Fast Technology reported on May 21st that this week Huawei officially launched the first HarmonyOS folding computer, Huawei MateBook Fold Extraordinary Master, and its price started at 23,999 yuan.

Now Huawei official website has given the official maintenance price of MateBook Fold, in which the normal price of screen components is as high as 14,879 yuan and the preferential price is 13,079 yuan.

The official refurbished special screen is priced at 9179 yuan. If you choose to exchange rights, the price of screen components is 6539 yuan and the special screen is 4589 yuan.

Specifically, the battery maintenance price of this product is 499 yuan, the motherboard is 5209 yuan (original price is 7399 yuan), the battery back cover/back cover bracket is 379 yuan, the motherboard back cover is 579 yuan, and the keyboard is 1499 yuan.

The computer is equipped with the world’s first 18-inch double-layer OLED display, adopting LTPO technology (first commercial application to PC field), supporting 3.3K resolution, 1600 nits HDR peak brightness and 2 million: 1 contrast ratio. The superposition of these technologies leads to the extremely high cost of the screen assembly itself.

In addition, in terms of hinge technology, MateBook Fold adopts 285mm basalt water drop hinge, uses zirconium-based liquid metal materials and mortise and tenon architecture technology, and its manufacturing cost and durability requirements far exceed those of traditional notebooks.

　　The transformation of cell fate is determined by precise and complex signal regulation and epigenetic regulation, and the study of its molecular mechanism is one of the core problems that need to be solved urgently in the development of cell biology. Studies have shown that mouse pluripotent stem cells have two different states in signal maintenance and function, namely, primitive Epiblast stem cells, EpiSCs) and naive Embryonic stem cells, ESCs). In vitro, these two kinds of pluripotent stem cells can transform each other. Under the stimulation of ActivinA and bFGF signals, naive ESCs can differentiate into primed EpiSCs. On the contrary, by overexpressing a single naive pluripotent gene, such as Esrrb, Klf2, Nr5a2, etc., the initial to naive transition (PNT) can also be realized. Studying the mechanism of cell fate change in mouse PNT process can provide reference for isolating or inducing naive pluripotent stem cells from different species, but the main molecular mechanism of cell fate change in mouse PNT is still unclear.
　　On May 11th, Pei Duanqing’s research group and Liu Jing’s research group of Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences published a research paper entitled BMP4 resets mouse epi blast stem cells to naive proliferation through zbtb7a/b-mediated chromatin remolding online in the journal Nature Cell Biology. In this study, we first found that BMP4 can induce PNT in mice, and established an efficient PNT induction system with clear components. Subsequently, high-throughput sequencing techniques such as ATAC-seq were used to reveal the specific molecular mechanism of mouse PNT process.
　　At first, researchers found that growth factor BMP4 can induce PNT in mice. With the help of visual reporting system and screening of compound library, it was found that EZH2 inhibitor EPZ6438 and DOT1L inhibitor EPZ5676 can significantly improve the induction efficiency, and then a mouse PNT induction system with a clear chemical composition with an induction efficiency of 80% within 8 days was established.
　　On the basis of this platform, researchers combined bioinformatics analysis based on chromatin transposase accessibility sequencing (ATAC-Seq). The dynamic changes of chromatin accessibility in the process of PNT induced by small chemical molecules in mice were described, and it was found that the most critical factor in this system, BMP4, mediated the progress of PNT by regulating chromatin accessibility, on the one hand, inhibiting the opening of differentiation-related sites, on the other hand, promoting the opening of naive pluripotent gene sites. By analyzing the gene sites where BMP4 opens and activates expression, the researchers found that the new downstream targets of BMP4, Zbtb7a and Zbtb7b, regulate the function of PNT by influencing chromatin remodeling. Furthermore, chromatin immunoprecipitation (Chip) proved that Zbtb7a directly binds to and activates the expression of naive pluripotent genes such as Esrrb, Klf2, Nr5a2, thus regulating the occurrence of PNT.
　　To sum up, this study established an efficient technical platform for chemical induction of mouse PNT, revealed the molecular mechanism and found new targets from the perspective of chromatin accessibility, and made new discoveries in the study of cell fate transformation mechanism, which provided a new understanding and breakthrough point for the study of chemical regulation of cell fate transformation, and also provided a very meaningful reference direction for other research systems, such as the acquisition of naive pluripotent stem cells in human system.
　　Researchers Pei Duanqing and Liu Jing are the corresponding authors of this paper. Doctoral students Yu Shengyong and Zhou Chunhua, Ph.D. students Cao Shangtao and He Jiangping are the co-first authors of this paper.
　　Paper link
　　Cell fate transition process, chromatin changes and intervening regulatory proteins

In order to optimize the advertising operation order of the reception desk, encourage and commend honest, professional and high-quality advertising agencies, the General Manager’s Office of the Central Radio and Television General Station comprehensively evaluated the advertising agencies according to relevant management measures, and selected the 4A-level and 3A-level advertising agencies in 2022. The list is as follows.

A, the central radio and television station in 2022 4A advertising agency:

1. CTV Telex Media Co., Ltd.

2. Changrong Media Co., Ltd.

3. Beijing Yadea Advertising Co., Ltd.

4. Zhongcheng Achievement (Hainan) Rong Media Technology Co., Ltd.

5. Jiangsu ingram micro Culture Media Co., Ltd.

6. Beijing Century Runhua Advertising Co., Ltd.

7. Zhongshi Jinqiao Advertising Co., Ltd.

8. Beijing Dunhe International Film Media Co., Ltd.

9. Century Cultural Tourism Co., Ltd.

10. Zhongshi Zhiyang Sports Culture Industry (Beijing) Co., Ltd.

11. Beijing Guangyao Tianrun Advertising Co., Ltd.

Guangdong Advertising Group Co., Ltd.

13. Beijing Chinese and Foreign Celebrity Culture Technology Co., Ltd.

14. Beijing Tonglu Technology and Culture Co., Ltd.

15. Shanghai Zhongshi International Advertising Co., Ltd.

16. Jiangxi Guangheying Advertising Co., Ltd.

17. Beijing Henggao Culture Development Co., Ltd.

18. Anhui Jinyunlai Culture Media Co., Ltd.

19. Beijing Weiyang Creation Media Co., Ltd.

20. CCTV Creation Media Co., Ltd.

21. Beijing Shunfeng International Advertising Co., Ltd.

22. Beijing punctual boiling international advertising co., ltd.

23. Vision Attack Times (Beijing) Cultural Media Co., Ltd.

24. Beijing Zhongshi Guangjing Culture Development Co., Ltd.

25. Beijing Zongheng Times Advertising Co., Ltd.

26. Sanrenxing Media Group Co., Ltd.

27. Qunyi (Shanghai) Advertising Co., Ltd.

28. Huafeng Meteorological Media Group Co., Ltd.

29. Shenzhen Shengshi Haoye Culture Communication Co., Ltd.

30. Zhongshi Qianwei Film and Television Media Co., Ltd.

Two, the Central Radio and Television General Station in 2022 3A advertising agency:

1. Beijing Tomorrow Sunshine Advertising Co., Ltd.

2. Gravity Media Co., Ltd.

3. Beijing Xinglv International Media Co., Ltd.

4. Huayang Lianzhong Digital Technology Co., Ltd

5. Nanjing Yindu Ogilvy Advertising Co., Ltd.

6. Beijing Sun Flame International Media Co., Ltd.

7. Guizhou Tianma Media Co., Ltd.

8. Beijing Huacai Chuangjia Culture Communication Co., Ltd.

9. Lhasa Ruijie Jianbang Culture Media Co., Ltd.

10. Shanghai Prospect Media Co., Ltd.

11. Beijing Zhongshi Haocheng International Advertising Co., Ltd.

12. Beijing Tianchang Hongsheng Advertising Co., Ltd.

13. Beijing Xingguang Meichuan Culture Communication Co., Ltd.

14. Zhejiang New Orange Mutual Entertainment Culture Media Co., Ltd.

15. Shanghai Merlot Advertising Co., Ltd.

16. Qushui Tianqing Advertising Co., Ltd.

17. Hanyaboshi Cultural Media (Beijing) Co., Ltd.

18. Jin Juan Media Technology Co., Ltd.

19. Yangguang Jinxin (Beijing) Culture Media Co., Ltd.

20. Beijing Zhongshi Jingling Culture Media Co., Ltd.

21. Beijing Yilong Culture Media Co., Ltd.

22. Zhongshi Sports Entertainment Co., Ltd.

23. Beijing Radio and Television New Viewpoint Advertising Co., Ltd.

24. Beijing Zhenghe Zhongshi Advertising Co., Ltd.

25. Beijing Zhongshi Bainuo Advertising Media Co., Ltd.

26. Beijing Zhonggang Culture Media Co., Ltd.

27. Beijing Zhongtian Riyue Advertising Co., Ltd

28. Beijing Zhibo International Cultural Media Co., Ltd.

In order to encourage large customers to make good use of the high-quality communication resources of the reception desk for brand building, to encourage advertising agencies to improve the communication effect of customers with professional services, and to further strengthen the trinity cooperation among the reception desk, advertising agencies and customers, this year, on the basis of combing and summarizing the cooperation effect in the past year, the General Manager’s Office of the reception desk selected the classic cases of brand marketing communication of CCTV in 2021, which are divided into two categories. The list is as follows.

First, the Central Radio and Television General Station in 2021, "Brand Power Project" integration and dissemination of classic cases:

1. China Kweichow Moutai Distillery (Group) Co., Ltd.

2. Shandong Lu Hua Group Co., Ltd.

Alibaba (China) Co., Ltd.

4. COFCO Group Co., Ltd.

5. Shijiazhuang Junlebao Dairy Company Limited

6. Zhuhai Gree Electric Company Limited.

7. Yihai Kerry Food Marketing Co., Ltd.

8. Qingdao Haier Electric Sales & Service Co., Ltd.

9. Jiangsu Yanghe Winery Co., Ltd.

10. Yunnan Baiyao Group Co., Ltd

11. Beijing Zitiao Network Technology Co., Ltd.

12. Sichuan Langjiu Company Limited

Lenovo (Beijing) Co., Ltd.

14. China Mobile Communications Co., Ltd.

15. OCT Group Limited

Dalian Wanda Group Co., Ltd.

China Post Group Co., Ltd.

18. Huawei Terminal Company Limited

19. Bozhou Gujing Sales Co., Ltd

20. LU ZHOU LAO JIAO CO.,LTD Limited by Share Ltd.

Blue Moon (China) Co., Ltd.

22. Guangxi JD.COM Xinjie Electronic Commerce Co., Ltd.

Hangzhou Wahaha Group Co., Ltd.

24. Inner Mongolia Yili Industrial Group Co., Ltd.

25. Foshan Shunde Country Garden Property Development Co., Ltd.

26. Tasly Holding Group Co., Ltd.

27. Hebei Yangyuan Zhihui Beverage Co., Ltd.

28. Heilongjiang Feihe Dairy Co., Ltd.

29. China Telecom Company Limited

30. Hubei Jinpai Health Wine Co., Ltd.

China United Network Communication Co., Ltd.

32. Beijing Sankuai Online Technology Co., Ltd.

33. Anhui Kouzi Liquor Marketing Co., Ltd.

34. Henan Shuanghui Investment Development Co., Ltd.

35. Shandong Provincial Department of Culture and Tourism

36. Zhejiang Geely Holding Group Co., Ltd

37. Foshan Haitian Seasoned Food Co., Ltd.

Guangzhou Pharmaceutical Group Co., Ltd.

39. Huaqiang Fangte Culture and Technology Group Co., Ltd.

40. Agricultural Bank of China Limited by Share Ltd.

41. China Industrial and Commercial Bank Co., Ltd.

42. China UnionPay Company Limited

43. China Everbright Bank Limited

2. Excellent communication partners of the Central Radio and Television General Station for the 2021-2022 "Double Olympic Games":

1. Anta Sporting Goods Group Co., Ltd.

2. Shanghai Dream Information Technology Co., Ltd. (Pinduoduo)

3. Beijing Huayi Huilong Network Technology Co., Ltd. (Aauto Quicker)

4. China First Automobile Co., Ltd. (Hongqi)

5. Shu Yi Shu Er Cultural Media (Shanghai) Co., Ltd. (Xiaohongshu)

6. Bank of China Limited

7. Beijing Lianjia Real Estate Agency Co., Ltd.

8. Beijing Mercedes-Benz Sales Service Co., Ltd.

9. Toyota (China) Investment Co., Ltd.

10. FAW-Volkswagen Sales Co., Ltd. (FAW-Volkswagen, Audi)

11. Beijing Huapin Borui Network Technology Co., Ltd. (directly employed by BOSS)

12. Allianz (China) Insurance Holdings Limited.

　　CCTV News:In order to further enhance people’s awareness of network security, according to the deployment of "Net Net 2022" special action, the network police brigade of Zhong Kai High-tech Zone Branch of Huizhou Public Security Bureau and volunteers from Shuguang Community of Chen Jiang Street went deep into the community to carry out network security publicity activities to popularize network security knowledge and practical prevention skills for people in the area.

　　At the activity site, the Cyber Police Brigade and volunteers from Shuguang Community in Chen Jiang, by hanging propaganda banners, setting up propaganda desks and distributing publicity materials, publicized the police mainly around the common network traps, online fraud methods and personal information protection methods in real life, popularized the protection skills to the masses, patiently answered questions for the masses, and reminded them to enhance their awareness of self-protection and jointly created a harmonious, safe and stable network environment.

　　It is understood that this publicity campaign distributed more than 300 brochures and received more than 40 consultations from the masses, which effectively improved the public’s awareness of network security and basic protection skills and played a positive role in creating a safe, harmonious and stable network environment in the whole region. (General Desk reporter Yang Zhen)

　　CCTV News (Focus Interview): Taking the expressway has become one of the main ways for everyone to travel. 307.07 million vehicles, this figure is the cumulative traffic volume of the national expressway network in the past May Day holiday, with an average of more than 61 million vehicles driving on the expressway every day. This figure is nearly 20% higher than the May Day holiday in 2019 before the epidemic. At present, in view of the huge demand and road pressure, there are about 5,000 kilometers of expressway sections in the national expressway network, including the Hubei section of Beijing-Hong Kong-Macao Expressway, which has been in operation for more than 20 years.

　　The upgrading and reconstruction project of Hanjiang Bridge was completed five months ahead of schedule. Before the May Day holiday, the Hubei section of Beijing-Hong Kong-Macao Expressway resumed truck traffic. In just a few days, the traffic volume rose rapidly. Throughout the May Day holiday, Beijing, Hong Kong and Macao — — The daily traffic volume of this busiest expressway in Hubei exceeds 260,000 vehicles, and nearly 70% of them are logistics freight vehicles from south to north.

　　Wang Bo, instructor of the 2nd Squadron of Caidian Brigade, No.1 Team of Hubei High Police Corps: Dongxihu District of Wuhan City is equivalent to a transit point of national logistics. It is distributed from Dongxihu Lake of Wuhan City first, and then radiated to the periphery of the country, and began to deliver goods. We understand that the majority of freight car drivers are willing to take the old Beijing-Zhuhai Expressway. The so-called Beijing-Zhuhai Expressway is now called Beijing-Hong Kong-Macao Expressway, and they are willing to take this expressway.

　　It starts in Beijing, with a total length of 2,285 kilometers, and passes through the North China Plain, Jianghan Plain, Central Hunan Plain, Nanling Plain and Pearl River Delta Plain, and finally reaches the ports of Hong Kong and Macao through eight provinces and cities such as Beijing, Hebei, Henan, Hubei, Hunan and Guangdong. The Beijing-Hong Kong-Macao Expressway, which was built in the 1980s, is one of the earliest traffic arteries running through the north and south in China, and it is also the "national comprehensive three-dimensional traffic network in 2035".

　　Bin Fan, Deputy Director of Engineering Management Department of Highway Bureau of Ministry of Transport: The most impressive figure of the national comprehensive three-dimensional traffic network is a diamond-shaped map, which has four poles, namely, the northernmost part of Beijing-Tianjin-Hebei, the southernmost part of Guangdong-Hong Kong-Macao Greater Bay Area, the Yangtze River Delta in the east and Chengdu-Chongqing in the west. In the middle of these four poles, a diamond-shaped six-axis is constructed, and Beijing-Hong Kong-Macao is just within the main axis in the north-south direction. The Beijing-Hong Kong-Macao Expressway is the most important north-south passage in China.

　　After more than 20 years of operation, the Beijing-Hong Kong-Macao Expressway has been extended all the way, supporting the coordinated development of Beijing-Tianjin-Hebei, the implementation of the Yangtze River Economic Belt and Guangdong-Hong Kong-Macao Greater Bay Area’s national strategy, and also driving and witnessing the rapid development of the areas along the route. Wuhan is the epitome of it. The thoroughfare of nine provinces and the Beijing-Hong Kong-Macao Expressway have made it one of the most developed cities in Central China in 20 years. Wuhan Dongxihu District, which is close to Beijing-Hong Kong-Macao Expressway, has become the most extensive logistics transit and distribution center in Central China.

　　The Hubei section of Beijing-Hong Kong-Macao Expressway has a total length of more than 290 kilometers. When construction started in 1998, it was the first expressway with a design speed of 120 kilometers per hour in Hubei Province. The rapid economic growth has brought about a rapid increase in passenger and freight traffic, and the Hubei section of the Beijing-Hong Kong-Macao Expressway has long been unable to meet the demand. In China’s 177,000-kilometer expressway network, some expressways built earlier are facing similar problems more or less.

　　Bin Fan: Especially in the central and eastern regions, some economically developed areas, the capacity of highways can no longer fully meet the travel needs of local people and the corresponding needs of passenger and freight transport. After the aorta is opened, the microcirculation is unblocked, and the aorta is opened, the vitality of the whole economy will be instantly driven.

　　After the reconstruction and expansion projects of Hebei and Henan sections of Beijing-Hong Kong-Macao Expressway were completed successively, the reconstruction and expansion project of the northern section of Hubei Province was officially launched. Hubei’s plan is to upgrade and expand the original two-way four-lane old road into a two-way eight-lane new road by widening subgrade and bridge.　

　　It doesn’t sound complicated. For Hubei, there are problems they must face. One of the challenges is that the whole reconstruction and expansion project must be carried out under the condition of ensuring the normal and safe passage of the whole road. Because the Beijing-Hong Kong-Macao Expressway is the north-south aorta, it cannot be cut off. This is the first time for Hubei.

　　Shen Diandong, commander of the reconstruction and expansion headquarters of Jiaotou Beijing-Hong Kong-Macao Expressway in Hubei Province: Our first multi-party meeting involved 42 units, and it was difficult to coordinate. The 42 units coordinated and acted in unison. This difficulty can be imagined.

　　The Hubei section of Beijing-Hong Kong Expressway is connected with many highways and railways, and dozens of related units need coordination. This is a test of the coordination of local departments. Two months ago, the reinforcement and upgrading of the Hanjiang Bridge on the Beijing-Hong Kong-Macao Expressway needed to be completed under the condition that half of the bridge deck was kept open. With the cooperation of traffic police, road administration, operating units and construction parties, the task of traffic guidance and reform was successfully and safely completed.

　　Sean, Captain of the 3rd Brigade of Beijing-Zhuhai Detachment of Hubei Traffic Expressway: This reconstruction and expansion is the first time in Hubei Province to try to construct while opening to traffic, including management experience and pressure from the construction unit, which we have never seen before. When we first started construction, we said that we would go all out to support and unconditionally choose to complete the task with good quality and quantity.

　　On the Hanjiang Bridge, half of the vehicles on the bridge deck pass normally in both directions, and the other half are under construction, which is rare in previous expressway construction. On the one hand, construction, on the other hand, freight and passenger vehicles whizzed past, which became a unique landscape in the reconstruction and expansion project of the northern section of Hubei Province of Beijing-Hong Kong-Macao Expressway.

　　Hubei, where great rivers flow, is a province of thousands of lakes. The Beijing-Hong Kong-Macao Expressway passes through rivers, lakes and many wetlands here. These areas have soft soil and high water content. The existing highway subgrade has been stable since it was opened to traffic for more than 20 years. However, the settlement of the widened new subgrade needs to be controlled to avoid potential safety hazards, which is another difficult problem in the reconstruction and expansion of Hubei section of Beijing-Hong Kong-Macao Expressway. They need to find local solutions. In the reconstruction and expansion section of East and West Lake of Beijing-Hong Kong-Macao Expressway, precast piles with an average length of 40 meters are being hammered into soft soil one by one.

　　Liu Baiping, Director of Wuhan Branch of the Beijing-Hong Kong-Macao Expressway Reconstruction and Expansion Headquarters in Jiaotou, Hubei Province: The technology of pre-cast piles is widely used in the building system, because the scope of building is relatively limited, but the highway is linear and occupies a wide range. The reason why we consider piling in this place is that the soft soil below is very thick, ranging from 10 to 20 meters thick to 40 to 50 meters thick.

　　Under the 9-kilometer-long pavement, precast piles will be densely covered, and the new road will be built on the subgrade reinforced by precast piles. This is also the first attempt in Hubei.

　　Liu Baiping: There is also a hat on the pile, which is equivalent to a stool. There are legs below, and a hat is worn on one leg. Most of the area is mainly stressed on the pile, forming a composite subgrade.

　　In addition to the treatment of soft soil subgrade, there are many attempts to adapt to local conditions in the process of reconstruction and expansion. In the choice of bridge width, Hanjiang Bridge is a newly built twin-tower cable-stayed bridge in parallel with it, while Fulunhe Bridge is a newly built pile-column assembled bridge like building blocks in parallel with the old bridge.

　　It is precisely because one needs to meet the navigation requirements of the Han River, and the other can save more time and construction cost, including the new use of construction waste, such as the waste asphalt mixture generated when milling and planing the road surface, which will be collected and reused. These practices are accumulating experience for more highway reconstruction and expansion in the future.

　　Bin Fan: As far as we know, the total mileage of the expressway reconstruction and expansion project under implementation has exceeded 5,000 kilometers. The reconstruction and expansion will be carried out immediately, including the Leiyang-Yizhang section of Hunan Province, including the northern section of Beijing-Zhuhai, which is the northern section of Guangdong Province, including the Beijing-Hong Kong-Macao Expressway. The national expressway aorta has been gradually opened, especially in promoting regional coordination and high-quality development, which has played a more obvious role.

　　In Hubei, the builders of the reconstruction and expansion of the Beijing-Hong Kong-Macao Expressway are still making a brand-new attempt. In the precast beam yard of Fulun River Bridge, the birth of each beam, from steel processing, concrete mixing, pouring and demoulding to steam curing of this beam before leaving the factory, has achieved digital control of the whole process. Before the appearance, each beam will be affixed with a QR code that belongs only to it. Like an ID card, it records all the information about this beam. And these information will also enter the building information model of Hubei section of Beijing-Hong Kong-Macao Expressway in the background. In reality, at the same time of reconstruction and expansion, a digital expressway is also being built simultaneously. This represents one of the most advanced management methods of expressway construction today.

　　After driving the rapid development of the areas along the route for more than 20 years, it is a new vision of the old expressway of Beijing, Hong Kong and Macao to help China’s economy develop with high quality in the new era. Before the May Day holiday, Shen Diandong, commander of the reconstruction and expansion of the Beijing-Hong Kong-Macao Expressway in Jiaotou, Hubei Province, specially invited the commander and engineers who built the old Beijing-Zhuhai Expressway more than 20 years ago to the scene of the reconstruction and expansion. A Beijing-Hong Kong-Macao Expressway, known as the "First Road" at that time, was a monument in the hearts of a whole generation. Now, it will glow with new vitality under the feet of a new generation of road builders. In the evening, the logistics park started the busiest time of the day again. These goods, which are related to our food, clothing, housing and transportation, will run in our direction on the expressway and in Beijing, Hong Kong and Macao in the trucks of drivers.

　　By the end of 2022, the total expressway scale in China has reached 177,000 kilometers, ranking first in the world. At the same time, the number of motor vehicles in China has also exceeded 400 million. In order to further open the highway aorta, it is estimated that 25 thousand kilometers of newly rebuilt expressway will be completed during the 14 th Five-Year Plan period. This will play an important role in supporting the national major strategy, improving the national comprehensive three-dimensional transportation network and promoting the high-quality development of transportation infrastructure. Smooth the aorta and help the great circulation. With the gradual progress of the project, everyone’s travel will be more convenient and smooth in the future.

　　What is "internet plus"? How does it affect our life step by step? Simply put, "internet plus" is the combination of traditional industries and the Internet. Relying on advanced Internet technology, Internet platform and Internet industry chain, various traditional industries have deeply integrated the Internet with traditional industries and created new economic forms. Worldwide, internet plus has set off an upsurge of upgrading traditional industries.

　　In this upsurge, both large and medium-sized enterprises and small and micro enterprises are gearing up for transformation. When all enterprises are seeking transformation, relying on their unique resources, platforms and user advantages, large enterprises can often quickly connect with the Internet in a very short time. For example, Intime Department Store teamed up with Alibaba to build an online payment platform; Midea and Xiaomi married and launched intelligent induction air conditioning.

　　Faced with the transformation of large and medium-sized enterprises, some small and micro enterprises began to become anxious. The transformation of large enterprises is either a platform, a system or an industrial chain. They have rich resources, huge user groups and detailed data … which small and micro enterprises do not have. Without a platform, data, users, resources and internet marketing technology, how can small and micro enterprises transform?

　　Fortunately, the opportunities that the Internet brings to everyone are equal. Make good use of Internet technology to make the Internet the source of its own power, and every enterprise in the development of the Internet industry has the opportunity to achieve itself on the Internet.

　　This book is different from the previous books about "internet plus". There is no lofty theory or unreachable routine. It is all about concrete, operable and ready-to-use strategies for internet plus’s transformation.

　　In this book, I summed up my many years of working experience and practical experience in guiding small and medium-sized enterprises all over the country, and discussed in detail how small and micro enterprises can achieve themselves with "internet plus", and how small and micro enterprises and entrepreneurial enterprises can survive in the cracks when all walks of life are carrying out "internet plus".

　　Under the current situation, there are many entrepreneurial enterprises at home and abroad, with a large base. Faced with the opportunities brought about by the vigorous development of the Internet, many young people want to join in and break out of their own world.

　　Then, in the Internet age, young people want to start a business and small and micro enterprises want to develop. How should they do their own Internet marketing? In fact, as long as we make good use of some artifacts on the Internet, both individual entrepreneurs and small and micro enterprises can achieve good development.

　　Liu Pengfei, a young man born in 1980s from a poor mountainous area, discovered a business opportunity by an unexpected opportunity-selling Kongming lanterns. Kongming Lantern has a simple structure and almost no technical content. Liu Pengfei can do it himself.

　　After getting the salary of 1,400 yuan in the first month, Liu Pengfei fired his boss "Squid", and used 400 yuan to buy more than 100 Kongming lanterns to start e-commerce.

　　Through online inquiry, Liu Pengfei found that no one sold Kongming Lantern on Alibaba and China-made platforms, but there were merchants abroad searching for Kongming Lantern through Google search engine. Liu Pengfei thought it was an opportunity and began to make great efforts to produce Kongming lanterns. At this stage, Liu Pengfei found the first bucket of gold in his life.

　　In 2008, the number of manufacturers of Kongming lanterns in China increased sharply, and the competition was fierce. The major manufacturers started a price war. Liu Pengfei realized that Kongming Lantern must be promoted to the international market. As a result, Liu Pengfei introduced the "Flying China Lantern" to the world through Alibaba’s export link and Google search engine.

　　In August, 2008, Liu Pengfei accepted the order of 1.5 million Kongming lanterns from the third largest German retailer. He expanded the scale of the enterprise, which made the enterprise’s benefits grow by leaps and bounds again and again, and realized the soaring 400 yuan to 70 million yuan.

　　It doesn’t matter if you don’t have a platform, just use the existing platform. Without its own platform, Liu Pengfei, a young man born in 1980s, can still succeed in starting a business, which gives us profound enlightenment. In the Internet age, as long as you are good at using all available Internet resources around you, you can also succeed in starting a business.

　　What are the most available resources around us for small and micro enterprises and some individual entrepreneurs? Mobile apps such as WeChat and Weibo are indispensable in people’s daily life.

　　The pace of modern life is accelerating, and mobile phones have become an important part of people’s daily life. As long as we can make a fuss about customers’ mobile phones, we can attract customers to the maximum extent and complete the perfect connection between enterprises and the Internet.

　　How to make good use of existing resources to do a good job in internet plus marketing? We must master four modes and four stages of fan marketing.

　　What are the four marketing models in internet plus? It is a fan mode, a free mode, a mobile Internet mode and a self-media mode. None of these four modes requires enterprises to invest too much manpower and material resources, but the effect is obvious. For example, the sliding screen unlocking software means that by cutting into the user’s mobile phone, the mobile phone user can download other APP applications through sliding screen unlocking, and can get corresponding benefits, which greatly mobilizes the user’s enthusiasm for participation.

　　What are the four stages of fan marketing in internet plus? We often say "no fans, no marketing". In the Internet age, if you want to keep your fans, you need to do these four stages: First, get your circle of friends; Second, learn to run your own WeChat official account; Third, you must have your own APP；; Fourth, establish your own ecological circle.

　　Through gradual deepening and upgrading step by step, every start-up enterprise or individual can master the essence of internet plus, make internet plus’s theory and routines work for me, and do well in the Internet field.

There are many people who blindly look at the vehicle dynamic parameters when buying a car. In fact, the greater the value, the better the experience. Today, Xiaobian picked a car in a medium-sized car and introduced it to everyone. It is. So whether this car is a mule or a horse, let’s take a look at its actual performance.

First of all, from the appearance, the front face of BMW i4 gives people a very stable and atmospheric feeling, which is very sporty. The headlights are very beautiful and look very cute as a whole. The car is equipped with LED daytime running lights, automatic opening and closing, adaptive far and near light, delayed closing and so on. Coming to the side of the car, the body size of the car is 4785 mm * 1852 mm * 1455 mm. The car adopts full lines, and the car side presents a cold design style, with large-sized thick-walled tires, and smooth lines run through the whole car side. In the design of the rear end, the rear end looks more capable, and the taillights give people a very concise feeling, and the overall shape is still very attractive.

In terms of interior, the interior of BMW i4 presents an atmospheric design style, and the visual effect is very good. The car’s steering wheel shape is eye-catching, equipped with the functions of manual steering wheel up and down+front and rear adjustment, steering wheel heating, etc., and the feel experience is good. Take a look at the central control. The car is decorated with an elegant touch-control LCD central control screen, which makes the interior design quite layered and the details are still in place. The dashboard and the seat are equally eye-catching, and the dashboard design is remarkable, which is very soft. The car uses leather seats, equipped with functions such as electric adjustment of auxiliary seat, electric adjustment of seat with memory, and seat proportion falling down, so it is very comfortable to ride.

The BMW i4 is equipped with a motor with a total power of 400KW and a total torque of 795N.m It has good acceleration, excellent cruising range and good power performance.

Next, look at the configuration. The BMW i4 is equipped with car networking, driving mode selection, remote control key, interior atmosphere light, traction control (ASR/TCS, etc.) and other configurations.

After reading this car, I believe you also have a general understanding. This level of models can often take into account the cost performance and practicality, and is often considered by most consumers as the first choice when buying a car.

On September 22nd, the pre-sale officially started, including three models, with a pre-sale price of 24.99-31 9,900 yuan. The new car is based on the SDA architecture, combining SUV and pickup truck design, positioning medium and large high-end smart electric SUV, which is called "China’s version of Cybertruck" by consumers. Providing pure electric and range extension power forms to choose from, the car will be officially launched in October.

In terms of appearance design, the Changan Qiyuan E07 features C-shaped headlights, and the central logo area uses a liquid crystal display, which can realize various interactive functions and is very cool. The body size is 5045/1996/1695 mm, the wheelbase is 3120 mm, and it adopts a 5-seat layout, which belongs to the standard medium and large SUV size.

The 3120mm long wheelbase combined with the rear compartment’s loading capacity of up to 300kg, after opening the trunk, there is enough length to load camping and cycling equipment. This "one car to many cars" flexibility is suitable for users who need to deal with multiple travel needs at the same time, especially when loading large outdoor equipment (such as motorcycles, mountain bikes, alpine scooters, etc.), it is an ideal choice for camping and cycling enthusiasts.

The flexibility of the Changan Qiyuan E07 is one of its biggest selling points. It is more than just an SUV. Through innovative sliding rear dome design, Air Lock electric partition and electric flat flip tailgate, it can easily switch between SUV and pickup truck to meet the needs of users in different scenarios.

In terms of interior design, the Changan Qiyuan E07 center console is simple, eliminating the traditional physical instrument screen and integrating almost all functions into the central control screen. A folding screen is hidden above the passenger’s head, which can be awakened and opened or put away through the voice assistant to meet the entertainment needs of the passenger in the passenger.

The five-screen linkage interaction in the car is also good, including a 28.86-inch HUD head-up display, a sunflower screen, a queen co-pilot screen, and a 2D/naked eye 3D-∞ in the rear, further enhancing the overall sense of technological luxury in the car.

In order to give the occupants a more luxurious driving experience, the Changan Qiyuan E07 comes standard with front double zero-gravity seats with leg rests, which is an absolute advantage in the same class of models. Secondly, the front and rear seats have electric adjustment, heating, ventilation and 12-point massage functions.

Changan Qiyuan E07 provides intelligent magic carpet suspension technology, which is dynamically adjusted by air springs and the CDC intelligent computer electronic control system, and automatically adjusts the suspension stiffness and height according to road conditions and driving modes, providing a smooth and smooth driving experience regardless of road conditions.

In terms of intelligence, Changan Qiyuan E07 claims to have human-like intelligence. Based on the SDA Tianshu architecture, it adopts the scene programming technology of Changan AI voice model, supports voice interaction in all scenes in 9 sound zones, and there is no dead angle voice control coverage inside and outside the car. Users in different locations can also get exclusive services. It can also voice control more than 20 core modules and more than 100 sub-functions of the whole car, including common functions such as HUD display, wipers and double flash.

Changan Qiyuan E07 is equipped with L2 + intelligent driving auxiliary features, and adopts Changan’s self-developed intelligent driving pilot assistance system. 2 lidars and multiple line-of-sight sensors, supported by 254 TOPS computing power Orin-X chip, provide an efficient and accurate AI intelligent driving experience. NOA pilot assistance driving, automatic lane change, overtaking and path planning functions all make driving easier and more comfortable.

Changan Qiyuan E07 provides two power options: pure electric and extended range. The pure electric car is based on the 800V high-voltage architecture and has a two-wheel drive version and a four-wheel drive version. The two-wheel drive version is equipped with a maximum power of 252 kW (343 horsepower) drive motor, and the maximum speed can reach 201km/h. The four-wheel drive version is equipped with 188/252 kW (256 horsepower/343 horsepower) front and rear motors, and the 100-kilometer acceleration is 4 seconds. The new car is equipped with a golden bell jar battery. According to different configurations, the CLTC has a range of 551km, 651km, 701km and 1000km respectively. The extended version is equipped with a battery pack with a capacity of 39.05 kWh, and provides pure electric battery life of 185 kilometers and 200 kilometers. In addition, the official said that the new car can achieve 365Km battery life in about 15 minutes of charging.

On the whole, Changan Qiyuan E07 brings users a driving experience beyond the same level with its rich comfort configuration, intelligent functions, large space cyber variable form, and the practicality of "one car to many cars". Whether it is camping, riding, fishing and other outdoor activities, or daily commuting, the car can meet the various needs of users. And the pre-sale price from 249,900 yuan is full of sincerity.

[Autohome News] Recently, we have obtained some configuration information from Geely’s small SUV – Geely ICON Chocolate. The new car will be equipped with Geely Jinqing 1.5TD high-efficiency power system in the future, and will be equipped with FACE CONNECT facial recognition intelligent system, a new generation of Galaxy OS smart car machine, etc., to enhance the driving experience.

In terms of appearance, Geely ICON chocolate adopts a colorful aesthetic design concept, which is more fashionable as a whole. Specifically, the front face of the new car is different from the current Geely ICON "back" font elements. The front grille adopts concave "bow-shaped" elements, which are divided into upper, middle and lower parts as a whole. While strengthening the sense of visual hierarchy, it also makes the vehicle more recognizable.

Looking at the side of the body, the new car will be blackened with A/B/C pillars to create the current popular floating roof design. With the bright paint color scheme below and the hidden door handle, it not only adds a sense of style, but also strengthens the sense of technology. At the rear, the overall styling elements of the new car echo the front face, and the taillights with a great sense of design make this car have a good recognition. In addition, the car will be equipped with 19-inch double five-spoke wheels.

In terms of configuration, the new car will be equipped with FACE CONNECT facial recognition intelligent system (FACE ID facial recognition successfully after the foot on the brake can be automatically ignited, while the main driver seat and the external rearview mirror memory linkage), 10.25 + 12.3 inch S-type floating dual screen (Geely Galaxy OS car system, E02 car standard chip, 12nm process technology, 8-core CPU, 6G memory, 64G storage), DTS immersive cinema sound field, worry-free departure, induction electric tailgate, etc. In terms of intelligent safety, the car is also equipped with L2 intelligent driver assistance system, with ICC intelligent pilot system, ACC full-speed adaptive cruise system and LKA lane departure assistance system, ELK emergency lane keeping assistance, TSR traffic sign intelligent recognition, IHBC far and near light adaptive system, AEB pre-collision safety system and other 17 active safety functions. It is worth mentioning that the new car integrates camera and navigation information, which can recognize speed limit signs and automatically adjust far and near light.

In addition, the car is also equipped with functions such as 540 ° panoramic image + chassis perspective, traced reversing and narrow road exploration. ICON Chocolate can remember the last 50 meters of driving path. Not only that, the high definition reversing image equipped with ICON Chocolate has dynamic route assistance, but also equipped with the original 360 ° driving recorder. In terms of comfort and environmental protection, ICON Chocolate is equipped with a CN95 high-efficiency composite air conditioner filter element, which has a dust filtration efficiency of more than 95% and a PM2.5 filtration efficiency of more than 99%, which can effectively clean the air. The new car also comes standard with an antibacterial steering wheel, which is wrapped in materials certified by Guangwei with a 99% antibacterial rate.

In terms of power, the new car will be equipped with a new generation of Jinqing 1.5TD inline four-cylinder engine with a maximum power of 133kW and a maximum torque of 290N · m. In terms of transmission, it is matched with a new 7-speed wet dual-clutch transmission. According to the official, the car’s 0-100km/h acceleration time is 7.9 seconds. At the same time, the new car is based on the BMA platform architecture to create a standard front McPherson rear multi-link independent suspension for all series. (Text/Autohome Zhouyi)

　　[car home Information] On February 27th, 2023, LI announced its financial reports for the fourth quarter and the whole year of 2022, with both revenue and delivery reaching record highs. At the same time, Ideal announced that it will challenge all luxury SUV markets in the price range of 300,000 yuan to 500,000 yuan to win 20% market share this year.

　　Specifically, the ideal revenue in the fourth quarter was 17.65 billion yuan, a year-on-year increase of 66.2%; The quarterly delivery volume reached 46,319 vehicles, a year-on-year increase of 31.5%. The annual revenue was 45.29 billion yuan, a year-on-year increase of 67.7%; 133,246 vehicles were delivered throughout the year, a year-on-year increase of 47.2%. In addition, LI’s gross profit margin returned to health in the fourth quarter, reaching 20.2%, and the gross profit margin for the whole year reached 19.4%. Under the background of continuously increasing investment in R&D and capability, by the end of the fourth quarter, LI’s cash reserves reached 58.45 billion yuan.

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　　This financial report shows that LI’s operating profit (excluding equity incentives) in the fourth quarter exceeded 500 million yuan, reaching 568.7 million yuan, with an operating profit margin of 3.2%. In addition, the net profit in the fourth quarter was 265.3 million yuan, and the quarterly free cash flow was 3.26 billion yuan. At the same time, LI insists that more than 10% R&D investment is used to support the long-term self-developed technology development of enterprises. In the fourth quarter, LI’s R&D expenditure was 2.07 billion yuan, accounting for 11.7%. From the perspective of the whole year, the R&D expenditure in 2022 was 6.78 billion yuan, accounting for 15.0% of the annual expenditure, which doubled the R&D investment expenditure in 2021 and increased by 106.3% year-on-year. In addition, LI’s sales, general and management expenses in the fourth quarter were 1.63 billion yuan, accounting for 9.2% of the quarterly expenses.

　　Based on this, LI has given a new prospect for 2023. This year, it will challenge all luxury SUV markets in the price range of 300,000 yuan to 500,000 yuan to win 20% market share. It is estimated that the delivery volume in the first quarter will be between 52,000 and 55,000, with a year-on-year increase of 64.0% to 73.4%. The total income is expected to be 17.45 billion yuan to 18.45 billion yuan, up 82.5% to 93.0% year-on-year.

　　　As of January 31, 2023, LI has 296 retail centers nationwide, covering 123 cities; There are 320 after-sales maintenance centers and authorized car body panel spraying centers, covering 222 cities. The ideal sales expenses in 2022 have been lower than the R&D expenses. In 2023, we will continue to improve the proportion of sales expenses to revenue.

　　LI implements modular management of the supply chain. While maintaining close and mutually beneficial cooperation with suppliers, it also actively strengthens the self-research and self-production of core categories related to the product strength of smart electric vehicles and the vertical integration of the industrial chain, thus achieving a good balance between upstream cost and risk control. In the past three years, Ideal has begun to build its own core components such as range extender and electric drive assembly to ensure the stability of quality and supply. (Compile/car home Duandi)