How to write a frightening and thought-provoking mystery novel?

Time:July 30th (Friday) 20:00-21:00

Location:Litchi podcast

Guest:Zhuang Qin (thriller mystery novel writer) and Inspector Tie (manager of Sanhuqiao Detective Agency)

Litchi Podcast Suspense Live Week series activities, this field invited mystery novel writer Zhuang Qin to talk with Inspector Tie, the manager of Sanhuqiao Detective Agency. The biggest goal of Zhuang Qin’s writing is to write a frightening and thought-provoking mystery novel, and strive to combine Hitchcock’s suspense with Poe’s horror. So how can we do it?

What kind of mystery novel has the potential of film and television?

Time:July 30th (Friday) 21:00-22:30.

Location:Litchi podcast

Guest:Kwai Taguchi (mystery writer), Afra (manager of whispering), An Zhiyong (screenwriter), Cao Yun (producer and script planner)

Many mystery novel films have been remake into TV dramas, with good box office and good reputation. So what kind of mystery novel has the potential of film and television? Litchi Podcast Suspense Live Week series activities, this field invites mystery writers and screenwriters and producers in the film and television circle to talk about the topic of film and television.

Deciphering the era of pressure: how to scientifically "stress mountain"

Time:July 31st (Saturday) 10:00-11:00.

Location:Sina Weibo @ Shanghai Library Messenger

Speaker:Li Shijia (Associate Professor, School of Psychology and Cognitive Science, East China Normal University)

Stress is the "spice of life" and the sharpening stone of a strong self. Stress and coping experience shape lifestyle and mind, just like getting sick after being infected with bacteria or viruses, and gaining immunity after recovery. Taking stress as a mirror, we can know ourselves better and love ourselves more. How do we deal with emotions and coexist with stress? On Saturday morning, Sina Weibo @ Shanghai Library Messenger watched the online sharing meeting.

Citing the past, evaluating the degree, and the order of etiquette: poetry and gentleman’s interpretation in Zuo Zhuan

Time:July 31st (Saturday) at 18:30.

Location:Tencent conference (ID: 81585448056)

Speaker:Ke Martin (Chair Professor, Princeton University)

Among the many unusual features of Zuo Zhuan (compared with any other historical writing in all ancient civilizations around the world), two are interrelated: first, the quotation and performance of traditional texts, especially the poem; Secondly, a kind of comment and historical appreciation (that is, one of several evaluation methods) on a specific level caused by "gentleman saying". A gentleman is not any specific figure, but an anthropomorphic representative of Confucianism in the Warring States period. His comments on historical narrative are independent of the narrative and wander in it, thus blurring and diluting the boundary between "text" and "comment". Secondly, what the gentleman said is closely related to quoting the ancient times, especially the poem, and is always presented in a moral preaching mode. The purpose of this lecture is to analyze the phenomenon that quoting Poems is closely related to "Gentleman’s Saying", and put forward that they actually serve two important purposes: first, to put the original materials of Zuo Zhuan under the ideological framework of Confucianism in the Warring States Period; Secondly, it teaches readers of Zuo Zhuan how to evaluate history morally and how to immerse themselves in traditional classics and idealized cultural practices. To sum up, Zuo Zhuan not only has expressiveness and performance, but also teaches readers how to become a gentleman and how to master the biography of Poetry.

From books and documents to information flow: on the development of literary research in sinology in North America

Time:August 3rd (Tuesday) 15:30-17:00.

Location:ZOOM conference

Speaker:Xu Mingde (postdoctoral fellow, Institute of Oriental Studies, Oxford University)

Under the influence of the history of books and the history of new culture, the history of reading has made great progress in the past 30 years, which not only makes us pay more attention to the way of text generation and the editor’s mentality of proofreading, but also makes us rethink many stereotypes and conventions in the original literary history. In recent years, the history of reading is more based on information science, trying to understand the streaming of literary texts from the aspects of information collection, classification, processing, dissemination, storage and retrieval. In this speech, I hope to illustrate the development and trend of this kind of research by using three specific cases: (1) writing manuscripts in the Middle Ages, (2) Song Ci, and (3) the study of bookshops in the Ming and Qing Dynasties.

Darkness, Thriller, Profound and Interesting —— The Unique Soul World of Female mystery novel Writers

Time:August 3rd (Tuesday) 19:00-20:00.

Location:Litchi podcast

Guest:Ye Congling (mystery novel writer), Shui Mei Yiren (mystery novel writer), Qi Diao Xing (mystery novel writer) and Xiao Yao UU (mystery novel writer).

What are the characteristics of female mystery novel writers’ works? Litchi Podcast Suspense Live Week series, in which four women are invited to share their writing.

The "Controversy" between the Classics and Social Schools in the Reasoning Circle

Time:August 4th (Wednesday) 19:00-20:00.

Location:Litchi podcast

Guest:Beaver (science fiction writer, children’s literature writer), Shichen (mystery writer), Hu Yanyun (mystery writer), Wasby (mystery researcher)

In the last activity of Litchi Podcast Suspense Live Week, four distinguished guests were invited to talk about a topic that has been debated for a long time in the reasoning circle: Is it a stereotype or a social school?

Hakata, a port city in Asia

Time:August 5 (Thursday) at 14:00

Location:Tencent conference (ID: 72297741, password: 1977)

Speaker:Koji Ito (Professor, Institute of Comparative Social Culture, Kyushu University)

Koji Ito is mainly engaged in the research on the history of Japan’s medieval foreign relations, the history of East Asian seas, the history of diplomatic documents and the history of Zen temples. His main works include Hakata and Asia in the Middle Ages (2021). In this lecture on the frontier of East Asian history, we invite Professor Yukio Ito to give a lecture on Hakata, a port city in Asia.

Attachment: Preview of offline activities

Beijing | Scotland and Scottish Nation at the Crossroads

Time:July 31st (Saturday) 15:00-17:00.

Location:SKP RENDEZ-VOUS, Floor 4, Beijing SKP Shopping Center, No.87 Jianguo Road, Chaoyang District

Guest:Meng Huaxuan (representative of the Scottish government in China), Xu Heqian (director of the international news department of Caixin Media), Xu Yitong (translator) and Gao Lin (writer and book reviewer).

The Scottish Nation: A Modern History is one of the "Scottish Trilogy" written by British scholar T.M. Devine. It describes in detail the history of Scotland from 1700 to 2007 for nearly 300 years, so as to help readers better understand why the alliance between Scotland and England, two independent nations, lasted for 300 years, the current situation of Scotland, and the historical origin of England and even Britain. On the afternoon of July 31st, when the Chinese version of The Scottish Nation was officially launched in Oracle Bone Inscriptions, we were fortunate to invite Martin McDermott, the representative of the Scottish government in China, Xu Yitong, the translator of this book, Xu Heqian, the director of the international news department of Caixin Media, who studied in Scotland, and Gao Lin, a writer who is familiar with European history, to review and analyze the past and present of Scotland, and to discuss the formation of Scotland’s "national image", its accession to the United Kingdom, Scotland and the European continent.

Beijing | Materialized Poetic Imagination —— A Seminar on Mark Tuzhou’s Poems of the "90s Generation"

Time:July 31st (Saturday) 15:00-18:00.

Location:Coder Bookstore, Floor 1, Building 15, Far East Instrument Company, No.6 Hepingli North Street, Dongcheng District

Guest:Mark Tuzhou (poet), Liu Nianjiu (poet, poetry critic), etc.

In fact, the incarnation of reason represents an important turn of modern philosophy, which has made considerable progress in maurice merleau-ponty’s phenomenology of body, and also spread throughout radical philosophy such as Alain Badiou’s claim to Pessoa. Bartius asked what kind of philosophy could be worthy of Pessoa’s poems, and we had to ask reversely, did our current poems keep up with the call of philosophy of the times, or could lead a more novel philosophy?

Beijing | Story of Cruel Youth —— A screening of "Rest on a Horse"

Time:July 31st (Saturday) 19:00-21:00.

Location:4-1 One-way Space, North Zone, Dongfeng Art District, No.6 Nanlijia, Jiuxianqiao Tuofangying, Chaoyang District

The Young Man of Grambe is a collection of stories consisting of six short stories and a novella, and the film "Rest on a Horse" is adapted from one of the novellas. On July 31, One-way Space will hold an offline free movie viewing activity of "Rely on the Horse".

Shanghai | Reread the classic The Catcher in the Rye: Are you lonely in the crowd, too?

Time:July 30th (Friday) 19:00-21:00

Location:Sinan Bookstore, No.517 Fuxing Middle Road, Huangpu District

Guest:Wang Zhan Hei (writer) and Zheng Shiliang (executive editor of The Paper Shanghai Book Review)

Seventy years ago, on July 16th, American writer J.D. Salinger’s novel The Catcher in the Rye came out, which influenced the youth of generations. On the evening of July 30th, guests Wang Zhan Hei and Zheng Shiliang will come to Sinan Bookstore to take you into the inner world of the protagonist Holden again.

The Construction and Rise and Fall of Shanghai | the Millennium Capital: Talking about the Ancient Capital under the Historical Torrent from The Beauty Made in Japan

Time:July 30th (Friday) 19:00-21:00

Location:3/F, No.150 Pucheng Road, Pudong New Area, Shanghai Pudong Library Rong Study Room

Guest:Sha Qingqing (Deputy Director of Shanghai Library Historical Documentation Center) and Kang Hao (Lecturer of World History Department of Shanghai Normal University)

How was Kyoto, whose capital has been established for more than 1,200 years, built? How can the ancient capital, which has experienced numerous disasters and wars, be reborn? How do new political forces create new urban forms? How does the civic culture bred in it change or even dominate the fate of the city? Has Japan’s ancient capital been successfully transformed into a city suitable for the new era? What is the difference between Kyoto under the lens of tourists and Kyoto living in it? On Friday night, Lujiazui Reading Club invited Sha Qingqing and Kang Hao, Japanese historians, to talk with us about how the ancient Japanese capital was built under the historical torrent and how it became what it is today.

Shanghai | Novels and Maps: Passionate Pursuit of "Truth" —— Tang Di’s New Book Sharing Meeting of Zero Kilometers

Time:July 30th (Friday) 19:00-21:00

Location:Xingfu Jihui, No.1331 Fuxing Middle Road, Xuhui District

Guest:Tang Di (writer and director), Konoha (critic and poet) and Ji Zhongxian (writer and teacher of East China University of Political Science and Law).

Zero Kilometers is the first novel of Tang Di, a post-80s writer and film director, which shows his creative ambition different from writing short stories or screenplays. On the evening of July 30th, Tang Di, critic, poet Konoha, and writer Ji Zhongxian, will be a guest at the Happy Gathering Blackstone Store to talk about the work Zero Kilometers and share with readers a strange journey from Zero Kilometers.

Shanghai | Classic Nourishes the Heart, Traditions Strengthen the New —— Reading Club of Classic Introduction of Chinese Excellent Traditional Culture

Time:July 31st (Saturday) 14:00-16:00.

Location:Sinan Literature House, No.505 Fuxing Middle Road, Huangpu District

Guest:Wen Haiming (Professor, Doctoral Supervisor, School of Philosophy, China Renmin University), Liu Qiang (Professor, School of Humanities, Tongji University) and Guo Meihua (Professor, School of Humanities, Shanghai University of Finance and Economics)

What does traditional culture mean to us today? Internally speaking, it can respond to our inner needs, nourish our hearts, and thus produce life ideals, ethical concepts and aesthetic tastes; Looking to the outside world, we can point to the educational goal of educating people in the new era, and use Chinese excellent traditional cultural classics to achieve the current cultural education and cultural power. "Those who get Chinese get the world, and those who get traditional culture get Chinese". What is the relationship between Chinese excellent traditional culture and the future development of teenagers? How should we view Chinese excellent traditional culture today? On the afternoon of July 31st, in Sinan Literature House, the creative team of "Introduction to Classic of Chinese Excellent Traditional Culture" will guide us into the classic of traditional culture, tell the story behind the classic, and explain why the classic becomes a classic, how the classic becomes a classic, what is the reading value of the classic, what is the reading method of the classic, and how we can learn from the classic.

Shanghai | Reconstruction of Classic Comic Books —— Signing Meeting of Zhuge Liang Biography (Comic Book Collection Edition)

Time:July 31st (Saturday) 14:00-16:00.　

Location:Art Bookstore, No.424 Fuzhou Road, Huangpu District

Speaker:Ye Xiong (comic book artist, researcher of painting and calligraphy in Shanghai Literature and History Museum)

On July 31st, Ye Xiong, a famous comic book artist, will hold a signing ceremony in the art bookstore with his masterpiece Zhuge Liang Chuan (comic book collector’s edition).

Shanghai | Across North America, Meet a Different Life? -The North American version of the cultural journey "North American Guest" writers face to face

Time:July 31st (Saturday) 14:00-16:00.

Location:The Biography Library on the 4th floor of Investment Press was built on the 1st floor of Jiayu Building, Building 8, No.18 Gongping Road, Hongkou District.

Guest:Liu Qun (writer), Tan Yuanbo (dance artist), Lin Panpan (impromptu body performer) and Wu Liqiang (artist).

On the afternoon of July 31st, Jiantou Bookstore will jointly collect Tianjuan and invite Liu Qun, the author of North American Guest, to share his 4-year, 9387-kilometer North American version of "Cultural Journey". During the activity, he will tell several life stories selectively, and dance artist Tan Yuanbo and impromptu body performer Lin Panpan will bring impromptu dance performances. Let’s meet interesting souls on the spot.

Shanghai | "Legend" Behind "Gossip" —— The release of the new book "Unknown Zhang Ailing"

Time:July 31st (Saturday) 15:00-16:30

Location:Duoyun Academy, 52nd Floor, Shanghai Tower, No.501 Yincheng Middle Road, Pudong New Area

Guest:Chen Zishan (researcher of Chinese Department of East China Normal University), Zhang Wei (research librarian of Shanghai Library) and Zhou Limin (executive deputy curator of Ba Jin’s former residence).

In addition to the Shanghai version of Legend and Gossip, Zhang Ailing also designed the binding of her own works? Zhang Ailing had a chance to leave images and sounds besides The Contrast? The Unknown Eileen Chang is the latest anthology of Chen Zishan’s discussion on Eileen Chang, which makes a new exploration, textual research, collation and interpretation of Eileen Chang’s literary historical materials, and "thinks that there is a new discovery". On the afternoon of July 24th, three distinguished guests, Chen Zishan, Zhang Wei and Zhou Limin, will come to the flagship store of Duoyun Academy to reveal the legend of Zhang.

Shanghai | The Awake Light-Benjamin and His The Sonnets

Time:July 31st (Saturday) 15:00-17:00.

Location:Poorthater area between 104 God Beasts, Phase 4, No.8 Bridge, No.457 Jumen Road, Huangpu District

Guest:Li Shuangzhi (researcher of German Department of Fudan University) and Wang Fanke (director of German Teaching and Research Section of Xiamen University)

The Sonnets is a rare literary work in walter benjamin. These eighty poems were all written in the author’s youth, which is an important witness of the author’s ideological transformation period, and is of great significance to understanding and studying Benjamin and German poetry. On the afternoon of July 31st, with the publication of the Chinese version of The Sonnets, the translator Wang Fanke and the school translator Li Shuangzhi will come between the beasts, and the two scholars will lead you to read and understand Benjamin as a poet.

Shanghai | Interpreting Wang Xifeng from the Modern Feminine Consciousness —— Appreciation and Sharing Meeting of Peking Opera "Wang Xifeng makes a scene in Ningguo Mansion"

Time:August 1st (Sunday) at 13:30.

Location:Duoyun Academy Drama Store, No.398 Changle Road, Huangpu District

Guest:Guo Chenzi (Associate Professor of Shanghai Theatre Academy) and Yang Yang (Peking Opera Actor)

The Peking Opera Wang Xifeng made a scene in Ningguo Mansion, which was adapted from A Dream of Red Mansions, one of Four Great Classical Novels, and has defied the stage for decades. This performance, based on the version of Tong Zhiling’s performance in 1982, focuses on combing Wang Xifeng’s action clues and psychological context, highlighting the human tragedy in the atmosphere of a specific era. On the afternoon of August 1st, Guo Chenzi, an associate professor of Shanghai Theatre Academy, and Yang Yang, a national first-class actor, will come to Duoyun Academy and Drama Shop to deeply interpret Wang Xifeng from the perspective of modern female consciousness.

Shanghai | Looking for Old Shanghai Coffee Feelings

Time:August 1st (Sunday) 14:00-16:00

Location:Floor 1, Art Bookstore, No.424 Fuzhou Road, Huangpu District

Guest:Sun Ying (Deputy Research Librarian of Minhang District Library) and Zhang Wei (Research Librarian of Shanghai Library)

In the mid-19th century, coffee, as an exotic product, took root in Shanghai, a land where Chinese and Western cultures merged, and then gradually merged into the texture of the city. Coffee culture has become an important part of Shanghai culture, and coffee has also become a unique business card of Shanghai. On August 1st, we invited Sun Ying, deputy research librarian of Minhang District Library, and Zhang Wei, research librarian of Shanghai Library, to give a lecture on "Looking for Old Shanghai Coffee Feelings" in the Art Bookstore. During the activity, the two guests will lead the readers to start a special "taste journey" around the interesting culture, celebrity complex and historical events related to coffee.

Shanghai | Come in, 1972! Belfast-Sharing Meeting of the New Book "Say Nothing: An Irish Murder"

Time:August 5 (Thursday) at 19:00

Location:Xuhui Tiandi LG1 Eryou Bookstore, No.1 Lane 458, Madang Road, Huangpu District

Guest:Sha Qingqing (deputy director of the Historical Documentation Center of Shanghai Library), Zheng Shiliang (executive editor of The Paper Shanghai Book Review), Xiong Yi-fang (translator).

One day at the end of 1972, Joan McConville, the mother of ten children, was kidnapped from her home in Belfast by a group of masked men, and her children never saw her again. This is the most notorious case in the Northern Ireland conflict. Who killed Joan McConville? At the launch of this new book, we invited three guests, Sha Qingqing, Zheng Shiliang and Xiong Yicheng, to introduce the contents of Don’t Say anything to readers and try to answer the question "What should Northern Ireland answer".

Hangzhou | Boundless Reality, Endless Journey —— Sharing Meeting of Tang Di’s "Zero Kilometers"

Time:July 31st (Saturday) 14:30-16:30

Location:One-way space 2F, B201, Yuanyang Ledigang Cultural Experience Zone, No.58 Lishui Road, Gongshu District

Guest:Tang Di (writer, director), Bad Bird (founder of the Federation)

On July 31st, Tang Di, a writer and film director, and Bad Bird, the founder of the Federation, will visit Hangzhou Ledigang Store in One-way Space to talk about the work Zero Kilometers and share with readers a strange journey from Zero Kilometers.

Hangzhou | Three Sad Tigers: The Birth of a Wonderful Book

Time:July 31st (Saturday) 15:00.

Location:Xiaofeng Bookstore in Mituo Temple, No.533 Tiyuchang Road, Xihu District

Guest:Fan Ye (Associate Professor, Department of Spanish-Portuguese, Peking University Foreign Studies University), Guo Guoliang (Professor, Doctoral Supervisor, School of Foreign Studies, Zhejiang University), Kong Yalei (novelist, translator).

Cabrera Infante is one of the most important writers in Latin America during the "literary explosion". Three Sad Tigers is his most important work. The background of the story is set in Cuba on the eve of the revolution. A group of bohemian artists and writers wander in Havana at night, shuttling between different bars and nightclubs. With this background, Infante fully reproduces the dreamy atmosphere of Havana at the end of 1950s. On July 31st, Fan Ye, the translator of this book, Kong Yalei, the novelist and translator, Guo Guoliang, a professor at the School of Foreign Languages of Zhejiang University, and Yang Quanqiang, the editor-in-chief of Xingsi Culture, will come to the Amitabha Temple Store in Xiaofeng Bookstore to discuss this wonderful work in the history of Latin American literature with readers, and tell about the author Infante and Three Sad Tigers, as well as the difficulties and happiness in the eight-year translation process.

Wuhan | Approaching Qian Jibo —— How the Master of Chinese Studies was Created?

Time:July 31st (Saturday) at 9:30.

Location:Changjiang lecture hall of Hubei Provincial Library, No.25 Gongzheng Road, Wuchang District

Speaker:Wang Yude (former Dean and Professor of School of History and Culture, Huazhong Normal University)

Qian Jibo is one of the most outstanding masters of Chinese studies in the 20th century. What achievements has he made in Chinese studies? Why is his achievements in Chinese studies universally recognized? How did he train his son Qian Zhongshu to become a master of Chinese studies? How did he spend the last ten years of his life in Wuhan? What does his life of Chinese studies enlighten us? This Saturday, welcome to listen to Professor Wang Yude from the School of History and Culture of Central China Normal University about "Approaching Qian Jibo-How the Master of Chinese Studies was Made".

Nanchang Uprising

Under the extremely severe situation that the revolution suffered serious failure, should we persist in the revolution? How to persist in the revolution? These are two fundamental issues before the Communist Party of China (CPC). The party gave a preliminary and clear answer to this with the actual action of armed uprising.

In order to revive the revolution, the party led the people in an arduous struggle. In mid-July, 1927, the Standing Committee of the Provisional Political Bureau of the Central Committee of the Communist Party of China sent Li Lisan, Deng Zhongxia, Tan Pingshan and Yun Daiying to Jiujiang, Jiangxi, to organize some forces of the National Revolutionary Army controlled and influenced by the Communist Party of China (CPC), and to unite with the commander-in-chief of the Second Army, Zhang Fakui, to return to Guangdong, so as to establish a new revolutionary base and carry out the agrarian revolution. On July 20th, when Zhang Fakui was found to be on Wang Ching-wei’s side, Li Lisan and others immediately abandoned the plan of relying on Zhang Fakui and proposed to launch an independent military action against the Kuomintang governments in Nanjing and Wuhan, namely the Nanchang Uprising. After learning the proposal of Li Lisan and others, the Standing Committee of the Provisional Political Bureau of the Central Committee formally confirmed the deployment of an armed uprising in Nanchang. Subsequently, the plan of the uprising was reported to the Communist International.

At this time, the 24th Division of the 11th Army under the jurisdiction of the Second Front Army of the National Revolutionary Army was commanded by communist party Ye Ting. The 73rd and 75th regiments of the 25th Division of the Fourth Army were organized by the Ye Ting Independent Regiment during the Northern Expedition, and the 30th Regiment of the 10th Division was held by communist party. The 20th Army was commanded by He Long (who joined the Communist Party of China (CPC) on the way south after the uprising) who was close to communist party. These troops have been transferred from Wuhan to Jiujiang in the name of "East Conquest against Chiang Kai-shek". In late July, Wang Ching-wei and Zhang Fakui felt that He Long and Ye Ting’s troops were "unstable" and tried to call He and Ye to Lushan in the name of a meeting to relieve them of their military power. Ye Jianying, the chief of staff of the Fourth Army, secretly rushed to Jiujiang from Lushan to discuss countermeasures with Ye Ting and He Long, and decided not to carry out the order of concentrating the troops under his jurisdiction in De ‘an, but to drive the troops to Nanchang and its nearby areas. In Nanchang, there are the Education Corps of the Third Army Officers of the Fifth Army and the Security Team of Nanchang Public Security Bureau, which were originally commanded by Zhu De and influenced by communist party. These troops are the main part of the regular revolutionary armed forces cultivated and exerted great influence by the Party during the Great Revolution, and they are also the main military forces that held the Nanchang Uprising.

On July 27th, Zhou Enlai arrived in Nanchang from Wuhan via Jiujiang. According to the decision of the Central Committee, the Front Committee of the Communist Party of China was established, consisting of Zhou Enlai, Li Lisan, Hui Daiying and Peng Pai, with Zhou Enlai as the secretary. The front Committee immediately decided to revolt on July 30.

While the preparations for the uprising were tense, the Central Committee of the Communist Party of China received a telegram from the Communist International according to the decision of the Communist Party of the Political Bureau of the Central Committee. The telegram pointed out: "If we are sure of success, we think your plan is feasible." After analyzing the situation, the Central Committee of the Communist Party of China believed that the Nanchang Uprising was sure of success, and decided to send Zhang Guotao, member of the Standing Committee of the Provisional Political Bureau of the Central Committee, to Nanchang as a representative of the Central Committee to convey the instructions of the Comintern and the Central Committee of the Communist Party of China. On the morning of July 30th, Zhang Guotao arrived in Nanchang. Because he still has illusions about Zhang Fakui, he advocates that Zhang Fakui’s consent must be obtained before an uprising can be held. This opinion was rejected by the front Committee. On July 31st, the Front Committee decided to hold an uprising in the early morning of August 1st.

In the early morning of August 1st, under the leadership of the Front Committee headed by Zhou Enlai, He Long, Ye Ting, Zhu De and Liu Bocheng led more than 20,000 troops under the direct control and influence of the Party to hold the Nanchang Uprising. After more than four hours of fierce fighting, the insurgents wiped out more than 3,000 people on the defensive and occupied Nanchang City. Nie Rongzhen and Zhou Shidi pulled out most of the troops of the 25th Division to take part in the uprising in Mahuiling, near Nanchang, and arrived in Nanchang on August 2nd.

In order to win over and unite some people in the Kuomintang who are willing to continue the revolution and expose Chiang Kai-shek and Wang Ching-wei’s betrayal of Sun Yat-sen’s revolutionary spirit, this uprising still uses the banner of the Kuomintang left. After the victory of the uprising, the Revolutionary Committee of the Chinese Nationalist Party was established, and 25 members including Soong Ching Ling, Deng Yanda (the above two have not been to Nanchang), He Long and Zhou Enlai were elected, and the presidium consisted of seven members including Soong Ching Ling and Deng Yanda. At the same time, in the name of Soong Ching Ling and others, he published the Declaration of the Central Committee, pointing out that Chiang Kai-shek in Nanjing and Wang Jingwei in Wuhan misinterpreted the Three People’s Principles, betrayed the cooperation between the Kuomintang and the Communist Party, and abandoned the three major policies of uniting Russia, uniting the Communist Party and helping the peasants and workers, which have become sinners of Sun Yat-sen’s cause; Call on all revolutionaries to unite, inherit Sun Yat-sen’s revolutionary legacy, and "continue to fight against imperialism and solve the land problem". Uprising troops used the designation of the Second Army of the National Revolutionary Army, and had three armies under their jurisdiction: the ninth, eleventh and twentieth armies. (Wei Chu, commander of the Ninth Army (not yet in position), Zhu De, deputy commander (soon to take over as commander), and Zhu Kejing, the party representative. Ye Ting, commander of the 11th Army, represented Nie Rongzhen. He Long, commander of the 20th Army, and Liao Ganwu, the representative of the Party —— Author’s Note) The Revolutionary Committee appointed He Long as the commander-in-chief of the Second Army of the National Revolutionary Army, and Ye Ting as the commander-in-chief of the former enemy.

On August 3rd, according to the decision made by the Central Committee before the uprising, the insurgents began to leave Nanchang, passing Linchuan (Fuzhou), Yihuang and Guangchang, and went south to Guangdong, with a view to restoring the revolutionary base areas in Guangdong, occupying the seaport, obtaining international assistance, and then resuming the Northern Expedition. But by this time, most of the National Revolutionary Army had turned to counter-revolution, and the Nanchang Uprising Force led by communist party was weak, so it was impossible to carry out a revolutionary war with the occupation of cities as the central goal, like the Northern Expedition during the Great Revolution. After withdrawing from Nanchang, the rebel army did not realize that it should go to the vast rural areas of Jiangxi, Hunan and Hubei nearby to combine with the peasant movement that has not been completely suppressed by counter-revolutionary forces, so as to gradually accumulate and expand revolutionary forces. Instead, it was busy going south to Guangdong to make expeditions and compete for cities and seaports. In this way, we will put ourselves in a disadvantageous position.

On the way to Guangdong, due to the weak leadership and political work of the Party and the hot weather, many soldiers fled and fell ill, and the number of troops was seriously reduced. Cai Tingkai, the commander of the 10th Division of the 11th Army, who was wavering during the uprising, led his troops to leave the revolutionary ranks when he arrived in Jiangxi to become a sage. On the way to the south, the rebels fought fiercely with the Kuomintang troops who came to intercept them. Although they won some victories, they also suffered great casualties. After the capture of Chao ‘an and Shantou in Guangdong in late September, the main troops marched westward to Tangkeng (now Fengshun County) via Jieyang, and a few troops stayed in Chao ‘an and Shantou. At the beginning of October, under the siege of the superior enemy forces, these troops all suffered serious failures. Only a small part of the 24 th Division of the Eleventh Army, led by Dong Lang and others, was transferred to Haifeng and Lufeng to join the local agricultural army. Nearly 800 insurgents stationed in Sanheba, led by Zhu De and Chen Yi, moved to the border areas of Guangdong, Jiangxi and Hunan to carry out guerrilla warfare. After the failure of the uprising, Zhou Enlai and other leaders arrived in Hongkong. After summing up the lessons, they decided that the rest of the insurgents should combine with the peasants on the spot and carry out armed struggle in the countryside.

The Nanchang Uprising fired the first shot of armed resistance against the Kuomintang reactionaries, and in the language of blood and fire, it declared the strong determination of the Communist Party of China (CPC) people to persist in the revolution without fear of violence. It set up a banner of revolutionary armed struggle in front of the whole party and the people of the whole country, marking the Communist Party of China (CPC)’s independent leadership of the revolutionary war and the creation of the people’s army (in July 1933, the provisional central government of chinese soviet republic passed a resolution, pointing out that the Chinese Red Army of Workers and Peasants was formed by the Nanchang Uprising, so it "approved the proposal of the Central Revolutionary Military Commission and stipulated that" August 1st "should be the anniversary of the Chinese Red Army of Workers and Peasants every year". This is the origin that August 1st became the Army Day of China People’s Liberation Army (the author’s note) and the beginning of the armed seizure of political power, so it is of great historical significance.

Looking at the news, recently, a data map about the infection efficiency of Kexing was circulated on the Internet, which indicated that, according to the latest data of the fifth round of epidemic in Hong Kong, the effective rate of Kexing in preventing Omicron was low. Even after the third injection, the effective rate of preventing infection was only 36% on the 14th day after inoculation, but only 8% after six months.

So, is this really the case?

This is not true statistics.

Tracing back to the source, we found that this picture was first seen in a simulation model of the epidemic development of Hong Kong universities reported by the Hong Kong investigative news agency Fax Agency in February this year. The data content is the calculated result of the model, not the real statistical data of Hong Kong society.

On February 10th, the School of Public Health of HKU released the simulation model of epidemic development in The 5th Wave [1], in which the efficiency of each vaccine combination in different periods was calculated based on the data of different medical studies. The study estimated that the effective rate of preventing Omicron variant virus infection was 36% on 14th day after the third dose of Kexing vaccine, and it dropped to 8% after 6 months.

So, what is the real situation?

According to the epidemic data released in Hong Kong on December 23rd, in the fifth round of epidemic (from December 31st, 2021 to December 21st, 2022), 2.32 million people were infected in Hong Kong, more than 7.04 million people have been vaccinated with at least one dose of vaccine, and 627,000 people have been vaccinated with the fourth dose of vaccine.

According to a rough calculation,There is no significant difference in infection ratio between inactivated vaccine and mRNA vaccine.

Taking the infection ratio after the fourth injection as an example, the average infection ratio of inactivated vaccine was 11.97%, while the infection ratio of mRNA vaccine was 8.99%, with a difference of 2.97%. This difference decreases with age. In the group over 80 years old, the proportion of infection between them is only 0.93%.

Moreover, with the increase of the number of vaccination agents, the effectiveness of preventing infection has increased.

The inactivation effect of anti-infection is slightly lower than that of mRNA vaccine.

Although there is no big difference in the actual infection rate, from the perspective of preventing infection,The effectiveness of inactivated vaccine against infection is indeed lower than that of mRNA vaccine.

According to the paper published by the Institute of Public Health of the University of Hong Kong in November this year [2], this study analyzed the effectiveness of Fubitai and Kexing COVID-19 vaccine through the serum survey of 5310 subjects in Hong Kong.

It was found that the effectiveness of inactivated vaccine (31%) was slightly lower than that of mRNA vaccine (47%) 7 days after inoculation.

Both of them are effective in preventing COVID-19 in the short term.

But by contrast,Inactivated vaccine has a short validity period.

The effective concentration of mRNA vaccine antibody remained in blood for a long time, and the effectiveness declined by half after 104 days. The semi-decline period of inactivated vaccine is about 40 days.

The strength of effectiveness may be related to the technology adopted by the vaccine.

The mRNA vaccine contains the messenger ribonucleic acid (mRNA) of the virus, and its working principle is to send instructions to the host cell to replicate the spike protein, so that the immune mechanism can produce antibodies in time to deal with the virus. The inactivated vaccine is injected with a complete, killed copy of the virus, making it impossible to replicate without causing disease.

The two technologies are different, so the effectiveness is different.

Inactivated vaccines are equally effective in preventing severe illness and death.

Although it is not effective in preventing infection, the effect of inactivated vaccine is equal to or even better than that of mRNA vaccine in preventing severe illness and death.

According to the paper published by the Medical College of the National University of Singapore in November this year [3], although the antibody response guided by inactivated vaccine is not as good as that of mRNA vaccine, inactivated vaccine can trigger a wide range of immune responses against different protein viruses.It is more effective against severe infection..

It is found that inactivated vaccines are more likely to produce T cell reactions against viral proteins than other types of vaccines. Inactivated vaccines stimulate cells called CD4 T, and when they recognize virus antigens, they release chemicals that become cytokines to help activate other types of immune cells.

Professor Antonio Bertoletti, who is in charge of the project, said that T cells are more effective in improving diseases than antibodies because of Omicron’s strong immune escape ability.

According to the actual data, in this round of epidemic in Hongkong, the total case fatality rate (or overall case fatality rate) is 0.71%, and the probability of the unvaccinated people dying of Covid-19 infection is 2.87%. The mortality of one dose of Kexing vaccine was 1.25%, two doses was 0.31%, and three doses was 0.04%.

In other words,The mortality rate of people without vaccination is 71.8 times higher than that of people with three doses of Kexing vaccine.

According to the paper published by the Institute of Public Health of the University of Hong Kong in July this year [4], after three injections, the effective rate of inactivated vaccine for preventing severe illness and death exceeded 95%.

On the average, inactivated vaccine is no different from mRNA vaccine. The effective rate of inactivated vaccine is 97.23%, which is only 1.18% lower than that of mRNA vaccine. In the prevention of COVID-19’s death, the effective rate of both reached 98%, and the difference was only 0.45%.

Even in some age groups, the effective rate of inactivated vaccine is better than that of mRNA vaccine. For example, for people over 80 years old, the efficiency of inactivated vaccine in preventing severe illness and death is higher than that of mRNA vaccine.

According to a paper published by the Chilean Ministry of Health in February this year [5],Inactivated vaccines are equally effective in preventing severe diseases in children and adolescents.

It was found that for children and adolescents aged 6 to 16, the effective rate of two inactivated vaccines against hospitalization was 91%, and the confidence interval was 87.8% to 93.4%. The effective rate of preventing severe illness (that is, staying in ICU) is 93.8%, and the confidence interval is 87.8% to 93.4%.

On the whole, whether it is inactivated vaccine or mRNA vaccine, booster vaccination can provide substantial protection against infection in Covid-19, including mild and asymptomatic cases.

Although Covid-19 infection in China has been adjusted to "Class B tube" at present, "keeping healthy and preventing severe diseases" is still the focus of epidemic prevention, and it is still necessary to continue to promote vaccination, especially for the elderly.

Related papers:

[1] HKU School of Medicine Briefing COVID-19 The 5th Wave epidemic development simulation model.

【2】Lau, J. J.,Cheng, S. M.,Leung, K.,Lee, C. K.,Hachim, A.,Tsang, L. C.,…& Wu, J. T. (2022). Population-based sero-epidemiological estimates of real-world vaccine effectiveness against Omicron infection in an infection-naive population, Hong Kong, January to July 2022.　medRxiv.

【3】Lim, J. M. E.,Hang, S. K.,Hariharaputran, S.,Chia, A.,Tan, N.,Lee, E. S.,…& Tan, A. T. (2022). A comparative characterization of SARS-CoV-2-specific T cells induced by mRNA or inactive virus COVID-19 vaccines.　Cell Reports Medicine,　3(11), 100793.

【4】McMenamin, M. E.,Nealon, J.,& Lin, Y. (2022). Vaccine effectiveness of one, two, and three doses of BNT162b2 and CoronaVac against COVID-19 in Hong Kong: a population-based observational study (vol 22, pg P1435, 2022).　LANCET INFECTIOUS DISEASES,　22(9), E239-E239.

【5】Jara, Alejandro, et al. "Effectiveness of an Inactivated SARS-CoV-2 Vaccine in Children and Adolescents: A Large-Scale Observational Study."

Original title: Kexing three-needle infection prevention rate is only 8%? We found that this is not the real world data, and the truth is actually like this.

Editor: wu si

Editor: Wu Zhonglan

Audit: Feng Fei

● Article 8 Car logo: 1972-1984

　　When it was sold to Birmingham Company in aston martin in 1972, because the helm of the company was changed to William Willson, the word "David Brown" appeared on the aston martin logo was obviously inappropriate, so a new aston martin logo was born. In addition to the letter "David Brown", the feathers on the logo were "combed" again, the lines on the inner and outer layers were connected into a whole, and the background of the logo turned light blue. This logo was first installed on V8 models after 1972. Subsequently, the V8 and models also used brand-new logos.

　　Since 1974, aston martin has been in turmoil again. In 1975, it was taken over by North American Peter Sprague and Canadian George Minden. In 1981, it was taken over by a private oil company led by Victor Gauntlett; In 1983, it was 100% acquired by the American distributor Automobile Investment Alliance; In October 1984, the Peter Livanos family owned 75% of the shares, and Victor Gauntlett owned the remaining 25%. It was not until 1987, when Auto acquired 75% of aston martin’s shares, that aston martin’s fate was temporarily calmed down. In 1994, Ford owned Aspen.
All the shares of don Martin.

● The ninth logo of aston martin: 1984-2002

　　During the turbulent years in aston martin, the logo of aston martin has undergone a change, which was in 1984, after the Peter Livanos family owned aston martin. At that time, the models produced in aston martin were still V8 and V8 Vantage. In that year, the 10,000 th model of aston martin rolled off the assembly line, so aston martin put on a brand-new logo. Of course, the change of this logo is still "changing the soup without changing the medicine", mainly for the internal lines and borders of the logo feathers. The interior of the logo has become more concise and the borders have become silver again.

　　After entering Ford, aston martin began to develop and launch a large number of new models. Not only did the DB naming method, which had been stopped for nearly 20 years, be re-launched in 1993, and DB7, DBS, DB9 and other models were launched respectively, but also brand-new V8, V8 Vantage, V8 Zagato and other models were launched, and the sales volume also increased gradually. In a few short years, the sales volume of aston martin was higher than the sum of the models produced in the past 80 years.

● Aston martin Tenth Car Logo: 2003-Up to now

　　2003 is an unusual year for aston martin, which is not only the 90th anniversary of the founding of aston martin Company, but also the new V8 Vantage released by aston martin at the north american international auto show held in Detroit, Michigan, USA, which reintroduced the classic V8 and greatly enhanced the company’s market competitiveness. At the same time, the DB9 model came out, replacing the DB7 model for ten years. In addition, in the same year, a new factory was established in Gordon, England, becoming the first professional factory in the history of aston martin. It was also in this year that the latest generation logo of aston martin, which you see now, was born.

　　The last time aston martin changed hands was in 2007, when a consortium led by British David Richards bought it from Ford at a cost of $959 million. That is to say, aston martin has returned to her native Britain again after years of travelling in other countries.

● The centenary of aston martin: 2013.

　　Today, all the models in aston martin still carry the logo of DB9. At the same time, on September 29th last month, aston martin also launched a centennial logo (only used by Aston Martin brand to celebrate its centenary birthday in 2013), which was designed by Marek Reichman, the design director of Aston Martin, and will be put into use in 2013 to commemorate the glorious centennial history of this classic luxury brand.

Summary:

　　In fact, since the second logo of aston martin, all the logos have kept a theme, that is, spreading a pair of wings, which was very popular in the era when the automobile industry just started. Today, after nearly a hundred years of ups and downs and evolution, aston martin logo is still full of design sense, and it is not out of date, and the previous design style has been completely passed down. Of course, it is not only the logo design that has been passed down, but also the brand of "high-quality car with high performance and perfect appearance" produced in aston martin. (Text/Figure Zhang Wenjun)

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> > Click on car home Culture Team to enter the interesting world of automobiles < <

It is difficult to remake, and it is even more difficult to remake judicial themes. Law, as the embodiment of the will of the ruling class, can well reflect the national conditions of a country. On the other hand, law will change social concepts and human behavior patterns. It is easy to translate a country’s laws, but it is difficult to move a country’s judicial practice patterns. After all, the laws printed on paper need to be operated by people, and the same procedures in different countries may result in completely different results.

Prosecutors in South Korea have great power, and most of the judicature is reflected in the self-realization of state violence. They have long been regarded as the hero of romantic dramas as "Su", or they are just incarnations of anti-corruption and combating social darkness, with "politics" but few "laws", and civil rights are rarely reflected.

In the past two years, prosecutors are no longer the omnipotent role of the hero, and lawyers and judges, the other two major components of the legal profession, have begun to receive much attention. South Korea’s water trial lawyer drama basically relies on remake, and the remake of American TV series "Proud Wife" and "Golden Lawyer" is unsuccessful. In Zuo Zhuan, it is said that "one drum is full of enthusiasm, and then it will fail, and three times it will be exhausted". It is reasonable to say that this type of test is unsuccessful twice. After all, the Korean remake of ethical dramas and criminal investigation themes has been done very well, and the market response is also very good. There is no need to give up on yourself.

But Koreans just want to understand the difficulty of remaking the legal type of Shu Dao. JTBC just created a "miracle of Hanjiang River" on cable TV with "City of the Sky" and then began to beat the drums to exhaustion, and took out a remake of the Korean version of the Japanese drama "Legal High" with the same name, and the ratings returned to the normal state of cable TV.

Korean drama "Legal High" poster

Legal High, a Japanese Fuji TV series starring Sakai Masato and Aragaki Yui and written by Ryota Kosawa, has an unshakable position in the hearts of China audiences. In previous years, every large-scale discussion involving legal issues, many screenshots of this TV series will be taken as the main argument, which is used more frequently than the screenshots of the TV series "The Queen’s Classroom" starring Amami Yuki.

Because the Japanese version starring in the audience has a good relationship and the TV series has a high popularity, it has become an insurmountable mountain in the hearts of China audiences. For the audience in China, both Japanese and Korean versions are imported, so they don’t need to experience the "localization" problem personally, just follow their own preferences and feelings. As long as the Korean version can’t surpass the original, it is unlikely to win the nostalgic audience in China. If the remake is not good, it will be miserable.

Douban score of the play

There is no need to say anything about what kind of story Legal High tells, but in order to point out the shortcomings of Korean dramas, we still have to say a few words. The Japanese version of the hero Gumeimen Kensuke (played by Sakai Masato) is a wonderful work of lawyers. He has been tempted on the edge of unconscionable for a long time. He is extravagant and lustful, but he can’t get it. On the whole, he is a comedy character. At the same time, he has a very powerful mouth, speaks like a cannon ball, and is as sharp as The Lancet. No matter what kind of opponents he faces, the audience also finds that this role is not unprincipled. De Mariko, played by Aragaki Yui, is described as "the heroine of the morning play". She is naive, kind and persistent, and is always played by the leading actor, which is the contrast of the leading actor.

Korean dramas basically maintain the comic character setting and comic exaggerated acting of Japanese dramas. The difference is that the overall temperament of the Japanese drama version is comic, especially the omnipotent Hattori uncle, whose existence is simply reminding the audience that this story can be set as semi-overhead.

However, the exaggeration of Korean dramas is not the whole, and only exists on the surface of the hero. In order to better "localize", the Korean version has added too many social problems in South Korea, such as power harassment, sexual harassment, gender equality, the gap between the rich and the poor, and so on. Xu Enxiu, the actress of Xu Zairen, starred in the famous Korean morning drama "My Golden Life" No.2, and in this drama, it is also a typical Korean "morning drama heroine" setting: Cinderella with a strong life. After the whole atmosphere was dismembered by these stereotyped elements of Korean dramas, Gao Tailin, the hero played by Jin Goo, was left to go crazy alone.

Jin Goo Shi Gao Tai Lin

Although every case in Legal High is social and reflects relatively profound social problems, its style is like comedy. Comedy is difficult to shoot, and the key lies in the kind of proper limit, where one point goes too far and one point doesn’t reach the designated position. The Japanese version is a fierce medicine that goes too far and stormed the audience. If this medicine is strengthened, it is basically equivalent to madness.

In order not to let the hero who is crazy alone be lonely, the Korean version diluted the crazy suicide methods in three ways. One is to drag the plot very slowly. The Korean version has a single episode of one hour, JTBC Golden Land File has two episodes every week, and the premiere week lasts for two hours, but the content is only equivalent to 37 minutes of the Japanese version.

The second method is to add suspense plots that do not exist in the original, and at the same time smash the suspense carefully set by the original. The former is, for example, the assassination of the hero by an unknown third party, while the latter is, for example, the appearance of the No.2 universal helper around the hero in advance, which makes the heroine find that one of the important roles in encouraging public opinion in the stage of collecting evidence is the intentional arrangement of the hero, which becomes boring.

The third is to add the usual tragic elements in Korean dramas. When the heroine was a child, she had an intersection with the defendant. She was considerate of her father’s pain and didn’t let him know the pain caused by her departure … What about a good comedy?

Xu enxiu decorated Xu zairen

The Korean version of Legal High is directed by Jin Zhengxian and Jin Shanghao, who directed Mrs. Cop 2, and written by Park Sung-jin, who once wrote Major Crimes. Compared with comedies full of banter and satire, it is better at suspense and real social problems. If we give up the comedy style of the Japanese version and adapt it into a pure Korean realistic suspense lawyer drama, we must give up the comic performance method and variety sound effects. Comedy is the most difficult, and comedy that adds drama to oneself is a disaster. The Korean remake of Legal High is such a disaster.

　　On the evening of January 28th, a speedboat carrying more than 20 tourists from China and 3 local workers capsized in the waters near Huantan Island in Sabah. Up to now, it has been confirmed that 20 tourists from China have been rescued, 3 tourists from China have been killed and several others are missing.

　　这些天里，这艘快艇和上面的中国游客，牵动了国人的心。目前经过确认，游客中有9名江苏游客，其中7人安全1人遇难1人失联。

　　中方态度：加大协调力度 绝不漏掉一人

　　中共中央总书记、国家主席、中央军委主席最高领袖立即就此作出重要指示，要求外交部和我国驻马来西亚使领馆加强与当地有关部门的联系，加大协调力度，全力做好搜救工作。交通运输部、国家旅游局等有关部门要立即启动应急机制，协助马方尽快开展救援。

　　中共中央政治局常委、国务院总理李克强作出批示，要求敦促马方加大力度，全力搜救我国失联游客，绝不漏掉一人。在境外中国公民保护机制框架下，妥善处理相关事宜，维护好我国公民合法权益，并会同有关地方做好游客家属信息通报、安抚等工作。

　　马方态度：不设时限 加快调查进度

　　马来西亚总理纳吉1月30日下令彻查沙巴游船沉没事件。他通过推特表示：“我严正看待沙巴游船失事，我要的是对此的详细调查，以查明肇事原因。”

　　沙巴警方表示已经对整个事件进行多维度的调查，并且不设时限，他们已经加快了调查进度。并表示会成立专案组，针对事故是否涉及刑事成份进行调查。

　　Progress: Malaysia has expanded its scope and Brunei has joined the search.

　　Malaysian maritime law enforcement officials said on January 30 that the search and rescue operation has not found the missing person in the shipwreck in Sabah. Malaysian police said that the owner and two crew members of the wrecked ship had been arrested to assist in the investigation.

　　The Malaysian Maritime Law Enforcement Bureau said that the scope of search and rescue was expanded to 3,000 square nautical miles that day, and about 20 surface ships and planes were sent by maritime law enforcement agencies, Malaysian navy, air force, police and Brunei to search and rescue. Search and rescue has entered the final stage of the golden rescue time, and the search and rescue efforts will be strengthened. Ahmad Puji, director of the Malaysian Maritime Law Enforcement Bureau, said that the search and rescue operation once found three people suspected of being in distress, but later confirmed that they were not shipwrecked.

　　The number of missing persons has been revised to 6, and the information remains to be verified.

　　A cruise ship carrying tourists from China sank on the way from Kota Kinabalu, the capital of Sabah, to the nearby scenic spot Huantan Island on January 28th. Malaysian police said that after investigation, there were only 27 China tourists on board at the time of the incident.

　　According to the current investigation, a tourist from China may think that there are too many people on board, so there may actually be only 27 tourists from China on the wrecked ship. In addition, a surviving China tourist boarded the ship with his wife and a 10-year-old daughter, but only his name was written at the time of registration. At present, his wife and daughter have not been found.

　　Regarding Malaysia’s above statement, the Consulate General of China in Kota Kinabalu said that the number of people could not be confirmed for the time being, and the relevant information needs further verification. The Consulate General of China in Kota Kinabalu has opened a temporary hotline. Zonghe

　　Seven tourists from Suzhou come from three families and know each other.

　　On the afternoon of January 31, the reporter learned from the Suzhou Foreign Affairs Office that in the sinking incident of the Malaysian speedboat, it was confirmed that there were 7 Suzhou citizens among the tourists. At present, 5 people are safe, 1 person was killed and 1 person lost contact. According to the reporter’s interview, the three families in Suzhou know each other and build a WeChat group to encourage each other to tide over the difficulties.

　　Family members are wary of strangers and are unwilling to be interviewed.

　　At about 1: 30 pm on January 31, the reporter arrived at the community of Shen, a lost person. When the reporter arrived, the entrance guard of the downstairs unit door was always open, as if to leave the door for relatives and friends.

　　In front of the reporter, a man and a woman were walking, and they were whispering something. Before the reporter had time to ask, the two had already entered the building, which seemed to be more vigilant.

　　The reporter was about to knock on the door when a man came up downstairs, looking dignified and more alert when he met a stranger. He asked, "Who are you?" What are you doing here? " When the reporter identified himself, the man said, "We don’t accept interviews now. Go, go." Before the reporter spoke again, the man was urged again and the reporter had to go downstairs. After the reporter left the unit door, the man went downstairs warily, closed the unit door and turned upstairs.

　　Subsequently, the reporter asked about the community security, but the community security only knew about the loss of the ship and knew nothing about the tourists.

　　The three families knew each other and were classmates of the victims.

　　At about 2 pm on January 31, the reporter got the news that at the entry and exit window of the one-stop service center in Suzhou Industrial Park, a related person who claimed to be a shipwreck in Malaysia needed to apply for a passport and immediately rushed to the scene.

　　When the reporter pushed open the door, he found that the center was obviously still in a long vacation state-it was empty, only there was a security guard at the front desk, and several rows of seats on the left side were near the corner of the door, sitting silently with a man and a woman, about forty or fifty years old. Look low and sad. Seeing someone push the door in, the two quickly stepped forward to ask if it was XXX.

　　About five minutes later, a middle-aged man with a sad face and tears in his eyes rushed to the airport. After a few simple words, the man was taken to the entry-exit photo office by the two waiting people. Then, the waiting man was taken to the entry-exit window to go through the relevant formalities, while the waiting woman turned around and stopped the reporter in the hall, forbidding the reporter to approach the entry-exit window. About a quarter of an hour later, the formalities were basically completed and the three left.

　　In the meantime, the woman had a brief exchange with reporters. She said that the three families in Suzhou are all their friends and know each other. They and their families are very sad that this happened. They know that all walks of life are very concerned about this matter, but at present they are not in the mood for an interview. I hope everyone will understand. "Everything is subject to the information released by the government. We are now listening to the government’s arrangements. "

　　After preliminary inquiry, Mr. Tao, who came to apply for a passport, was familiar with three families in the shipwreck in Malaysia and was a classmate of the victim Xie. "I heard that they have also formed a WeChat group, and the families of three families communicate in the group, exchange information, encourage each other and tide over the difficulties together."

　　According to Zhang Minhua, the captain of the Exit-Entry Management Brigade of the Public Security Bureau of Suzhou Industrial Park, at noon that day, she suddenly received a phone call from the Loufeng police station in Suzhou Industrial Park, saying that there was a related person who claimed to be a shipwreck in Malaysia and asked for a passport at the police station. Therefore, she and the relevant staff came immediately. "In the shipwreck accident in Malaysia, there are people from Suzhou. We have already made preparations for this matter."

　　Special office for relatives’ passports

　　Zhang Minhua told the Yangzi Evening News reporter that during the communication, they found that another family member of huqiu district did not have a passport at present, so they asked Mr. Tao to inform him to go through the formalities. According to Zhang Minhua, passport processing is generally 10 working days, and expedited is 5 working days. This time it belongs to the special affairs office. "Passports are issued by the ministries and agencies, and we have already sent relevant information to the ministries and agencies. They can take the high-speed train to Nanjing this afternoon and go to the provincial office to get their passports. "

　　The departure date of family members has not yet been determined.

　　Yesterday morning, entrusted by Zhou Naixiang, member of the Standing Committee of the Provincial Party Committee and secretary of the Suzhou Municipal Party Committee, Qu Futian, deputy secretary of the Suzhou Municipal Party Committee and mayor, presided over an emergency meeting to make special arrangements for implementing the spirit of the important instructions of the central leadership and the work requirements of the provincial party Committee and government, and doing a good job in emergency rescue and appeasing the families of the citizens involved.

　　The Yangzi Evening News reporter learned that the list of Suzhou’s family groups going to Malaysia has not yet been determined, and the departure date has not yet been determined. "The situation here in Suzhou is more complicated, and the list of family members is also being adjusted. At present, it is inconvenient to rush."

　　A mother and daughter in Jinhu, Huai ‘an confirmed their safety.

　　According to the Yangzi Evening News reporter, the father and uncle of the rescued Yang Yaoru have flown to Malaysia to visit their mother and daughter, who are currently being treated in a local hospital in Malaysia. On the afternoon of January 31, the person in charge of Jinhu County Tourism Bureau in Huai ‘an told reporters on the phone that when they heard the news that Yang Yaoru and her mother were all safe, their hanging hearts were finally put down.

　　The reporter learned that there are a pair of Huai ‘an Jinhu mother and daughter among the survivors of the shipwreck accident in Malaysia. Her mother is Wang Xianzhong, an employee of Jinhu County’s transportation system, and her daughter is Yang Yaoru, who just graduated from university and works in Nanjing. According to the Director of Tourism Departure Department of Huai ‘an Tourism Bureau, Wang Xianzhong’s mother and daughter traveled freely in Malaysia, without going through any travel agency. The outbound tour was arranged by her daughter Yang Yaoru.

　　"I know about the shipwreck in Malaysia, and I know that there is a mother and daughter who are Golden Lakers, but I didn’t expect it to be Lao Yang’s wife and daughter." The person in charge introduced that because he and Lao Yang are old friends, the relationship between the two families is also very good. On January 29, Lao Yang called him to inquire about the passport to Malaysia, and he learned that Lao Yang’s wife and daughter were also among the tourists in the shipwreck accident. "After the incident, Yang Yaoru’s father, Lao Yang, was also very anxious when he didn’t get any news from Wang Xianzhong’s mother and daughter." The person in charge told the reporter that at 10 o’clock on the evening of January 29, when there was no news from Wang Xianzhong’s mother and daughter, the county government arranged for the leader of the Transportation Bureau of Wang Xianzhong’s unit, and the leader of the Commerce Bureau of Lao Yang’s unit to go to Lao Yangjiazhong to appease him. On the same day, the Public Security Bureau opened a green passage for Lao Jack yang’s wife and brother and handled a passport to Malaysia.

　　"At 2: 00 am on January 30th, Lao Yang sent me a message" Mother and daughter are safe ",and I replied a message" If you are surprised, you will have a happy future ".The person in charge told the reporter that after learning that Wang Xianzhong’s mother and daughter are safe, Lao Yang couldn’t wait to fly to Malaysia to visit his wife and daughter. In order to take care of Lao Yang on the way, the Tourism Bureau decided to include Lao Yang’s wife and brother in the arrangements for family members to deal with the aftermath. On January 31st, Jack yang’s wife and brother flew from Nanjing to Guangzhou, and then from Guangzhou to Malaysia.

　　Huai’ an girl tells how to survive two days and one night-

　　Everyone held hands in the water and formed a circle. The little girl of three or four years old never cried.

　　The director of the local Queen Elizabeth Hospital told reporters that it is expected that China tourists injured in the shipwreck will be hospitalized for about a week, and a few of them may be discharged early. According to the information provided by the hospital, at present, 20 tourists from China have different degrees of sunburn and dehydration symptoms, and a few of them are seriously injured and may need surgery, but they are not life-threatening.

　　Everyone spontaneously formed a circle.

　　Yang Yaoru, a 24-year-old native of Huai ‘an, Jiangsu, works in Nanjing. This time, she took her mother abroad to play during the Spring Festival holiday, but she didn’t expect to encounter a shipwreck.

　　Xiao Yang recalled that she and her mother took the boat from a pier in Kota Kinabalu to play around the beach island on the morning of January 28. After about 40 minutes, the boat suddenly broke down. Then someone found that the situation was not good. "The water began to enter the back of the cabin." With more and more water in the cabin, everyone began to jump into the sea one by one. "When we first got into the water, many people panicked," Xiao Yang said.

　　Everyone soon found it useless to cry, so they began to wait patiently for help. The instinct of survival makes everyone hold hands with each other in the water and form a circle. "Because everyone knows that if we are together, the chances of survival will be higher." She said, "In fact, everyone is very scared, but if everyone is surrounded, they will not be so scared."

　　The power of holding a group inspired everyone. They made many attempts, some trying to search for cell phone signals, and some trying to find nearby islands. Xiao Yang also said that they found a bottle of water in the bag, and everyone took a sip in turn, leaving the water to the children.

　　The life jacket burst and the female passenger drifted away.

　　Xiao Yang recalled a fellow passenger. This "excellent" mother in her mouth not only organized everyone to save themselves after the incident, but also encouraged everyone to say: "If you don’t want to die, you must work hard!"

　　Xiao Yang said that the mother’s daughter is also very strong. She may be only three or four years old, but she has never cried from beginning to end. When her mother was dying, she was running out of strength herself, but every few minutes she would ask, "Mom, are you okay?" And my mother’s answer is: "I’m glad you are good."

　　"Later, the young mother’s life jacket was broken. Although everyone really didn’t want to let go of her hand, there was no way." Speaking of this, Xiao Yang choked up.

　　Drifting on the vast sea, Xiao Yang and other passengers firmly believe that they will be rescued. "As long as we see the sun tomorrow, there will be helicopters and many ships coming to us, and we will definitely find us." With faith, Xiao Yang and his mother encouraged each other, survived the storm and the pain of skin soaking in seawater. In the evening of the next day, Xiao Yang and several people struggled to swim to a passing ship, which attracted the attention of the crew and saved everyone.

　　Xiao Yang said that she had thought about giving up at a critical moment, but when she thought of her mother and family, she rekindled her belief in survival. At the same time, she firmly believes that there is a powerful country behind her, and the China Embassy will send people to rescue her. Xiao Yang said that on the way to Kota Kinabalu after being rescued, many people were still wondering whether they would be directly hung on the shore after landing, and they had to walk to the embassy by themselves. "Later, I found that everyone was waiting for us, so I was relieved at once." She said. "I still remember that there were two white clouds in the sky when I was rescued. It was beautiful." Fawan

　　Most of the routes around the beach island are online shopping day trips.

　　The reporter learned that the island around the beach that the accident ship went to is one of the two popular islands for Chinese to travel to Sabah. Many people arrive in Sabah’s capital freely, and then order local day trips through various channels.

　　Searching for "Island Around the Beach" on Taobao can appear as many as four pages of tourism products, of which the most is a one-day tour. A tour guide who specializes in tourism products in Sabah told reporters that there are few accommodation facilities on the island around the beach, so most of the tourists go for one-day tours, and the lowest price is more than 300 yuan, including a picnic, snorkeling and other tourism projects, while the more expensive ones cost thousands of dollars, and there are also two-day tour routes that spend the night on the island. Many Taobao shops have sold thousands of such tour routes.

　　"The island around the beach is an island that has only emerged in recent years. Compared with the famous mermaid island, there are relatively few tourists. Some travel companies can package a whole beach for tourists to enjoy, but the disadvantage is that sometimes the wind and waves on the road are not small."

　　The tour guide told reporters that when going out to sea from Sabah, you usually take a boat from the tourist pier, and the voyage to the island around the beach takes about one and a half hours to two hours. Most of the boats are small speedboats. Because the road is not short, the occasional heavy wind and waves in Sabah will also make some tourists’ riding experience discounted. "Most regular speedboats have a load of about 20 people, and each boat will have three to four crew members. They are not only responsible for sailing, but also for cooking lunch on the beach, and can teach you to snorkel. Besides the life jacket that everyone must wear, there should be lifebuoys. Regular cruise ships will also use various buoys to delimit safe areas when snorkeling, which can be life-saving equipment at critical moments, so the safety is guaranteed without overcrowding." The tour guide also said that there were nearly 30 tourists in this accident, and it is very likely that there is overcrowding. In addition, the dock on board the ship was also exposed as an illegal dock.

　　Accident investigation: The accident vessel was temporarily chartered with 12 people on board and nearly 30 people on board.

　　According to the reporter’s investigation, the business license of the local supernatural tourism company in Sabah, Malaysia, which undertook this sea trip, is being cancelled, and the ship carrying tourists is also rented from another local company.

　　According to the reporter’s investigation, the business license of the local supernatural tourism company in Sabah, Malaysia, which undertook this sea trip, is being cancelled, and the ship carrying tourists is also rented from another local company.

　　According to Xinhua News Agency, among the China tourists who suffered the shipwreck in Sabah, 12 of them ordered the day-trip products through Shenzhen Langhuaduo International Travel Service. The staff of Shenzhen Langhuaduoduo International Travel Service told the reporter that the one-day tour product is a product that cooperates with local travel agencies and acts as an agent. The staff of Shenzhen Municipal Bureau of Culture, Sports and Tourism told The Paper that Shenzhen Langhuaduo International Travel Service sold the products of one-day tour around the beach island launched by "Malay Supernatural Tourism Company" through Tmall.

　　An anonymous staff member of Shenzhen Langhuaduo International Travel Service said that the supernatural travel company is one of the three major local travel agencies in Sabah. However, a tour guide in Sabah, Malaysia told reporters that the supernatural travel company is not a large travel agency, but a very ordinary travel agency.

　　The wrecked ship was temporarily chartered.

　　The ship that happened was not the ship of the supernatural travel company, but was leased by the supernatural travel company from another local company. According to Kelly, an employee of the lessor company, the night before the accident, the supernatural travel company rented a catamaran from them.

　　The employee also introduced that cruise ship rental is a regular thing in supernatural companies, and if there are too many tourists, they will come to rent it. It is understood that the Sabah government stipulates that the tour boat can only carry up to 12 people, including the captain and crew, while the tourists and crew on the wrecked boat are nearly 30 people. The news from the police is that the cruise ship hit a palm tree. "Shihua Daily" quoted Datuk Seri Shahidan Kahin, Minister of the Prime Minister’s Office, as saying that at that time, the wind was high and the waves were urgent, and all passengers had put on life jackets and tied them together in batches to wait for rescue. The newspaper also reported that when tourists put on life jackets, they found that most of them had lost their function, and there were only five lifebuoys on the cruise ship.

　　The weather was terrible that day.

　　According to the report of the local maritime department, the waves on the day of the incident were as high as 3 to 5 meters. Regarding the cause of the sinking of the speedboat, Malaysia is investigating the details of the sinking of this speedboat and whether it is suitable for carrying tourists. The captain of the speedboat revealed that the speedboat was "damaged" and sank after being hit by powerful waves. At that time, all the tourists were tied together and washed away by the waves. Datuk Seri Shahidan Kahin, Minister in charge of security affairs in Malaysia’s Prime Minister’s Office, pointed out that "the weather conditions in (the location of the incident) are very bad and the waves are very big, which makes people question whether it is suitable for ships to go out to sea that day".

　　When the reporter called the Sabah ground connection of "Supernatural Travel Company", a man of the company said that he knew about it and said that the cause of the accident was bad weather. When asked if there were other reasons, the company refused to answer.

　　It took more than 12 hours to report the case.

　　Kelly, an employee of the company that rented the cruise ship, said that there was no Chinese tour guide in the sinking of the cruise ship, and the emergency response to the accident was not enough, which was the key point.

　　The cruise ship is equipped with fireworks flares. If the crew releases the flares at the first time of the accident, there are many boats around the beach island, and all the cruise ships on the island should go to the rescue.

　　According to a report by China News Service, the police in Sabah, Malaysia will investigate whether the Tanjung Ya Road Wharf used by ship owners and relevant travel companies illegally operates passengers and why it took more than 12 hours to report the accident. (Comprehensive report Xue Mayi Zhu Dingzhao Liu Liu)

Original Wuyuan Li Na and other SIFIC infection horizons　

Author: Wu Yuan Li Na Jin Wenting Ma Yuyan

Review: Hu Bijie and Pan Jue

First, a brief introduction to medical history

Male, 63 years old, from Shanghai, was admitted to the Infectious Diseases Department of Zhongshan Hospital for the second time on November 23, 2022.

Chief complaint: indwelling catheterization with repeated urine color turbidity for 2 months and then 8 days.

Current medical history:

On September 19, 2022, I went to a hospital in Shanghai for fatigue, anorexia and dysuria. WBC 10.12×10 9/L, N 87.6%, Hb 53g/L, hsCRP 135.22mg/L, ESR 62mm/H, albumin 30.1g/L, Scr 589μmol/L, K 2 were examined. Urine routine: WBC 3892/ul, occult blood 3+/RBC 5579/ul, protein 2+; Chest CT: bilateral pleural effusion, partial atelectasis of lower lobe of both lungs; Abdominal pelvic CT: Bilateral middle and upper ureteral dilatation and renal pelvis and calyceal dilatation, the patch in the right part of calyceal is slightly high density, the bladder wall is thickened, there is a little flocculent blur around the left renal fat sac and ileocecal part, and there is a little effusion in the pelvic cavity. A large amount of turbid urine was drained by indwelling catheter. Urine culture showed that Klebsiella pneumoniae was positive. Considering urinary tract infection, acute kidney injury, hypokalemia and severe anemia, patients were given symptomatic support treatment such as anti-infection, bladder irrigation, antioxidation, potassium supplementation and blood transfusion. The symptoms of patients improved and the urine was slightly clarified. 10-18 Review urine routine: WBC3+, RBC3+, protein 1+, SCR 263 μ mol/L.

I was admitted to our department on October 19, 2022. Blood routine: WBC 5.08X10 9/L, N 66.1%, inflammatory markers: ESR 19mm/H, hsCRP 52.3mg/L, PCT 0.52ng/ml, Scr 257μmol/L, and urine routine: WBC 28493/μ. Urinary color Doppler ultrasound: hydronephrosis, bilateral ureteral dilatation, bladder wall thickening significantly; Abdominal pelvic CT: hydronephrosis of both renal pelvis and ureter, thickening of ureter wall (inflammatory change), inflammatory change of bladder and ureter may be large, the volume of both kidneys increases and the substance is thin. Meropenem 1g q12h is given for empirical anti-infection. Urology consultation considers the acute stage of infection, so it is not suitable to put double J tubes. If necessary, pyelostomy can be done, but it does not improve renal function much. Bladder irrigation is recommended. 10-20 middle-stage urine culture (sampling on October 19): Klebsiella pneumoniae was positive; 10-22 urine culture drug sensitivity: Carbapenem-resistant Klebsiella pneumoniae (CRKP), adjusted to ceftazidime and abamectin 2.5g q12h for anti-infection, and daily bladder irrigation. After treatment, the urine color of the patients gradually became clear, and the urine white blood cell and bacterial count gradually decreased during follow-up. The urine bacterial culture was negative on November 1 and November 4. Check the urine routine on November 09: WBC 28/uL, RBC 4/uL, urine protein+,bacterial count 29/UL;Blood WBC 7.64×10 9/L, N 76.5%, hs-CRP 0.4mg/L, ESR 25mm/H, PCT 0.18ng/mL, Scr 175μmol/L, which were significantly improved compared with those at admission. Stop ceftazidime and abamectin on November 11 and be discharged.

On November 15, 2022, the patient appeared turbid urine again, and there was no fever and other discomfort. On November 23, he was admitted to the hospital for a second diagnosis and treatment.

Past history: In September, 1991, T12-L1 comminuted fracture was treated with internal fixation. After operation, the catheter was retained for half a year due to urinary incontinence, and then the catheter was removed after urination. There was no urinary tract infection during this period. Diabetes for 16 years, insulin therapy, blood sugar control can be; Hypertension for 5 years, oral amlodipine to reduce blood pressure, blood pressure control can be.

Second, the admission examination (admitted on November 23, 2022)

[physical examination]

T: 36.2℃ P: 90 times/min R: 20 times/min BP: 176/105 mmHg.

Stay in bed, feel refreshed and calm, lose weight, and muscle atrophy of lower limbs; Breathing sounds in both lungs are thick, and dry and wet rales are not heard; The rhythm of the heart is regular, the abdomen is soft, without tenderness and rebound pain, without mass, without percussion pain in both kidneys, without tenderness at ureter point and rib and waist point, and the lower abdomen does not touch the enlarged bladder. During indwelling catheterization, the urine in the urine collection bag is turbid and more white flocs are deposited. Limbs are not swollen.

[Laboratory examination]

Blood routine: WBC 7.85×10 9/L, N 81.3%, HB 121g/L, PLT 170×10 9/L.

Urine routine: WBC 2775/μ l; RBC 2/μl, bacterial count: 39879/μl, nitrite positive, leukocyte esterase+++.

Inflammation markers: hs-CRP 17.9mg/L, ESR 68mm/H, PCT 0.12ng/mL.

Biochemistry: ALT/AST 23/21U/L, Alb 47g/L, Scr 199μmol/L, eGFR 30ml/min/1.73m2, na/k 140/5.5mmol/l.

Third, clinical analysis

Characteristics of medical history: middle-aged and elderly male, indwelling catheter, with repeated urinary turbidity and abnormal urine routine. Urine culture showed CRKP one month ago, and it improved after ceftazidime-ababactam treatment, but urine turbidity reappeared three days after drug withdrawal, blood inflammatory index increased, urinary leukocyte and bacterial count increased significantly, and the diagnosis of urinary tract infection was clear. The reasons for short-term recurrence after antibacterial drug treatment improved were considered:

Recurrence of CRKP infection: The patient has been indwelling catheter for 2 months, and there may be biofilm formation of catheter and abnormal urinary tract structure, which makes it difficult to completely eliminate the infection and relapse after stopping taking the drug. Therefore, urine culture and drug sensitivity test can be improved.

New infection: the patient has high risk factors of recurrent urinary tract infection, and the pathogen may be different each time. The patient’s previous CRKP infection treatment was effective, and the possibility of new pathogen infection should be considered in the short term, until the urine culture is perfect and clear.

Multiple infections: patients with abnormal urinary tract structure, indwelling catheter and other risk factors can not be removed, so it is necessary to be alert to the possibility of multiple pathogens including fungi combined with infection, repeat the cultivation of urine bacteria, mycoplasma, fungi and mycobacteria, and improve urine mNGS to help clarify the infected pathogens.

Four, further examination, diagnosis and treatment process and treatment response

On November 23, 2022, the middle urine smear was used to find bacteria: moderate amount of G- bacilli, and continued ceftazidime and abamectin 2.5g q12h ivgtt for anti-infection and bladder irrigation.

On November 26, 2022, the bacterial drug sensitivity of the middle-stage urine culture (sampling on November 23) was CRKP, ≥ 100,000 /ml, and urine mNGS: a large number of Klebsiella pneumoniae (species strict sequence number: 406,866) was detected.

On November 29, 2022, the abdominal and pelvic CT was reexamined: bilateral dilated hydronephrosis accompanied with inflammatory changes of ureter, and the parenchyma of both kidneys was thin, and the inflammatory changes of cystitis might be larger, similar to that of 22-10-20 slices.

November 30, 2022 (sampling on November 29): Enterococcus faecalis was positive. On December 2, according to the drug sensitivity, fosfomycin 3g qod was added orally, and ceftazidime and abamectin were suspended.

Repeated urine cultures on March, April and June, December, 2022: Enterococcus faecalis was positive and CRKP was negative.

On December 8, 2022, the urine WBC was 38738/μ L, and the bacterial count was 43285/μ L; Urine culture: CRKP positive, Enterococcus faecalis negative.

Phage therapy was carried out from the afternoon of December August, 2022: Phage cocktail (composed of 5 strains of Klebsiella pneumoniae phages A103KP172, A106KP176, A121KP192, A49KP106 and A58KP118, 5mL each), injected with 225mL physiological saline (according to the estimated bladder volume), and the total volume was 250mL, and then the catheter was clamped.

Urine routine on the third day of phage treatment on December 11, 2022: white blood cell count: 235/uL, bacterial count: 722/uL；; Urine bacterial culture was negative.

Urine routine on the 5th day of phage therapy on December 13th, 2022: white blood cell count: 279/uL, bacterial count: 92/ul; Urine bacterial culture was negative; Blood WBC 6.35X109/L, N 70%, hs-CRP 0.9mg/L, ESR 26mm/H, and inflammatory index decreased compared with before; Re-examination of urinary color ultrasound showed that bilateral renal pelvis separation and upper ureteral dilatation were better than before (10-20), and the thickness of bladder wall was reduced (12-25mm→13mm).

He was discharged from hospital on December 14, 2022 for follow-up.

V. Final diagnosis and diagnosis basis

Final diagnosis:

Complex urinary tract infection (CRKP, Enterococcus faecalis)

Neurogenic bladder, hydronephrosis and hydroureter (indwelling catheter)

Renal insufficiency

Diagnostic basis:

The patient is a middle-aged and elderly male with neurogenic bladder caused by paraplegia, indwelling catheter, turbid urine with flocs, increased CRP and PCT, significantly increased WBC and bacterial count in urine, repeated CRKP positive in urine culture, positive in enterococcus faecalis, abdominal basin CT: hydronephrosis of renal pelvis and ureter, anti-infection, normal inflammatory markers and urine routine after phage treatment, clear urine and negative urine culture, so complicated urinary tract infection.

The patient suffered from anorexia and dysuria, and the serum creatinine increased obviously. Abdominal CT showed that both kidneys were enlarged, the cortex was thin, and bilateral urinary tract was hydronephrosis. After active treatment such as controlling infection and improving renal function, the serum creatinine decreased, so the diagnosis of renal insufficiency was clear.

Six, experience and experience

Phage is a targeted sterilization virus in nature and a sterilization star in the "pre-antibiotic era". Phage therapy has a history of more than 100 years, but the discovery and application of broad-spectrum antibiotics have gradually marginalized it. With the increasingly serious problem of bacterial drug resistance, phages have once again received attention and become the most promising supplement and alternative therapy for treating superbugs. The clinical application of phage in China is relatively late, but it has developed rapidly in recent years. In 2017, the Shanghai Institute of Phage and Drug Resistance was established, with Professor Hu Bijie as an academic member. Since 2018, the institute has carried out the first clinical trial of phage therapy in China. At present, it has treated nearly 100 patients with drug-resistant bacterial infections from all over the country and accumulated rich clinical experience in phage therapy, which is a leading position in the field of clinical phage therapy in China.

Phage has many advantages, such as host bacteria dependence, targeted specific sterilization, no infection to eukaryotic cells (little influence on normal flora), no influence on bacterial drug resistance, synergy with antibacterial drugs, penetration of biofilm and so on. The cure rate of acute bacterial infection is high, and the therapeutic effect of chronic bacterial infection is no less than that of antibacterial drugs, and the safety of phage treatment is also extremely high. A systematic retrospective study showed that the vast majority of patients who received phage therapy had no or only slight adverse reactions, 86.7% patients’ clinical symptoms improved, and 78.8% patients achieved the eradication of pathogenic bacteria. Our clinical trials also show that more than 70% of patients have achieved good therapeutic effects, and there are no obvious cases of adverse reactions. This patient was repeatedly infected with Klebsiella pneumoniae due to long-term paraplegia, abnormal urinary tract structure, indwelling catheter and other factors. The diagnosis of complicated urinary tract infection was unquestionable, and the choice of antibacterial drugs was limited due to multi-drug resistance and renal insufficiency. Phage therapy is very suitable.

The disadvantages of phage therapy include narrow host spectrum, individualized plan (it is difficult to treat empirically), no unified standard for the best treatment decision, and rapid tolerance. Phage cocktails, combined antibacterial drugs and multiple treatments are usually used in clinic to improve the curative effect. At present, the targeted pathogens of phage therapy in our team mainly include: multi-drug resistant Gram-negative bacteria (Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecalis); Covering respiratory system, urinary system, abdominal cavity, bones and joints, skin and soft tissue and other infected sites; Treatment depends on the site of infection, and intravenous application of phage is still being explored. In this case, the patient didn’t have percutaneous nephrostomy because of the little clinical benefit, so he was treated by transurethral bladder perfusion, and the phage could not cover the whole urinary tract evenly. Although the pathogen turned negative in a short period of time and was well tolerated, its long-term curative effect may not be good, and it needs repeated phage treatment.

Phage therapy has huge clinical demand and broad market. In recent years, our team has focused on the clinical application (treatment and prevention and control of nosocomial infection) and basic research of phage therapy, with a view to becoming a powerful weapon to curb drug-resistant bacteria in the future.

references

[1] Uyttebroek S, Chen B, Onsea J, Ruythooren F, Debaveye Y, Devolder D, Spriet I, Depypere M, Wagemans J, Lavigne R, Pirnay JP, Merabishvili M, De Munter P, Peetermans WE, Dupont L, Van Gerven L, Metsemakers WJ. Safety and efficacy of phage therapy in difficult-to-treat infections: a systematic review. Lancet Infect Dis. 2022 Aug; 22(8):e208-e220.

[2] Chegini Z, Khoshbayan A, Taati Moghadam M, Farahani I, Jazireian P, Shariati A. Bacteriophage therapy against Pseudomonas aeruginosa biofilms: a review. Ann Clin Microbiol Antimicrob. 2020 Sep 30; 19(1):45.

[3] Lusiak-Szelachowska M, Weber-Dabrowska B, Gorski A. Bacteriophages and Lysins in Biofilm Control[J]. Virol Sin, 2020,35(2):125-133.

Every Monday night

The Department of Infectious Diseases of Zhongshan Hospital affiliated to Fudan University in Shanghai will be with you!

Photo: Xiaoxiao

Original title: "Detective Case: The Nemesis of Super Bacteria is Coming"

Read the original text

Yue ke Gao zi [2021] No.222

Around the level of the Municipal Science and Technology Bureau (Commission), the relevant units:

　　In order to further promote the construction of a new pattern of science and technology incubation and breeding system in our province and realize new promotion, the Special Action Plan for High-quality Development of Science and Technology Incubation and Breeding System in Guangdong Province (2021-2025) is hereby printed and distributed to you, please implement it carefully.

Provincial science and technology department

December 3, 2021

Special Action Plan for High-quality Development of Science and Technology Incubation System in Guangdong Province (2021-2025)

　　This action plan is formulated in order to fully implement the spirit of the 19th National Congress of the Communist Party of China and the 2nd, 3rd, 4th, 5th and 6th Plenary Sessions of the 19th National Congress, the important instructions of the Supreme Leader General Secretary on scientific and technological innovation and Guangdong’s work, meet the requirements of high-quality development, and further promote the construction of a new pattern and new promotion of the science and technology incubation system in our province.

　　First, the overall thinking and objectives

　　Focusing on the overall positioning goal given to Guangdong by the General Secretary of the Supreme Leader, we will implement the "1+1+9" work plan of the Provincial Party Committee, seize the opportunity of the construction of the pioneering demonstration zones in Guangdong-Hong Kong-Macao Greater Bay Area and Shenzhen, and strengthen the "two-city linkage" between Guangzhou and Shenzhen, so as to realize the transformation of the development of the incubation system in our province from scale growth to high-quality development, and take the promotion of incubation kinetic energy and acceleration of industrial incubation as the main line. We will further promote six special actions, including the cultivation of industrial incubation clusters, the promotion of characteristic incubation carriers, the innovative development of university science parks, the "quality Shuang Sheng" of incubating enterprises, the "expansion and quality improvement" of entrepreneurial tutors, and the financial support for innovation and entrepreneurship, and accelerate the formation of a "one core, one belt and one district" pattern of regional coordinated development, which is guided by the "dual cores" of Guangzhou and Shenzhen, with the high-quality development of the core area of the Pearl River Delta and the characteristic development of the eastern and western wings of the coastal economic belt and the northern ecological zone.

　　By 2023, the province’s incubation and breeding system has made a breakthrough in terms of scale and quality, regional layout, short-board reinforcement and supporting development.

　　—— Incubation carrier realizes "stable quantity and rising quality". The number of incubators and creative spaces remains the first in China, and the number of state-level incubators and national creative spaces ranks among the top in China, with professional incubators accounting for over 40%, focusing on building a number of professional and branded incubators with global influence.

　　—— The characteristic incubation carrier realizes the new layout. Accelerate the full coverage of provincial accelerators in the national high-tech zones in the province; Accelerate the full coverage of provincial university science parks in high-level universities, and build 3 ~ 5 national university science parks with national demonstration effect; We will build more than 150 incubators for Hong Kong, Macao and Taiwan and international technology enterprises.

　　-New breakthroughs have been made in the indicators of regional innovation capability business incubation. The total number of entrepreneurial tutors in the province ranks first in the country, and the ratio of the number of entrepreneurial tutors in the average incubator to the number of incubating enterprises reaches 1: 1; The cultivation of graduate enterprises has achieved substantial results, with an average of 6 graduate enterprises in the incubator that year; The scale of incubation funds has grown steadily, and the average annual growth rate of incubator funds in the province has reached 30%. —

　　-High-quality employment and economic development achieve "double support". The province’s incubation carrier has absorbed more than 620,000 jobs, including more than 10,000 entrepreneurs who have returned from overseas study; Cultivate more than 1,000 enterprises with an operating income of more than 50 million and incubate a number of listed enterprises in science and technology innovation board; Cultivate a number of tens of billions of industrial incubation clusters in the new generation of information technology, biomedicine, high-end equipment manufacturing and other professional fields.

　　By 2025, we will take the lead in building a national pioneering place for high-quality innovation and entrepreneurship and a new highland for international innovation and entrepreneurship, which will provide important support for promoting the development of strategic pillar industries and strategic emerging industries in our province, cultivating future industries, enhancing regional innovation capabilities and building Guangdong-Hong Kong-Macao Greater Bay Area International Science and Technology Innovation Center.

　　Second, the key tasks

　　(a) industrial incubation cluster cultivation action.

　　Constructing a collaborative innovation model of supply chain led by leading enterprises. Guide leading enterprises to build their own incubation carriers or open industrial innovation platforms, open application scenarios for small and medium-sized enterprises, and release the research and development needs of key technologies and reserve technologies. By integrating the industrial chain and supply chain resources of raw material production, spare parts supply, scale production and market sales, small and medium-sized enterprises and large enterprises will be promoted to cooperate and cooperate in depth, and a new industrial incubation ecology with innovative collaboration, capacity sharing and supply chain interoperability among large and medium-sized enterprises will be established.

　　Promote incubation carriers, focus on professional fields and accelerate industrial incubation. Encourage accelerator-based incubation carriers to focus on the common industrial needs in sub-sectors and develop in the direction of specialization and industrialization. By constructing industrial incubation service systems such as industrial design, concept verification, intermediate test and small batch trial production, inspection and testing, product experience and market sales, we will provide standardized and universal professional services for the industrialization development of enterprises in residence, and formulate personalized industrial service plans to accelerate industrial incubation in combination with the needs of enterprises of different industrial types and different development stages.

　　Cultivate industrial incubation clusters in combination with the direction of local industries. Around the strategic pillar industries, strategic emerging industries and the future industrial construction direction of Guangdong Province, a number of industrial incubators and accelerators with deep integration with industries are arranged. Focus on promoting the integration of industrial resources in the national high-tech zones in the Pearl River Delta region, build and gather a number of industrial incubation carriers around the fields of new generation information technology, biomedicine and high-end equipment manufacturing, take the lead in building industrial incubation clusters, form a regional agglomeration incubation effect, inject fresh water into the local industrial development, and cultivate new ideas, new models and new subjects for the industry.

　　(2) Promotion of characteristic incubation carriers.

　　Cultivate incubation carriers of Hong Kong, Macao and Taiwan and international technology enterprises. Improve the incubation service capabilities of incubation platforms such as Hong Kong, Macao and Taiwan, international incubation carriers and overseas students’ pioneer parks, and focus on building a number of Hong Kong, Macao and Taiwan characteristic incubation carriers and benchmark incubators with international influence in Shenzhen Qianhai and Zhuhai Hengqin, so as to promote the transformation of Hong Kong, Macao and Taiwan and international scientific and technological achievements in our province. Encourage incubators to "go global" to carry out overseas layout, and give priority to setting up offshore science and technology incubation bases or demonstration institutions for the transfer and transformation of scientific and technological achievements in international sister cities, international innovative talents-intensive areas and countries along the Belt and Road, so as to gather global high-end innovation resources, promote the two-way incubation of international scientific and technological achievements, and create a new highland for international innovation and entrepreneurship.

　　Encourage scientific and technological innovation carriers and platforms to build professional incubation carriers. Support provincial universities, scientific research institutions and other scientific and technological innovation carriers, and provincial laboratories, high-level innovation research institutes and other innovation platforms fully combine the advantages of professional disciplines and scientific research forces to build professional incubation carriers; Relying on innovative achievement transformation platforms such as Guangdong-Hong Kong-Macao Greater Bay Area National Technology Innovation Center, we will provide incubation services such as technology research and development, technology transfer, pilot verification and R&D fund, and promote more scientific and technological innovation research and development to realize achievement transformation and incubation.

　　Promote the high-tech zone to speed up the layout of a number of accelerators. Encourage high-tech zones above the provincial level to strengthen open innovation, strengthen the development and sharing of scientific and technological resources, build a number of accelerators in related fields around the layout of characteristic industries in local high-tech zones, gradually build professional incubation chains, and cultivate emerging forces for local industries. By 2025, the national high-tech zone will achieve full coverage of provincial accelerators.

　　(3) Innovative development actions of university science parks.

　　Promote the incremental upgrading of university science parks. Guide local cities to build a number of provincial-level university science parks with distinctive discipline characteristics, obvious technological advantages, concentrated innovation elements and strong industrial driving force, and strive to achieve full coverage of provincial-level university science parks by 2025. Guide provincial university science parks to create national university science parks, and gradually form a gradient development pattern of provincial and national university science parks.

　　Innovate the transfer and transformation mode of scientific and technological achievements. Support the introduction or construction of technology transfer institutions in university science parks, set up a team of specialized technology brokers, and support the transformation of scientific and technological achievements. Strengthen the cooperation of "school+park+enterprise" in innovation and entrepreneurship, integrate the scientific and educational resources of technological innovation centers, key laboratories, collaborative innovation centers and engineering centers in schools, build a full-chain service platform from research and development, pilot-scale ripening to industrial trial production, carry out engineering and industrial development to meet the needs of industrial development, and promote the transfer and transformation of technological achievements with application prospects.

　　Strengthen the cultivation of innovative and entrepreneurial talents. Explore the establishment of entrepreneurship colleges, innovation and entrepreneurship practice bases and practice training bases, provide practical platforms for college students’ innovation and entrepreneurship, enhance their innovative spirit, entrepreneurial awareness and innovative and entrepreneurial ability, and cultivate a group of innovative and entrepreneurial reserve forces with entrepreneurial spirit. Support college graduates to start businesses on the spot, and encourage the formation of joint entrepreneurial teams with college teachers and college alumni.

　　(D) "Quality Shuang Sheng" action of incubating enterprises.

　　Accelerate the cultivation of scientific and technological entrepreneurial enterprises. Support incubation carriers to join entrepreneurial training institutions, establish a "full companion" counseling mechanism for key enterprises, carry out systematic and in-depth innovation and entrepreneurship cultivation for high-quality incubating enterprises with strong technology research and development foundation and good market prospects, promote enterprises to establish a patent pre-application evaluation mechanism, carry out high-value patent layout, and guide the growth and development of incubating enterprises in an all-round way. Strengthen the linkage between incubator identification and evaluation of small and medium-sized scientific and technological enterprises, improve the scientific and technological content of enterprises cultivated by incubators, and intensify efforts to cultivate high-quality enterprises such as small and medium-sized scientific and technological enterprises, high-tech enterprises and listed (listed) enterprises.

　　Enhance the endogenous development momentum of incubating enterprises. Promote the "joint innovation plan for large, medium and small enterprises", guide small and medium-sized enterprises to leverage resources such as supply chain, management and capital of large enterprises, accelerate the endogenous kinetic energy of innovation and development, and form an industrial ecosystem where large, medium and small enterprises are integrated. Encourage leading enterprises to form innovation consortia, drive small and medium-sized enterprises to carry out innovation activities, jointly undertake national, provincial and municipal research and development plans in key areas, and promote small and medium-sized enterprises to enhance their technological innovation and industrial transformation capabilities.

　　Smooth the graduation passage of incubating enterprises. Promote the construction of a number of professional incubation chains with accelerators as the main body, gradually open up the docking channels between incubators and accelerators, promote the incubation carriers to actively revitalize the existing stocks, and accelerate the graduation of incubating enterprises.

　　(V) Entrepreneurship mentor’s action of "expanding capacity and improving quality".

　　Improve the filing system for entrepreneurial tutors. Issue the Guidelines for the Filing of Entrepreneurial Mentors in Guangdong Province, clarify the definition, filing conditions, process and mentor service content of entrepreneurial mentors, and establish a normalized and dynamic filing mechanism for entrepreneurial mentors; Cooperate with various resources, fully tap different types of entrepreneurial tutors such as enterprise management, technological innovation, technology and finance, scientific and technological services and carrier operation, establish a database of entrepreneurial tutors in Guangdong Province, and improve the management system of entrepreneurial tutors in our province.

　　Improve the service ability of entrepreneurial tutors. Carry out comprehensive ability training for entrepreneurial tutors, continuously improve the cultivation system of entrepreneurial tutors, and enhance the personalized and professional entrepreneurial service capabilities that entrepreneurial tutors need for different types of entrepreneurs and enterprises at different stages of development. Through the activities of "Entrepreneurial Mentors Traveling in Cities and Parks", field visits and problem diagnosis are carried out to provide entrepreneurs and enterprises with more targeted and broader entrepreneurial counseling services.

　　Establish an incentive mechanism for entrepreneurial tutors. Encourage qualified cities to give subsidies to entrepreneurial tutors with outstanding service performance. It is recommended to enter the expert database of Guangdong incubation and breeding system construction, recommend qualified entrepreneurial instructors to enter the expert database of Guangdong science and technology enterprises, recommend entrepreneurial instructors to participate in the selection of outstanding dual-innovation talents at all levels, and regularly carry out the selection of "Guangdong Excellent Entrepreneurship Instructors" to effectively expand the team of instructors.

　　(VI) Financial support actions for innovation and entrepreneurship.

　　Expand the total scale of incubation funds in our province. In the performance evaluation of provincial incubation carriers, the establishment of incubation funds and the assessment of investment and financing should be strengthened. Encourage cities to give subsidies to financial institutions that build incubation funds with incubation carriers, and set up a fund pool for risk compensation of science and technology loans for enterprises that are incubating (entering), effectively expanding the scale of incubation funds in our province.

　　Promote the deep integration of business incubation and technology and finance. Support industry associations to jointly incubate carriers, technology and finance Comprehensive Service Center and various financial institutions, carry out special matchmaking meetings, promote "entrepreneurial mentors" and "technology and finance commissioners" to pair up and serve incubating enterprises, and increase Pratt & Whitney technology and finance’s service to incubating carriers and incubating (settled) enterprises. Governments at all levels are encouraged to increase investment risk compensation for venture capital funds and industrial investment funds for incubating enterprises. Give full play to the guiding role of SDIC (Guangdong) Venture Capital Fund for the Transformation of Scientific and Technological Achievements and the parent fund for the Transformation of Scientific and Technological Achievements of China Academy of Sciences, and increase the cultivation and investment of entrepreneurial projects, start-ups and growth enterprises.

　　Improve the docking ability between incubation and capital market. Encourage local cities to reduce the cost of listing by means of awards and subsidies, promote the listing of qualified incubation carriers and enterprises in the Guangdong Science and Technology Innovation Board and the New Third Board, further promote the listing in the North Exchange, science and technology innovation board, Growth Enterprise Market, Main Board and overseas capital markets, and accelerate the formation of a gradient development system for listing and listing.

　　Third, safeguard measures

　　(1) Improve the working mechanism. Establish a cross-departmental collaborative promotion mechanism such as the Provincial Development and Reform Commission, the Provincial Department of Education, the Provincial Department of Science and Technology, the Provincial Department of Finance, and the Provincial Department of People’s Social Welfare, strengthen macro guidance and coordination of the province’s incubation carriers, strengthen supervision and implementation of key tasks of the special action plan, and regularly report the progress of relevant work to guide the healthy and orderly development of various incubation carriers. Establish a "one-to-many" counterpart cooperation mechanism between the core area of the Pearl River Delta and the eastern and western wings of the coastal economic belt and the northern ecological development zone to promote the overall improvement of the incubation carrier in the province.

　　(2) Improve policy guarantee. Combined with the key promotion direction of regional innovation ability, the performance evaluation system is formulated. Provinces and cities should cooperate to strengthen financial support, encourage local cities to study and introduce innovative policies to improve the ability of business incubation, as well as supporting policies in land planning, talent introduction incentives and financial support to support the construction of local university science parks, guide leading enterprises and scientific research institutions to build incubation carriers, and accelerate the construction of university science parks in colleges and universities.

　　(3) Strengthen dynamic management. Implement dynamic management of the province’s incubation carriers and strengthen the elimination mechanism of provincial incubation carriers. Improve the statistical index system, add accelerators and university science parks for statistics and filing. Establish a dynamic monitoring mechanism to dynamically monitor the construction of business incubation indicators in our province and scientifically guide the development of the industry.

　　(4) Optimize the entrepreneurial environment. Support high-quality incubation carriers to form chain incubation brands with Guangdong characteristics, build brands of Guangdong business incubation activities such as "Yuekechuang" and Guangdong Innovation and Entrepreneurship Competition, and continuously enhance the national influence of Guangdong incubation. Construct a multi-level training system for personnel in the incubation industry to improve the professional ability of incubation service personnel in all directions; Continue to improve the incubation industry organizations in cities and strengthen the linkage and cooperation between provincial and municipal industry associations. Strengthen the construction of the service platform of the province’s science and technology incubation system, strengthen the data interconnection between provinces and cities, and promote the exchange and sharing of the province’s incubation service resources.

Chapter I General Provisions

　　Article 1 In order to implement the spirit of the State Council’s Opinions on Promoting the High-quality Development of Innovation and Entrepreneurship to Create an Upgraded Version of "Innovation and Entrepreneurship", accelerate the implementation of the Special Action Plan for the High-quality Development of Science and Technology Incubation System in Guangdong Province (2021-2025), establish a database of entrepreneurial tutors in the province, improve the team of entrepreneurial tutors in the province, strengthen the classified guidance of entrepreneurial tutors, give full play to their professional service ability and improve the service level of innovation and entrepreneurship in the province, these work guidelines are specially formulated.

　　Article 2 For the purposes of these Guidelines, the registered entrepreneurial mentors (hereinafter referred to as entrepreneurial mentors) mainly refer to enterprise management experts, technical innovation experts, technology and finance experts, technical service experts, and carrier operation experts who can provide professional and practical counseling services to entrepreneurial enterprises and entrepreneurs.

　　Article 3 The Department of Science and Technology of Guangdong Province shall provide professional guidance to entrepreneurial tutors in the whole province. Entrust a professional organization to be responsible for the implementation of daily work.

Chapter II Filing Conditions and Categories

　　Article 4 An entrepreneurial tutor shall meet the following basic requirements:

　　(1) Abide by national laws and regulations and have good ideological and political quality.

　　(two) physical and mental health, love entrepreneurship, good professional ethics, a strong sense of social responsibility and dedication, voluntary entrepreneurship guidance.

　　(three) familiar with the national and local policies and regulations on innovation and entrepreneurship, with a high level of policy theory and professional and technical level, familiar with enterprise management and market operation rules.

　　(four) have rich experience or professional expertise in entrepreneurship guidance, entrepreneurship training, starting or managing enterprises, and actively participate in entrepreneurship guidance activities in our province, and can provide various counseling services for entrepreneurial enterprises and entrepreneurs.

　　Article 5 Entrepreneurial mentors mainly include the following categories:

　　(1) Enterprise management. Leading enterprises, industry backbone enterprises, innovative enterprises and other relevant responsible persons or executives.

　　(2) Technological innovation. Universities, scientific research institutions, new R&D institutions, high-level innovation research institutes, enterprises and other experts who provide technical guidance for innovation and entrepreneurship in professional and technical fields.

　　(3) technology and finance. Experts with investment and financing counseling experience in financial institutions such as venture capital companies, securities companies and banks.

　　(4) scientific and technological services. Experts in universities, scientific research institutions, relevant government departments, etc. who carry out research, management and guidance of innovative and entrepreneurial activities, as well as scientific and technological service institutions to carry out financial, legal, market and intellectual property services.

　　(5) Carrier operation. Incubation carriers of science and technology enterprises such as Zhongchuang Space, Incubators and Accelerators, and operation managers of carriers such as University Science Park.

　　(6) Others. Other mentors who provide double-creation counseling for entrepreneurs and enterprises in the province.

Chapter III Filing Process and Mechanism

　　Article 6 Entrepreneurial tutors shall be filed in the following ways:

　　(1) Normalized collection. Professional institutions are responsible for the normal collection of entrepreneurial tutors.

　　(2) declaration. Those who meet the requirements of entrepreneurial tutors can apply through personal recommendation, unit recommendation, invitation from outside the province, etc., fill in the Application Form for Entrepreneurship Tutors in Guangdong Province, and provide their identity certificates, resumes and typical cases.

　　(3) review. Professional institutions conduct qualification examination according to the conditions of entrepreneurial tutors.

　　(4) filing. Eligible entrepreneurial tutors are included in the "Guangdong Entrepreneurship Tutor Database" and an electronic filing certificate for entrepreneurial tutors is issued.

　　Article 7 Entrepreneurial tutors adopt a dynamic filing mechanism, and the filing period is valid for 2 years. During the validity period, relevant counseling tasks can be carried out, and they can automatically continue to file, otherwise they need to resubmit their applications.

　　Article 8 During the filing period, an entrepreneurial tutor will be disqualified from filing under any of the following circumstances:

　　(1) Engaging in activities outside the scope of duties of an entrepreneurial mentor in the society in the name of an entrepreneurial mentor, causing adverse effects.

　　(2) divulging the business secrets of an entrepreneurial enterprise.

　　(3) Failing to fulfill the responsibilities and obligations of the entrepreneurial tutor.

　　(four) the entrepreneurial tutor voluntarily applies for cancellation of the record.

　　(five) because of other reasons can not work as a business mentor.

Chapter IV Service Contents and Incentive Measures

　　Article 9 Entrepreneurial mentors shall undertake the responsibility of counseling entrepreneurial enterprises and entrepreneurs, and provide consulting and guidance services for all kinds of entrepreneurs who are willing to start a business or are in the early stage of starting a business; Docking incubation carriers, university science parks and accepting employment, actively providing counseling and services for start-up enterprises. The main service contents of entrepreneurial tutors are:

　　(1) Entrepreneurship counseling. Participate in brand activities such as entrepreneurial tutors’ trips to cities and parks, and provide professional guidance for entrepreneurial enterprises in industrial chain resource docking, project evaluation, market analysis, investment and financing, enterprise management and capital operation; Jointly form an innovative strategic consulting team with professional institutions to connect with cutting-edge technical teams for high-quality incubation projects of large enterprises.

　　(2) Entrepreneurship training. As a double-innovation training lecturer, he provides entrepreneurs with entrepreneurship training in technology research and development, business model and internationalization.

　　(3) Entrepreneurial activities. As a special guest of the important double-creation activities in the province, we will share the entrepreneurial experience and create an entrepreneurial atmosphere.

　　(4) Policy research. As an expert in innovation and entrepreneurship research, he conducted research on the policy of dual innovation, studied the development trend of dual innovation, and put forward countermeasures and suggestions to provide decision-making reference for government management departments.

　　Article 10 After professional training, entrepreneurial instructors are recommended to enter the expert database of incubation and breeding system construction in Guangdong Province. Recommend qualified entrepreneurial instructors to enter the expert database of enterprise science and technology commissioners in Guangdong Province. Entrepreneurial tutors are recommended to participate in the selection, study and inspection of outstanding dual-creative talents at the national and provincial levels.

　　Eleventh to help entrepreneurial tutors docking high-quality incubation projects, innovative talents, technology and finance, incubation carrier and other dual-innovation resources.

　　Twelfth regularly carry out the evaluation of entrepreneurial tutors, and those who actively provide entrepreneurial counseling and have good service performance are selected as "excellent entrepreneurial tutors in Guangdong Province". Outstanding cases of entrepreneurial tutors coaching entrepreneurs will be publicized and promoted through public networks, magazines and other media.

　　Thirteenth to encourage qualified cities to give subsidies to entrepreneurial tutors with outstanding service performance.

Chapter V Supplementary Provisions

　　Article 14 The Guangdong Provincial Department of Science and Technology shall be responsible for the interpretation of these Guidelines, which shall come into force as of the date of promulgation.

Related Links: Policy Interpretation of Special Action Plan for High-quality Development of Science and Technology Incubation and Breeding System in Guangdong Province (2021-2025)

The former phrase "Far ahead" can be said to have gained a lot of attention and traffic for Huawei Yu Chengdong, but it is also this phrase "Far ahead" that has made Yu Chengdong the target of public criticism in the marketing circle, and even more, it has been "forbidden" for allegedly violating the advertising law.

Although Mr. Yu repeatedly publicly denied the rumor that he was banned from being "far ahead" once, and said that because "those four words" were called rotten by everyone, Mr. Yu was unwilling to say it, and there was no fine. Ren Zhengfei, founder of Netcom Huawei, forbids Yu Chengdong to use "far ahead", and every time he mentions "far ahead", he will be fined 10,000 yuan. In this regard, Yu Chengdong has responded that it is a rumor.

Yu chengdong’s new term "generational leadership"

On September 10th this year, at Huawei’s autumn new product launch conference, Yu Chengdong, the chairman of Huawei BG Terminal, once again released his words: "Unmodestly speaking, Huawei’s ADS3.0 intelligent driving system is the most powerful and safest intelligent driving system in the world at present after comprehensive evaluation, and it is the" generational leading ","generational leading "and the world’s strongest and safest new words and extreme words once again put Yu Chengdong on suspicion.

According to the introduction of professional legal practitioners, China’s advertising law aims to curb the excessive propaganda behavior of enterprises, explicitly prohibit the use of extreme words such as "most" in advertisements, and highlight its own products by belittling its opponents. This regulation sets strict requirements on the authenticity, legality and integrity of advertising content, and ensures that advertisements will not mislead consumers, which is its core principle. However, Yu Chengdong’s previous expressions, such as "far ahead", are controversial because they touch the extreme vocabulary boundary of advertising law. To this end, he once chose "far beyond" as an alternative, in order to better meet the requirements of laws and regulations.

However, in the recent introduction of smart driving, Yu Chengdong once again adopted new limit expressions, such as "leading by generations" and "the best in the world". These words can easily be regarded as excessive exaggeration, which goes against the basic principles of advertising law. As a leading enterprise in the world, Huawei’s brand image and reputation are undoubtedly crucial. Therefore, when promoting products, Huawei should pay more attention to the authenticity and integrity of advertisements and avoid using false or misleading advertising terms that may mislead consumers.

At the same time, Huawei also needs to further strengthen the internal audit and management mechanism to ensure the compliance and integrity of advertising content, so as to safeguard its brand image and consumer rights. Although from the marketing effect, expressions such as "far ahead" and "the best in the world" have really attracted a lot of attention and achieved the purpose of gaining traffic, there are still defects in compliance. To sum up, although Yu Chengdong’s marketing strategy has achieved remarkable results in attracting attention, Huawei still needs to balance the relationship between marketing effect and advertising compliance to ensure the authenticity and integrity of advertising content, so as to maintain its long-term brand image and consumer trust.

Technological innovation behind "generational leadership"

Since Yu Chengdong put the word "far ahead" on fire, in fact, many business owners are following suit. For example, Lei Jun also used the word "far ahead" to make fun at his press conference. Objectively speaking, neither "far ahead" nor "leading by generations" can be used casually. If there is no matching technical strength, it is an exaggerated fraud.

Although Yu Chengdong was nicknamed "Yu Dazui" because he often made exaggerated remarks, most of his "big talk" came true according to the subsequent actual results. This style of doing things makes many users think that his remarks are not pure bragging, but based on objective facts. Although there are many exaggerated elements in them, they are not much different from the facts on the whole.

In the field of intelligent driving, the advent of Huawei ADS2.0 indicates that Huawei has become a leader in this field in China, and this position has been widely recognized by the industry. So far, no car company executives dare to claim to surpass Huawei in intelligent driving, and at most they just claim that they are also in the first echelon.

Judging from the actual performance, Huawei’s smart driving has a far greater presence on the Internet than other brands, which can be seen from the smart driving experience video and the small video of hedging that car owners spontaneously share. Huawei ADS2.0 is indeed in the leading position in China, and the launch of ADS3.0 has significantly improved the processing ability of complex scenes, and the driving experience is smoother, which has made significant progress compared with ADS2.0.

While other car companies are still trying to catch up with ADS2.0, Yu Chengdong claims that ADS3.0 has achieved "generational leadership". Although it is boastful, this statement is not entirely groundless. For competitors, if we despise Yu Chengdong’s remarks, it may be the moment when they face a crisis. Huawei is famous for its R&D strength. Once it has established its leading position, it will continue to increase its investment and expand its advantages, which is exactly what makes Huawei a "long-distance runner". Therefore, although Yu Chengdong’s remarks are exaggerated, the strength of Huawei in the field of intelligent driving reflected behind it cannot be underestimated.

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