Beijing time on March 28th news, according to foreign media reports, "Dune 2" global box office exceeded 500 million US dollars, and currently accumulated 580 million US dollars, including 237 million US dollars in North America.
Dune 2′ s global box office has already surpassed the 434 million of Dune 1 (the streaming media was launched simultaneously), and it has also become the first movie with a global box office of over 500 million dollars after Wonka. Both films are starring Timothée Chalamet. Wonka has accumulated 629 million US dollars worldwide, and Dune 2 is expected to reach 750 million.
This film continues Paul Cui Di’s journey to the desert after his meeting with freeman people. Timothée Chalamet, Zendaya, Rebecca Ferguson, josh brolin, javier bardem, Dave Batista, Stran Scarsgaard, etc. have returned to play, and newly joined Austin Butler, Florence Pew, Christopher Walken, Leia Saidu, Sohra Jacob, Tim Blake Nelson, etc. Denis villeneuve returned to direct the screenwriter, and Hans Zimmer scored the music.
The space epic science fiction film Dune was released in 2021. Eric Ross, Jon Spaihts and Villeneuve jointly wrote the script. The plot was adapted from the first half of Frank Herbert’s 1965 English science fiction novel Dune of the same name, which is the first of two adaptation films. It tells that Paul UrCui Di, a young heir from a noble family, shoulders the responsibility of protecting the most precious assets and the most important elements in the galaxy.
Dune premiered at the 78th Venice Film Festival on September 3rd, 2021, and landed in North America and streaming media HBO Max on October 22nd. It was well received for its visual effects, worldview and ambition, and earned a global box office of $396 million at a cost of $165 million. The film was selected as one of the top ten films in 2021 by the American National Critics Association and the top ten films of the year by the American Film Institute, and won six awards at the 94th Academy Awards.
1905 movie network news The coldest crime film was released nationwide on November 17th. This excellent word-of-mouth work, which was written and directed by the cutting-edge director Dong Yue and starring Duan Long and Jiang Yiyan, has won many praises from audiences inside and outside the industry since its release. Some viewers commented that "the crime is the shell, the times are the meat, the human heart is the core, and 1997, a crazy little person, is black and absurd", and the media even praised "The blizzard is coming, which shows us the rich aspects of crime, and the crime is just an introduction. What it really wants to discuss is the rupture of social ties and the distortion of human nature in the transitional period".
In addition to the profound story, the cool pictures and excellent production of the film throughout have also captured the hearts of a large number of fans. The winter in a small town with continuous ice and rain, the approaching snowstorm, the people in a small town who once lived quietly and the upcoming reform trend, all these intentions, under the control of photography and art by Dong Yue, a director who started as a photographer, have created a unified visual style — — There are almost no bright color pictures and cold and disordered steel structures, and the implementation of the idea of "the devil has his own harvest" has also turned into a continuous rain. Among them, what impressed the audience the most was a 6-minute chase scene from the steel factory to the railway tracks. It was commented that "only fighting in the rain is worth the ticket price", "The chase scene was absolutely filmed, and the industrial level was online all the time", "The panoramic empty mirrors of the factory and the tube-shaped building and the factory chase scene were really amazing".
This 6-minute chase took place in the first half of the film. Guowei Yu, the security chief played by Duan Long, used his own "fishing" technique to post photos of the crime scene at the gate of the factory, which attracted the attention of the murderer. With his apprentice Xiao Liu, Guowei Yu started this thrilling road of chasing the murderer. From the factory gate, to the tall steel boilers and mechanical transmission beams, and then to the transport rails washed by heavy rain, Guowei Yu approached the murderer several times, but he escaped several times. One of the most breathtaking scenes is that Guowei Yu was caught off guard by the murderer who jumped off the top of the train, and then he strangled him with a chain. After Guowei Yu tried his best to break free, the murderer escaped again. After that, Guowei Yu never saw the murderer again. The only gain was that the murderer left a "labor shoes", but his apprentice Xiao Liu was killed because he fell to the steel frame in the process.
As can be seen from the split-shot script of the film, this 6-minute chase after the murderer has condensed the efforts of this professional film team. When talking about this scene, director Dong Yue said, "At that time, Guowei Yu’s apprentice Xiao Liu fell from a height, and all our scene plans were rejected. But when I happened to see the scenery of the iron stairs, I thought it was too cool, so I temporarily changed it to here. The texture of this steel bar is perfect for shooting crime films. " The story background of "Blizzard is Coming" originally happened in the southern industrial town around the steel factory, which was full of the "cold" steel structure of the whole film, creating a special "coldest" temperament for the film. In this 6-minute chase, except for a red flame in the steel boiler, there is no warm color in the picture, and black gloom occupies the whole picture. Coupled with the excellent atmosphere soundtrack, the industrial decadent voice mixes electronic sounds, and the emotions conveyed by the film are pushed to the extreme.
In the rainstorm chase, another amazing thing is Duan Long’s "immersion" acting. The footage was about 6 minutes long, but it took 8 days to shoot. In these eight days, Duan Long acted in the rain every day, so she suffered from neurocystitis and had a fever. There was an ambulance on the set at any time. In this regard, Duan Long said, "As an actor acting with his own body, the cold rain can’t open his eyes, that’s right. It is necessary to follow this natural physiological reaction and run on such a bumpy road. It is this strange environment and this crazy energy that let me know that I am an old man, not an old man! " Persevering eyes when chasing a murderer, blushing face when being strangled by a chain, and muscular strength when struggling desperately, Duan Long, a "play demon", broke out with powerful acting skills, which made the new Tokyo-winning actor a well-deserved spokesperson.
In such a winter, because of its "cold", "Blizzard is coming" is destined to be a special film and an unforgettable film. In the eyes of the audience who understand it, Blizzard Coming is a "strong imprint of the times and a stylized director’s work". "The whole film is creating a low-pressure atmosphere of storms and laid-off tides, and individual memories are ruthlessly crushed, pointing the murderer at the whole frustrated and depressed era." In the latest list of "icons" released by the authoritative film WeChat official account Iris, "Blizzard is Coming" ranks 5th among domestic films in 2017. After being praised by many professional film critics and filmmakers, I hope that more ordinary audiences will not be scared away by this "cold" and go into the cinema to understand and feel the 1997 -2008 years that passed in the film and feel the "blizzard is coming".
The coldest crime film, Blizzard is Coming, was written and directed by Dong Yue, a cutting-edge director, and produced by Cao Baoping, a crime film master who joined hands with the film industry, starring Duan Long and Jiang Yiyan. At present, the film is being shown nationwide.
CCTV News:Since April this year, the General Administration of Customs has launched a special campaign to promote cross-border trade facilitation in 2023 in 12 provinces (autonomous regions and municipalities) and 17 port cities across the country. The reporter learned from the briefing held by the General Administration of Customs yesterday (August 31) that all localities have actively combined with the actual situation and introduced supporting measures to create a first-class business environment and achieved remarkable results.
The General Administration of Customs and the National Development and Reform Commission and other five ministries and commissions jointly launched 19 reform and innovation measures in five aspects, focusing on local development demands and concerns of enterprises. The digital transformation of "smart ports" has continued to deepen, the "single window" of international trade has realized information sharing and business linkage between departments, and measures such as "direct delivery by ship" for imported goods, "direct loading at port" and "linkage loading and unloading" for exported goods have reached a scale level, such as "one big form" for cross-border customs clearance in Guangdong-Hong Kong-Macao Greater Bay Area, this year; In July, 64,000 bills of lading and 52.89 million pieces of goods were declared.
Through the innovation of supervision mode, multi-local customs promote the upgrading of foreign trade industry and promote the sustainable development of new formats. For example, Shenzhen implemented the "air express line" for imported chilled aquatic products, Shanghai, Beijing and other places improved the "white list" mechanism for biomedical R&D drugs, and Ningbo pioneered the supervision mode of cross-border e-commerce export pre-warehouse.
Domestic and foreign trade goods are transported on the same ship in many places, which promotes the development of "double cycle" at home and abroad. The coastal ports along the Yangtze River and the Yangtze River Delta realize "joint unloading", and each TEU saves logistics costs. 100 yuan — 400 yuan. Chongqing opened the "Shanghai-Chongqing Express Line", which shortened the processing time of water transport transit procedures by more than 90%. Qingdao opened the "Central Asia through train", reaching 54 cities in 23 countries along the SCO and the Belt and Road Initiative.
Since the beginning of this year, all localities and relevant departments have continued to promote the publicity system of the list of port charges and dynamically updated it, realizing no charges outside the list.
According to preliminary statistics, this year 1-mdash; In July, Ningbo, Shanghai, Shenzhen and other coastal ports have achieved a directional reduction of the pilotage (berthing) expenses of international navigation ships by about 150 million yuan.
Cctv newsAt 8 o’clock every day, CCTV will sort out the big and small things that happened around us within 24 hours.
The Central Committee of the Communist Party of China the State Council sent a congratulatory message to the China sports delegation of the 16th Paralympic Games.
The Overall Plan for the Construction of Hengqin Guangdong-Macao Deep Cooperation Zone was released, and Guangdong Provincial Governor and Macao Chief Executive jointly served as the directors of Hengqin Guangdong-Macao Deep Cooperation Zone.
Feedback was completed during the seventh round of inspections by the 19th Central Committee, and the risks of integrity in school-run enterprises and other fields were more prominent.
Vaccination in COVID-19 has exceeded 2.1 billion doses nationwide, and the plan of strengthening replanting with the third dose of Sinopharm has been submitted for approval.
The State Council inspection team made an unannounced visit: Shizuishan in Ningxia is now the "exclusive agent" for safety and liability insurance, and the emergency department is suspected of monopoly.
Xiamen plans to set up an exemption list for more than 50 minor illegal acts such as mobile vendors occupying the road.
The yield per mu of Yuan Longping Super Rice Mengzi Base has exceeded 1,100 kg for four consecutive years.
Brazil found cases of mad cow disease and suspended beef exports to China.
Afghan refugees bask in the US military base: only a few pieces of chicken and fruit have to wait 12 hours for the next meal.
IUCN: More than 38,000 species are threatened with extinction.
Flat support for 9 hours, 30 minutes and 1 second! A man in Australia broke the world record of flat support.
A pickup truck fell into a ravine in Taihu County, Anhui Province, killing 12 people and injuring 2 others.
A woman died in Sichuan after being vaccinated with COVID-19 vaccine. Officially, the woman went to see a doctor because of abnormal liver function. After the doctor injected the drug, the patient died after suffering from symptoms such as loss of consciousness and cardiac arrest. The incident has nothing to do with vaccination.
Online celebrity officially apologizes for bread pastoral: it exceeded the standard because gluten was added to the formula. Previously, WeChat official account, the official WeChat of Shanghai Consumer Protection Committee, issued two articles saying that many nutritional components of pastoral were inconsistent with the actual measurement.
The military training performance of freshmen in Guang ‘an No.1 Middle School in Sichuan was held in the rain, and the school leaders were not absent. The school responded: Because parents wanted to see the results of military training, they insisted on finishing the performance. The school tried to shorten the time as much as possible, and the school canteen also prepared ginger soup. At present, no students have been unwell.
A cinema in Wuzhou City, Guangxi Zhuang Autonomous Region was fined 5000 yuan for misleading consumers to buy 3D glasses by misleading propaganda.
Plastic brotherhood! A man in Bozhou, Anhui Province was reported drunk by a drinking friend at the same table, and his driver’s license was revoked, and he could not obtain a driver’s license for 5 years.
Like it! The 9-year-old girl invited around 200 sanitation workers, disabled people and lonely old people to have a love breakfast on her birthday: helping others is really happy.
Respect is the best gift.
— — Beijing Evening News commented that "Shenzhen No.1 Middle School Scholars Committee mobilized all classes to buy gifts for Teacher’s Day"
On September 4th, the staff displayed the digital RMB "hard wallet" at the booth of China Bank in the exhibition area of the National Convention Center.
Hainan gibbon, an extremely endangered species, likes to add two babies.
Xing Yifan, a freshman with gradual freezing disease weighing 18kg, reported to Beihang University: 645 points in the college entrance examination, determined to be "Hawking" in China.
Author: Ni Wan, vice president, professor and doctoral supervisor, School of Journalism and Communication, Shandong University
Since the party’s symposium on news and public opinion work was held in 2016, marked by a series of important speeches by the Supreme Leader General Secretary, our understanding of news and public opinion work has entered a new stage. At present, the ecology of public opinion, the pattern of media and the mode of communication have undergone profound changes, and the work of news public opinion is facing new challenges. In 2020, the epidemic in COVID-19 made us deeply realize the importance of the news and public opinion front. At the deployment meeting of coordinating the prevention and control of epidemic situation and economic and social development in COVID-19, the General Secretary of the Supreme Leader particularly emphasized that it is necessary to "improve the effectiveness of news and public opinion work", which is also the inevitable path for China to realize the modernization of national governance capacity in the field of public opinion. In the all-media era, the whole process of news gathering, production, distribution, reception and feedback has undergone tremendous changes. Generally speaking, improving the effectiveness of news public opinion work should meet ten basic requirements.
One of the requirements: effectively judge the information environment.
In the era of all-media, new features have emerged in China’s information environment. First, in terms of international information environment, western media, represented by the United States, still have a monopoly position in the international public opinion field, and they do everything they can to strengthen the leading position of information technology and stabilize the monopoly of information field. Second, in terms of social and ideological environment, it is facing a great change that has never happened in a hundred years. The ecology of public opinion and the ideological situation of the public in China are more complicated and changeable, and the collision of ideas is more intense. There are different social ideological trends behind it, and capital forces representing different positions are involved in different degrees. At the same time, with the in-depth application of emerging media, the opinions of netizens show a typical trend of group polarization. Thirdly, in the aspect of media application environment, media application shows the core characteristics of socialization, mobility, intelligence and data, media content presents the mainstream expression of audio-visual, and media forms converge into a platform operation mode.
To effectively judge the international information environment, we must fully understand the ideological struggle behind the information environment and the long-term and difficult struggle for international discourse power; To effectively judge the social ideological environment, we must fully understand the characteristics and influence of the changes in China’s social ideological trend in the new era, and lay an ideological and cognitive foundation for the modernization of the national governance system and governance capacity; To effectively judge the media application environment, it is necessary to have a deep understanding and control of the ecology of information content production and dissemination under the background of high-speed iteration of media technology.
Requirement 2: Grasp the communication opportunity effectively.
Time effect is the yardstick to test the work level of news public opinion. Whether it is theme propaganda, typical propaganda, achievement propaganda, or emergency reporting, hot spot guidance, and public opinion supervision, we must focus on time and efficiency and reflect the requirements of time and efficiency.
First, effectively grasp the opportunity from the law of news and public opinion communication. Grasping the opportunity is an inevitable requirement to follow the law of news public opinion dissemination, which depends on the different attributes of different events: some need to speak out immediately and be tit for tat; Some need to release public opinion and gradually guide; Some need to plan as a whole and move at the right time.
The second is to effectively use the opportunity from the operation law of the communication platform. From a global perspective, a diversified head platform matrix with obvious advantages has been formed, and the operating characteristics of each head platform are different, forming different communication characteristics and laws. The systematic use of cross-platform communication chain is an important guarantee for effectively grasping the communication opportunity.
The third is to effectively grasp the opportunity from the time law of user behavior. As far as the media resources used by all kinds of users are concerned, there are significant differences in the distribution of usage time, duration and type among different user groups, and at the same time, it also shows obvious regularity. Grasping the law of users’ use time is the practical basis for effectively grasping the communication opportunity.
The third requirement: effectively plan communication strategies.
How to plan the communication strategy effectively? We should seize the opportunity, grasp the rhythm, pay attention to strategies, be good at setting topics, and let the hot heat up and the cold cool down through the continuous supply of high-quality content.
First, the timing is accurate and the information is true. In the era of all-media, the network information from major media platforms is complex and has strong communication, but the content is inevitably biased and difficult to trace and verify. On the one hand, news media workers are required to pay more attention to the timeliness, authenticity and accuracy of information dissemination; on the other hand, higher requirements are put forward for the construction of the guiding force of new mainstream media: we should not only grasp the communication opportunity, but also always uphold the principle that authenticity is the life of news.
The second is to reflect the overall situation and grasp the rhythm. "What to report, what not to report, what to publicize more and what to publicize less must proceed from the overall situation and reflect the requirements of the overall situation." In the dialectical relationship between quantitative change and qualitative change, we should set topics, grasp the rhythm, and stress the systematic and effective balance between national reports and local reports, first reports and follow-up reports, news reports and in-depth reports.
The third is to enrich the content and respond to concerns. For the principles and policies of the party and the government and the issues that the people are concerned about, we should not stop at the simple presentation of information, but fully consider the people’s understanding ability and concern when formulating communication strategies, and fully interpret the major policies and specific policies of the party and the government.
Requirement 4: Effectively construct internal and external relations.
From the perspective of organizational communication, building a new mainstream media and shaping an all-media communication system requires the effective construction of a coordinated internal relationship among all components within the organization and a benign interaction with the external environment, which is the organizational guarantee for improving the effectiveness of news and public opinion work.
In terms of internal relations construction, the new mainstream media, as a special social organization, adheres to the party’s leadership over news and public opinion work, which is the premise for the operation of this news and public opinion organization. In specific work links, it is necessary to have an effective internal work coordination operation mechanism, an effective upper and lower communication management control mechanism, and an effective emergency management decision-making mechanism.
In terms of the construction of external relations, the media, as an integral part of the social system, is bound to face the problem of dealing with the external environment. Specifically, it is necessary to effectively coordinate the relationship with party and government organs, enterprises and institutions, social organizations, the general public and other media.
As General Secretary of the Supreme Leader requested, "We should establish the concept of propaganda, mobilize all fronts and departments to do it together, and more closely integrate propaganda and ideological work with administrative management, industry management and social management in various fields." The coordination of internal and external relations is the basis for completing this requirement.
Requirement 5: Effective production of media content
Under the background of all media, we should adhere to the advanced technology as the support and content construction as the foundation, and implement the requirements of the Supreme Leader General Secretary "to build a socialist ideology with strong cohesion and leading force, so that all the people can be closely United in ideals, beliefs, values and moral concepts".
Facing the new development situation at home and abroad, the effective production of media content should be presented strategically on the basis of implementing the "four self-confidences". For content production, we should be especially good at expressing, and the profound truth should impress and convince people by telling stories.
In terms of domestic communication, keeping integrity and innovation is the core of telling a good story. Keeping the right is to consolidate the foundation and cultivate the yuan, and always keep the direction, position, root vein and bottom line; Innovation means pioneering and innovating, and solving new problems with new ideas, ideas, methods and means. This requires news media workers to change their style of writing, bend down, calm down, examine the truth, tell the truth, move the truth, and strive to create works with thought, temperature and quality.
In terms of international communication, storytelling is the best way of international communication. We should make great efforts to strengthen the construction of international communication ability, including building a foreign discourse system and consolidating the semantic foundation of telling China’s story; Integrate new concepts, new categories and new expressions at home and abroad to lay a pragmatic foundation for telling China’s story well; Promote media integration, create key media for external publicity, and build a channel foundation for telling the story of China, so as to accelerate the promotion of the international influence of China’s discourse, so that the whole world can hear and hear China’s voice clearly.
Requirement 6: Effective use of communication skills.
In order to make the policy of giving priority to positive publicity achieve good results, we must effectively improve communication skills. A condescending, empty and tasteless news report with blunt language and rigid form can’t really touch people’s hearts, even if the content is no matter how good. Good ideas, concepts and contents should be expressed through vivid forms and various means in order to achieve the best publicity effect. It is necessary to adopt more popular forms, constantly enhance the vividness and visibility of news propaganda, and strive to improve the quality and level of news propaganda.
First, under the requirements of the in-depth development of media integration, with the help of the opportunity of all-media development, we should give full play to the advantages and characteristics of emerging media such as "two micro and one shake", various news clients, websites and forums.
Second, news, summary, sidelights, editorials, comments, charts, diagrams, short videos, H5, cartoons and other forms should be comprehensively used to enrich news language and creative skills.
The third is to improve interactivity, especially to innovate discourse forms and enhance the user stickiness of new mainstream media while ensuring positive publicity, so as to enhance the publicity effect.
The fourth is to be good at creating and exploring hot spots, while not blindly chasing hot spots. We should not only pay attention to the hot spots that netizens pay attention to, but also keep the seriousness, accuracy and politics of mainstream media.
Requirement 7: Effectively analyze user data.
With the continuous development of media technologies such as 5G, big data, cloud computing, Internet of Things, artificial intelligence, etc., mobile media with socialization, intelligence and data as the main line has entered an accelerated development stage. From audience to netizens to users, every individual on the Internet can be accurately digitally portrayed.
Effective user data analysis is of great practical significance to the development of news public opinion work. By analyzing the data, we can not only know user attributes, user preferences and user influence, but also modify the communication strategies of media organizations according to the analysis results, and predict user behavior and guard against a series of ideological risks.
In recent years, domestic journalism has paid more and more attention to the measurement and use of user data. The data analysis function of byte system platform can capture real-time hot spots and predict possible hot spots in the future based on massive behavior data and article data of user groups, and provide data analysis of hot events for media organizations. It does not collect news in the real sense, but through the capture and analysis of data such as user attributes and reading behaviors, it re-integrates and finds users’ concerns in the massive content published on the platform, so as to reproduce news.
Requirement 8: Effectively distribute accurate information.
At present, cross-platform and intelligent information distribution mechanism is gradually taking the lead. First, multi-platform linkage communication: under the trend of platformization, the same news event and the same content material are distributed on different media platforms after processing, resulting in linkage resonance effect. Second, intelligent distribution: personalized content push led by algorithms has become the mainstream of news distribution, especially artificial intelligence technology including robot writing is changing all aspects of news topic planning, information collection, content generation and product distribution, leading to increasingly blurred boundaries between news production, distribution and consumption.
Accurate distribution of information is not only a problem of technology and market, but also a guidance and control problem that needs to be effectively solved in news and public opinion work. Therefore, the General Secretary of the Supreme Leader specifically pointed out that "it is necessary to explore the application of artificial intelligence in news gathering, production, distribution, reception and feedback, and comprehensively improve the ability of public opinion guidance" and control the "algorithm" with mainstream value orientation.
Requirement 9: Effectively evaluate the communication effect.
For news opinion workers, the pursuit of effect and actual effect should be the starting point and the end result of public opinion guidance, so as to effectively enhance the ability of public opinion guidance.
The evaluation of communication effect plays an important role in improving the effectiveness of news public opinion work. Its premise is to judge from the ideological level whether the news and public opinion work has adhered to guiding people with correct public opinion, and that all work is conducive to upholding the Communist Party of China (CPC)’s leadership and China’s socialist system, promoting reform and development, enhancing the unity of people of all ethnic groups throughout the country, and maintaining social harmony and stability. From a practical point of view, on the one hand, an effective evaluation of communication effect should be able to directly reflect the concrete results of news public opinion work at home and abroad, society and individuals, organizations and groups from three overlapping dimensions of cognition, attitude and behavior; On the other hand, through the evaluation of communication effect, we can effectively sum up the experience and lessons of news public opinion work and better guide future work.
Requirement 10: effectively shape the ecology of public opinion
To effectively improve the communication, guidance, influence and credibility of news public opinion is to effectively shape a good public opinion ecology.
First, there must be a scientific top-level design. It is necessary to adapt to the trend of differentiated communication and accelerate the construction of a new pattern of public opinion guidance. Since the 18th National Congress of the Communist Party of China, the central government has rearranged the ecological pattern of public opinion in China from a strategic perspective, and now it has achieved remarkable results.
Second, we must grasp the relationship between online and offline. Nowadays, more and more people are used to expressing their demands and opinions through the Internet. The General Secretary of the Supreme Leader stressed that it is necessary to "respond to social concerns, especially the concentrated demands of the masses in a timely manner, not avoid contradictions, and actively promote problem solving", and listen carefully to well-intentioned criticisms, opinions and suggestions. To do a good job in online public opinion monitoring, we should accurately grasp and effectively respond to people’s concerns and demands expressed through the Internet, properly solve the problems reflected as soon as possible, and realize the benign interaction between online and offline.
Third, we must run on the track of the rule of law. Effective news public opinion work should not only stimulate positive energy and promote truth, goodness and beauty in the whole society, but also resolutely crack down on malicious spreading of false information and creating panic, so as to ensure that a good public opinion ecology runs on the track of the rule of law.
Visualization of Original Ugly Sister’s Patent Analysis
Dogs are our friends and family members. As dogs get older, many dogs will develop tumors like people. At present, domestic pet hospitals can provide very few treatment schemes for pet tumors, only surgery and chemotherapy, and radiotherapy for small animals is still prohibited in our country.
In recent years, there have been many breakthroughs in the treatment of human tumors, such as PD-1, CAR-T cell immunotherapy, etc. These methods have shown good therapeutic effects on tumors, and some can even be completely cured.
Therefore, when the dog who has been with us for more than ten years is old and has a tumor, and it can’t be operated and the chemotherapy effect is not good, of course we can’t just give up. Try to find out whether there is a tumor immunotherapy program suitable for dogs, inhibit tumors, let them live with cancer, and be happy and healthy to accompany us for a few more years.
Today, this article introduces the current scheme that can be used for pet tumor treatment by analyzing related patents.
PART 1 retrieval strategy
Technical scope of patent search: This search is mainly aimed at the technology of tumor immunotherapy involving pets. Therefore, the key words include: dog, cat, pet, cancer and tumor, and the IPC classification numbers involved are C12N (bio-related) and A61K or A61P (drug-related).
Geographical scope of patent search: the current search is to provide domestic pet owners with a treatment plan in China, and the technical feasibility in places too far away like the United States and Europe is not high. Therefore, the applicant’s address is limited to Chinese mainland and Japan (considering that Japan’s medical technology is developed and close to us, many Chinese patients go to Japan for treatment of cancer).
Manual reading and screening: after the number of patent documents is limited to the range that can be read manually through the above retrieval, manual reading is started to screen useful information. The basic requirement of the standard of artificial screening is to make it clear that it can be used for tumor treatment in dogs, and more preferably, it can give experimental data in the examples to confirm that it does have anti-tumor effect in dogs.
PART 2 analysis results
Through analysis, the treatment schemes that can be tried in domestic tumor immunotherapy for pets are sorted out as follows:
1. Beijing Weijiexin Biotechnology Co., Ltd
CN110590959A, recombinant canine PD-1 fusion protein, its preparation method and application, filed on September 19, 2019.
This patent application provides a recombinant canine PD-1 fusion protein, and in its example, it shows that this treatment scheme has been used in pet cats and dogs. It should be the second half of 2019 in a pet hospital in Beijing for clinical trials.
Therapeutic effect: The overall objective remission rate is 20%-30%.
The inventor of this patent application, Dr. Luo Haoshu, is an associate professor and master/doctoral supervisor of the School of Biology, China Agricultural University.
2. Beijing Conoco Fu Biotechnology Co., Ltd.
WO2019149039A1, an anti-tumor protein composition and its application, filed on January 9, 2019.
The patent application relates to an anti-tumor method using cytokine fusion protein, which comprises an anti-tumor composition, including proteins IL12, GMCSF and IL2, and achieves the technical effect of good inhibition on tumors at all stages and slight adverse reactions.
This cytokine fusion protein is a broad-spectrum anti-tumor drug. The protein anti-tumor drug is directly injected into the tumor to adjust the immune environment inside the tumor and realize the inhibition of the tumor. Experiments on sarcoma, oral melanoma and breast cancer in dogs and cats have been done in the examples, and the data show that most tumors have been suppressed, even shrunk and subsided.
Further search found that Conoco Clothing Company and the inventor of this patent, Zhang Jinyu, also applied for two other patents and published a paper in The Lancet’s sub-journal EBioMedicine. Although these two patents and journals did not explicitly say that they were used to treat Wang Wang tumor, their technical contents were very relevant to this application:
WO2018184484A1, cytokine combination, with the earliest priority date of April 6, 2017, relates to a cytokine combination, which comprises at least three cytokines, and the cytokines are selected from the following groups: IL12, GMCSF, FLT3L, IL2, IL15 and IL21；;
WO2020024922A1, protein heterodimer and its use, the earliest priority date is July 30, 2018, and it relates to a protein heterodimer, which comprises a first polypeptide chain and a second polypeptide chain, wherein the first polypeptide chain comprises IL12a and a first factor fused with IL12a, and the second polypeptide chain comprises IL12b and a second factor fused with IL12b, and the first factor and the second factor are selected from IL2 and GMCSF.
The paper "In Situ Administration of Cytokine Combinations Induces Tumour Regression in Mice" also involves the treatment of tumors with IL-12+GMCSF+IL-2.
Through reading the above patents, Xiao Bian understands that they use the cytokine composition to treat tumors (WO2018184484A1), then use protein heterodimer (WO2020024922A1) to make these cytokines into a cytokine fusion protein, and then use this cytokine fusion protein to treat tumors (WO2019149039A1), and treat tumors in dogs.
The applicant should think that this technology is more important and has better effect, so all the applications are PCT patent applications. Because they have been applied in recent two years, they have not seen the published texts of other countries.
3. Japan Quanyao Industry Co., Ltd.
Japan Quanyao Industrial Co., Ltd. has two patent applications in pet tumor immunotherapy.
Patent application 1: cn110603056a, a method for inhibiting the infiltration of regulatory T cells based on CCR4 blockade and a method for treating tumor diseases in dogs, filed on April 26th, 2018.
Patent application 2: wo2016006241a1, anti-canine -PD-1 antibody or anti-canine-PD-L1 antibody. The earliest priority date is July 9, 2014. This patent has been granted in Europe, Japan and the United States.
Founded in 1946, Japan Quanyao Industry Co., Ltd. is a research and development enterprise engaged in animal medicines. Its current animal drugs include some conventional veterinary drugs, such as anti-inflammatory, analgesic, fever-reducing, anthelmintic and so on.
However, judging from the above two patents, Japanese Quanyao should be engaged in the research and development of animal antitumor drugs. I continue to check the inventors of these two patents. They are not researchers of Quanyao in Japan, but researchers of Tokyo University and Yamaguchi University in Japan. This shows that Quanyao Industrial Co., Ltd. is cooperating with Japanese universities to develop animal antitumor drugs.
Continuing to search with the inventors of the above two patent applications, I found two Japanese scientific research institutions specializing in the treatment and research of Wang Wang tumor.
4. Laboratory of Veterinary Clinical Pathology, University of Tokyo, Japan
CN110603056A, a method for inhibiting the infiltration of regulatory T cells based on CCR4 blockade and a method for treating tumor diseases in dogs, by former Tian Zhen Wu.
The patent application relates to a pharmaceutical composition for treating canine tumors, which contains a compound that blocks the combination of canine CCL17 and canine CCR4 as an active ingredient. The pharmaceutical composition is a broad-spectrum antineoplastic agent, and can be used for treating transitional epithelial carcinoma, prostate cancer, breast cancer, malignant melanoma, squamous cell carcinoma and lung adenocarcinoma.
Before treatment, it is necessary to analyze the Treg (Regulatory T Cell) infiltration analysis in the tumor tissue of dogs and confirm the CCR4 expression in the tumor infiltration Treg. (Xiao Bian’s understanding: First of all, we should do pathological examination to see if the tumor of the dog has Treg infiltration and CCR4 expression. If so, the treatment with the pharmaceutical composition of this application may be effective. Just like treatment with PD-1, tumor cells need to express PD-1. Xiaobian is not in the biological field, please pat it if it is wrong)
Then, in the example of this patent application, the therapeutic effect data of pet dogs are given, which proves that the anti-CCR4 antibody (Mojiamuzumab) in this patent application is an effective therapeutic drug with less side effects on various tumors in dogs.
The inventor of this patent application is former Tian Zhen Wu of the Veterinary Clinical Pathology Laboratory of the University of Tokyo.
This Maeda teacher should be a very caring and enthusiastic person, and even found his personal website, which specifically introduces his veterinary clinical pathology laboratory at the University of Tokyo.
Moreover, their laboratory is currently recruiting clinical evaluation of anti-regulatory T cells (CLEAR), which is the anti-Treg treatment scheme related to the above patent.
The recruitment copy says:
がんをぅたちのためにののををぅぅさにのの12357
For Wang Wang who has cancer, for the shovel officer who thinks of his beloved Wang Wang, and for those who have cancer, it will be a great honor if this project can make a little contribution.
I hope this project can be successful and I can come to China in the future to give Wang Wang, who has cancer, more hope.
5. Laboratory of Veterinary Molecular Diagnosis and Therapy, Faculty of Common Veterinary Medicine, Yamaguchi University, Japan
WO2016006241A1, anti-canine -PD-1 antibody or anti-canine-PD-L1 antibody, inventor: Nobuya Mizuno.
This patent has been authorized in Europe, Japan and the United States. His inventor, Takuya Mizuno, is also a professor in the Laboratory of Veterinary Molecular Diagnosis and Therapy, Faculty of Common Veterinary Medicine, Yamaguchi University, Japan.
The research currently being carried out in the Laboratory of Veterinary Molecular Diagnostics and Therapeutics, where Professor Mizuno Toyo is located, includes:
Wang Wang oncolytic virus therapy, a kind of therapy that specifically infects cancer and destroys cancer cells. It has been proved that it can kill cancer cells in dogs to fight against various cancers.
Wang Wang PD-1 antibody drugs, including therapeutic methods for immunomodulation purposes, such as molecular suppression of immune checkpoints, and cytotoxic antibodies using antibodies against cancer cell surface molecules. This technology should be the PD-1 technology that was searched above and developed in cooperation with Japan Quanyao.
Wang Wang CAR-T immune cell therapy, which uses immune cells collected from dogs with cancer to prepare genetically modified immune cell CAR-T cells in vitro, is a very popular research direction of tumor treatment at present.
CN109452229A, preparation method and application of canine PD-1 genetically modified animal model, filed on November 19th, 2018.
The patent application provides an sgRNA capable of specifically targeting Pd-1 gene, a canine-derived animal model of PD-1 gene, a method for preparing an sgRNA vector of the canine-derived animal model, a preparation method of the canine-derived animal model and related applications, and a genetically modified canine-derived mouse is prepared, which can normally express PD-1 protein containing the functional domain of the canine PD-1 protein. The example of this patent provides relevant experimental data on tumor inhibition in mice, but there is no relevant patent on clinical experimental data of tumor in dogs.
Beijing Baiao Saitu Gene Biotechnology Co., Ltd. is a gene biotechnology company located in Daxing, Beijing, and its management team is all doctors in the field of biomedicine. At present, 84 patents have been applied, most of which are related to humanized genetic modification technology. This company mainly develops human antibody drugs, and only the above patent involves PD-1 in dogs.
It is also found in the Eye of the Sky that Beijing Baiao Saitu has registered a Maple Leaf Pet Hospital (Beijing) Co., Ltd. in March this year, and it should start to enter the field of immunotherapy for pet tumors. But I haven’t seen them start business yet. I hope to get up and start business quickly and give the dogs more hope.
7. Beijing Xinuogu Biotechnology Co., Ltd.
CN110194799A, an anti-canine PD-1 antibody that binds to canine PD-1, filed on Jun. 3, 2019.
The patent relates to an anti-canine PD-1 antibody and a preparation method thereof, and the canine PD-1 antibody can be combined with canine PD-1 for application in drugs for treating canine cancer. The patent only discloses the experimental data of mice, but there is no clinical experimental data of dogs.
Xiao Bian has an impression on Sinovalley Biotechnology Company because they specialize in cloning cats and dogs, cloning 380,000 dogs.
Summary of analysis results of PART 3
At present, there are not many options to treat small animal tumors in China. After analysis, it is found that the following three are more reliable in terms of technical strength and experimental effect:
The cytokine fusion protein of Beijing Conoco Fu Biotechnology Co., Ltd. has been used in more than 300 cases of pets, most of which have achieved the effect of inhibiting tumor growth, and some of them have been completely relieved, and it is a broad-spectrum anti-tumor drug that can be tried;
Beijing Baiao Saitu Gene Biotechnology Co., Ltd., with strong technical strength, has 84 patent applications. It hopes to be used as a human medicine and also for the treatment of Wang Wang tumor. From the perspective of patent technology, it mainly involves PD-1 antibody, and their Maple Leaf Pet Hospital has just been established. It is expected that it will not start clinical trials for dogs until September this year, which is also a treatment plan worth looking forward to.
Japan Quanyao Industrial Co., Ltd., and its two scientific research institutions, the Laboratory of Veterinary Clinical Pathology of Tokyo University and the Laboratory of Veterinary Molecular Diagnosis and Therapeutics of the Faculty of Veterinary Medicine of Yamaguchi University, have entered the clinical trial stage. One is a regulatory T cell infiltration inhibition method based on CCR4 blockade, and the other is PD-1, which should be reliable, but it is not convenient to be applied in China at present, and it is recommended to Japanese shovel officials.
PART 4 Application of Patent Analysis Results
Ugly sister wanted to do this research because my ugly sister had been sneezing and running nose since the end of last year. At first, she thought it was rhinitis, but she didn’t get better after treatment for a long time. As a result, she went to the hospital for CT at the beginning of March this year and was highly suspected of being a nasal tumor.
An ugly younger sister with a runny nose when she sleeps.
The doctor said that if you have an operation, you should open your head, and it will recur soon. Ugly sister is 16 years old and can’t bear such a big operation. Chemotherapy is not effective for nasal cavity tumors. People who get nasal cavity tumors are usually treated with radiotherapy, but there is no place to treat small animals with radiotherapy in China at present.
Don’t you just let the tumor grow up? Now there are so many new methods for the treatment of human tumors, and our ugly sister can give it a try.
How can I know where I can give my dog tumor immunotherapy? So Ugly Sister analyzed all the patents about immunotherapy of dog tumors at present and found the above companies that are doing research in this field. After so many years of patent analysis, I finally feel useful.
Then, according to our actual situation, we can select the treatment options.
First of all, it is not convenient to go to Japan, so we ruled out two scientific research institutions in Japan first, but we are still looking forward to the related drugs of Japan Quanyao Industrial Co., Ltd. to achieve good results and successfully pass clinical trials.
Secondly, because the ugly sister is 16 years old, the ugly mother’s request is not to do any examination that requires general anesthesia, that is, not to do CT (dogs need general anesthesia when doing CT) and not to do pathological examination (because the tumor is in the nasal cavity, if you want to do pathological examination, you need to take samples with nasal endoscope under general anesthesia). Without biopsy, we don’t know what kind of tumor it is, and we don’t know if PD-1 is expressed.
So, in the end, we chose the cytokine fusion protein of Conoco. Because Conoco’s mature treatment plan is to inject drugs directly into the tumor, but our ugly sister’s nasal cavity tumor is in a bad position, so if she wants to inject it, she must be under general anesthesia, and ugly mother doesn’t agree. So we tried a new anti-tumor drug from Conoco Clothing Company, which was treated by intravenous injection, so that there was no need for anesthesia. So we ugly became the first Wang Wang in Chengdu to try this therapy.
On March 29th, Ugly Mommy took Ugly to the hospital to take venous blood, and the staff of Conoco Service Company took the blood sample away and sent it to their company’s laboratory. Then send it back after an operation in the laboratory.
On April 5th, Ugly received the first intravenous treatment.
Ugly receives the first treatment.
After treatment, I thought I would have a fever, but I didn’t have a fever at all.
I was going to have a second treatment the next week. As a result, just two days before preparing for the second treatment, Ugly suddenly had stomach cramps, pulled blood and vomited. The doctor diagnosed it as upper gastrointestinal bleeding, and quickly treated it. It took several days to stop bleeding and stop vomiting.
Because Ugly Ugly had digestive tract problems ten days before treatment, we don’t know whether this sudden upper gastrointestinal bleeding was caused by the poor digestive tract, the side effects of treatment, or the presence of lesions in the digestive tract.
However, Ugly Mom was afraid that Ugly would bleed if she was treated again, so she didn’t want to give Ugly a second treatment. We also want to get it in shape first.
Then Ugly Mom atomizes Ugly three times a day, and then drops some eye drops to stimulate it, so that it can sneeze hard to beat out the secretions inside.
Zhong Ugly does atomization three times a day.
On May 15, more than a month after the treatment, one day Ugly sneezed and sneezed a lot of secretions.
Ugly sneezing secretions from the nose.
Ugly mom said that the whole dog looks happier since it hit such a big lump, and it has to grind its teeth, which means that its nose doesn’t hurt.
On May 21st, I sneezed again and produced a lot of secretions.
Ugly sneezing secretions from the nose.
Then ugly mom said that ugly’s left nostril was open, and two points of water vapor could be seen when atomizing. In the past, the left nostril was blocked because of a tumor.
When atomizing, you can see the water vapor produced by the exhalation of two nostrils.
Now Ugly Ugly has completely stopped sneezing and running nose, and the previous symptoms have completely disappeared.
The staff of Conoco Clothing told us that it was a course of treatment for three times, but Ugly Mom saw the effect after the first treatment, and she was afraid that she would have stomach bleeding again, so she was hesitant to do it again.
Because ugly mom doesn’t want to take ugly to do CT, so we don’t know what the effect of tumor treatment is this time, just consider it effective. Ugly sister boldly guessed that the tumor might have shrunk, the nostril passage became larger, and all the secretions deposited in it were typed out, and then it was easy.
In a word, under the careful care of Ugly Mommy, the symptoms of Ugly Nose are gone now, and my mental state is good. Besides being clumsy when I am old, I can occasionally fight.
Ugly just celebrated her 17th birthday a few days ago. I hope she will always be healthy and happy.
postscript
Thanks for the technical support given by Lihua, Youhe and Teacher Mao, the small partners in the biological field, during the search for related patents; I would also like to thank Zhan Xing and Xin Rui for helping to contact the inventors. Thanks to the scientists and staff of Conoco Service, we can live a healthy life now.
Writing this article, I hope I can give you some information. If your master has a tumor, don’t give up. It would be a great honor if this article could make a little contribution.
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Original title: How to Save Your Dog’s Life with Patent Analysis
He learned from a famous family and led the team to study the preparation and application technology of chlorine dioxide, breaking the technological monopoly of multinational companies;
Based on production, he proposed a talent training mode combining innovation and entrepreneurship education with "production-learning-research" to train practical talents in the industry.
[Profile]
Nie Shuangxi, male, Han nationality, born in November 1985 in Huanggang, Hubei Province, is an associate professor, doctoral supervisor and young academic leader in light industry technology and engineering. Leading the team to overcome difficulties in clean pulping and high-value utilization of biomass, the developed chlorine dioxide preparation and bleaching technology has been successfully applied to large paper enterprises at home and abroad, which has promoted the leap-forward development of clean bleaching technology in China’s paper industry.
▲ Nie Shuangxi, Associate Professor, College of Light Industry and Food Engineering, Guangxi University
As we all know, papermaking in four great inventions of ancient china has provided a good carrier for the spread of world culture, and the development of the world is still inseparable from the great contribution made by the papermaking industry. Therefore, papermaking technology has always been regarded as one of the important representatives of China culture.
However, at present, all countries in the world are facing more or less environmental protection problems, and China has also put forward the important slogan of "green life". Therefore, at present and in the future, the development goal of China’s paper industry is not limited to the quality of paper, but more importantly, how to further promote its green and healthy development. In recent years, China has made great achievements in this field, and there are also many enterprises and experts who have made great contributions in Guangxi. Among them, Nie Shuangxi, a high-level talent introduced from Guangxi University, is included.
Love comes from the hard work of the day after tomorrow.
Nie Shuangxi’s love for papermaking was discovered when he was studying under Professor Wang Shuangfei at the university and often soaked in the laboratory.
In 2006, Nie Shuangxi took the college entrance examination. Like many ordinary middle school students, he doesn’t have a clear plan for his future, and he doesn’t even know his hobbies. When he volunteered for the college entrance examination, he chose the major of light chemical engineering in Guangxi University. He believes that light chemical products have become an indispensable material for all relevant departments of the national economy and a necessity for people’s daily life, and the work prospect of this major should be good.
After entering the university as he wished, Nie Shuangxi discovered that this major is actually all-encompassing, involving pulp and paper, fine chemicals, light industry and environmental protection. In his professional study, he often had to do various chemical experiments, from which he found pleasure. It was at this time that he found that his interest was more inclined to chemistry. In the light chemical engineering, papermaking, a traditional industry with a long history in China, has attracted him a lot. In this way, he made clear the direction of his future efforts and chose to deepen the paper industry.
However, with the enhancement of people’s awareness of environmental protection, and paperless operation has gradually moved from concept to practical application, many people think that paper will gradually withdraw from the historical stage and the paper industry will gradually decline. Of course, some people are bearish and some people are optimistic. Nie Shuangxi believes that the reason why the public is not optimistic is because the paper in their eyes is often limited to writing paper. In fact, in addition to the increasing consumption of household paper, the multi-application scenarios of special paper have also opened up a new direction for the development of the paper industry, and the overall development trend of the industry is still improving. Facts have proved that Nie Shuangxi’s judgment was correct. According to the survey data of China Paper Association, the national paper and paperboard production in 2019 was 107.65 million tons, an increase of 3.16% over the previous year. The consumption was 107.04 million tons, up by 2.54% over the previous year. According to the statistics of the National Bureau of Statistics, the main business income of 2524 papermaking enterprises from January to December 2019 was 765 billion. In 2019, the average annual growth rate of production and consumption of household paper was 5.51% and 5.65% respectively.
▲ Nie Shuangxi (former) conducted analysis and research on pulp fiber characteristics during co-cultivation in Limerick Pulp and Paper Research Center, Canada.
In 2010, after graduating from college, Nie Shuangxi chose to continue to study with Teacher Wang Shuangfei, specializing in clean pulping and papermaking. After graduating from Ph.D., he worked in the front line of teaching and scientific research and made outstanding contributions to the development of disciplines and the promotion of technological progress in the industry. He participated in the research project "Key Technologies and Applications of Typical Wastewater Recycling and Ultra-low Emission in Papermaking and Fermentation" and won the second prize of National Science and Technology Progress Award in 2016; As a key member, he completed the scientific research project "Large-scale chlorine dioxide preparation system and key technology and application of chlorine-free bleaching of pulp", which won the second prize of Guangxi Science and Technology Progress Award in 2017, the first prize of Technology Invention Award of Ministry of Education in 2018 and the second prize of National Technology Invention Award in 2019.
Every gratifying achievement is made by pouring sweat. Looking back now, Nie Shuangxi’s deepest and most memorable memories are always the time spent in the laboratory, the careful guidance of the tutor and the hands-on teaching of the scientific research predecessors … In order to realize clean pulping and papermaking, he enjoyed the laboratory at two o’clock in the morning and also saw the campus at four o’clock in the morning. The boring laboratory years have now become the best testimony of his growth and progress.
Breaking the technological monopoly of multinational corporations
The importing country jumped to become an exporting country.
The most interesting thing about Nie Shuangxi and his team is that they have made great breakthroughs in the preparation and application technology of chlorine dioxide, breaking the monopoly of foreign companies on China’s pulp bleaching chlorine dioxide preparation technology, making China jump from an importer of chlorine dioxide preparation technology to an exporter, and promoting the leap-forward development of clean bleaching technology in China’s paper industry.
When it comes to the paper industry, the public first thinks that it is often pollution. Indeed, in the past, domestic paper-making enterprises used the traditional chlorine-containing bleaching method to bleach pulp. These chlorine-containing bleaching agents are easy to form chlorinated hydrocarbons, chlorophenols, chloramines, etc., which are harmful to fish and human bodies, and will also pollute underground water sources and the environment, which is not conducive to environmental protection. This traditional practice was eliminated by developed countries in North America and Europe as early as 1990, and chlorine dioxide clean bleaching technology was used instead. Compared with chlorine-containing bleaching agents, chlorine dioxide not only has better bleaching performance, but also does not form harmful substances.
However, at that time, the preparation technology of chlorine dioxide was monopolized by several large companies in Sweden and Canada. If Chinese enterprises want to adopt this technology, they must import it in full. As a result, not only the purchase of equipment is expensive, but also the later maintenance cost is very high. For chlorine dioxide, there is a huge demand in the domestic market, but at the same time the technology faces shortcomings. Therefore, with the original intention of "solving the problem of backward technology and improving the level of clean papermaking", Nie Shuangxi’s R&D team focused on this and began to develop a new generation of chlorine dioxide preparation and bleaching technology.
▲ Nie Shuangxi participated in the research and development of "large-scale chlorine dioxide preparation system and key technology and application of chlorine-free bleaching of pulp" and won the second prize of National Technological Invention Award.
In 2010, the first chlorine dioxide preparation system developed by Nie Shuangxi’s team finally ran successfully. Once the products were put on the market, the sales were very hot, which not only broke the foreign technology monopoly, but also produced good economic benefits. "The level of our technology is basically the same as that of foreign countries, but the cost is only 1/4 to 1/3 of that of imports, so it is very competitive." Good products bring good reputation. Soon, foreign companies also heard the news. In 2013, the whole set of technology was successfully exported overseas. At present, it has been widely used in large paper enterprises in ASEAN countries such as Indonesia, India and Thailand, providing an economical and effective solution to the pollution problems brought by paper enterprises in various countries.
Youth guide Guangxi youth role model
Mencius said: "A gentleman has three pleasures … to be educated by the world’s talents, and the three pleasures are also." It is undoubtedly the greatest wish of every teacher to share his own knowledge and feelings, so that knowledge can produce greater value, and at the same time, to cultivate students into excellent pillars of the country.
Nie Shuangxi is not only a scientific research worker, but also a university teacher. His students include undergraduates, postgraduates and doctoral students. He has been tirelessly guiding students to correctly understand themselves, find their goals and move forward in a down-to-earth manner. He believes that the most important thing in teaching and educating people is to guide students to correct their attitude towards study and work and help them to establish a correct outlook on life. Nie Shuangxi admits that he is the beneficiary in this respect. During my college years, thanks to the guidance of my tutor and other teachers, I had a correct understanding of myself and found a clear direction for my efforts.
In 2015, Nie Shuangxi, who just turned 30, was hired as the head teacher of Class 151 of Light Industry and Food Engineering College of Guangxi University. Under his guidance and influence, many students in the class came to him and asked to do some research with him. Upon graduation, two undergraduate students directed by Nie Shuangxi published SCI papers as the first authors. Some students under the guidance of other teachers in the class have also published papers in international and domestic core journals. Such achievements are rare among undergraduate graduates.
Nietzsche once said, "A wise man will lose nothing as long as he can know himself." Although 360 lines make a champion, if we can have an open mind and better position ourselves, we can achieve twice the result with half the effort and will be more conducive to our success. Nie Shuangxi said: "I have always felt that there are no bad majors, only subjects that are not suitable for me. To learn a major well, the most important thing is to correct your learning attitude in the process of learning basic courses. Among them, it is inseparable from the guidance of teachers. "
After hard work, you will be lucky enough to be favored. Nie Shuangxi, who took part in the work, gained praise and glory year after year. He was selected as the first batch of training targets of the "Training Plan for 1,000 Young and Middle-aged Key Teachers in Guangxi Colleges and Universities" and the first batch of "Doctor’s Young Teachers’ Innovative Talent Training Award Plan". In 2016, he won the honorary title of "Double First-class" Construction Outstanding Contribution Award of Guangxi University. He was awarded the title of "Three Education Principles" advanced individual of Guangxi University in 2015-2017 academic year, "Excellent Head Teacher" of Guangxi University in 2016-2017 academic year, and "Excellent Communist party member" of Guangxi University in 2015-2019. In 2017, he won the third prize of Guangxi Higher Education Teaching Achievement Award, and in 2019, he won the annual "May 4th Guangxi Youth Model-Youth Guide".
In the teaching process, Nie Shuangxi put forward the training mode of engineering talents combining innovation and entrepreneurship education with "production-learning-research", emphasizing the research direction of solving problems according to the needs of industrial production, and guiding teaching accordingly. He gave full play to the leading role of the innovation and entrepreneurship competition, took the national innovation and entrepreneurship competition as the carrier, integrated education into the competition, and promoted the improvement of students’ professional quality. In the past five years, he has been undertaking the guidance of national innovation and entrepreneurship competitions such as "Challenge Cup", "internet plus" and "Creating Youth".
▲ Nie Shuangxi (first from the left in the front row) and the Nasai Science and Technology Team of Guangxi University that he set up and guided.
The "Nasai Science and Technology Team of Guangxi University" established and directed by Nie Shuangxi won the second prize at the provincial level in the Guangxi Youth Entrepreneurship and Innovation Competition in 2015; In 2016, he won the National Bronze Award in the 10th "Challenge Cup" National Undergraduate Entrepreneurship Plan Competition; In 2016, he was awarded the title of "Xiaoping Science and Technology Innovation Team for College Students" (selected once every two years, and only 50 teams/individuals in the country won the prize each time), and was invited to participate in the awarding ceremony of the "Tenth China Youth Science and Technology Innovation Award" held in the Great Hall of the People; In 2017, he won the National Bronze Award in the 3rd China "internet plus" Innovation and Entrepreneurship Competition, so he won the Outstanding Innovation and Entrepreneurship Tutor Award in the 3rd China "internet plus" Innovation and Entrepreneurship Competition in 2017.
▲ In 2016, "Nasai Science and Technology Team of Guangxi University" won the title of "Xiaoping Science and Technology Innovation Team for College Students" nationwide.
Nie Shuangxi believes that as a student, whether an undergraduate, a master’s student or a doctoral student, we should give priority to study and research, and concentrate on it. If you can’t settle down and concentrate on doing one thing well, then even if you do more, everything else will only have a shiny surface, and there is no real talent to help the world.
Photo: Popular Science Central Kitchen | Beijing Science and Technology News Ge Yubing
Original title: "Nie Shuangxi: Young Talents Committed to Whitening Paper"
Wang Dongwei, a Fujian businessman who has been doing business in Yichang for many years, was not only involved in the case of Guo Youming, the former vice governor of Hubei Province, but also took the initiative to expose and bring down two deputy mayors of Yichang City.
Wang Dongwei, 44, is the chairman of Hubei Huaxiang Investment Development Co., Ltd.. In addition to bribing Guo Youming 10.2 million yuan, he also paid bribes of 3.6 million yuan and 810,000 yuan to Wang Hongqiang and Zheng Xinghua, former vice mayors of Yichang.
Recently, "Hubei Huaxiang Investment Development Co., Ltd. and Wang Dongwei Unit Bribery First Instance criminal judgment" published by China Judgment Document Network disclosed the above case.
Criminal judgment, who made public the above-mentioned first trial, also showed that in order to seek illegal benefits for the company, Wang Dongwei used the company’s funds to pay bribes to the above-mentioned three state employees, with a total amount of 14.61 million yuan. On December 14th, 2016, Wang Dongwei was sentenced to three years’ imprisonment with a suspended sentence of five years.
The year before Wang Huawei’s verdict was pronounced in the first instance, Guo Youming’s bribery case was also pronounced in the first instance.
Guo Youming is on trial.
Xinhua News Agency previously reported that on December 9, 2015, Nanyang Intermediate People’s Court held a public hearing on the bribery case of Guo Youming, former vice governor of Hubei Province.
Nanyang Intermediate People’s Court found the defendant Guo Youming guilty of accepting bribes, sentenced him to 15 years’ imprisonment and confiscated his personal property of RMB 2 million. The property obtained from bribery crimes shall be recovered and turned over to the state treasury. Guo Youming said in court that he would obey the verdict.
The biggest briber in Guo Youming case
Earlier media reports said that Nanyang People’s Procuratorate accused the defendant Guo Youming of taking advantage of his position as deputy secretary of Yichang Municipal Committee of the Communist Party of China, mayor of Yichang Municipal People’s Government, secretary of Yichang Municipal Committee of the Communist Party of China, and deputy governor of Hubei Provincial People’s Government from 2001 to 2013, directly or indirectly through his wife Zhang, his son Guo, his brother Guo Youzi, and a special related person Xiao Mou to illegally accept property totaling RMB 23,808,331.
Guo Youming accepted RMB 1.314 million from Yu Chu Yun, Chairman of Yichang Three Gorges Hongming tourism real estate Development Co., Ltd.; Wang Dongwei, the chairman of Hubei Huaxiang Investment Development Co., Ltd., received a total of RMB 10,258,120; Received property from Yu Hongzhi, chairman of Yichang Fulianjiang Composite Materials Co., Ltd., and Ma Zheng, director of Yichang Fulianjiang Composite Materials Co., Ltd., equivalent to a total of RMB 9,236,211, including 1 million shares; Received RMB 3 million from Cai Hongzhu, Chairman of Hubei Daohuaxiang Group.
Among the above four allegations of bribery, Wang Dongwei, the chairman of Hubei Huaxiang Investment Development Co., Ltd., was the biggest briber in the Guo Youming case.
On November 27th, 2013, the website of the Supervision Department of the Central Commission for Discipline Inspection reported that Guo Youming, vice governor of Hubei Province, was suspected of serious violation of discipline and law and was under investigation.
Twenty days before Guo Youming’s fall, Wang Dongwei, the biggest briber, was taken away by the relevant case-handling department for investigation.
According to criminal judgment, the first trial of bribery of Hubei Huaxiang Investment Development Co., Ltd. and Wang Dongwei Company, the defendant Wang Dongwei, male, born on November 14, 1973, Han nationality, undergraduate, chairman of Hubei Huaxiang Investment Development Co., Ltd., and his domicile is Quanzhou, Fujian Province. On November 7, 2013, he was placed under residential surveillance by Xihua County Public Security Bureau, as decided by Zhoukou Municipal People’s Procuratorate. On April 30, 2014, he was released on bail pending trial upon the decision of Zhoukou Municipal People’s Procuratorate for allegedly committing bribery in the company.
Criminal judgment, the above-mentioned first-instance judge, also showed that from the first half of 2005 to the second half of 2012, the defendant Wang Dongwei, the chairman of Hubei Huaxiang Investment Development Co., Ltd., bribed Guo Youming, then mayor of Yichang, secretary of CPC Yichang Municipal Committee and vice governor of Hubei Province, 9 million yuan in cash for obtaining the right to use 57.88 mu of land belonging to Yichang Intermodal Company, returning the land transfer fee, obtaining loans from Yichang Rural Commercial Bank, and building supporting roads for Huaxiang Commercial Center.
Eight times to the vice governor’s brother 9 million.
Most of the money that Wang Dongwei paid bribes to Guo Youming was collected through his brother Guo Youzi.
Criminal judgment of the first instance showed that from July to August to November, 2012, the defendant Wang Dongwei paid a cash bribe of 9 million yuan to Guo Youming through Guo Youzi, the younger brother of Guo Youming.
In order to thank Guo Youming for his help in the Huaxiang Commercial Center project of Hubei Huaxiang Investment Development Co., Ltd., in July and August, 2012, Wang Dongwei, the chairman of the company, proposed to let Guo Youming introduce the construction enterprise for its Huaxiang Commercial Center project, thus delivering benefits to Guo Youming. Guo Youming then arranged for Guo Youzi to contact Wang Dongwei to handle this matter.
After the meeting, Wang Dongwei proposed to let Guo Youzi participate in the earthwork project, and to provide Guo Youzi with benefits of more than 8 million yuan by increasing the engineering quantity. Considering that there were too many links in the earthwork project, Guo Youzi disagreed, and later asked Wang Dongwei to provide him with cash directly on the grounds that he needed funds for his business.
Therefore, from July, August to November, 2012, Wang Dongwei gave Guo Youzi 9 million yuan in cash in eight times at the parking lot of Yidao Hotel in Yichang and under the Gezhouba Bridge. Hou Guo Youzi and Wang Dongwei informed Guo Youming of the situation respectively.
According to Wang Dongwei’s confession and defense, he went to Yichang to inspect the project in 2004 and got to know Guo Youming, then the mayor of Yichang. In 2010, he invited Dr. Zhang to the Junyao Hotel in Yichang to give Guo Youming a massage, and Guo Youming’s younger brother Guo Youzi also came for a massage, so he met Guo Youzi.
"In June and July of 2012, one day Wang Dongwei told me that he wanted to find some powerful construction enterprises with Chinese prefix to participate in the construction, and asked me to help him introduce a good construction team. I understand the meaning of his words. Obviously, I want to take the opportunity to give me benefits, because I have given Wang Dongwei great support and help in land acquisition, land transfer fee return and coordination of project promotion. " Witness Guo Youming testified that.
"Guo Youzi also called me and said that Wang Dongwei gave him 9 million agency fees. The so-called agency fee is an excuse for Wang Dongwei to send me money. I also know the construction. The agency fee can’t be so high. Wang Dongwei is obviously a benefit fee to thank me. " Guo Youming said in his testimony, "Guo Youzi only received this 9 million on my behalf, and I never thought about getting it back from Guo Youzi. I wanted to help Guo Youzi."
Before going abroad for inspection, please ask the vice governor and his wife to massage and send 200,000 US dollars.
In addition, Wang Dongwei also gave Guo Youming $200,000 through Guo Youming’s wife in the name of Guo Youming’s study abroad after the massage in Guo Youming.
Criminal judgment of the first instance showed that in October 2012, in order to thank Guo Youming for his help in the Huaxiang Commercial Center project of Hubei Huaxiang Investment Development Co., Ltd., Wang Dongwei paid Guo Youming a cash bribe of 200,000 US dollars at Junyao Hotel in Yichang.
"In October 2012, I heard from Guo Youming’s secretary that Guo Youming was going abroad for inspection, so he prepared $200,000 in cash in advance and put it in a tea box; After Dr. Zhang gave Guo Youming a massage, when Guo Youming and his wife left, they handed the tea box to Guo Youming’s wife Zhang. " Wang Dongwei’s confession and defense said.
According to Guo Youming’s testimony, Wang Dongwei paid for Dr. Zhang’s massage. One day in October 2012, after the massage treatment, Wang Dongwei handed his wife a handbag with a tea box. After two or three days, his wife told him that the tea box contained $200,000. It accepted by default, and this $200,000 was kept by his wife.
"One day in October 2012, Wang Dongwei asked Dr. Zhang to come to Yichang to give Guo Youming and me a massage treatment in the room of Junyao Jinjiang International Hotel. At that time, Wang Dongwei was also chatting with us in the room. After the massage treatment, when Guo Youming and I were about to leave, Wang Dongwei handed us a handbag and said,’ Take this to Governor Guo’. Guo Youming didn’t say anything at that time. I took the handbag and took it home. When I got home, I opened my handbag and found a tea box inside. The tea box contained $200,000 in cash, so I put the $200,000 away. After a few days, I told Guo Youming that there was $200,000 in the tea box that Wang Dongwei gave me that day. " The testimony of witness Guo Youming’s wife Zhang said.
Take the initiative to report down two deputy mayors.
Criminal judgment of the first trial also showed that it was also found out that Wang Dongwei used the unit’s funds to pay bribes to three state employees for illegal interests, totaling 16.38 million yuan. Truthfully confessed to bribing Guo Youming 10.2 million yuan many times; He voluntarily confessed that the amount of bribes paid to Wang Hongqiang and Zheng Xinghua was 5.37 million yuan and 810,000 yuan respectively. On November 25, 2016, the defendant Hubei Huaxiang Investment Development Co., Ltd. voluntarily paid a fine of 500,000 yuan.
The public prosecutor believes that Wang Dongwei’s ability to provide the case-handling organ with important clues about the suspected crimes of Wang Hongqiang (handled separately) and Zheng Xinghua (handled separately) is a meritorious service and should be punished in accordance with Article 68 of the Criminal Law of People’s Republic of China (PRC). Request to be sentenced according to law.
The court found through trial that from 2009 to 2012, the defendant Wang Dongwei gave Wang Hongqiang RMB 2 million (RMB 1,851,067.73 after tax deduction), US$ 20,000, HK$ 350,000 and a BMW X6 off-road vehicle (with a value of RMB 107,500) to help Wang Hongqiang (then deputy mayor of Yichang Municipal Government and deputy director of the Standing Committee of Yichang Municipal People’s Congress).
Among them, in the first half of 2009, Hubei Huaxiang Investment Development Co., Ltd. gave Wang Hongqiang a BMW X6 off-road vehicle, which was used by Wang Hongqiang’s son. Later, Wang Hongqiang reimbursed the company for 138,431 yuan.
The Paper (www.thepaper.cn) reporter noted that the court of first instance found that the amount of bribes paid by Wang Dongwei to Wang Hongqiang was about RMB 3.6 million, which was far from the amount of RMB 5.37 million voluntarily confessed by Wang Dongwei.
In addition, from 2008 to 2013, Wang Dongwei gave Zheng Xinghua 20,000 US dollars, 200,000 Hong Kong dollars and 3 gold bars (weighing 1,500 grams in total, valued at 519,601 yuan) in order to thank and continue to get the help from Zheng Xinghua (then Deputy Secretary-General of Yichang Municipal Government, Director of Yichang Municipal Bureau of Land and Resources and Deputy Mayor of Yichang Municipal Government) in obtaining the land use right and exempting the late payment fee.
The People’s Court of dancheng, Henan Province held that the defendant Hubei Huaxiang Investment Development Co., Ltd. paid bribes to state employees for illegitimate interests, and the circumstances were serious. The behavior of the defendant unit and its directly responsible supervisor, Wang Dongwei, has constituted the crime of bribery by the unit. The charges charged by the public prosecution agency were established.
Wang Dongwei, as the person in charge of the unit, voluntarily confessed the bribery of the unit to Wang Hongqiang and Zheng Xinghua. According to the provisions of the first and second paragraphs of Article 7 in the Interpretation of the Supreme People’s Court and the Supreme People’s Procuratorate on Several Issues Concerning the Specific Application of Laws in Handling Criminal Cases of Bribery: If the bribery case is solved by voluntarily confessing the bribery, the provisions of Article 68 of the Criminal Law on meritorious service are not applicable to the briber. Should be in accordance with the provisions of the second paragraph of Article 390 of the Criminal Law, can be given a lighter punishment. The directly responsible person shall also be given a lighter punishment.
On December 14, 2016, the People’s Court of dancheng City, Henan Province made a first-instance judgment, sentenced the defendant Hubei Huaxiang Investment Development Co., Ltd. to the crime of bribery, and fined 1 million yuan (after deducting 500,000 yuan that has been voluntarily paid, the remaining 500,000 yuan will be paid within 30 days after the judgment takes effect); Defendant Wang Dongwei was sentenced to three years’ imprisonment, suspended for five years, for the crime of unit bribery.
Some netizens left a message to see (import), and today it came. Next, let’s take a look with Xiaobian.
Let’s take a look at the appearance of the BMW i5 (imported). The design of the BMW i5 (imported) front is very simple and looks sporty. Coupled with the headlights of young personality, it has a great visual impact. The car is equipped with LED daytime running lights, automatic opening and closing, adaptive far and near light, automatic steering, delayed closing and so on. Coming to the car side, the car body size is 5060MM*1900MM*1505MM. The car adopts simple and fashionable lines, and the car side looks very clean. With large-sized thick-walled tires, the shape is quite simple. In terms of the rear end, the overall shape of the rear end echoes the front face, and the taillights look very sharp, creating a good gas field.
After getting into the car, the interior of BMW i5 (imported) looks cleaner and fresher, which enhances the sense of individuality. The steering wheel of the car is very in line with the interior style, equipped with electric up and down+front and rear adjustment, steering wheel memory, steering wheel heating and other functions, which looks a little more comfortable. From the central control point of view, the central control screen with 14.9-inch touch-sensitive LCD makes the interior style impressive and looks very calm. Let’s take a look at the dashboard and seats again. The car is equipped with a young dashboard, and the trendy design elements make people remember it at a glance. The car uses leather seats, which are wrapped in place and the overall comfort is acceptable.
BMW i5 (imported) matched gearbox, 442KW, 795N.m, with good power performance.
The car is equipped with car networking, driving mode selection, remote control key, UWB digital key, interior atmosphere light, traction control (ASR/TCS, etc.) and other configurations, which fully ensures the convenience and comfort of the car experience.
The model class introduced today is the most considered class when many people buy their first car, mainly because the size of this class is moderate and the price is reasonable. You can learn more about what you like!
On May 25th, Xu Xin, the attorney of Liu Dawei’s case, revealed that he had received a criminal ruling from the Supreme People’s Court and approved the retrial judgment of Fujian High Court on Liu Dawei’s case of seven years and three months’ imprisonment. In response to this result, lawyer Xu Xin said that the next step will be to communicate with Liu Dawei’s parents before considering whether to continue to appeal, and hope that Liu Dawei can apply for commutation and parole.
Online shopping for 24 simulation guns was sentenced to life.
Retrial was sentenced to 7 years and 3 months.
In July 2014, Liu Dawei, who just turned 18, spent more than 30,000 yuan to buy 24 simulation guns from a seller through online shopping, and the goods were seized by Fujian Customs in transit. On August 31, 2014, Liu Dawei was detained by Shishi Customs Anti-smuggling Branch, and was arrested on September 29 with the approval of Quanzhou People’s Procuratorate.
On April 30, 2015, Quanzhou Intermediate People’s Court of Fujian Province made a first-instance judgment, and Liu Dawei was convicted of smuggling weapons and sentenced to life imprisonment. Liu Dawei refused to accept the appeal. On August 25th, the Fujian Provincial High Court rejected the appeal and upheld the original judgment. Liu Dawei’s family then appealed for retrial and held a retrial in Zhangzhou Intermediate People’s Court of Fujian on August 10, 2018.
On the morning of December 25, 2018, Liu Dawei’s case of "online shopping for 24 simulation guns was sentenced to life" was retried in the Intermediate People’s Court of Zhangzhou City, Fujian Province. Liu Dawei was sentenced to 7 years and 3 months in prison for smuggling weapons.
So far, Liu Dawei has been detained for more than four and a half years.
Ten reasons for application are not approved.
Supreme law: retrial judgment and appropriate sentencing
Lawyer Xu Xin, Liu Dawei’s defender, once submitted an application to the Supreme Court for "requesting disapproval and revoking the retrial judgment of Liu Dawei’s case", which listed that it was against common sense to identify toy guns as weapons; The Reply of the Supreme People’s Court and the Supreme People’s Procuratorate on the Conviction and Sentencing of Criminal Cases Involving Compressed Gas-powered Firearms and Air Gun Lead Bullets should be applied, but it is not applied. The labels of physical evidence are inconsistent, and the identity cannot be guaranteed; Liu Dawei does not have the criminal intention of smuggling weapons; Ten reasons for the wrong application of the gun identification standard of 1.8 Joule/cm2 muzzle specific kinetic energy.
According to the criminal ruling of the Supreme Law, the court held that Liu Dawei violated customs regulations, evaded customs supervision, and bought 20 guns from Taiwan Province sellers to smuggle them into the country, which constituted the crime of smuggling weapons. Although Liu Dawei did not have a statutory mitigating circumstance, since he did not actually obtain the guns he bought, the guns involved did not flow into the society, which was less harmful to society, and the muzzle of the guns involved was smaller than the kinetic energy, with less injury force, and there was no evidence to prove that it was easy to improve the injury force through restructuring.
In addition, Liu Dawei was just 18 years old when he committed the crime. He was a first-time offender and other special circumstances, and he could be sentenced to a penalty below the statutory penalty. The retrial judgment of Fujian Higher People’s Court found that the facts were clear, the evidence was sufficient, the conviction was accurate and the sentence was appropriate.
After receiving the Supreme Court ruling, Xu Xin, Liu Dawei’s attorney, said that he would discuss with Liu Dawei and his family before deciding whether to continue his complaint.
In addition, Xu Xin hopes that the relevant departments can comprehensively consider, let Liu Dawei return to society as soon as possible, and release Liu Dawei on parole in accordance with the law. "His sentence has been more than half of seven years and three months, which is eligible for parole." Xu Wei said.
