[car home Professional Evaluation] The scene of getting Tesla Model Y is somewhat similar to that of two years ago. When the imported Model 3 just entered China, we also got the test car first at the beginning of the new year. Time flies, and we can’t catch it. In the past two years, Tesla’s sales and market value have doubled continuously. The gathering of attention also makes the arrival of Model Y more direct than that of Model 3. Therefore, in this article, you can not only see the measured product data, but also see the changes in Tesla products in details.

60 seconds to quickly understand the full text:

　　1. Under the test standard of car home EV AH-100, the high-speed endurance performance (90 2 km/h) of the 2021 Tesla China Model Y long-endurance all-wheel drive model (hereinafter referred to as Model Y) is as follows.356km; Urban low-speed endurance (30 2 km/h)387km;

　　2. The measured acceleration of the car at 0-100km/h is 5.06 seconds; 100-0km/h braking measured 37.89 meters;

　　At present, Tesla Model Y has only launched two models in China, the long-life version and the high-performance version. Our test car this time is2021 Tesla China Model Y long-life all-wheel drive model.. As for the performance of high-performance models, we will also bring you practical tests in the future.

● Endurance test

　　In this test, we used the latest version of car home EV AH-100 test standard, and made some adjustments in some test details and results display. If you want to know the adjustment details of the new test standard, please click here to read the interpretation article of the new standard.

○ Endurance test at low speed.

　　It should be noted in advance that the outdoor ambient temperature of Tesla Model Y is about -5℃ during the endurance test under high and low speed conditions, so this endurance test is a winter test, and the low temperature will have a negative impact on the endurance of pure electric vehicles.Before starting the endurance test at low speed, we fully charge the vehicle, and after the first full battery jump, we conduct three times of charging operation to avoid virtual power.

　　Although the NEDC cruising range of Model Y is 594km, the remaining cruising range after full charge is only 489km. After verifying with Tesla officially, the cruising range of the car isDynamic display based on EPA working conditionTherefore, the battery life of its full meter will vary according to the driver’s comprehensive car habits, vehicle electrical appliances, environmental temperature and other factors; However, turning off the air conditioner or turning on the air conditioner will not affect its battery life.

　　Tesla Model Y does not provide traditional driving modes such as energy saving and sports, and it is an "energy saving state" to adjust the acceleration mode to be relaxed; At the same time, the kinetic energy recovery intensity of the vehicle is only two levels adjustable, and the "standard" means that the kinetic energy recovery intensity is the largest; "Stop Mode" is set to "Hold", that is, the vehicle will not creep at low speed. Of course, before we start the endurance test, we have to turn on the air conditioner to 23℃ for automatic air volume and zero the subtotal mileage.

　　Regarding air conditioning, Tesla Model 3 used PTC air conditioning before, while the new Model 3 and Model Y used heat pump air conditioning. PTC air conditioner has strong heating capacity and high energy consumption. When the ambient temperature is not very low, the heat pump air conditioner has good heating efficiency and low energy consumption, but when the ambient temperature is lower than -10℃ or even colder, the heating effect of the heat pump air conditioner will be relatively general. For the ambient temperature of -5℃ in this test, heat pump air conditioning should be able to play a high efficiency advantage.

　　According to the test standard of EV AH-100, we stopped the endurance test of Model Y at low speed after driving 100.7km. The average vehicle speed was 30.98km/h, and its apparent power consumption was 14.6kWh/100km. After the test, we immediately recharged it, and finally charged it with 20.06kWh, but failed to start it three times. Finally, we get that the energy consumption of the car in this low-speed endurance test is19.9kWh/100kmAccording to the capacity calculation of vehicle power battery, the cruising range of the vehicle under low-speed working conditions is387km. For a medium-sized pure electric SUV, its low-speed energy consumption performance is normal.

　　In that endurance phase of the low-speed work condition,The reduction ratio of actual mileage and apparent cruising range of vehicles is maintained at about 1:1.05.That is, the vehicle travels 20km, and the battery life is reduced by about 21km. Regardless of the endurance of Model Y, its dynamic endurance display based on EPA working conditions can indeed provide more valuable reference for our daily car.

○ Endurance test at high speed.

　　Before starting the high-speed endurance test, we also fully charged the vehicle and recharged it for three times. When the vehicle was fully charged, the cruising range was 488km. At the same time, we will speed up to the easy mode, the kinetic energy recovery will be adjusted to the standard mode, the air conditioner will be turned on to 23℃ for automatic air volume, and the subtotal mileage will be cleared.

　　According to the test standard of EV AH-100, we stopped this high-speed endurance test after driving for 204.2km, and the remaining power of the vehicle was 48%, with a remaining cruising range of 233km.

　　Finally, we charged it with 44.07kWh of electricity. According to the actual mileage and charging amount, the energy consumption of Model Y under this high-speed endurance test is calculated as follows21.6kWh/100kmThe cruising range of the car under this working condition is356km.

　　In the endurance part of high-speed working conditions, the ratio of the actual mileage and the apparent cruising range of the vehicle before 40km is about 1:1.6, that is, the vehicle travels 20km and the apparent cruising range is reduced by about 32km.

　　With the continuous increase of mileage, the proportion of vehicle power failure is slowly decreasing and tends to be stable; After driving for 100km,The reduction ratio of actual mileage and apparent cruising range of vehicles can basically be stabilized at about 1:1.1.High-speed battery life once again verified our point of view given in low-speed battery life:The battery life of Model Y can provide more valuable reference for our daily car..

Charge rate test

　　After the endurance test, we also tested the fast charging speed of Model Y. It takes 52 minutes to charge the car from 30% to 80% on the 120kW DC fast charging pile of State Grid, which is not fast. In the process of fast charging, we recorded the charging power of the vehicle, and the highest charging power was about 47.9kW and the lowest charging power was about 42.9kW.

Summary:

　　According to the actual endurance test results, we calculated the comprehensive endurance performance of Tesla Model Y according to the ratio of 35%+65% intercity high speed+urban low speed.376km；Compared with the NEDC cruising range of Model Y, the actual cruising performance of this car is basically about 60% off. In the low temperature environment, such endurance is not excellent, but it should not be bad. Finally, let’s preview it. In the near future, we will also launch the actual endurance test results of Model Y at room temperature, so stay tuned.

On the evening of July 27th, sogou announced that he had received an offer for the privatization of Tencent. Specifically, Tencent plans to acquire other shares of sogou at a price of $9 per share. If the transaction is successful, sogou will be delisted from the US stock market and become an indirect wholly-owned subsidiary of Tencent.

Subsequently, Sogou CEO Wang Xiaochuan responded in the WeChat circle of friends: "Thanks to Tencent for its recognition of sogou’s value, technical capabilities and product innovation capabilities. Next, we will seriously discuss and measure the related issues, so that sogou can continue to create greater value for users. 」

An industry insider said that he was not surprised to learn this news. After all, the collaboration between sogou and Tencent’s current business is getting higher and higher. Surprisingly, he didn’t expect Tencent to move so quickly. In addition to the wholly-owned acquisition of game companies, Tencent really wholly-owned a medium-sized mainstream Internet enterprise, and sogou should be regarded as one.

After the news, not only did sogou’s share price soar by 48%, but Sohu’s share price also rose by nearly 40%.

AI is the core value.

In fact, Tencent was already the largest shareholder in sogou before the tender offer was made. According to sogou’s 2019 annual financial report, Tencent holds 39.2% of the shares of sogou and Sohu holds 33.8%.

The official relationship between Tencent and sogou dates back to September 2013. At that time, Tencent injected US$ 448 million into sogou with some sincere conditions.

This is a big gift package. Ma Huateng, the founder of Tencent, wrote in the internal letter of the company: "Tencent merged the search and QQ input methods with the existing business in sogou to form a brand-new sogou company. This brand-new sogou will continue to operate independently as a subsidiary of Sohu.

In June, 2014, sogou search announced its official access to WeChat WeChat official account data. From then on, you can browse or query related WeChat official account and all articles by using sogou search. At the beginning of this year, Wang Xiaochuan mentioned in an internal letter that in 2019, sogou promoted the sustained and steady growth of search business with differentiated content and AI innovation.

Wang Xiaochuan specifically mentioned: "In terms of ecological construction of content services, we will deepen cooperation with WeChat WeChat official account, supplement content through cooperation with official websites, experts and academic websites, and explore opportunities for intelligent triage with medical care as the starting point. On this basis, the coverage and accuracy of the first direct answer of intelligent question and answer will continue to lead the industry level. 」

Holding hands with Tencent to open up the content resources of WeChat Ecology is an important supplement to the search pool in sogou. But cooperation does not stop there. If Tencent’s acquisition of sogou is successful, the two companies will cooperate in more business aspects in the future.

At present, sogou is the second search company in China. At the same time, with sogou input method, Sogou browser and other products, sogou has accumulated a large number of users. According to the financial report in the first quarter of this year, the daily active users of Sogou mobile phone input method exceeded 480 million, and the daily average voice request peak of Sogou mobile phone input method reached 1.4 billion, which continued to be the largest voice recognition application in China.

More importantly, sogou is a technology company focusing on AI research in the language field. Its accumulated technical capabilities such as speech recognition and translation are also among the top in China. This is also the key factor for Tencent to actively acquire sogou.

In recent years, with the incorporation of Tencent AI Lab, Tencent Youtu, WeChat Zhiling and Dingdang voice platforms into CSIG, Tencent’s layout in the field of artificial intelligence has begun to move on the right track.

At the Tencent Forum of the 2020 World Artificial Intelligence Conference, Si Xiao, Dean of Tencent Research Institute, officially released the "Tencent Artificial Intelligence White Paper: Ubiquitous Intelligence". For the first time, the white paper reveals Tencent’s internal understanding of AI technology and the thinking of intelligent business layout, which is mainly divided into five latitudes-macro environment, technology research, landing application, innovative economy and institutional guarantee.

Machine learning, computer vision, intelligent speech and natural language processing are defined as the development direction of artificial intelligence by this white paper. The technical research on AI, especially the research on natural language processing, is exactly the direction that sogou focuses on.

The new infrastructure was written into the government work report for the first time this year, and artificial intelligence is the seven major areas of new infrastructure. For Tencent, which holds high the banner of industrial Internet, only by strengthening its own AI technology capabilities can it better realize its capability output and empower the industry.

Therefore, the current business collaboration between sogou and Tencent is getting higher and higher. AI is the relative shortcoming of Tencent, but it is the core value of sogou. It is understood that the board of directors of sogou Company will form a special committee composed of independent directors to consider Tencent’s acquisition proposal.

Wang Xiaochuan’s "Breakthrough"

From the outside world, sogou was originally a company with search engine as its core business. After listing on NYSE in November 2017, Wang Xiaochuan quickly released sogou’s future AI strategy to the public.

This strategy consists of two parts. First, it is human-computer interaction, which involves the understanding of language at the perceptual and cognitive levels; Secondly, it takes language as the core and improves its reading and reasoning ability around machines, which is called knowledge computing.

Wang Xiaochuan said, "The crown jewel of artificial intelligence is natural language processing. In natural language, the ultimate question is question and answer. How to make the machine master the ability of acquiring knowledge or reasoning and thinking with language as the core is what we are doing. And this problem, no one knows the optimal solution yet, everyone is trying.

On the talk show "Thirteen Invitations", Xu Zhiyuan once asked Wang Xiaochuan a question, "What is the thing that excites you now? "Wang Xiaochuan said," there are some problems that no one can solve, but you have found a way to solve them. 」

The greatest charm of language is that it is a tool for us to know the world. What is the problem that Wang Xiaochuan hopes to solve with AI technology in this field?

At the IF conference held in Geek Park at the end of 2019, sogou introduced a new generation of AI translation. The general AI translation is to listen first, and then translate the text understanding. Sogou, on the other hand, is a translator who can see and think.

When a guest speaks PPT on the stage, the machine can read his PPT, extract the concept mentioned in the middle, and then find the explanation and related content of this concept according to the background knowledge base or knowledge map. After the release of this system, compared with traditional machine translation, the error rate will drop by 40%.

Wang Xiaochuan said, "In the long run, AI in the language field may eventually become your virtual personal assistant. Personal assistants need to have two abilities, one is to communicate with you, and the other is to master knowledge in some fields, which can turn information into knowledge and even provide you with wisdom. 」

If we can sum up what sogou has been doing in one sentence, it is to make it easier to express and obtain information.

AI research is a frontier investment for the future. Frontier means that for a company, it may be a business that needs a lot of money and resources for a long time and cannot be realized quickly. Therefore, if AI research is to be sustainable, the company’s basic disk must be solid.

At the beginning of this year, Wang Xiaochuan wrote an internal letter to all employees. In the letter, he regards "breakthrough" as the key word for sogou this year. He explained that in an environment that is both an opportunity and a challenge, breakthrough means getting rid of existing cognition and rules, dare to think and fight, and dare to find new directions and boundaries.

Hand in hand with Tencent can, to some extent, bring sogou the expected stability. On the basis of the existing business, it also brings more opportunities for sogou to break through. The relationship between the two is like a company holding the seeds of future technology and a fertile soil that needs future technology supply.

Editor in charge: Jing Yu

　　BEIJING, Feb. 1 (Leng Haoyang) Today, the 40-day Spring Festival travel rush kicked off. According to China Railway Corporation, in 2017, a new line of 3,038 kilometers was put into operation, and the "four vertical and four horizontal" high-speed rail network was completed and put into operation ahead of schedule. This also means that a number of railways will meet the first Spring Festival travel rush exam. Which new railway lines will help you go home during the Spring Festival this year? Do these railway lines pass through your hometown?

　　Chongqing-Guizhou Railway: Chengdu-Chongqing Quickly "Hand in Hand" in the Pearl River Delta

　　Every year, Spring Festival travel rush, Chengdu and Chongqing are the key areas where it is difficult to grab tickets. This year, an important railway line in Spring Festival travel rush will give people in this area a more convenient choice to "go home".

　　On January 25, 2018, the Chongqing-Guiyang Railway was put into operation, which became a fast railway channel to connect Chengdu-Chongqing area and even southwest area to South China and East China, and then connected with the existing high-speed railway lines such as Guiguang, Chengdu-Chongqing and Shanghai-Kunming. A large-capacity transportation channel will help Spring Festival travel rush.

　　The Chongqing-Guiyang Railway leads from Chongqing West Railway Station, passes through Qijiang, Zunyi and Xifeng, and finally reaches Guiyang North Railway Station, with a total length of 347 kilometers. It is a double-track electrified railway with passenger and freight lines. Twelve stations, including Chongqing West, Luohuang South, Qijiangdong, Rushui East, Tongzi North, Tongzi East, Loushanguannan, Zunyi, Longkeng, Zunyi South, Xifeng and xiuwen county, have been newly built, with an initial maximum operating speed of 200 kilometers per hour.

　　At the beginning of the opening of Chongqing-Guiyang Railway, 66 pairs of passenger trains will be arranged, and the running time of Chengdu, Chongqing-Guiyang, Guangzhou, Kunming and Changsha will be greatly shortened.

　　Xicheng high-speed railway: the history of "difficult roads" has been rewritten.

　　Joining Spring Festival travel rush’s army for the first time this year is Xicheng High-speed Railway.

　　"It’s difficult to get through the Shu Road, but it’s difficult to get into the sky", which has always hindered the traffic development between the north and the south of Qinling Mountains. However, with the opening of the Xicheng high-speed railway, the history of "difficult roads" has been rewritten.

　　On December 6 last year, Xicheng high-speed railway was officially opened for operation. Xicheng high-speed railway leads from Xi ‘an, Shaanxi Province, passes through Ankang and Hanzhong in Shaanxi Province to Guangyuan and Mianyang in Sichuan Province, and connects with Mianyang-Chengdu-Leshan Railway at Jiangyou Station, reaching Chengdu, with a total length of 658 kilometers.

　　Xicheng high-speed railway operates at a speed of 250 kilometers per hour. The shortest travel time between the two places is reduced to 3 hours and 27 minutes, which is 7 hours shorter than the original shortest travel time between the two places.

　　The opening of Xicheng high-speed railway will greatly ease the pressure of Spring Festival travel rush between Xi ‘an and Chengdu. On the afternoon of January 31st, the reporter inquired about the train tickets between Xi ‘an and Chengdu on February 14th (the 29th of the twelfth lunar month) and February 21st (the 6th day of the first lunar month) through the 12306 client, and found that many high-speed trains still had tickets left.

　　Data Map: Last December 28th, with Shijiazhuang — The D1611 train from Qingdao North left Shijiazhuang Railway Station, and the Shijiazhuang-Jinan high-speed railway was opened for operation. The picture shows the first train of D1611. China News Service reporter Yujia Zhai photo

　　Shiji high-speed railway: Shanxi, Hebei and Shandong provinces realize high-speed railway connection

　　On December 28th last year, the Shijiazhuang-Jinan high-speed railway was put into operation, and there was no direct high-speed railway between the capital cities of Hebei and Shandong provinces. The last section of China’s "four verticals and four horizontals" high-speed railway network officially closed.

　　Shijiazhuang, Hebei Province and Jinan, Shandong Province are the two capital cities of Shiji High-speed Railway, with a total length of 298 kilometers. Its east and west ends are connected with Jiqing High-speed Railway and Shitaike Special Railway respectively, which enables Shandong, Hebei and Shanxi provinces to realize high-speed rail connection.

　　The line also connects with Beijing-Guangzhou high-speed railway at Shijiazhuang Station and Beijing-Shanghai high-speed railway at Dezhou East Station, with 11 stations in total. In addition to Shijiazhuang and Dezhou East Station, there are 9 new stations in Shijiazhuang East, Gaocheng South, Xinji South, Hengshui North, Jingzhou, Pingyuan East, Yucheng East, Qihe and Jinan East.

　　At present, there are plenty of tickets for Spring Festival travel rush-Shijiazhuang High-speed Railway. On 31st, the reporter found that there are plenty of tickets for the trips between the two cities from February 12th to 15th before the Spring Festival and from February 20th to 22nd after the Spring Festival.

　　Data Map: The first G2028 train of Baolan High-speed Railway will run to Xuzhou, Jiangsu, a thoroughfare city of five provinces more than 1,500 kilometers away. Yang yanmin

　　Baolan High-speed Railway: Take the High-speed Railway to the Silk Road.

　　What kind of experience is it to take the high-speed train home on the Silk Road?

　　On July 9, last year, Baolan High-speed Railway was put into operation, with a total length of 401 kilometers, with eight stations including Baoji South, Tianshui South, Qin ‘an, Tongwei, Dingxi Northwest and Lanzhou West, with an operating speed of 250 kilometers per hour. Now, from Lanzhou, you can reach Xi ‘an in 3 hours at the earliest, and it takes only 8 hours and 20 minutes to reach Beijing.

　　Baolan high-speed railway is connected with Xi ‘an-Baoji high-speed railway and Lanxin high-speed railway, which have been opened to traffic, respectively, from the east and west directions. With the opening of this "last mile", it means that from Xi ‘an, Shaanxi Province, the starting point of the ancient Silk Road, to Urumqi, Xinjiang, a "high-speed railway silk road" with a length of more than 2,300 kilometers runs through the whole line, and the northwest of China is fully integrated into the national high-speed railway network, and the high-speed railways in eastern, central and western China have achieved full interoperability.

　　Similar to Xicheng High-speed Railway and Shiji High-speed Railway, the opening of Baolan High-speed Railway also eased the pressure on Spring Festival travel rush. On the afternoon of the 31st, the reporter found that on February 13th and 14th of the pre-holiday peak, and on the 20th and 21st of the post-holiday peak, there were sufficient tickets for the high-speed rail between Xi ‘an and Lanzhou, and there were also a small number of tickets left in the business seats and first-class seats of some trains from Beijing to Lanzhou.

　　Zhanghu High-speed Railway: Inner Mongolia Entering the "High-speed Railway Era"

　　People in Inner Mongolia can also take the high-speed train home in Spring Festival travel rush this year!

　　The first new high-speed railway in Inner Mongolia, Zhanghu high-speed railway from Wulanchabu to the eastern section of Hohhot, was officially opened for operation on August 3 last year. After the opening, the running time from Hohhot to Wulanchabu was shortened to 40 minutes.

　　Zhanghu High-speed Railway (Wulanchabu to the east section of Hohhot) starts from Hohhot East Station, passes through its Yingnan Station and Zhuozi East Station, and finally reaches Wulanchabu Station, with a total length of 126 kilometers and an operating speed of 250 kilometers per hour.

　　In the future, Zhanghu high-speed railway will also be connected with the Beijing-Zhangjia high-speed railway under construction, forming a fast passenger passage from Beijing to Hohhot within 3 hours.

　　Data Map: On September 29th last year, the first train K4518 from Lanzhou to Chongqing set off, marking the opening and operation of the whole line of lanzhou-chongqing railway, which took nine years to build. Yang yanmin

　　Lanzhou-chongqing railway: The northwest and southwest are more closely linked.

　　In addition to the above-mentioned Chongqing-Guizhou Railway and Xicheng High-speed Railway, there is also a railway connecting the southwest that will help Spring Festival travel rush and facilitate people in the southwest to travel.

　　This is the grand railway passage connecting the southwest and northwest of China — — Lanzhou-chongqing railway.

　　Lanzhou-Chongqing Railway passes through Gansu, Shaanxi, Sichuan and Chongqing provinces, one city and 22 cities and counties. It is a national I-class railway with double-track electrification of passenger and cargo. The main line is 886 kilometers long, with a design speed of 160 kilometers per hour, and 200 kilometers per hour is reserved for conditional sections.

　　Nowadays, the transportation distance from Lanzhou to Chongqing has been shortened from 1,453 kilometers to 886 kilometers, and the bus running time has been shortened from 21 hours to the current 12 hours, which greatly facilitates the travel of passengers between the southwest and northwest regions.

　　Jiujing-Qu Railway: Ending the History of Many Places Closed to Traffic

　　During this year’s stay in Spring Festival travel rush, people in Poyang, Duchang, Jingdezhen and other places will have a more convenient way to go home.

　　Jiujingqu Railway was opened to traffic on December 28th last year. It is a double-track electrified express railway with a design speed of 200 kilometers per hour. It starts from jiujiang railway station, Jiangxi Province and ends at Quzhou Station, Zhejiang Province, with a total length of 333.3 kilometers.

　　Jiujingqu Railway constitutes the auxiliary connecting line of Beijing-Kowloon and Shanghai-Kunming, which connects with Hefu high-speed railway at Wuyuan Station, plays an important role in connecting east and west and connecting north and south in the road network node, and is another convenient passage for Central China and Southwest China to closely connect with the Yangtze River Delta and the southeast coast.

　　With the official operation of Jiujingqu Railway, there are no trains in Poyang and Duchang, and it has become history that Jingdezhen has no trains. (End)

Original Tencent medical code

Many people have taken or are planning to take a shot of flu vaccine, but they may be blindsided as soon as they come to the vaccination clinic-how can there be so many kinds of flu vaccines?

● There is "inactivation" and "inactivation";

● There are "injections" and "nasal sprays";

● There are "trivalent" and "tetravalent";

● There are "cracking" and "subunits".

And each kind, there are different brands and different prices of products. In another hospital, I found that there are different choices.

I just want to get a good vaccine. Why is it so difficult and brain-wasting?

How to choose the flu vaccine?

For the flu season in 2023/2024, there are the following flu vaccines in mainland China [4]:

● Children from 6 months to 3 years old: trivalent inactivated influenza vaccine and tetravalent inactivated influenza vaccine are available;

● Children and adults over 3 years old: trivalent inactivated influenza vaccine and tetravalent inactivated influenza vaccine are available;

● Children aged 3 to 17: There is also a trivalent live attenuated influenza vaccine.

Is it a little winding? It doesn’t matter, a table shows clearly:

At present, influenza vaccines that need intramuscular injection are all "inactivated" vaccines (commonly known as "dead vaccines").

The "dead" vaccine does not contain live viruses, and vaccination will not make people get the flu. Generally, sufficient immunity is generated after 2 to 4 weeks of inoculation.

The flu vaccine that needs nasal spray is an attenuated live vaccine, which is suitable for people aged 3 to 17.

Studies have shown that nasal spray can produce nasal mucosal antibodies in as little as 3 days [5].

Therefore, for those children who are particularly afraid and resistant to "injection" or have skin diseases in their upper arms and no suitable injection site, "nasal spray" vaccine seems to be a more friendly choice.

However, those children who have immunodeficiency diseases, received other attenuated live vaccines (such as measles vaccine, chicken pox vaccine, etc.) within one month, or have severe rhinitis, nasal congestion, runny nose and other symptoms are not suitable for vaccination.

Of course, no matter inactivation or inactivation, it has a good protective effect and can be selected as needed.

The "price" in the vaccine name does not mean "price", but refers to the type of the same pathogen.

For example, "trivalent pneumonia vaccine" can prevent infections caused by 13 kinds of pneumococci; The "9-valent HPV vaccine" can prevent infections caused by 9 kinds of HPV (human papillomavirus).

The higher the "price", the more types of pathogens are covered, and the wider the infection can be prevented (many people will mistakenly write it as "intermediary" and "rank", which is wrong).

Influenza viruses that can infect humans and cause widespread epidemic are mainly H1N1 and H3N2 subtypes of influenza A and Victoria and Yamagata strains of influenza B..

The tetravalent influenza vaccine can prevent one more influenza virus (Yamagata strain B) than the trivalent influenza vaccine.

At the end of September this year, the World Health Organization (WHO) believed that since March 2020, Yamagata strain of influenza B had not been monitored and isolated worldwide [6].

This may be related to the epidemic situation in COVID-19 in recent three years and its prevention and control, especially the changes in people’s living habits and behaviors (such as wearing masks, reducing travel and increasing social distance) [7].

However, the fact that the virus has not been detected for the time being does not mean that the virus has "completely disappeared" and there is still the possibility of making a comeback in the future. As a precaution, WHO continues to provide recommendations on the composition of tetravalent influenza vaccine [6].

Therefore, for this year, playing 3 prices is enough; At 4 prices, you won’t lose. When choosing a flu vaccine, you don’t have to worry about the specific price.

Some people may have found that the same "inactivated" vaccine is also divided into "split" and "subunit". What’s the difference?

In fact, inactivated vaccine is to completely "kill" pathogens (such as influenza virus), take their "corpses" and make them into vaccines after processing.

Some inactivated vaccines use whole bodies, such as inactivated hepatitis A vaccine, rabies vaccine and COVID-19 vaccine.

The "split" vaccine is to split, disintegrate, filter and purify the dead virus, which greatly reduces the adverse reactions of the vaccine [8].

The "subunit" vaccine goes a step further, removing the internal protein of the virus and only extracting some components (such as neuraminidase and hemagglutinin of influenza virus), with less impurities [9] and better safety.

However, at present, the production of "subunit" influenza vaccine is relatively small and the price is more expensive.

The Technical Guide for Influenza Vaccine Vaccination in China issued by China Center for Disease Control and Prevention indicates that people who can vaccinate vaccine products of different types and manufacturers can voluntarily vaccinate any kind of influenza vaccine, and there is no prior recommendation [4].

In other words, any kind of flu vaccine can provide us with good protection. What is important is to vaccinate in time, not to choose or wait.

May each of us spend this coming winter safely and healthily!

Audit expert: Wang Qing

Chief physician, Department of Immunization Planning, Xicheng District Center for Disease Control and Prevention, Beijing

references

1.https://wjw.beijing.gov.cn/bmfw_20143/jkzs/mzyq/202310/t20231024_3285888.html

2.http://wjw.jiangsu.gov.cn/art/2023/10/27/art_49513_11054944.html

3.https://ivdc.chinacdc.cn/cnic/zyzx/lgzb/202310/t20231026_270329.htm

4. China Center for Disease Control and Prevention. Technical Guide for Influenza Vaccination in China 2023-2024.

5.Barría Maria Ines, Luis G J , Cheryl S , et al.Localized mucosal response to intranasal live attenuated influenza vaccine in adults.[J].Journal of Infectious Diseases, 2013(1):115-124.DOI:10.1093/infdis/jis641.

6.https://www.who.int/publications/m/item/recommended-composition-of-influenza-virus-vaccines-for-use-in-the-2024-southern-hemisphere-influenza-season

7.Koutsakos, M., Wheatley, A.K., Laurie, K. et al. Influenza lineage extinction during the COVID-19 pandemic? . Nat Rev Microbiol 19, 741–742 (2021). https://doi.org/10.1038/s41579-021-00642-4

8. Wang Lijie, Huang Weijin, Wang Youchun. Progress in research and development of universal influenza vaccine [J]. China Food and Drug Administration, 2023,05:18-23.

9. Yang Xiaoming, Gao Fu, Yu Yongxin, et al. Contemporary new vaccines [M]. Beijing: Higher Education Press, 2020.

* Produced by Tencent Medical Content Team

Read the original text

　　10moon17sunThe 6th China Academy of Sciences and 14th Beijing Workers’ Track and Field Games were held in the National Olympic Sports Center. Li Chi Ngai, secretary of the Party Committee of the Institute of Zoology and head of the delegation, led the athletes and the audience about.80People took part in the sports meeting.

　　morninghalf past eight,The sports meeting held a grand opening ceremony. The phalanx of athletes of the animal team entered the stadium with neat steps. In front of the phalanx was a giant panda representing the characteristics of animals. The athletes launched the slogan "Keep fit, devote themselves to science and serve the country" to convey the concept of service dedication. Subsequently, the ninth set of broadcast gymnastics exhibition competition kicked off the sports meeting, and the team represented by animals.twentyA total of 100 athletes participated in the competition.

　　In the one-day competition, the athletes of the animal representative team participate in the following events.Broadcast gymnastics,60riceRun with the ball、100rice、1500rice、four×100riceShot put, long jump, double shuttlecock kicking, football shooting, etc. The athletes fought bravely on the field, showing the sportsmanship of never giving up. Among them, Li Chi Ngai took the initiative and participated.60riceRunning with the ball lifted the athletes’ morale. Li Mei in the pest room won the fourth place in the women’s shot put in Group C, and Ge Ming in the stem cell room won the men’s shot put in Group A.1500riceFourth place, broadcast gymnastics won the Excellence Award.

　　　 The sports meeting was highly valued by the leaders of the Institute, supported by various offices and research groups, carefully organized by trade unions, and actively coordinated by graduate students’ associations and trade unions.After complicated organizational preparations such as athletes’ registration, practice, preliminaries and audience collection, as well as the support and enthusiastic participation of employees and graduate students, the athletes and audience of the Animal Institute of this Games fully demonstrated the spirit of unity and forge ahead with practical actions.For this reason, the sports delegation of the Institute of Zoology won the "Excellent Organization Award".

The team of athletes from the Institute of Zoology entered the venue.　

Secretary Li Chi Ngai runs fast.　

Researcher Sun Yue Hua shot vigorously.

Li Mei threw a hard throw.

Wang Jiangning flies across the sky

Ge Ming sprints with all his strength.

Wang Chengmin is ready to go.

　　Photo courtesy of vision china

　　Gene therapy can "correct" the mutant genes that cause diseases, thus bringing hope for the patients suffering from congenital genetic diseases. But recently, in a clinical trial of gene therapy conducted by a biotechnology company in the United States, two children who participated in the trial died unfortunately.

　　After decades of twists and turns, gene therapy has brought new hope for the treatment of major human diseases, especially many genetic defects. However, gene therapy has recently suffered setbacks.

　　Recently, an American biotechnology company (Audentes Therapeutics) issued a letter saying that among the 17 children with neuromuscular rare diseases who participated in the company’s "AT132" gene therapy, two children died after receiving high-dose gene therapy.

　　The key research of this gene therapy began in 2017, aiming at treating a fatal disease caused by a single gene mutation — — X chromosome linked myotubular myopathy. The treatment was originally intended to be submitted this year and expected to be approved by the US Food and Drug Administration by the end of the year, but the plan has now been shelved.

　　Some children died while receiving gene therapy 20 years ago. What are the differences between the gene therapy at that time and this gene therapy? After decades of development, what improvements have been made in gene therapy and what problems are still facing? In this regard, the Science and Technology Daily reporter interviewed relevant experts.

　　"What is missing makes up for what is missing" and "corrects" mutated genes.

　　In human body, there is a gene named "MTM1", which is used for the development and maintenance of muscle cells by expressing a protein called "Myocardin". X chromosome linked myotubular myopathy is caused by the mutation of "MTM1" gene.

　　X chromosome linked myotubular myopathy mainly affects skeletal muscle, and its symptoms are muscle weakness and hypotonia. Muscle lesions will damage the patient’s ability to sit, stand and walk, even cause difficulty in eating and breathing, and may also lead to ophthalmoplegia, facial muscle weakness and muscle reflex disappearance.

　　At present, the main treatments for the disease include physical therapy and the use of support equipment such as ventilators. Studies have shown that the chemical drug "pyridostigmine" may be beneficial to improve clinical symptoms, but no formal clinical trial has been carried out. Generally speaking, there is no effective treatment for this disease at present.

　　To this end, researchers began to explore the use of gene therapy to "correct" mutated genes. "Based on ‘ What is missing is what is needed ’ The gene therapy uses adeno-associated virus (AAV) as a vector to transfer normal ‘ MTM1’ Genes are introduced into muscle cells to produce myotubes with normal function, thus repairing the function of damaged muscle cells. " Qiu Zilong, a researcher at the Center for Excellence and Innovation in Brain Intelligence of China Academy of Sciences, said that this is a "permanent cure" treatment method, and under ideal conditions, it can even achieve "one treatment and lifelong benefit".

　　How to realize this "correction" process? "The whole process and ‘ Drip ’ Very similar. " Qiu Zilong pointed out that the researchers injected the adeno-associated virus loaded with normal "MTM1" gene into the patient’s blood, delivered the adeno-associated virus vector to muscle cells through blood circulation, and produced "myosin protein" with normal function in it.

　　Before these children participated in clinical trials, the gene therapy had been pre-clinical studied, including verifying the safety and effectiveness of the therapy in cell and mouse disease models cultured in vitro, and the therapy was generally safe.

　　But in order to improve the therapeutic effect, the researchers tested a higher dose of gene therapy. "High doses are particularly important for neuromuscular diseases, because more copies of genes are needed to reach the targeted tissues through blood circulation." Dr. Cheng Cheng, from the School of Bioengineering, East China University of Science and Technology, said that the dose used in this gene research is the highest dose in gene therapy: 300 trillion copies of genome per kilogram of body weight.

　　The upgraded transmission carrier is safer.

　　In recent years, gene therapy has developed rapidly. The event that the "brake button" was also pressed occurred in 1999. An 18-year-old American patient named Jesse Kissinger died in a clinical trial of gene therapy with adenovirus as the carrier.

　　At that time, researchers used adenovirus as a vector to insert genes into patients’ cells to replace those parts that were lost or dysfunctional and caused diseases. A few days later, Jesse died of multiple organ failure due to severe immune response, which poured cold water on those who were initially optimistic about gene therapy.

　　After the tragedy of Jesse Kissinger’s death due to gene therapy, the researchers reduced the size of the laboratory and focused on finding safer virus vectors. Finally, they discovered and promoted the use of adeno-associated viruses.

　　Adeno-associated virus (AAV) is a kind of single-stranded DNA deficient virus with the simplest structure found at present. Adeno-associated virus gene therapy uses adeno-associated virus as a carrier to deliver therapeutic genes to specific tissues and organs, and these therapeutic genes stably exist and express in the form of free bodies in these non-splinter cell, thus effectively treating monogenic genetic diseases.

　　At present, adeno-associated virus (AAV) is the mainstream carrier platform for gene therapy, and there are also adenovirus and lentivirus gene therapy. Qiu Zilong pointed out that compared with adenovirus, adeno-associated virus vector has the advantages of high safety, low immunogenicity, longer curative effect and easy modification, and the newly discovered adeno-associated viruses such as AAV8 and AAV9 are 10-mdash stronger than adenovirus in transferring genes into cells. A hundred times. Lentiviruses, on the other hand, have the characteristics of randomly integrating genomes, and there is a potential risk of destroying normal gene functions.

　　In addition to the rare diseases caused by single gene mutation reported in this report, gene therapy is also used to treat Parkinson’s disease, Alzheimer’s disease, cancer and other complex diseases at home and abroad. At present, about 42 companies and nearly 100 drug research and development projects use adeno-associated virus vectors for gene therapy. In this fatal accident, the carrier used by researchers for gene therapy was AAV8.

　　Too high dose is easy to produce toxic and side effects.

　　Regarding the insecurity of gene therapy, Cheng Cheng believes that in the case of "AT132" gene therapy, the cause of children’s death may be that they received an excessive dose of adeno-associated virus intravenous injection, which produced a large number of antibodies against adeno-associated virus. The combination of virus and antibody can further activate complement pathway or innate immune response, thus causing strong toxic and side effects.

　　"Another kind of insecurity is the dislocation expression of normal genes." Cheng Cheng took the gene therapy of spinal muscular atrophy "Zolgensma" as an example, saying that intravenous injection would lead to excessive accumulation of normal genes carried by "Zolgensma" in the liver, but this gene did not play a role in the liver, which triggered a common hepatotoxicity after treatment, which was manifested by the increase of transaminase.

　　As early as a few years ago, james wilson, an American scientist who was a pioneer in gene therapy and one of the developers of adeno-associated virus, expressed concern about the high-dose vector used in gene therapy. In February 2018, the Wilson team published a paper saying that after high-dose injection of adeno-associated virus, it caused serious toxic reactions in rhesus monkeys and piglets, and one rhesus monkey had to be euthanized due to liver failure. To this end, Wilson called on researchers to carefully monitor similar toxic effects during gene therapy.

　　Wilson’s collaborator, Professor Gao Guangping of the Massachusetts Institute of Technology, once expressed similar views. In an interview in 2019, he expressed concern that the rapid development of this field would make people less cautious and might make Jesse Kissinger happen again.

　　"Scientific and technological progress will experience setbacks." Qiu Zilong said that although this high-dose gene therapy caused the death of the patient, the effectiveness of gene therapy cannot be denied. In the face of the lack of effective treatment for rare diseases with single gene, gene therapy has indeed brought hope to many patients and their families. At present, there are still many shortcomings in gene therapy, which needs continuous improvement and perfection by experts and scholars in the field to make it safer and more effective, and should not be abandoned because of choking.

　　In promoting the development of gene therapy, Qiu Zilong suggested that it is necessary to constantly transform to obtain new types of adeno-associated viruses with special tissue affinity, reduce the immune response of the human body after injection, achieve more accurate delivery of normal genes, and further reduce toxic and side effects; At the same time, research and develop better gene regulatory elements, so that normal genes delivered to patients can produce functional proteins in a timely and appropriate way.

　　Cheng Cheng also suggested that the production and purification process of adeno-associated virus can be further optimized to reduce impurities in the virus and improve its purity. Choose a better carrier delivery mode, such as intrathecal injection or intraventricular injection for diseases of nervous system.

Wu Zhenyu, the two film emperors’ rival in love, spoiled Sun Honglei on the spot.

　　"The Warring States" is based on the unprecedented tragic hegemony of the Seven Heroes of the Warring States in history, and describes the epic legend that two legendary militarists, Sun Bin and Pang Juan, evolved from close brothers to enemies and finally fought a decisive battle on the battlefield. Sun Honglei plays Sun Bin, who is kind-hearted, and Wu Zhenyu plays Pang Juan, who is fierce. The fate of the Warring States troubled times makes the two film emperors struggle in the play and become rivals in love. When it comes to the conflict between love and friendship, Sun Honglei faltered and finally reluctantly said, "Brothers come first, love comes second." Wu Zhenyu said helplessly, "I choose beauty, but beauty doesn’t choose me. When I chose my brother, my brother left me. "

　　"I think Sun Bin is wandering between a genius and an idiot. He has great talent in military affairs, but he doesn’t even have the basic ability to live in life. This time it’s more risky, and I hope it won’t thunder everyone." In order to experience the role, Sun Honglei also came to Sun Bin’s hometown and made a trip. "Bitter risks, cross the rubicon, deviance, etc. are all strategies used by Sun Bin in the movie." Sun Honglei said that the film shows the interlocking military strategies in a suspenseful way.

　　Although Wu Zhenyu has always been famous for playing a role with strange personality, he gently spoiled Sun Honglei at the scene that day. At that time, the host asked Wu Zhenyu to call Sun Honglei in three identities: brother, rival in love and enemy. Wu Zhenyu was shy and shouted, "Mmm!" Make a scene.
　

Securities code Securities abbreviation Latest price Last week’s ups and downs Up and down this month Up and down this year 52-week ups and downs BB blackberry $2.79 -0.36% 0% -21.19% -32.77% AAPL apple $182.31 -3.46% -1.13% -5.31% 19.51% MSFT Microsoft $404.06 -3.92% 1.63% 7.45% 56.58% 01810 Xiaomi group -W HK$ 13.42 7.88% 8.93% -13.97% 5.67% 00285 Byd electronic HK$ 30.90 7.67% 15.51% -15.57% 18.39% 02382 Shunyu optics technology HK$ 50.55 4.98% 5.86% -28.65% -48.1% 02018 Ruisheng technology HK$ 18.28 2.93% 4.1% -21.21% -1.19% 02038 Fuzhikang group HK$ 0.49 2.06% 1.02% -18.85% -46.2% 01478 Qiutai technology HK$ 3.05 -0.65% 10.91% -31.31% -37.5%

Author An Xiao

Edit the nuts

Cover source 丨 Unsplash

The wind of explosive reform finally blew to Yonghui.

Recently, Yonghui Zhengzhou Xinwan Plaza Store, which was "reformed" by Fat East, finally opened. In the 19-day rectification, Fat Donglai started from three dimensions: people, goods and fields, and strived to "save Yonghui first".

People, that is, organizational culture upgrading, humanized management, to achieve "all-staff salary increase", the salary of employees has increased from 2,500/month to 4,500/month, and the 8-hour working day system has been strictly implemented. Employees can enjoy 10 days of annual leave after working for one year.

Goods, that is, product structure upgrade, 10841 goods with unstable quality and sales volume were removed from the shelves, and 12581 items were re-planned, achieving 80% of new items, and the combed product structure reached more than 90% of the product structure of Pangdonglai.

The field, that is, the terminal scene is upgraded, the forced line is cancelled, the channel of the store is widened, and the alcohol and tobacco cabinets and customer rest areas are added, so that the supermarket and the store are more integrated and the experience is more consistent.

According to customers who have been to the scene, Yonghui, which has been "reformed", has to wait for more than half an hour in the hottest period of the day. In the morning, the supermarket began to limit its flow just 30 minutes after its opening, and other merchants in the store also ran around the queue to attract customers, which can be said to directly save the whole dying shopping mall.

In recent years, Fat Donglai has almost been honored by the retail industry, and many well-known supermarkets have invited the boss Yu Donglai to touch it. However, the fat Donglai has always been worried that he can’t get out of Xuchang. This explosive reform can be said to be another exploration of Pangdonglai’s "going out of Xuchang", but many previous attempts have failed to get out of the way. Can you get through this time by putting on Yonghui’s shell?

one

Pangdonglai is trapped in a square inch.

Since Yu Donglai introduced the "volume-selling" format to Xuchang in 1999, with the help of the 10-fold development of the domestic market, Pangdonglai tried all kinds of formats and initially completed the gorgeous turn from a street shop to a modern business group in the past ten years from 2000 to 2011.

However, in 2012, Yu Donglai suddenly stopped the expansion of Fat Donglai in Xuchang under the situation that the brand was in full swing. From January to September of that year, he closed a total of 16 profitable stores owned by Fat Donglai.

In this regard, Yu Donglai said, "We are expanding a little fast, and we are not doing as well as before. The service is not up to standard, which disappoints customers and wastes employees’ youth. This is the bitter fruit of my early blind development. " This is the first time in the history of the development of Pangdonglai to take the initiative to stop.

Looking back on 2005, Pang Donglai, who was still in infancy at that time, walked into Xinxiang. In 2015, because the store services and products could not keep up with the unified standards, Yu Donglai took the initiative to stop again and announced the cancellation of Xinxiang Store. After Xinxiang people and officials struggled to retain them, they decided to open the store again in 2016 after rectification.

Yu Donglai’s two suspensions have allowed Pangdonglai to develop into only 13 stores since 1999, including 10 in Xuchang, 2 in Xinxiang and 1 in Yuzhou.

Many foreign consumers say that the products and services from Fat East are so good that they can’t be opened to big cities. Apart from the subjective idea of founder Yu Donglai, this is more caused by objective factors with high costs in all aspects.

In 2015, Xinxiang store almost closed due to rising rents, not to mention other high-speed cities. Yu Donglai takes Zhengzhou as an example. If Zhengzhou opens a shop, the basic salary of front-line employees will be around 5,000 yuan, but the house price in Zhengzhou is currently around 15,000 yuan. Employees who have worked hard for ten years without eating or drinking may not be able to afford a house.

With the salary level of Xuchang store, it is difficult to find suitable talents in Zhengzhou. Without suitable talents, the high-level service of Fat Donglai will not be displayed. Some people may say, then take out the profits and give employees more wages, so that the store can open in Zhengzhou.

However, as we all know, the profit of products from Fat East is very low. Last year, it rushed to the hot search because "a down jacket only earned 3 cents".

Moreover, Fat Donglai implements a "three-three-three" distribution mechanism for annual profits, that is, 30% is used to pay the cost of the next year, 30% is distributed to all employees, and the remaining 30% is used for social donations. The boss only keeps 10%, which means he can’t rob people in the market with high salary.

Maybe Fat Donglai can lower the standards of products and services, and start in high-tier cities first. Anyway, Fat Donglai’s reputation has been played out and there are no consumers. But that would run counter to Yu Donglai’s original intention of establishing Fat East. It is not so much a Fat East as an ordinary supermarket with the signboard of "Fat East".

2

"DL Fat Donglai" Brand Out of Xuchang

Although Shangchao from Fat East has not yet left Xuchang, the brand "DL Fat East" has gone out first. Spiral Lab noticed that the online shopping mall of Pangdonglai has been able to choose other cities except Xuchang.

The online shopping mall is divided into three sections: Fat Donglai Supermarket, Fat Donglai Jewelry and Fat Donglai Tea. The goods in the online shopping mall are all self-operated brand products of Fat Donglai. In the supermarket sector, there are five categories, including daily use, grain and oil, food and beverage, books and Donglai gift boxes.

Judging from online supermarkets, there are basically not many products that Fat Donglai can supply at present, especially for some self-operated products with high consumer recognition, Fat Donglai can only rely on offline supermarkets to ship.

In the process of transforming BBK supermarket, in terms of product structure, Fat Donglai removed 70% of BBK products in one breath, and introduced its own brand, especially the best-selling products. This move was also immediate. After adjustment, the "DL Fat Donglai" series of products accounted for 1/3 of the sales of BBK supermarkets.

Yonghui Supermarket has also introduced a large number of self-operated products from Pangdonglai, including Pangdonglai mango juice, free love white wine, oatmeal, etc. Among them, the hook products from Pangdonglai online celebrity big moon cake and DL brewed wheat beer are even more popular.

Once upon a time, because the self-operated supply chain of Pangdonglai could not rapidly expand its production capacity, the stores of Pangdonglai in Xuchang and Xinxiang were often out of stock, not to mention the supply of online supermarkets and supermarkets such as Yonghui and BBK.

This time, Fat Donglai not only completed the export of its own brand, but also realized the channel expansion of "DL Fat Donglai", which is essentially expansion, using other people’s "field" to sell its own "goods". Because it is a self-operated brand of Pangdonglai, the pricing and profit are also in the hands of Pangdonglai himself.

This is due to the unique supply chain system behind Fat Donglai. In fact, as early as 2001-2002, Xuchang Pangdonglai Trading Group, Nanyang Wandelong Company, Xinyang Xiya Hemei Commercial Co., Ltd. and Luoyang Dazhang Company jointly initiated, jointly established and jointly developed a "voluntary chain" organization, namely "four-way joint mining". In order to reduce the cost of supply chain, a larger purchase volume is exchanged for a better price and the lowest purchase price is obtained.

In the past two years, the production capacity of the "four-way joint mining" system has expanded and shipments have become more stable. Coupled with the improvement of logistics and distribution conditions, Fat Donglai has the spare capacity to help other supermarkets.

Fat Donglai has been trying to build its own logistics system since its establishment. In January, 2021, the Xinxiang Pangdonglai Logistics Center with an investment of over 100 million yuan was completed. The construction and use of this logistics center brought a more solid and abundant reserve capacity to Pangdonglai. After two years of operation, the logistics center can not only quickly replenish the stores of Fat Donglai, but also provide strong support for online supermarkets, Yonghui, BBK and other stores selling "DL Fat Donglai" products.

three

How long can the effect of "explosive reform" last?

When the "explosive reform" is cooled at high temperature, let’s compare the scale of Pangdonglai and Yonghui. I have to say that for Yonghui, Fat Donglai can only help here.

Although the performance of each store in Pangdonglai is good, the overall scale is only 13 stores, and most of them are concentrated in Xuchang. We know that the core ability of Shangchao is to control the product supply chain, and only good and cheap goods can keep consumers buying back.

Yu Donglai once said: "The brand Fat Donglai is very advantageous in Xuchang, and many suppliers are willing to cooperate with Fat Donglai at a small profit, and still produce the highest quality products. But when you leave Xuchang, you go to someone else’s site. Not to mention various costs, many businessmen and suppliers will crowd out and suppress you. This is a very real problem. "

Moreover, the long-standing supply chain model of Pangdong is not easy. As early as 2002, Shanghai Yongle and Beijing Dazhong Electric established "Zhongyong Tongtai" in conjunction with seven household appliance chain alliances in other regions, and then in 2004, the first supermarket purchasing alliance in China was "Shanghai Jialian Purchasing Alliance". However, due to various internal and external reasons, only the "four-party purchasing alliance" in Xuchang, Henan Province was left behind.

At present, Yonghui Supermarket has developed more than 1,000 supermarket chains in China, covering 29 provinces and nearly 600 cities. This layout of national brands may not be suitable for the regional operation and management mode of Fat East, and the "four-way joint mining" supply chain mode of Fat East is even more unacceptable. As a regional retailer, Fat Donglai may find it difficult to solve this most critical problem.

However, for the self-operated brand of Fat Donglai, which has initially formed a market reputation, the distribution of goods through Yonghui’s broad channels will also help Fat Donglai gain greater scale advantages and further reduce the cost of making self-operated products.

Since the establishment of Fat Donglai, the service model and product structure have been thoroughly understood by the outside world. Every day, there are a lot of Shangchao bosses who come to Pangdong to steal the teacher’s skills. Pangdong never takes precautions, and directly hangs the list and telephone number of all product suppliers on the wall for the bosses to take pictures.

For consumers, being able to buy self-operated products from Fat Donglai in more Yonghui supermarkets and even enjoy the service experience similar to that of Fat Donglai may be another way for Fat Donglai to get out of Xuchang.

　　[Global Times Comprehensive Report] The Supreme Leader of president, China held talks with visiting European Council President Michel in the Great Hall of the People on December 1. The Supreme Leader pointed out that the more turbulent the international situation, the more prominent the global challenges, and the more prominent the world significance of China-EU relations. China will continue to view and develop China-EU relations from a strategic and long-term perspective, and is willing to strengthen strategic communication and coordination with the European side to promote a stable and far-reaching comprehensive strategic partnership between China and the EU. Michelle is the first EU leader to visit China after The 20th National Congress of the Communist Party of China（CPC）. He said that the EU cherishes the opportunity to meet face to face with China at the highest level soon after the 20th National Congress of the Communist Party of China, and is willing to promote dialogue and cooperation with China on important issues in all aspects of EU-China relations and properly handle differences in the spirit of mutual respect and frankness. This is Michelle’s first visit to China since she became president of the European Council in December 2019. Many media have noticed that there have been frequent interactions between China and Europe recently. In addition to German Chancellor Angela Scholz’s visit to China, many European leaders met offline with the Chairman of the Supreme Leader during the G20 Summit. Experts from China interviewed by Global Times on the 1st believe that under the trend of Europe’s deep energy crisis and the outflow of European manufacturing enterprises, European high-level officials seem to have reached a certain consensus: they hope to keep in touch with China, clarify misunderstandings through dialogue, seek communication and promote mutual understanding.

　　"A frank and sincere conversation"

　　During the talks with Michelle, the Supreme Leader said: "Comrade Jiang Zemin died in Shanghai yesterday due to ineffective medical treatment. During his tenure as the leader of China countries, Comrade Jiang Zemin attached great importance to and cared about the development of China-EU relations. He visited European countries many times and maintained close contacts with the leaders of the European Union and European countries, which promoted the establishment of the China-EU leaders’ meeting mechanism and promoted dialogue and cooperation between the two sides in various fields. We will inherit his legacy and continue to consolidate and develop China-EU relations. "

　　米歇尔祝贺最高领袖再次连任中共中央总书记，代表欧盟对江泽民同志因病逝世表示沉痛哀悼。

　　最高领袖说，米歇尔主席代表欧盟全体成员国在中共二十大结束后不久访华，体现了欧盟发展对华关系的良好意愿。谈到中欧关系发展，最高领袖提出四点看法：一是要秉持正确认知。中欧之间没有根本战略分歧和冲突。中方不想称王称霸，从不搞、今后也不会搞制度输出。二是要妥善管控分歧。中欧历史文化、发展水平、意识形态存在差异，双方在一些问题上看法不同很正常，应该以建设性态度保持沟通协商，关键是尊重彼此重大关切和核心利益，特别是尊重主权、独立、领土完整，不干涉对方内政，共同维护中欧关系的政治基础。三是要开展更高水平合作。欧洲是中国快速发展的重要伙伴，也是受益者。中国将实行高水平对外开放，加快构建新发展格局，欢迎欧方继续参与、继续共赢。四是要加强国际协调合作。中欧都主张维护以联合国为核心的国际体系，可以共同践行真正的多边主义，合力应对挑战，共同维护世界和平与发展。

　　According to the European News Network, Michelle’s spokesperson said that the meeting between the two lasted about three hours and was "a frank and sincere dialogue." Michelle wrote on Twitter that "frankly discussing all aspects of bilateral relations with China is the only way ahead." Michelle also mentioned that China is willing to hold a China-EU human rights dialogue on the basis of equality and mutual respect.

　　"China and president oppose all forms of ‘ New Cold War ’ 。” On the 1st, DPA paid attention to the four points put forward by the Chairman of the Supreme Leader. According to the report, China president hopes that EU institutions and member states will establish an objective and correct understanding of China, adhere to peaceful coexistence and win-win policy towards China, and transcend cold war mentality and ideological opposition and institutional confrontation.

　　"The four points put forward by the Chairman of the Supreme Leader on the development of China-EU relations show the importance of developing China-EU relations." Cui Hongjian, director of the European Institute of China Institute of International Studies, told the Global Times reporter on the 1 ST that Michelle, as the president of the European Council, represents the EU as a whole. His current visit to China also reflects the mainstream view and rational voice that most EU countries want to get in touch with China under the complicated geopolitical and economic environment.

　　The Associated Press said on the 1st that Chinese and European leaders also exchanged views on the Ukrainian crisis that day. During the talks, when the Supreme Leader expounded China’s principled position, he pointed out that there is an old saying in China that "the city gate is on fire and the fish in the pool are harmed". Resolving the Ukrainian crisis through political means is in the best interests of Europe and the common interests of all countries in Asia and Europe. Under the current situation, it is necessary to avoid the escalation of the crisis, persist in persuading and promoting talks, control the spillover effects of the crisis, and be alert to the camp’s confrontation with risks.

　　The EU is willing to continue to push forward the process of EU-China investment agreement with China.

　　Michelle’s visit to China is highly concerned by western media. CNN)1 said on the 1st that many things have changed since the EU leaders visited China four years ago. The COVID-19 outbreak, the conflict between Russia and Ukraine and the tit-for-tat sanctions between China and European parliamentarians have strained relations between the two sides. However, Michelle’s visit provides a "timely opportunity" for Europe and China to contact on issues of "common concern". Euronews TV said on the 1st that the goal of Michelle’s visit is to explore ways to strengthen cooperation with China on key issues and add new impetus to EU-China relations. EU officials told the Associated Press that Michelle’s visit will last for one day, but he will express the EU’s desire to increase exports to China.

　　As European officials said, Michelle mentioned in her talks with the Chairman of the Supreme Leader that the European side is willing to continue to advance the process of EU-China investment agreement with China, enhance the stability and mutual trust of the supply chain, and deepen mutually beneficial cooperation between Europe and China in various fields.

　　Data show that in the first 10 months of this year, the bilateral trade volume between China and the EU reached US$ 711.4 billion, up 6.3% year-on-year. CNN1 reported on the 1st that many top European companies are eager to invest in the world’s second largest economy. Castro, deputy director of the European Policy Center, told CNN Financial Channel that Europe is not seeking to "decouple" from the lucrative China market. Adam Dunnett, secretary-general of the European Union Chamber of Commerce in China, also said in an interview with the media that "European companies are doing very well here (China) and the long-term prospects are very positive."

　　"China attaches great importance to developing relations with Europe and is committed to deepening mutually beneficial and win-win cooperation between the two sides, maintaining the stability and smoothness of the global industrial chain supply chain and maintaining international economic and trade rules and order." On the 1st, China’s Ministry of Commerce spokesperson Shu Jueting stressed that "this is a balanced, high-level, mutually beneficial and win-win agreement, which is beneficial to China, the EU and the world. China and the EU should work together to promote the signing and entry into force of the agreement and benefit the enterprises and people of both sides at an early date. "

　　Zhao Chen, a researcher at the European Institute of China Academy of Social Sciences, told the Global Times reporter on the 1st that it can be seen that the actual decision-making or executive departments in Brussels still have a strong will to push forward the approval process in China-EU Comprehensive Agreement on Investment. However, due to the obstruction of ideology and the European Parliament, as well as the negative impact of the Russian-Ukrainian conflict, the ratification of the agreement is not optimistic in the short term. However, in the long run, China-EU Comprehensive Agreement on Investment is expected to recover.

　　Zhao Chen believes that on economic and trade issues, Chairman Supreme Leader emphasized the mutual benefit of economic globalization and China-EU economic and trade relations, encouraged more European enterprises to invest in China, and at the same time raised China’s concern, that is, opposed to politicizing and weaponizing economic and trade scientific and technological exchanges, and hoped that the EU would eliminate interference and provide a fair and transparent business environment for China enterprises.

　　"EU adheres to strategic autonomy"

　　During the talks on the 1st, Michelle particularly emphasized that the EU adheres to strategic autonomy and is committed to strengthening its own capacity building and promoting European integration. The EU adheres to the one-China policy, respects China’s sovereignty and territorial integrity, and will not interfere in China’s internal affairs. The EU is willing to be a reliable and predictable partner of China. The EU is willing to conduct high-level exchanges with China in the next stage, reduce misunderstandings and misjudgments by strengthening direct dialogue and cooperation, strengthen communication and cooperation, and better cope with global challenges such as energy crisis, climate change and public health.

　　Some western media have noticed that while Michelle is visiting China, French President Macron is holding talks with US President Joe Biden in Washington, D.C., to show their cards on the issue of the Inflation Reduction Bill. And the EU’s second foreign policy official — — Sannino, Secretary-General of the EU External Action Agency, will hold a biannual dialogue with US Deputy Secretary of State Sherman on China. Stech, an expert in German think tank Merics, thinks that this may even give people the impression that transatlantic relations are cracked.

　　In recent weeks, some European governments are attacking the US economy and China policy. The South China Morning Post quoted a diplomat as saying that most EU countries "don’t want to be forced to make a choice" and "don’t want the world to split into two camps".

　　Xinhua, director of the European Union Research Center of Shanghai International Studies University, told the Global Times reporter on the 1st that since the first half of this year, Biden’s government has frequently sent all kinds of goodwill signals to Europe, hoping to win over Europe to jointly implement some kind of strategic cooperation with China and tie Europe to the "chariot" of strategic competition between the United States and China. However, the continuous contact between Europe and China shows that although Europe is inevitably dependent on the United States and NATO for security, its determination to achieve strategic autonomy in other fields, especially in the economy, is increasing.

　　It is reported that after Michelle, many European leaders, such as Italian Prime Minister meloni and French President Macron, plan or are planning to visit China.

　　[Special correspondent of Global Times in France and Germany Yu Chaofan Zhao Dong Global Times reporter Zhao Juekun Fan Anqi Wang Yi Liu Zhi]