodimer and its use, the earliest priority date is July 30, 2018, and it relates to a protein heterodimer, which comprises a first polypeptide chain and a second polypeptide chain, wherein the first polypeptide chain comprises IL12a and a first factor fused with IL12a, and the second polypeptide chain comprises IL12b and a second factor fused with IL12b, and the first factor and the second factor are selected from IL2 and GMCSF.

The paper "In Situ Administration of Cytokine Combinations Induces Tumour Regression in Mice" also involves the treatment of tumors with IL-12+GMCSF+IL-2.

Through reading the above patents, Xiao Bian understands that they use the cytokine composition to treat tumors (WO2018184484A1), then use protein heterodimer (WO2020024922A1) to make these cytokines into a cytokine fusion protein, and then use this cytokine fusion protein to treat tumors (WO2019149039A1), and treat tumors in dogs.

The applicant should think that this technology is more important and has better effect, so all the applications are PCT patent applications. Because they have been applied in recent two years, they have not seen the published texts of other countries.

3. Japan Quanyao Industry Co., Ltd.

Japan Quanyao Industrial Co., Ltd. has two patent applications in pet tumor immunotherapy.

Patent application 1: cn110603056a, a method for inhibiting the infiltration of regulatory T cells based on CCR4 blockade and a method for treating tumor diseases in dogs, filed on April 26th, 2018.

Patent application 2: wo2016006241a1, anti-canine -PD-1 antibody or anti-canine-PD-L1 antibody. The earliest priority date is July 9, 2014. This patent has been granted in Europe, Japan and the United States.

Founded in 1946, Japan Quanyao Industry Co., Ltd. is a research and development enterprise engaged in animal medicines. Its current animal drugs include some conventional veterinary drugs, such as anti-inflammatory, analgesic, fever-reducing, anthelmintic and so on.

However, judging from the above two patents, Japanese Quanyao should be engaged in the research and development of animal antitumor drugs. I continue to check the inventors of these two patents. They are not researchers of Quanyao in Japan, but researchers of Tokyo University and Yamaguchi University in Japan. This shows that Quanyao Industrial Co., Ltd. is cooperating with Japanese universities to develop animal antitumor drugs.

Continuing to search with the inventors of the above two patent applications, I found two Japanese scientific research institutions specializing in the treatment and research of Wang Wang tumor.

4. Laboratory of Veterinary Clinical Pathology, University of Tokyo, Japan

CN110603056A, a method for inhibiting the infiltration of regulatory T cells based on CCR4 blockade and a method for treating tumor diseases in dogs, by former Tian Zhen Wu.

The patent application relates to a pharmaceutical composition for treating canine tumors, which contains a compound that blocks the combination of canine CCL17 and canine CCR4 as an active ingredient. The pharmaceutical composition is a broad-spectrum antineoplastic agent, and can be used for treating transitional epithelial carcinoma, prostate cancer, breast cancer, malignant melanoma, squamous cell carcinoma and lung adenocarcinoma.

Before treatment, it is necessary to analyze the Treg (Regulatory T Cell) infiltration analysis in the tumor tissue of dogs and confirm the CCR4 expression in the tumor infiltration Treg. (Xiao Bian’s understanding: First of all, we should do pathological examination to see if the tumor of the dog has Treg infiltration and CCR4 expression. If so, the treatment with the pharmaceutical composition of this application may be effective. Just like treatment with PD-1, tumor cells need to express PD-1. Xiaobian is not in the biological field, please pat it if it is wrong)

Then, in the example of this patent application, the therapeutic effect data of pet dogs are given, which proves that the anti-CCR4 antibody (Mojiamuzumab) in this patent application is an effective therapeutic drug with less side effects on various tumors in dogs.

The inventor of this patent application is former Tian Zhen Wu of the Veterinary Clinical Pathology Laboratory of the University of Tokyo.

This Maeda teacher should be a very caring and enthusiastic person, and even found his personal website, which specifically introduces his veterinary clinical pathology laboratory at the University of Tokyo.

Moreover, their laboratory is currently recruiting clinical evaluation of anti-regulatory T cells (CLEAR), which is the anti-Treg treatment scheme related to the above patent.

The recruitment copy says:

がんをぅたちのためにののををぅぅさ𞈖にのの𞖸𞈪𞈪12357

For Wang Wang who has cancer, for the shovel officer who thinks of his beloved Wang Wang, and for those who have cancer, it will be a great honor if this project can make a little contribution.

I hope this project can be successful and I can come to China in the future to give Wang Wang, who has cancer, more hope.

5. Laboratory of Veterinary Molecular Diagnosis and Therapy, Faculty of Common Veterinary Medicine, Yamaguchi University, Japan

WO2016006241A1, anti-canine -PD-1 antibody or anti-canine-PD-L1 antibody, inventor: Nobuya Mizuno.

This patent has been authorized in Europe, Japan and the United States. His inventor, Takuya Mizuno, is also a professor in the Laboratory of Veterinary Molecular Diagnosis and Therapy, Faculty of Common Veterinary Medicine, Yamaguchi University, Japan.

The research currently being carried out in the Laboratory of Veterinary Molecular Diagnostics and Therapeutics, where Professor Mizuno Toyo is located, includes:

Wang Wang oncolytic virus therapy, a kind of therapy that specifically infects cancer and destroys cancer cells. It has been proved that it can kill cancer cells in dogs to fight against various cancers.

Wang Wang PD-1 antibody drugs, including therapeutic methods for immunomodulation purposes, such as molecular suppression of immune checkpoints, and cytotoxic antibodies using antibodies against cancer cell surface molecules. This technology should be the PD-1 technology that was searched above and developed in cooperation with Japan Quanyao.

Wang Wang CAR-T immune cell therapy, which uses immune cells collected from dogs with cancer to prepare genetically modified immune cell CAR-T cells in vitro, is a very popular research direction of tumor treatment at present.

6. Beijing Baiao Saitu Gene Biotechnology Co., Ltd.

CN109452229A, preparation method and application of canine PD-1 genetically modified animal model, filed on November 19th, 2018.

The patent application provides an sgRNA capable of specifically targeting Pd-1 gene, a canine-derived animal model of PD-1 gene, a method for preparing an sgRNA vector of the canine-derived animal model, a preparation method of the canine-derived animal model and related applications, and a genetically modified canine-derived mouse is prepared, which can normally express PD-1 protein containing the functional domain of the canine PD-1 protein. The example of this patent provides relevant experimental data on tumor inhibition in mice, but there is no relevant patent on clinical experimental data of tumor in dogs.

Beijing Baiao Saitu Gene Biotechnology Co., Ltd. is a gene biotechnology company located in Daxing, Beijing, and its management team is all doctors in the field of biomedicine. At present, 84 patents have been applied, most of which are related to humanized genetic modification technology. This company mainly develops human antibody drugs, and only the above patent involves PD-1 in dogs.

It is also found in the Eye of the Sky that Beijing Baiao Saitu has registered a Maple Leaf Pet Hospital (Beijing) Co., Ltd. in March this year, and it should start to enter the field of immunotherapy for pet tumors. But I haven’t seen them start business yet. I hope to get up and start business quickly and give the dogs more hope.

7. Beijing Xinuogu Biotechnology Co., Ltd.

CN110194799A, an anti-canine PD-1 antibody that binds to canine PD-1, filed on Jun. 3, 2019.

The patent relates to an anti-canine PD-1 antibody and a preparation method thereof, and the canine PD-1 antibody can be combined with canine PD-1 for application in drugs for treating canine cancer. The patent only discloses the experimental data of mice, but there is no clinical experimental data of dogs.

Xiao Bian has an impression on Sinovalley Biotechnology Company because they specialize in cloning cats and dogs, cloning 380,000 dogs.

Summary of analysis results of PART 3

At present, there are not many options to treat small animal tumors in China. After analysis, it is found that the following three are more reliable in terms of technical strength and experimental effect:

The cytokine fusion protein of Beijing Conoco Fu Biotechnology Co., Ltd. has been used in more than 300 cases of pets, most of which have achieved the effect of inhibiting tumor growth, and some of them have been completely relieved, and it is a broad-spectrum anti-tumor drug that can be tried;

Beijing Baiao Saitu Gene Biotechnology Co., Ltd., with strong technical strength, has 84 patent applications. It hopes to be used as a human medicine and also for the treatment of Wang Wang tumor. From the perspective of patent technology, it mainly involves PD-1 antibody, and their Maple Leaf Pet Hospital has just been established. It is expected that it will not start clinical trials for dogs until September this year, which is also a treatment plan worth looking forward to.

Japan Quanyao Industrial Co., Ltd., and its two scientific research institutions, the Laboratory of Veterinary Clinical Pathology of Tokyo University and the Laboratory of Veterinary Molecular Diagnosis and Therapeutics of the Faculty of Veterinary Medicine of Yamaguchi University, have entered the clinical trial stage. One is a regulatory T cell infiltration inhibition method based on CCR4 blockade, and the other is PD-1, which should be reliable, but it is not convenient to be applied in China at present, and it is recommended to Japanese shovel officials.

PART 4 Application of Patent Analysis Results

Ugly sister wanted to do this research because my ugly sister had been sneezing and running nose since the end of last year. At first, she thought it was rhinitis, but she didn’t get better after treatment for a long time. As a result, she went to the hospital for CT at the beginning of March this year and was highly suspected of being a nasal tumor.

An ugly younger sister with a runny nose when she sleeps.

The doctor said that if you have an operation, you should open your head, and it will recur soon. Ugly sister is 16 years old and can’t bear such a big operation. Chemotherapy is not effective for nasal cavity tumors. People who get nasal cavity tumors are usually treated with radiotherapy, but there is no place to treat small animals with radiotherapy in China at present.

Don’t you just let the tumor grow up? Now there are so many new methods for the treatment of human tumors, and our ugly sister can give it a try.

How can I know where I can give my dog tumor immunotherapy? So Ugly Sister analyzed all the patents about immunotherapy of dog tumors at present and found the above companies that are doing research in this field. After so many years of patent analysis, I finally feel useful.

Then, according to our actual situation, we can select the treatment options.

First of all, it is not convenient to go to Japan, so we ruled out two scientific research institutions in Japan first, but we are still looking forward to the related drugs of Japan Quanyao Industrial Co., Ltd. to achieve good results and successfully pass clinical trials.

Secondly, because the ugly sister is 16 years old, the ugly mother’s request is not to do any examination that requires general anesthesia, that is, not to do CT (dogs need general anesthesia when doing CT) and not to do pathological examination (because the tumor is in the nasal cavity, if you want to do pathological examination, you need to take samples with nasal endoscope under general anesthesia). Without biopsy, we don’t know what kind of tumor it is, and we don’t know if PD-1 is expressed.

So, in the end, we chose the cytokine fusion protein of Conoco. Because Conoco’s mature treatment plan is to inject drugs directly into the tumor, but our ugly sister’s nasal cavity tumor is in a bad position, so if she wants to inject it, she must be under general anesthesia, and ugly mother doesn’t agree. So we tried a new anti-tumor drug from Conoco Clothing Company, which was treated by intravenous injection, so that there was no need for anesthesia. So we ugly became the first Wang Wang in Chengdu to try this therapy.

On March 29th, Ugly Mommy took Ugly to the hospital to take venous blood, and the staff of Conoco Service Company took the blood sample away and sent it to their company’s laboratory. Then send it back after an operation in the laboratory.

On April 5th, Ugly received the first intravenous treatment.

Ugly receives the first treatment.

After treatment, I thought I would have a fever, but I didn’t have a fever at all.

I was going to have a second treatment the next week. As a result, just two days before preparing for the second treatment, Ugly suddenly had stomach cramps, pulled blood and vomited. The doctor diagnosed it as upper gastrointestinal bleeding, and quickly treated it. It took several days to stop bleeding and stop vomiting.

Because Ugly Ugly had digestive tract problems ten days before treatment, we don’t know whether this sudden upper gastrointestinal bleeding was caused by the poor digestive tract, the side effects of treatment, or the presence of lesions in the digestive tract.

However, Ugly Mom was afraid that Ugly would bleed if she was treated again, so she didn’t want to give Ugly a second treatment. We also want to get it in shape first.

Then Ugly Mom atomizes Ugly three times a day, and then drops some eye drops to stimulate it, so that it can sneeze hard to beat out the secretions inside.

Zhong Ugly does atomization three times a day.

On May 15, more than a month after the treatment, one day Ugly sneezed and sneezed a lot of secretions.

Ugly sneezing secretions from the nose.

Ugly mom said that the whole dog looks happier since it hit such a big lump, and it has to grind its teeth, which means that its nose doesn’t hurt.

On May 21st, I sneezed again and produced a lot of secretions.

Ugly sneezing secretions from the nose.

Then ugly mom said that ugly’s left nostril was open, and two points of water vapor could be seen when atomizing. In the past, the left nostril was blocked because of a tumor.

When atomizing, you can see the water vapor produced by the exhalation of two nostrils.

Now Ugly Ugly has completely stopped sneezing and running nose, and the previous symptoms have completely disappeared.

The staff of Conoco Clothing told us that it was a course of treatment for three times, but Ugly Mom saw the effect after the first treatment, and she was afraid that she would have stomach bleeding again, so she was hesitant to do it again.

Because ugly mom doesn’t want to take ugly to do CT, so we don’t know what the effect of tumor treatment is this time, just consider it effective. Ugly sister boldly guessed that the tumor might have shrunk, the nostril passage became larger, and all the secretions deposited in it were typed out, and then it was easy.

In a word, under the careful care of Ugly Mommy, the symptoms of Ugly Nose are gone now, and my mental state is good. Besides being clumsy when I am old, I can occasionally fight.

Ugly just celebrated her 17th birthday a few days ago. I hope she will always be healthy and happy.

postscript

Thanks for the technical support given by Lihua, Youhe and Teacher Mao, the small partners in the biological field, during the search for related patents; I would also like to thank Zhan Xing and Xin Rui for helping to contact the inventors. Thanks to the scientists and staff of Conoco Service, we can live a healthy life now.

Writing this article, I hope I can give you some information. If your master has a tumor, don’t give up. It would be a great honor if this article could make a little contribution.

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Original title: How to Save Your Dog’s Life with Patent Analysis

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He learned from a famous family and led the team to study the preparation and application technology of chlorine dioxide, breaking the technological monopoly of multinational companies;

Based on production, he proposed a talent training mode combining innovation and entrepreneurship education with "production-learning-research" to train practical talents in the industry.

[Profile]

Nie Shuangxi, male, Han nationality, born in November 1985 in Huanggang, Hubei Province, is an associate professor, doctoral supervisor and young academic leader in light industry technology and engineering. Leading the team to overcome difficulties in clean pulping and high-value utilization of biomass, the developed chlorine dioxide preparation and bleaching technology has been successfully applied to large paper enterprises at home and abroad, which has promoted the leap-forward development of clean bleaching technology in China’s paper industry.

▲ Nie Shuangxi, Associate Professor, College of Light Industry and Food Engineering, Guangxi University

As we all know, papermaking in four great inventions of ancient china has provided a good carrier for the spread of world culture, and the development of the world is still inseparable from the great contribution made by the papermaking industry. Therefore, papermaking technology has always been regarded as one of the important representatives of China culture.

However, at present, all countries in the world are facing more or less environmental protection problems, and China has also put forward the important slogan of "green life". Therefore, at present and in the future, the development goal of China’s paper industry is not limited to the quality of paper, but more importantly, how to further promote its green and healthy development. In recent years, China has made great achievements in this field, and there are also many enterprises and experts who have made great contributions in Guangxi. Among them, Nie Shuangxi, a high-level talent introduced from Guangxi University, is included.

Love comes from the hard work of the day after tomorrow.

Nie Shuangxi’s love for papermaking was discovered when he was studying under Professor Wang Shuangfei at the university and often soaked in the laboratory.

In 2006, Nie Shuangxi took the college entrance examination. Like many ordinary middle school students, he doesn’t have a clear plan for his future, and he doesn’t even know his hobbies. When he volunteered for the college entrance examination, he chose the major of light chemical engineering in Guangxi University. He believes that light chemical products have become an indispensable material for all relevant departments of the national economy and a necessity for people’s daily life, and the work prospect of this major should be good.

After entering the university as he wished, Nie Shuangxi discovered that this major is actually all-encompassing, involving pulp and paper, fine chemicals, light industry and environmental protection. In his professional study, he often had to do various chemical experiments, from which he found pleasure. It was at this time that he found that his interest was more inclined to chemistry. In the light chemical engineering, papermaking, a traditional industry with a long history in China, has attracted him a lot. In this way, he made clear the direction of his future efforts and chose to deepen the paper industry.

However, with the enhancement of people’s awareness of environmental protection, and paperless operation has gradually moved from concept to practical application, many people think that paper will gradually withdraw from the historical stage and the paper industry will gradually decline. Of course, some people are bearish and some people are optimistic. Nie Shuangxi believes that the reason why the public is not optimistic is because the paper in their eyes is often limited to writing paper. In fact, in addition to the increasing consumption of household paper, the multi-application scenarios of special paper have also opened up a new direction for the development of the paper industry, and the overall development trend of the industry is still improving. Facts have proved that Nie Shuangxi’s judgment was correct. According to the survey data of China Paper Association, the national paper and paperboard production in 2019 was 107.65 million tons, an increase of 3.16% over the previous year. The consumption was 107.04 million tons, up by 2.54% over the previous year. According to the statistics of the National Bureau of Statistics, the main business income of 2524 papermaking enterprises from January to December 2019 was 765 billion. In 2019, the average annual growth rate of production and consumption of household paper was 5.51% and 5.65% respectively.

▲ Nie Shuangxi (former) conducted analysis and research on pulp fiber characteristics during co-cultivation in Limerick Pulp and Paper Research Center, Canada.

In 2010, after graduating from college, Nie Shuangxi chose to continue to study with Teacher Wang Shuangfei, specializing in clean pulping and papermaking. After graduating from Ph.D., he worked in the front line of teaching and scientific research and made outstanding contributions to the development of disciplines and the promotion of technological progress in the industry. He participated in the research project "Key Technologies and Applications of Typical Wastewater Recycling and Ultra-low Emission in Papermaking and Fermentation" and won the second prize of National Science and Technology Progress Award in 2016; As a key member, he completed the scientific research project "Large-scale chlorine dioxide preparation system and key technology and application of chlorine-free bleaching of pulp", which won the second prize of Guangxi Science and Technology Progress Award in 2017, the first prize of Technology Invention Award of Ministry of Education in 2018 and the second prize of National Technology Invention Award in 2019.

Every gratifying achievement is made by pouring sweat. Looking back now, Nie Shuangxi’s deepest and most memorable memories are always the time spent in the laboratory, the careful guidance of the tutor and the hands-on teaching of the scientific research predecessors … In order to realize clean pulping and papermaking, he enjoyed the laboratory at two o’clock in the morning and also saw the campus at four o’clock in the morning. The boring laboratory years have now become the best testimony of his growth and progress.

Breaking the technological monopoly of multinational corporations

The importing country jumped to become an exporting country.

The most interesting thing about Nie Shuangxi and his team is that they have made great breakthroughs in the preparation and application technology of chlorine dioxide, breaking the monopoly of foreign companies on China’s pulp bleaching chlorine dioxide preparation technology, making China jump from an importer of chlorine dioxide preparation technology to an exporter, and promoting the leap-forward development of clean bleaching technology in China’s paper industry.

When it comes to the paper industry, the public first thinks that it is often pollution. Indeed, in the past, domestic paper-making enterprises used the traditional chlorine-containing bleaching method to bleach pulp. These chlorine-containing bleaching agents are easy to form chlorinated hydrocarbons, chlorophenols, chloramines, etc., which are harmful to fish and human bodies, and will also pollute underground water sources and the environment, which is not conducive to environmental protection. This traditional practice was eliminated by developed countries in North America and Europe as early as 1990, and chlorine dioxide clean bleaching technology was used instead. Compared with chlorine-containing bleaching agents, chlorine dioxide not only has better bleaching performance, but also does not form harmful substances.

However, at that time, the preparation technology of chlorine dioxide was monopolized by several large companies in Sweden and Canada. If Chinese enterprises want to adopt this technology, they must import it in full. As a result, not only the purchase of equipment is expensive, but also the later maintenance cost is very high. For chlorine dioxide, there is a huge demand in the domestic market, but at the same time the technology faces shortcomings. Therefore, with the original intention of "solving the problem of backward technology and improving the level of clean papermaking", Nie Shuangxi’s R&D team focused on this and began to develop a new generation of chlorine dioxide preparation and bleaching technology.

▲ Nie Shuangxi participated in the research and development of "large-scale chlorine dioxide preparation system and key technology and application of chlorine-free bleaching of pulp" and won the second prize of National Technological Invention Award.

In 2010, the first chlorine dioxide preparation system developed by Nie Shuangxi’s team finally ran successfully. Once the products were put on the market, the sales were very hot, which not only broke the foreign technology monopoly, but also produced good economic benefits. "The level of our technology is basically the same as that of foreign countries, but the cost is only 1/4 to 1/3 of that of imports, so it is very competitive." Good products bring good reputation. Soon, foreign companies also heard the news. In 2013, the whole set of technology was successfully exported overseas. At present, it has been widely used in large paper enterprises in ASEAN countries such as Indonesia, India and Thailand, providing an economical and effective solution to the pollution problems brought by paper enterprises in various countries.

Youth guide Guangxi youth role model

Mencius said: "A gentleman has three pleasures … to be educated by the world’s talents, and the three pleasures are also." It is undoubtedly the greatest wish of every teacher to share his own knowledge and feelings, so that knowledge can produce greater value, and at the same time, to cultivate students into excellent pillars of the country.

Nie Shuangxi is not only a scientific research worker, but also a university teacher. His students include undergraduates, postgraduates and doctoral students. He has been tirelessly guiding students to correctly understand themselves, find their goals and move forward in a down-to-earth manner. He believes that the most important thing in teaching and educating people is to guide students to correct their attitude towards study and work and help them to establish a correct outlook on life. Nie Shuangxi admits that he is the beneficiary in this respect. During my college years, thanks to the guidance of my tutor and other teachers, I had a correct understanding of myself and found a clear direction for my efforts.

In 2015, Nie Shuangxi, who just turned 30, was hired as the head teacher of Class 151 of Light Industry and Food Engineering College of Guangxi University. Under his guidance and influence, many students in the class came to him and asked to do some research with him. Upon graduation, two undergraduate students directed by Nie Shuangxi published SCI papers as the first authors. Some students under the guidance of other teachers in the class have also published papers in international and domestic core journals. Such achievements are rare among undergraduate graduates.

Nietzsche once said, "A wise man will lose nothing as long as he can know himself." Although 360 lines make a champion, if we can have an open mind and better position ourselves, we can achieve twice the result with half the effort and will be more conducive to our success. Nie Shuangxi said: "I have always felt that there are no bad majors, only subjects that are not suitable for me. To learn a major well, the most important thing is to correct your learning attitude in the process of learning basic courses. Among them, it is inseparable from the guidance of teachers. "

After hard work, you will be lucky enough to be favored. Nie Shuangxi, who took part in the work, gained praise and glory year after year. He was selected as the first batch of training targets of the "Training Plan for 1,000 Young and Middle-aged Key Teachers in Guangxi Colleges and Universities" and the first batch of "Doctor’s Young Teachers’ Innovative Talent Training Award Plan". In 2016, he won the honorary title of "Double First-class" Construction Outstanding Contribution Award of Guangxi University. He was awarded the title of "Three Education Principles" advanced individual of Guangxi University in 2015-2017 academic year, "Excellent Head Teacher" of Guangxi University in 2016-2017 academic year, and "Excellent Communist party member" of Guangxi University in 2015-2019. In 2017, he won the third prize of Guangxi Higher Education Teaching Achievement Award, and in 2019, he won the annual "May 4th Guangxi Youth Model-Youth Guide".

In the teaching process, Nie Shuangxi put forward the training mode of engineering talents combining innovation and entrepreneurship education with "production-learning-research", emphasizing the research direction of solving problems according to the needs of industrial production, and guiding teaching accordingly. He gave full play to the leading role of the innovation and entrepreneurship competition, took the national innovation and entrepreneurship competition as the carrier, integrated education into the competition, and promoted the improvement of students’ professional quality. In the past five years, he has been undertaking the guidance of national innovation and entrepreneurship competitions such as "Challenge Cup", "internet plus" and "Creating Youth".

▲ Nie Shuangxi (first from the left in the front row) and the Nasai Science and Technology Team of Guangxi University that he set up and guided.

The "Nasai Science and Technology Team of Guangxi University" established and directed by Nie Shuangxi won the second prize at the provincial level in the Guangxi Youth Entrepreneurship and Innovation Competition in 2015; In 2016, he won the National Bronze Award in the 10th "Challenge Cup" National Undergraduate Entrepreneurship Plan Competition; In 2016, he was awarded the title of "Xiaoping Science and Technology Innovation Team for College Students" (selected once every two years, and only 50 teams/individuals in the country won the prize each time), and was invited to participate in the awarding ceremony of the "Tenth China Youth Science and Technology Innovation Award" held in the Great Hall of the People; In 2017, he won the National Bronze Award in the 3rd China "internet plus" Innovation and Entrepreneurship Competition, so he won the Outstanding Innovation and Entrepreneurship Tutor Award in the 3rd China "internet plus" Innovation and Entrepreneurship Competition in 2017.

▲ In 2016, "Nasai Science and Technology Team of Guangxi University" won the title of "Xiaoping Science and Technology Innovation Team for College Students" nationwide.

Nie Shuangxi believes that as a student, whether an undergraduate, a master’s student or a doctoral student, we should give priority to study and research, and concentrate on it. If you can’t settle down and concentrate on doing one thing well, then even if you do more, everything else will only have a shiny surface, and there is no real talent to help the world.

Photo: Popular Science Central Kitchen | Beijing Science and Technology News Ge Yubing

Original title: "Nie Shuangxi: Young Talents Committed to Whitening Paper"

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Wang Dongwei, a Fujian businessman who has been doing business in Yichang for many years, was not only involved in the case of Guo Youming, the former vice governor of Hubei Province, but also took the initiative to expose and bring down two deputy mayors of Yichang City.

Wang Dongwei, 44, is the chairman of Hubei Huaxiang Investment Development Co., Ltd.. In addition to bribing Guo Youming 10.2 million yuan, he also paid bribes of 3.6 million yuan and 810,000 yuan to Wang Hongqiang and Zheng Xinghua, former vice mayors of Yichang.

Recently, "Hubei Huaxiang Investment Development Co., Ltd. and Wang Dongwei Unit Bribery First Instance criminal judgment" published by China Judgment Document Network disclosed the above case.

Criminal judgment, who made public the above-mentioned first trial, also showed that in order to seek illegal benefits for the company, Wang Dongwei used the company’s funds to pay bribes to the above-mentioned three state employees, with a total amount of 14.61 million yuan. On December 14th, 2016, Wang Dongwei was sentenced to three years’ imprisonment with a suspended sentence of five years.

The year before Wang Huawei’s verdict was pronounced in the first instance, Guo Youming’s bribery case was also pronounced in the first instance.

Guo Youming is on trial.

Xinhua News Agency previously reported that on December 9, 2015, Nanyang Intermediate People’s Court held a public hearing on the bribery case of Guo Youming, former vice governor of Hubei Province.

Nanyang Intermediate People’s Court found the defendant Guo Youming guilty of accepting bribes, sentenced him to 15 years’ imprisonment and confiscated his personal property of RMB 2 million. The property obtained from bribery crimes shall be recovered and turned over to the state treasury. Guo Youming said in court that he would obey the verdict.

The biggest briber in Guo Youming case

Earlier media reports said that Nanyang People’s Procuratorate accused the defendant Guo Youming of taking advantage of his position as deputy secretary of Yichang Municipal Committee of the Communist Party of China, mayor of Yichang Municipal People’s Government, secretary of Yichang Municipal Committee of the Communist Party of China, and deputy governor of Hubei Provincial People’s Government from 2001 to 2013, directly or indirectly through his wife Zhang, his son Guo, his brother Guo Youzi, and a special related person Xiao Mou to illegally accept property totaling RMB 23,808,331.

Guo Youming accepted RMB 1.314 million from Yu Chu Yun, Chairman of Yichang Three Gorges Hongming tourism real estate Development Co., Ltd.; Wang Dongwei, the chairman of Hubei Huaxiang Investment Development Co., Ltd., received a total of RMB 10,258,120; Received property from Yu Hongzhi, chairman of Yichang Fulianjiang Composite Materials Co., Ltd., and Ma Zheng, director of Yichang Fulianjiang Composite Materials Co., Ltd., equivalent to a total of RMB 9,236,211, including 1 million shares; Received RMB 3 million from Cai Hongzhu, Chairman of Hubei Daohuaxiang Group.

Among the above four allegations of bribery, Wang Dongwei, the chairman of Hubei Huaxiang Investment Development Co., Ltd., was the biggest briber in the Guo Youming case.

On November 27th, 2013, the website of the Supervision Department of the Central Commission for Discipline Inspection reported that Guo Youming, vice governor of Hubei Province, was suspected of serious violation of discipline and law and was under investigation.

Twenty days before Guo Youming’s fall, Wang Dongwei, the biggest briber, was taken away by the relevant case-handling department for investigation.

According to criminal judgment, the first trial of bribery of Hubei Huaxiang Investment Development Co., Ltd. and Wang Dongwei Company, the defendant Wang Dongwei, male, born on November 14, 1973, Han nationality, undergraduate, chairman of Hubei Huaxiang Investment Development Co., Ltd., and his domicile is Quanzhou, Fujian Province. On November 7, 2013, he was placed under residential surveillance by Xihua County Public Security Bureau, as decided by Zhoukou Municipal People’s Procuratorate. On April 30, 2014, he was released on bail pending trial upon the decision of Zhoukou Municipal People’s Procuratorate for allegedly committing bribery in the company.

Criminal judgment, the above-mentioned first-instance judge, also showed that from the first half of 2005 to the second half of 2012, the defendant Wang Dongwei, the chairman of Hubei Huaxiang Investment Development Co., Ltd., bribed Guo Youming, then mayor of Yichang, secretary of CPC Yichang Municipal Committee and vice governor of Hubei Province, 9 million yuan in cash for obtaining the right to use 57.88 mu of land belonging to Yichang Intermodal Company, returning the land transfer fee, obtaining loans from Yichang Rural Commercial Bank, and building supporting roads for Huaxiang Commercial Center.

Eight times to the vice governor’s brother 9 million.

Most of the money that Wang Dongwei paid bribes to Guo Youming was collected through his brother Guo Youzi.

Criminal judgment of the first instance showed that from July to August to November, 2012, the defendant Wang Dongwei paid a cash bribe of 9 million yuan to Guo Youming through Guo Youzi, the younger brother of Guo Youming.

In order to thank Guo Youming for his help in the Huaxiang Commercial Center project of Hubei Huaxiang Investment Development Co., Ltd., in July and August, 2012, Wang Dongwei, the chairman of the company, proposed to let Guo Youming introduce the construction enterprise for its Huaxiang Commercial Center project, thus delivering benefits to Guo Youming. Guo Youming then arranged for Guo Youzi to contact Wang Dongwei to handle this matter.

After the meeting, Wang Dongwei proposed to let Guo Youzi participate in the earthwork project, and to provide Guo Youzi with benefits of more than 8 million yuan by increasing the engineering quantity. Considering that there were too many links in the earthwork project, Guo Youzi disagreed, and later asked Wang Dongwei to provide him with cash directly on the grounds that he needed funds for his business.

Therefore, from July, August to November, 2012, Wang Dongwei gave Guo Youzi 9 million yuan in cash in eight times at the parking lot of Yidao Hotel in Yichang and under the Gezhouba Bridge. Hou Guo Youzi and Wang Dongwei informed Guo Youming of the situation respectively.

According to Wang Dongwei’s confession and defense, he went to Yichang to inspect the project in 2004 and got to know Guo Youming, then the mayor of Yichang. In 2010, he invited Dr. Zhang to the Junyao Hotel in Yichang to give Guo Youming a massage, and Guo Youming’s younger brother Guo Youzi also came for a massage, so he met Guo Youzi.

"In June and July of 2012, one day Wang Dongwei told me that he wanted to find some powerful construction enterprises with Chinese prefix to participate in the construction, and asked me to help him introduce a good construction team. I understand the meaning of his words. Obviously, I want to take the opportunity to give me benefits, because I have given Wang Dongwei great support and help in land acquisition, land transfer fee return and coordination of project promotion. " Witness Guo Youming testified that.

"Guo Youzi also called me and said that Wang Dongwei gave him 9 million agency fees. The so-called agency fee is an excuse for Wang Dongwei to send me money. I also know the construction. The agency fee can’t be so high. Wang Dongwei is obviously a benefit fee to thank me. " Guo Youming said in his testimony, "Guo Youzi only received this 9 million on my behalf, and I never thought about getting it back from Guo Youzi. I wanted to help Guo Youzi."

Before going abroad for inspection, please ask the vice governor and his wife to massage and send 200,000 US dollars.

In addition, Wang Dongwei also gave Guo Youming $200,000 through Guo Youming’s wife in the name of Guo Youming’s study abroad after the massage in Guo Youming.

Criminal judgment of the first instance showed that in October 2012, in order to thank Guo Youming for his help in the Huaxiang Commercial Center project of Hubei Huaxiang Investment Development Co., Ltd., Wang Dongwei paid Guo Youming a cash bribe of 200,000 US dollars at Junyao Hotel in Yichang.

"In October 2012, I heard from Guo Youming’s secretary that Guo Youming was going abroad for inspection, so he prepared $200,000 in cash in advance and put it in a tea box; After Dr. Zhang gave Guo Youming a massage, when Guo Youming and his wife left, they handed the tea box to Guo Youming’s wife Zhang. " Wang Dongwei’s confession and defense said.

According to Guo Youming’s testimony, Wang Dongwei paid for Dr. Zhang’s massage. One day in October 2012, after the massage treatment, Wang Dongwei handed his wife a handbag with a tea box. After two or three days, his wife told him that the tea box contained $200,000. It accepted by default, and this $200,000 was kept by his wife.

"One day in October 2012, Wang Dongwei asked Dr. Zhang to come to Yichang to give Guo Youming and me a massage treatment in the room of Junyao Jinjiang International Hotel. At that time, Wang Dongwei was also chatting with us in the room. After the massage treatment, when Guo Youming and I were about to leave, Wang Dongwei handed us a handbag and said,’ Take this to Governor Guo’. Guo Youming didn’t say anything at that time. I took the handbag and took it home. When I got home, I opened my handbag and found a tea box inside. The tea box contained $200,000 in cash, so I put the $200,000 away. After a few days, I told Guo Youming that there was $200,000 in the tea box that Wang Dongwei gave me that day. " The testimony of witness Guo Youming’s wife Zhang said.

Take the initiative to report down two deputy mayors.

Criminal judgment of the first trial also showed that it was also found out that Wang Dongwei used the unit’s funds to pay bribes to three state employees for illegal interests, totaling 16.38 million yuan. Truthfully confessed to bribing Guo Youming 10.2 million yuan many times; He voluntarily confessed that the amount of bribes paid to Wang Hongqiang and Zheng Xinghua was 5.37 million yuan and 810,000 yuan respectively. On November 25, 2016, the defendant Hubei Huaxiang Investment Development Co., Ltd. voluntarily paid a fine of 500,000 yuan.

The public prosecutor believes that Wang Dongwei’s ability to provide the case-handling organ with important clues about the suspected crimes of Wang Hongqiang (handled separately) and Zheng Xinghua (handled separately) is a meritorious service and should be punished in accordance with Article 68 of the Criminal Law of People’s Republic of China (PRC). Request to be sentenced according to law.

The court found through trial that from 2009 to 2012, the defendant Wang Dongwei gave Wang Hongqiang RMB 2 million (RMB 1,851,067.73 after tax deduction), US$ 20,000, HK$ 350,000 and a BMW X6 off-road vehicle (with a value of RMB 107,500) to help Wang Hongqiang (then deputy mayor of Yichang Municipal Government and deputy director of the Standing Committee of Yichang Municipal People’s Congress).

Among them, in the first half of 2009, Hubei Huaxiang Investment Development Co., Ltd. gave Wang Hongqiang a BMW X6 off-road vehicle, which was used by Wang Hongqiang’s son. Later, Wang Hongqiang reimbursed the company for 138,431 yuan.

The Paper (www.thepaper.cn) reporter noted that the court of first instance found that the amount of bribes paid by Wang Dongwei to Wang Hongqiang was about RMB 3.6 million, which was far from the amount of RMB 5.37 million voluntarily confessed by Wang Dongwei.

In addition, from 2008 to 2013, Wang Dongwei gave Zheng Xinghua 20,000 US dollars, 200,000 Hong Kong dollars and 3 gold bars (weighing 1,500 grams in total, valued at 519,601 yuan) in order to thank and continue to get the help from Zheng Xinghua (then Deputy Secretary-General of Yichang Municipal Government, Director of Yichang Municipal Bureau of Land and Resources and Deputy Mayor of Yichang Municipal Government) in obtaining the land use right and exempting the late payment fee.

The People’s Court of dancheng, Henan Province held that the defendant Hubei Huaxiang Investment Development Co., Ltd. paid bribes to state employees for illegitimate interests, and the circumstances were serious. The behavior of the defendant unit and its directly responsible supervisor, Wang Dongwei, has constituted the crime of bribery by the unit. The charges charged by the public prosecution agency were established.

Wang Dongwei, as the person in charge of the unit, voluntarily confessed the bribery of the unit to Wang Hongqiang and Zheng Xinghua. According to the provisions of the first and second paragraphs of Article 7 in the Interpretation of the Supreme People’s Court and the Supreme People’s Procuratorate on Several Issues Concerning the Specific Application of Laws in Handling Criminal Cases of Bribery: If the bribery case is solved by voluntarily confessing the bribery, the provisions of Article 68 of the Criminal Law on meritorious service are not applicable to the briber. Should be in accordance with the provisions of the second paragraph of Article 390 of the Criminal Law, can be given a lighter punishment. The directly responsible person shall also be given a lighter punishment.

On December 14, 2016, the People’s Court of dancheng City, Henan Province made a first-instance judgment, sentenced the defendant Hubei Huaxiang Investment Development Co., Ltd. to the crime of bribery, and fined 1 million yuan (after deducting 500,000 yuan that has been voluntarily paid, the remaining 500,000 yuan will be paid within 30 days after the judgment takes effect); Defendant Wang Dongwei was sentenced to three years’ imprisonment, suspended for five years, for the crime of unit bribery.

Some netizens left a message to see (import), and today it came. Next, let’s take a look with Xiaobian.

Let’s take a look at the appearance of the BMW i5 (imported). The design of the BMW i5 (imported) front is very simple and looks sporty. Coupled with the headlights of young personality, it has a great visual impact. The car is equipped with LED daytime running lights, automatic opening and closing, adaptive far and near light, automatic steering, delayed closing and so on. Coming to the car side, the car body size is 5060MM*1900MM*1505MM. The car adopts simple and fashionable lines, and the car side looks very clean. With large-sized thick-walled tires, the shape is quite simple. In terms of the rear end, the overall shape of the rear end echoes the front face, and the taillights look very sharp, creating a good gas field.

After getting into the car, the interior of BMW i5 (imported) looks cleaner and fresher, which enhances the sense of individuality. The steering wheel of the car is very in line with the interior style, equipped with electric up and down+front and rear adjustment, steering wheel memory, steering wheel heating and other functions, which looks a little more comfortable. From the central control point of view, the central control screen with 14.9-inch touch-sensitive LCD makes the interior style impressive and looks very calm. Let’s take a look at the dashboard and seats again. The car is equipped with a young dashboard, and the trendy design elements make people remember it at a glance. The car uses leather seats, which are wrapped in place and the overall comfort is acceptable.

BMW i5 (imported) matched gearbox, 442KW, 795N.m, with good power performance.

The car is equipped with car networking, driving mode selection, remote control key, UWB digital key, interior atmosphere light, traction control (ASR/TCS, etc.) and other configurations, which fully ensures the convenience and comfort of the car experience.

The model class introduced today is the most considered class when many people buy their first car, mainly because the size of this class is moderate and the price is reasonable. You can learn more about what you like!

　　On May 25th, Xu Xin, the attorney of Liu Dawei’s case, revealed that he had received a criminal ruling from the Supreme People’s Court and approved the retrial judgment of Fujian High Court on Liu Dawei’s case of seven years and three months’ imprisonment. In response to this result, lawyer Xu Xin said that the next step will be to communicate with Liu Dawei’s parents before considering whether to continue to appeal, and hope that Liu Dawei can apply for commutation and parole.

　　Online shopping for 24 simulation guns was sentenced to life.

　　Retrial was sentenced to 7 years and 3 months.

　　In July 2014, Liu Dawei, who just turned 18, spent more than 30,000 yuan to buy 24 simulation guns from a seller through online shopping, and the goods were seized by Fujian Customs in transit. On August 31, 2014, Liu Dawei was detained by Shishi Customs Anti-smuggling Branch, and was arrested on September 29 with the approval of Quanzhou People’s Procuratorate.

　　On April 30, 2015, Quanzhou Intermediate People’s Court of Fujian Province made a first-instance judgment, and Liu Dawei was convicted of smuggling weapons and sentenced to life imprisonment. Liu Dawei refused to accept the appeal. On August 25th, the Fujian Provincial High Court rejected the appeal and upheld the original judgment. Liu Dawei’s family then appealed for retrial and held a retrial in Zhangzhou Intermediate People’s Court of Fujian on August 10, 2018.

　　On the morning of December 25, 2018, Liu Dawei’s case of "online shopping for 24 simulation guns was sentenced to life" was retried in the Intermediate People’s Court of Zhangzhou City, Fujian Province. Liu Dawei was sentenced to 7 years and 3 months in prison for smuggling weapons.

　　So far, Liu Dawei has been detained for more than four and a half years.

　　Ten reasons for application are not approved.

　　Supreme law: retrial judgment and appropriate sentencing

　　Lawyer Xu Xin, Liu Dawei’s defender, once submitted an application to the Supreme Court for "requesting disapproval and revoking the retrial judgment of Liu Dawei’s case", which listed that it was against common sense to identify toy guns as weapons; The Reply of the Supreme People’s Court and the Supreme People’s Procuratorate on the Conviction and Sentencing of Criminal Cases Involving Compressed Gas-powered Firearms and Air Gun Lead Bullets should be applied, but it is not applied. The labels of physical evidence are inconsistent, and the identity cannot be guaranteed; Liu Dawei does not have the criminal intention of smuggling weapons; Ten reasons for the wrong application of the gun identification standard of 1.8 Joule/cm2 muzzle specific kinetic energy.

　　According to the criminal ruling of the Supreme Law, the court held that Liu Dawei violated customs regulations, evaded customs supervision, and bought 20 guns from Taiwan Province sellers to smuggle them into the country, which constituted the crime of smuggling weapons. Although Liu Dawei did not have a statutory mitigating circumstance, since he did not actually obtain the guns he bought, the guns involved did not flow into the society, which was less harmful to society, and the muzzle of the guns involved was smaller than the kinetic energy, with less injury force, and there was no evidence to prove that it was easy to improve the injury force through restructuring.

　　In addition, Liu Dawei was just 18 years old when he committed the crime. He was a first-time offender and other special circumstances, and he could be sentenced to a penalty below the statutory penalty. The retrial judgment of Fujian Higher People’s Court found that the facts were clear, the evidence was sufficient, the conviction was accurate and the sentence was appropriate.

　　After receiving the Supreme Court ruling, Xu Xin, Liu Dawei’s attorney, said that he would discuss with Liu Dawei and his family before deciding whether to continue his complaint.

　　In addition, Xu Xin hopes that the relevant departments can comprehensively consider, let Liu Dawei return to society as soon as possible, and release Liu Dawei on parole in accordance with the law. "His sentence has been more than half of seven years and three months, which is eligible for parole." Xu Wei said.

　　Text/reporter Zhang Ziyuan

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Focus on improving the effectiveness of learning and comprehensively improve the efficiency of international communication

Fangjiangshan

　　In the important speech at the work conference on studying and implementing the theme of Socialism with Chinese characteristics Thought in the new era of the Supreme Leader, General Secretary of the Supreme Leader emphasized that ideological unity is the deepest, most lasting and most reliable guarantee for the unity and unity of the Party.

　　To carry out in-depth education on studying and implementing the theme of Socialism with Chinese characteristics Thought of the Supreme Leader in the new era, we should make great efforts in learning, believing and applying, learning, understanding and doing things, and show the vigor and enterprising strength of the director’s entrepreneurship. To carry out in-depth education on studying and implementing the theme of Socialism with Chinese characteristics Thought of the Supreme Leader in the new era requires us to organically integrate learning thoughts, strengthening party spirit, emphasizing practice and building new achievements, and persist in arming our minds, guiding practice and promoting work with the innovative theory of the Party in the new era. It is necessary to continuously enhance the political consciousness, ideological consciousness and action consciousness of studying Socialism with Chinese characteristics Thought of the Supreme Leader in the new era, continuously enhance the consciousness and initiative of combining theoretical study with propaganda practice, continuously produce high-quality news content with rich information and profound ideological weight, and continuously promote the high-quality development of all work.

　　General Secretary of the Supreme Leader emphasized in the Party’s Report to the 20th CPC National Congress: "Accelerate the construction of China discourse and China narrative system, tell the story of China well, spread the voice of China well, and show a credible, lovely and respectable image of China. Strengthen the construction of international communication capacity, comprehensively improve the efficiency of international communication, and form an international discourse right that matches China’s comprehensive national strength and international status. " We should comprehensively study, grasp and implement the important exposition of the Supreme Leader General Secretary on comprehensively improving the efficiency of international communication, strengthen theoretical study and strengthen theoretical arms with higher standards and stricter requirements, and make greater efforts to comprehensively improve the efficiency of international communication.

　　International communication refers to the transnational or trans-regional information dissemination for audiences in other countries or regions, which reaches specific people through information dissemination and then affects specific people. The effectiveness of international communication is a comprehensive index to measure the ability, efficiency, effectiveness and benefit of international communication, and it is the overall reflection of the arrival rate, visibility and influence of domestic information in the international public opinion field. Its main measurement criteria can be reflected in three aspects: information reaching, information decoding and information identification of specific people in other countries or regions, that is, the coverage of communication scope makes people "audible"; The affinity of spreading content makes people "understand"; The influence of spreading potential energy makes people "listen". In the new era and new journey, China’s international communication capacity building has a clearer starting point. "Forming an international discourse right that matches China’s comprehensive national strength and international status" is the goal of China’s international communication capacity building. Here, combined with doing a good job in international communication, focusing on improving the effectiveness of learning and comprehensively improving the efficiency of international communication, I would like to talk about some experiences.

In-depth study of the important exposition of the Supreme Leader General Secretary on comprehensively improving the efficiency of international communication

　　The development and prosperity of a big country will inevitably require the cultural communication power and the influence of civilization to be greatly enhanced, and the soft power and hard power will complement each other. It is an important task to tell the story of China, spread the voice of China and show the true, three-dimensional and comprehensive China. On May 31st, 2021, General Secretary of the Supreme Leader put forward "improving the efficiency of international communication in an all-round way" for the first time during the 30th collective study in the 19th the Political Bureau of the Central Committee. We must thoroughly study and implement the important exposition of the Supreme Leader General Secretary on comprehensively improving the efficiency of international communication, tell the story of China and spread the voice of China more actively, create a favorable external public opinion environment for building a socialist modern country in an all-round way, and make positive contributions to building a community of human destiny.

　　General Secretary of the Supreme Leader’s important exposition on comprehensively improving the efficiency of international communication is rich in connotation and profound in thought, with strong foresight, guidance and practicality. Let’s briefly sort it out here and study with you.

　　About telling the story of China well

　　A story is worth a dozen truths. It is the best way to improve the efficiency of international communication in an all-round way through the concept of story communication with temperature and grounding gas, convincing people with reason and moving people with emotion.

　　On February 19th, 2016, the General Secretary of the Supreme Leader pointed out that we should tell the story of Socialism with Chinese characteristics, the story of the Chinese dream, the story of Chinese, the story of China’s excellent culture and the story of China’s peaceful development. Storytelling means telling facts, images, emotions and reasoning. Telling facts can convince people, telling images can impress people, telling emotions can infect people, and reasoning can influence people. It is necessary to organize all kinds of wonderful and refined story carriers, and put China Road, China Theory, China System, China Spirit and China’s strength in them, so that people want to listen, think and gain. At the national conference on propaganda and ideological work held on August 21st, 2018, General Secretary of the Supreme Leader took "telling the story of China well and spreading the voice of China well" as one of the important contents of doing propaganda and ideological work well under the new situation, and profoundly pointed out that Socialism with Chinese characteristics Thought in the new era should be actively introduced, and the story of the Communist Party of China (CPC)’s governance of the country, the story of China’s people’s struggle for a dream, and the story of China’s insistence on peaceful development, cooperation and win-win situation should be actively told, so that the world can better understand China. With regard to the purpose of storytelling, the General Secretary of the Supreme Leader pointed out that we should not tell stories for the sake of telling stories, but should integrate Tao into stories, enlighten people into Tao through fascinating ways, and enlighten people through persuasive ways.Tao. "

　　In practice, General Secretary of the Supreme Leader has set an example for telling the story of China well. During many years of foreign visits and home diplomacy, he has personally told the story of China with simple and fresh language, beautiful and vivid words, simple content and easy-to-understand truth, which shows the profound learning and accumulation of politicians, shows the broad vision and broad mind of heads of state, and highlights the wise thinking and superb language art of leaders of great powers.

　　On constructing a good discourse system

　　Discourse system is the external expression of ideological system and knowledge system, and it is an important element of national cultural soft power. General Secretary of the Supreme Leader attaches great importance to the construction of foreign discourse system, and demands that China theory be used to explain China’s practice, and China’s practice be used to sublimate China’s theory, so as to create new concepts, new categories and new expressions that integrate China and foreign countries, and more fully and vividly show China’s story and the ideological and spiritual strength behind it.

　　On how to construct China’s discourse system, the Supreme Leader profoundly pointed out that it is necessary to innovate the way of expressing foreign discourse, study the habits and characteristics of different foreign audiences, adopt concepts, categories and expressions that integrate Chinese and foreign, combine what we want to tell with what foreign audiences want to hear, combine "expressing feelings" with "reasoning", and combine "telling by yourself" with "telling by others" to make the story more recognized by the international community and overseas audiences.

　　With regard to the content of constructing China’s discourse system, General Secretary of the Supreme Leader stressed that it is necessary to strengthen the propaganda and interpretation of the Communist Party of China (CPC), help foreign people realize that the Communist Party of China (CPC) really strives for the happiness of the people of China, and understand why the Communist Party of China (CPC) can, why Marxism works, and why Socialism with Chinese characteristics is good. Focusing on the spirit of China, the value of China and the strength of China, we should conduct in-depth research from political, economic, cultural, social and ecological perspectives, so as to provide theoretical support for international communication. It is necessary to better promote Chinese culture to go abroad, and explain and introduce more excellent cultures with China characteristics, China spirit and China wisdom to the world.

　　Regarding the use of new media and new technologies to enhance the creativity, appeal and credibility of foreign discourse, General Secretary of the Supreme Leader pointed out that we should grasp the trend of mobility, socialization and visualization in the field of international communication, work hard to build a discourse system for foreign communication, and work hard to be receptive and easy to understand, so that more foreign audiences can understand, listen and understand, and constantly improve the effect of foreign communication.

　　In the construction of China’s discourse system, the Supreme Leader’s General Secretary particularly emphasized the need to stick to the position of Chinese culture and enhance the influence of Chinese civilization. He pointed out that we should stick to the position of Chinese culture, refine and display the spiritual identity and cultural essence of Chinese civilization, speed up the construction of China discourse and China narrative system, tell the story of China well, spread the voice of China well, and show a credible, lovely and respectable image of China.

　　In practice, the General Secretary of the Supreme Leader always uses words with China characteristics to guide and influence international public opinion, and has successively put forward a series of major ideas such as the Chinese dream, promoting the building of a community of human destiny, building the Belt and Road Initiative, the common value of all mankind, the global development initiative, the global security initiative, and the global civilization initiative, which have been widely recognized by the international community. The Supreme Leader’s Talks on Governing the Country, Zhijiang New Language and Getting rid of Poverty are multilingual versions of important works.

　　On displaying the image of China.

　　At present, China’s image in the world is still "molded by others" rather than "molded by himself". The important task of improving the efficiency of international communication in an all-round way is to guide the international community to have a comprehensive, correct and objective understanding of contemporary China, understand China’s national conditions and China’s characteristics, and make China’s national image more concrete and shining.

　　On December 30, 2013, General Secretary of the Supreme Leader stressed during the 12th collective study in the Political Bureau of the Central Committee, the 18th CPC Central Committee: "We should pay attention to shaping China’s national image, focusing on displaying China’s image as a civilized country with profound historical background, diverse ethnic groups and diverse and harmonious cultures, as well as the image of an oriental country with clear politics, economic development, cultural prosperity, social stability, people’s unity and beautiful mountains and rivers, and persist in peaceful development, promote common development, safeguard international fairness and justice and make contributions to mankind. On August 21, 2018, at the National Conference on Propaganda and Ideological Work, General Secretary of the Supreme Leader profoundly pointed out that to do a good job in propaganda and ideological work under the new situation, we must consciously undertake the mission of raising flags, gathering people’s hearts, educating new people, rejuvenating culture and displaying image. Among them, the mission of "image exhibition" is to promote the construction of international communication ability, tell the story of China well, spread the voice of China well, show the real, three-dimensional and comprehensive China to the world, and improve the national cultural soft power and the influence of Chinese culture.

　　In practice, General Secretary of the Supreme Leader, in major international activities and international occasions, preached the concept of peace with one heart and one mind, and showed the image that China has always been a builder of world peace. Introduce the development concept of benefiting the world, mutual benefit and win-win, and show the image that China has always been a contributor to global development; Introduce the world view that the world is for the public and the world is the same, and show the image that China has always been the defender of the international order; Introduce the concept of civilization, tolerance is great, and show the image that China has always been an advocate of the common values of all mankind; Introducing the ecological concept of harmony between man and nature, showing the image that China has always been a leader in the construction of global ecological civilization, has set an example and provided successful experience for us to comprehensively improve the efficiency of international communication.

　　On developing good humanities exchanges

　　Strengthening the exchange and mutual learning of civilizations is an important way to comprehensively improve the efficiency of international communication and an important driving force to promote the progress of human civilization and the peaceful development of the world.

　　Civilization exchange and mutual learning is a concept of civilization put forward by the Supreme Leader General Secretary and has an important influence in the international community. General Secretary of the Supreme Leader stressed that it is necessary to improve the level of cultural exchanges with foreign countries, carry out deep-seated, diversified and pragmatic ideological and emotional exchanges, and be good at using ways that are easy for foreign people to understand and experience Chinese culture better. It is necessary to improve the mechanism of people-to-people communication, innovate ways of people-to-people communication, give full play to the role of various departments in various regions, and comprehensively use mass communication, group communication, interpersonal communication and other ways to show the charm of Chinese culture. The General Secretary of the Supreme Leader pointed out that it is necessary to promote the creative transformation and innovative development of Chinese civilization, activate its vitality, and carry forward the cultural spirit that spans time and space, transcends the country, is full of eternal charm and has contemporary value. The General Secretary of the Supreme Leader emphasized that the exchange and mutual learning of civilizations should adhere to mutual respect, equal treatment, beauty and beauty, openness, tolerance, mutual learning and mutual learning, and innovation and development. We should strengthen exchanges and mutual learning among different countries, nationalities and cultures in the world. We should not only make our own civilization full of vitality, but also create conditions for the development of other countries’ civilizations, make the world’s civilized gardens flourish and consolidate the humanistic foundation for building a community of human destiny.

　　General Secretary of the Supreme Leader stressed that it is necessary to carry out various forms of people-to-people exchanges in depth and promote people-to-people exchanges between China and other countries through various channels. We should innovate institutional mechanisms and transform our institutional, organizational and human advantages into communication advantages. It is necessary to give full play to the role of high-level experts and make use of important international conference forums, foreign mainstream media and other platforms and channels to speak out. All localities and departments should give full play to their own characteristics and advantages to carry out their work and display a colorful and vivid three-dimensional image of China.

Always regard the completion of the primary political task and the most important political responsibility as the primary practical standard and fundamental yardstick to test the overall improvement of the efficiency of international communication.

　　We should profoundly grasp the background of the times when the Supreme Leader General Secretary proposed "comprehensively improving the efficiency of international communication".

　　The urgency of comprehensively improving the efficiency of international communication is unprecedented.

　　Today, the world is experiencing a great change that has never happened in a hundred years, and China is in a critical period to realize the great rejuvenation of the Chinese nation. With China approaching the center of the world stage, the relationship between China and the world has undergone profound changes. Contemporary China is no longer a passive recipient of the international order, but an active participant, builder and leader. The international community is more and more eager to understand the ever-developing China and the ever-changing interaction between China and the world. At the same time, in the international public opinion field, the media pattern of "strong in the west and weak in me" has not fundamentally changed, and there are still some problems in China, such as "I can’t tell the truth", "I can’t spread it" and "I can’t spread it". It is still a long way to go to tell the story of China, spread the voice of China and show the true, three-dimensional and comprehensive China.

　　Self-confidence in comprehensively improving the effectiveness of international communication is unprecedented.

　　General Secretary of the Supreme Leader stressed: "We have the ability to do a good job in China, but we have not been able to tell the story of China? We should have this confidence! " From the perspective of the international environment, "East Rising and West Falling" and "South Rising and North Falling" have become an irreversible trend of the world and the times. The important ideas put forward by the Supreme Leader General Secretary, such as promoting the building of a community of human destiny and the common values of all mankind, and jointly building the "Belt and Road Initiative", global development initiative, global security initiative and global civilization initiative, have firmly occupied the commanding heights of morality and won more and more understanding, recognition and support from the international community.

　　Judging from the development of China, since the founding of New China for more than 70 years, especially since the reform and opening up for more than 40 years, we have achieved a miracle of rapid economic development and long-term social stability that is rare in the world. Since the 18th National Congress of the Communist Party of China, under the strong leadership of the CPC Central Committee with the Supreme Leader as the core, the cause of the party and the country has made historic achievements and changes, and the great rejuvenation of the Chinese nation has a more perfect institutional guarantee, a more solid material foundation and a more active spiritual strength, which has laid a solid foundation for us to comprehensively improve the effectiveness of international communication. The pioneering of China Road, the miracle of China, the struggle of China people, China’s contribution to world development, and the successful code of Chinese modernization are all the most vivid, vivid, rich and authentic materials for us to tell the story of China.

　　The difficulty of doing a good job in the struggle for foreign public opinion is unprecedented

　　The United States and the West deliberately provoked economic and trade frictions, maliciously stigmatized the "source of the epidemic", discredited China on issues related to Taiwan, Hong Kong, Xinjiang, Tibet and human rights, and rudely interfered in China’s internal affairs. At present, as the Ukrainian crisis continues to ferment, it puts forward higher requirements for doing a good job in external communication. In the foreseeable future, the international competition in the field of public opinion will be more profound and intense. To improve the efficiency of international communication in an all-round way, there are not only exchanges and exchanges, but also "wars". We should not only be "gentlemen" who tell the story of China well, but also be "warriors" who dare to fight and are good at fighting.

　　It is our primary political task and most important political responsibility to report the Supreme Leader’s General Secretary and publicize and explain the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era. To build a respected international first-class newspaper, it is necessary to further enhance the "effect consciousness" and inject more positive energy into the international public opinion field. This positive energy is, first of all, the international spread of the thoughts and images of the Supreme Leader General Secretary.

　　How to judge the accomplishment of the primary political task? It is very important to look at the communication effect and test the position with the actual effect. We are not talking loudly, but telling the truth to people’s hearts, so that our works can land effectively overseas. We should keep our advantages and international vision, tell our positions and viewpoints in internationally understandable words, and turn Chinese expressions into expressions that are loved by international audiences. It is necessary to publicize and explain the report of the General Secretary of the Supreme Leader and the important thoughts of the General Secretary of the Supreme Leader, adhere to stability, accuracy, high quality and efficiency, spread positive views, innovate and optimize narrative strategies, create key in-depth columns, enrich product presentation forms, tell the story of the General Secretary of the Supreme Leader in a vivid, amiable and credible way, and expand the effectiveness of the external communication of the report of the General Secretary of the Supreme Leader.

　　This year marks the 10th anniversary of General Secretary Supreme Leader’s proposal to promote the concept of building a community of human destiny and jointly build the "Belt and Road Initiative". We should combine our advantages and characteristics, use our brains to make overall planning, carry out large-scale interview activities, make good use of creativity and good works, explain and display the important ideas and major initiatives put forward by General Secretary Supreme Leader, and better accomplish our primary political tasks with masterpieces.

Fully implement the important requirements of the Supreme Leader General Secretary on comprehensively improving the efficiency of international communication.

　　In the field of international communication, "efficiency" means the correctness of the purpose and means of using behavior and the advantage of the effect. To study the important exposition of the Supreme Leader’s General Secretary, we should unify knowledge with action, truly integrate knowledge with practice, turn the important thoughts of the Supreme Leader’s General Secretary into a powerful driving force to promote the work, and contribute to telling the story of China, spreading the voice of China and showing the true, three-dimensional and comprehensive China.

　　We must have a "targeted consciousness" and steadily carry out the international public opinion struggle.

　　General Secretary of the Supreme Leader pointed out that backwardness will lead to beatings, poverty will lead to starvation, and aphasia will lead to scolding. In the field of international public opinion, others have talked nonsense about some hot issues. If they are not clarified and corrected in time, they will be "speechless" and "aphasia" in the pattern of international public opinion, which will spread false information and affect China’s image and national interests. We should actively and steadily carry out the guidance of international public opinion and the public opinion struggle in the ideological field, so as to ensure that the support should be stable and the target should be accurate. In view of the false statements such as "China threat theory", "China collapse theory" and "China free rider theory", we should take the initiative to clarify China’s policy stance and opinions through various channels and ways, clarify vague understanding in time, vigorously refute wrong arguments, and seize the commanding heights of morality and public opinion. We should strengthen our sensitivity and discrimination, always keep a sober, calm and prudent attitude towards hot topics, fully study the topic background, and be brave and good at fighting. It is necessary to strengthen positive narration, pay attention to speaking through foreign media, collect and make good use of overseas media reports and international community responses, guide the international community to form a correct view of China and the view of the Communist Party of China, and better understand and recognize that "China’s development cannot be separated from the world, and world development also needs China".

　　It is necessary to give full play to the advantages of comments and exclusive reports, attack accurately, constantly hit the sensitive points, festering points and bleeding points of the other side, grasp the problem accurately, clarify the context, explain the truth thoroughly, and vigorously carry out public opinion struggles, so as to achieve clear themes, stable support, accurate targeting, fine selection of materials and good results. To carry out the international public opinion struggle, we should always pay attention to standing at the commanding heights of human morality, be good at turning encounters into active wars, grasp the core issues, accurately refute them, clarify the truth and make clear the truth, and at the same time do not expand the scope of attack, engage in personal attacks or engage in low-end scolding wars. In short, we must carry forward professionalism, improve our professional ability, identify the target and pain points, grasp the problem more accurately, make the context clearer and explain the truth more thoroughly, and we will certainly achieve good public opinion results.

　　We should have a sense of "rushing to the beach" and actively guide international public opinion.

　　"beach awareness" is to take the initiative to attack, seize the opportunity of international public opinion guidance, carry out more targeted and targeted effective communication, and not always be led by other people’s issues. It is necessary to stress "timeliness and effectiveness" and effectively enhance the attractiveness, appeal and influence of international communication work. Grasping the "time" is to grasp the favorable opportunity to speak out, release authoritative information at the first time, actively and carefully set up topics with clear views, strong directivity and easy communication, and truly achieve "preconceptions" and voice. Grasping the "degree" means grasping the measure, mastering the temperature, and analyzing and controlling the density and intensity of sound according to the specific situation. For example, in response to the negative reports, attacks and slanders of some foreign media, it is necessary to be tit-for-tat, argue with reason, and be strategic and beneficial. Some issues can be ignored so as not to be led by foreign media; For another example, when promoting achievements, we should pay attention to the sense of occasion and proper limit, and not overdo it. We should not only talk about our development achievements, but also talk about the difficulties and problems we need to solve, so as to guide the international community to look at the development stage of China comprehensively and objectively. Grasping the "effect" is to be effect-oriented, to follow the law of communication and to emphasize the art of communication, to be both principled and flexible, and to organically combine what we want to say with what foreign audiences want to hear.Really let foreign audiences understand and listen.

　　To take the initiative to attack and actively "seize the beach", we must dare to plan independently and take the initiative to go deep into the front-line interview. Practice has proved that it is an important link in the guidance of international public opinion to prepare for the topic in advance. Think of what others think and fight a prepared battle, so as to be calm and win the initiative.

　　We should have "audience awareness", adhere to "one country, one policy", and carry out accurate agenda setting and effective communication with words, logic and forms close to foreign audiences.

　　There are cultural differences between different countries and nationalities, so we should adapt to local cultural traditions, acceptance habits and audience needs, and create high-quality products close to the local area with distinctive characteristics. "A key opens a lock", from the content point of view, it is necessary to grasp the concerns of audiences in different countries and regions, locate news products and communication targets more accurately, and produce and push accurate reports according to their concerns; It is necessary to grasp the doubts of audiences in different countries and regions, make targeted reports according to their questions, not only deconstruct the narrative framework of anti-China forces in the West, but also actively clarify their positions and solve doubts and doubts; We should grasp the empathy of audiences from different countries and regions, and show the spiritual outlook of Chinese people and the true image of China with empathy. For example, the concept of promoting the building of a community of human destiny and the common values of all mankind put forward by the Supreme Leader General Secretary has aroused the emotional resonance of people of all countries and laid a solid foundation for us to gather people’s hearts and gather their popularity. From the mechanism point of view, it is necessary to implement the localization strategy in depth, encourage the establishment of overseas localization production centers, communication centers and promotion centers, try to advance all aspects of work such as topic planning, production, communication and promotion, go deep into the cultural context of foreign audiences, understand their values, ways of thinking and discourse styles, and adopt more targeted, differentiated and personalized communication strategies.

　　The so-called "accuracy" means to adjust and optimize the topic setting, communication content, narrative method and expression form accordingly. For example, when spreading to "elites" such as foreign political and business circles, we should pay attention to the commonality and compatibility between China’s excellent traditional values and the common values of mankind, seek common ground while reserving differences, and constantly enhance their understanding and understanding of China’s political system and development mode; When spreading to the ordinary people and other "mass layers", the form needs to be more diverse and flexible, and the content should highlight the viewpoint and individuality, so as to spread China culture and China image in a scientific, innovative and international way.

　　We should have a "frontier consciousness", give full play to the important role of new media and new technologies, and strive to promote all-round innovation in concepts, contents, means, systems and mechanisms.

　　General Secretary of the Supreme Leader stressed: "We should grasp the trend of mobility, socialization and visualization in the field of international communication". With the rapid development of Internet and modern communication technology, the domestic and international media structure, public opinion ecology and audience have undergone profound changes, and the Internet has become an important battlefield for big countries to compete for the right to speak and influence the cognitive field. It is necessary to continuously promote, establish and operate foreign language websites and clients for overseas audiences in different countries, languages and regions, increase originality, improve content supply capacity, and continuously consolidate and expand the main positions and resource banks for Internet publicity. It is necessary to expand the guidance of public opinion by "going to sea by boat and climbing by ladder", operate media accounts according to the actual conditions of different countries, and attract foreign audiences through high-quality lightweight, visual videos, pictures, tables, etc., humanized network language and rich and diverse expressions.

　　Recently, new breakthroughs in artificial intelligence at home and abroad are constantly impacting the media industry. The media should have "crisis awareness" about the impact caused by the development of new technologies. On the one hand, we should be fully prepared to meet the challenges, on the other hand, we should see "organic in danger", make full use of the achievements of the information revolution, and promote the in-depth development of media integration. Explore the application of artificial intelligence in news gathering, production, distribution, reception and feedback, control the "algorithm" with mainstream value orientation, and achieve solid results in building a "full-process, holographic, full-staff and full-effect" media pattern.

　　We should have "brand awareness" and strive to build a good media think tank.

　　Building a media think tank is an active choice to explore and launch professional, in-depth and authoritative information products in the face of profound changes in the media structure, and it is also an innovative practice to exert social benefits and promote international communication. To build a media think tank into a well-known brand in the industry, we should not only have professional research and consulting functions, but also devote ourselves to building an open knowledge dissemination platform, and extend the media functions from simple information dissemination to public opinion judgment, public opinion collection, intellectual supply and value transmission, so as to continuously improve media capabilities and increase innovative communication value in the new era.

　　To enhance "brand power", we must have talent support. It is necessary to make good use of the factors of making full use of people, strive to forge an excellent team of media-melting talents, and explore the construction of an innovative, compound, applied and leading "four-type" team of international media-melting talents. The key to media competition is talent competition, and the core of media advantage is talent advantage. Career development depends on the support of wave after wave of talents. We should make more efforts in talent support, so that every media person can give full play to his potential, advantages and functions.

　　From the 30th collective study in 19th the Political Bureau of the Central Committee, which first proposed "improving the efficiency of international communication in an all-round way", to the party’s Report to the 20th CPC National Congress, which emphasized "forming an international discourse right that matches China’s comprehensive national strength and international status", General Secretary of the Supreme Leader put the overall improvement of the efficiency of international communication in a very important position. For doing a good job in international communication, this means a new mission and new opportunities. Whether we can seize the opportunity and overcome difficulties will determine the quality of our high-quality development. The general requirement of carrying out the education on Socialism with Chinese characteristics Thought in the new era of the Supreme Leader is to "learn ideas, strengthen party spirit, emphasize practice and make new contributions". We should implement the study and investigation in the tasks assigned by the 20th National Congress of the Communist Party of China, so as to promote the new achievements of high-quality development and test the achievements of theme education.

　　(The writer is deputy editor-in-chief and senior editor of People’s Daily. This article is compiled by the author’s exchange speech when he participated in the theme education seminar of the party branch he contacted)

Snow leopard family of four (data picture).

　　According to the average distribution density of snow leopards in China is 1 to 3 per 100 square kilometers, this is a large-scale snow leopard population found in a small area.

　　Sichuan will launch a field survey of snow leopards in Hengduan Mountain, which will take three years to find out the distribution and population status of snow leopards in the region.

　　According to the investigation results, targeted protection actions will be carried out to realize the increase of wild population.

　　On November 4 -5, at the first Hengduan Mountain Snow Leopard Protection Action Seminar held in Dujiangyan City, Wolong National Nature Reserve released a message saying that at least 26 snow leopards have "settled" on the 132 square kilometers of land in the reserve.

　　Experts attending the seminar agreed that according to the average distribution density of snow leopards in China of 1 to 3 per 100 square kilometers, this is a large-scale snow leopard population found in a small area, and the distribution density of wild snow leopards in Wolong ranks first in the country.

　　Participants also released the Wolong Snow Leopard Declaration. According to the Declaration, starting from this year, Sichuan will launch a field survey of snow leopards in Hengduan Mountain, which will take three years to preliminarily find out the distribution and population status of snow leopards in the region. At the same time, according to the survey results, targeted protection actions will be carried out to realize the increase of wild populations. In addition, the "Declaration" also proposes to strengthen the red line control of snow leopards and further improve the protection system of snow leopards.

　　In June this year, the field researchers of Wolong Nature Reserve conducted grid control with infrared cameras in an area of 132 square kilometers with an altitude of 4,000-5,700 meters, covering five snow leopard habitats and potential habitats, which was the largest snow leopard monitoring ever carried out in Wolong. The data collection shows that there are 47 infrared camera spots to capture Snow Leopard, and the total time to capture Snow Leopard video is 36 minutes.

　　Among the videos collected this time, there is a video and several photos, which record a warm picture of a family of four snow leopards. In the video, a mother snow leopard with three cubs moves around in the snow-covered bare rock zone. Judging from their size, the snow leopard cubs are not yet one year old, and they are rolling around behind their mother’s ass, which is embarrassing. According to experts, judging from the current known situation, the food chain of snow leopard in Wolong National Nature Reserve is sufficient, and its habitat is well protected, so it is natural for snow leopard families to "travel collectively".

　　In Sichuan, snow leopards are mainly distributed in Qionglai Mountain, Daxueshan Mountain, Minshan Mountain and Western Sichuan, covering 10 nature reserves, including Anzi River, Heishui River, Fengtongzhai, Siguniang Mountain, Caopo, miyaluo, Gongga Mountain, Wang Lang, Xuebaoding and Gexigou.

　　interlinkage

　　Will snow leopards pose a threat to giant pandas?

　　Wolong is the concentrated distribution area of snow leopards and the home of giant pandas. Will snow leopards and giant pandas meet in the wild? Will fierce snow leopards pose a threat to giant pandas?

　　"No." When the reporter threw this question to Shi Xiaogang, the stationmaster of Mujiangping Protection Station in Wolong National Nature Reserve, he responded categorically: the two cannot be touched at all. Taking Wolong as an example, the activity area of snow leopard is above 3500 meters above sea level, while the activity area of wild giant panda is mainly below 3200 meters above sea level.

　　The relevant person in charge of the Wild Protection Department of the Provincial Forestry Department confirmed that at present, no conflict cases between snow leopards and wild populations of giant pandas have been found in Sichuan.

　　Having dealt with snow leopards for many years, Shi Xiaogang said that the staple food of snow leopards in Sichuan is basically the same as that in other parts of the country, and herbivores such as Himalayan marmots and rock sheep are delicious in their mouths. But giant pandas are not among them. (Reporter Wang Chengdong)

　　On the afternoon of April 22nd, the 2023 China Online Media Forum "All Media Communication Shaping the New Pattern of Mainstream Public Opinion" was successfully held in Nanjing, Jiangsu Province, under the guidance of the Network Communication Bureau of the Central Network Information Office, sponsored by CCTV, the general radio and television station, and hosted by Tik Tok. The guests at the meeting revolved around "keeping integrity and innovation, enhancing the guidance of public opinion ‘ Four forces ’ " Themes such as "integration and intercommunication, building an all-media communication system" and "positive youth and positive energy" will explore ways to promote the in-depth development of media integration, further build mainstream public opinion positions, strengthen mainstream value guidance, and shape a new pattern of mainstream public opinion. Yu Lan, Deputy Editor-in-Chief of China News Service and President of China News Network, delivered a keynote speech at the forum, "Deepening the Three Fields and Building a New Pattern of Mainstream Public Opinion in Internal and External Publicity Linkage".

Yu Lan, deputy editor-in-chief of China News Agency and president of China News Network, delivered a keynote speech at the forum.

　　Report to the 20th CPC National Congress of the Communist Party of China put forward "strengthening the construction of all-media communication system and shaping a new pattern of mainstream public opinion", which put forward new requirements for mainstream media to accelerate media integration and expand mainstream public opinion. Yu Lan said that with the rapid development of media technology and fierce international public opinion struggle, the boundaries between communicators and audiences, internal publicity and external publicity are becoming increasingly blurred. At the same time, under the "anti-China paranoia", the public opinion offensive of infiltration and differentiation between the United States and the West has intensified, and the Internet has become the main position and the forefront of exchanges and confrontation.

　　Yu Lan introduced that, as a central key news website featuring external publicity, in recent years, China News Network has made great efforts to open up online and offline, internal publicity and external publicity resources and channels through network construction, so as to improve its communication efficiency.

　　The first is to leverage the characteristic groups to aggregate the domestic civil public opinion field. Under the all-media environment, the main body of communication is showing the characteristics of differentiation, popularization and personalization. How to gather public opinion and tell the story of China well? Yu Lan introduced that in recent years, China News Network, combining its own resources, focused on tapping the communication potential among non-party people, the new class, Generation Z, Hong Kong, Macao and Taiwan and other characteristic groups.

　　In 2022, on the eve of the 20th National Congress of the Communist Party of China, China News Network planned to launch a series of feature films entitled "Rejuvenation of Non-Party People’s Words". The column focuses on 35 representatives from various fields, starting from "Our Ten Years", telling what they witnessed in China’s new era and Chinese modernization, from the experience of "I" to the change of "we" and then to the change of "times" in the first person, step by step, evoking collective memory and emotional resonance. Their stories outline the image of China in the new era, show the cohesion and centripetal force of China society, and enhance the overseas visibility of three-dimensional China.

　　The second is to unite the "overseas China" public opinion field with the help of overseas Chinese. Yu Lan said that overseas Chinese, Chinese media and other "overseas China" groups are a natural bridge for China to communicate with the world. China News Agency and China News Network always regard this group as an important starting point for amplifying the voice of China and shaping mainstream public opinion.

　　Last year, on the eve of the Beijing Winter Olympics, western public opinion wantonly created a public opinion momentum to boycott the Beijing Winter Olympics. On the eve of the opening of the Winter Olympics, China News Network planned to launch the "24 Hours of Winter Olympics" global live broadcast, with overseas Chinese all over the world as the fulcrum, and fully mobilized overseas network resources to participate in the live broadcast interaction. At the same time, more than 100 Chinese media in more than 40 countries and regions around the world were linked to broadcast live on TV, website and new media account matrix. Thousands of accounts around the world participated in the live broadcast, and the reading volume of the whole platform exceeded 800 million in 24 hours.

　　The third is to leverage the key minority and skillfully enter the international mainstream public opinion field. "Communication, in the final analysis, is doing ‘ People ’ Work hard for ‘ Human heart ’ Whether the work can reach the hearts of the people and win the hearts of the people is the key to success. " Yu Lan introduced that since October 2021, Zhongxin.com has launched "East-West Question • China-foreign dialogue "column, around the hot topics, invited Chinese and foreign celebrities to have a dialogue, and retranslated China’s ideas by overseas famous mouths.

　　Yu Lan said that this column insisted on promoting cultural exchanges between China and foreign countries. On major issues, it invited international opinion leaders in related fields to talk and exchange in time to enhance communication and understanding. After participating in the dialogue, many foreign guests took the initiative to convey China’s voice on overseas social platforms and explain the real China. The mainstream western media also frequently quoted and reprinted relevant reports.

　　Yu Lan said that under the current international public opinion pattern, the more external forces create barriers, the more we should give full play to the role of the Internet, improve communication efficiency as much as possible, and expand mainstream public opinion. At the same time, we must also recognize that the Internet is a double-edged sword. Even if "everyone has a microphone" under the algorithmic blockade and the digital divide, it will not necessarily bring true discourse equality and inclusive understanding. "We must unite all forces that can be United and mobilize all positive factors that can be mobilized. In the process of adapting to changes and seeking changes, we must strengthen the construction of an all-media communication system and shape a new pattern of mainstream public opinion."