爱上海419论坛-阿拉上海后花园419-夜上海最新论坛社区-上海品茶工作室

　　From July 13th to September 26th, National Cultural Heritage Administration Underwater Cultural Heritage Protection Center, Liaoning Provincial Institute of Cultural Relics and Archaeology, and Dalian Institute of Cultural Relics and Archaeology jointly conducted an archaeological investigation on the wreckage of an iron sunken ship in Dalian waters, and confirmed that the ship was a far-off ship sunk by Beiyang Navy in the Sino-Japanese War of 1894-1895. This is another major achievement in underwater archaeology in China after Zhiyuan Ship. After the news was released, it triggered a heated discussion in society. On September 28th, the staff who participated in the archaeology gave more details about the sunken ship passing through the distant ship in the Sino-Japanese War in Dalian waters discovered by the underwater archaeological team.

　　Disappeared for a hundred years, the sinking ship appeared in Dalian waters.

　　The ship that disappeared for more than 100 years was found. Recently, the news released by National Cultural Heritage Administration triggered a hot discussion among netizens. Jingyuan Ship was an important warship of Beiyang Navy in the late Qing Dynasty, which was sunk by the Japanese in the Sino-Japanese War of 1894-1895, and its whereabouts were unknown for more than a century.

　　In the summer of 2014, an underwater archaeological team found the remains of an iron sunken ship in the south sea area of Laorenshi, Heidao, Zhuanghe, Dalian, Liaoning Province based on data clues and magnetometer geophysical data, and speculated that it was a passing ship, but it lacked decisive evidence. Therefore, from July 13th to September 26th this year, National Cultural Heritage Administration Underwater Cultural Heritage Protection Center, Liaoning Provincial Institute of Cultural Relics and Archaeology, and Dalian Institute of Cultural Relics and Archaeology jointly conducted an archaeological investigation on the iron wreck in Dalian waters, and confirmed that the remains of this ship were the Jing Yuan ship of Beiyang Navy.

　　On September 28th, Zhou Chunshui, the leader of National Cultural Heritage Administration Underwater Cultural Heritage Protection Center who participated in the underwater archaeology of the long-distance ship, wrote in official website, National Cultural Heritage Administration that the water depth of the site area was about 10 meters, and the visibility was poor, and the visibility was less than half a meter for a long time during the archaeological period. To this end, the investigation has increased the investment in geophysical exploration technology, and used many technologies such as multi-beam sea survey, three-dimensional imaging and differential positioning.

　　After a hundred years, the name of the ship is still hanging on the side of the ship

　　Zhou Chunshui and others said that this underwater archaeological investigation is divided into two stages. The main goal of the first stage is to search, locate and evaluate the sinking situation. The underwater archaeological team used equipment to collect relic data, and through data comparison and file analysis, combined with diving exploration, searched, found and confirmed the exact position of the passing ship, and found the ring protective armor belt "Tiejiabao" which can mark its identity. At the same time, according to the attitude and inclination of the hull, the hull should be inverted.

　　The goal of the second stage is to partially clean up, so as to confirm the identity of the sunken ship and find out the preservation status of the sunken ship. The underwater archaeological team carried out sand pumping operation on the starboard outer wall of the middle and rear section of the hull, and revealed the hull structure on the side one after another, including gangways, portholes, various pipeline facilities, etc., and all the components were in an inverted state, which confirmed the inference that the hull was upside down.

　　In order to determine the identity of the sunken ship, the underwater archaeological team made a special work plan, and finally found the name of the "Jingyuan" ship buried 5.5 meters below the seabed on September 15, and it has been hanging on the outer wall of the ship’s side for more than 100 years. Underwater archaeologists also unearthed a wooden sign with the word "Jingyuan" stamped on it during the site cleaning. Before the end of the work, the archaeological team covered the wooden ship names and backfilled all the extracted hull areas. Finally, zinc blocks are welded along the periphery of Tiejiabao by sacrificing anodes to delay the corrosion of iron ships by seawater.

　　Traces of fire can be seen in some cultural relics coming out of the water.

　　Zhou Chunshui and others introduced that a large number of relics were extracted from the water in this survey, and more than 500 specimens were selected by archaeologists. Among them, the representative cultural relics include: small iron boilers (providing steam power for windlass hoists), diagonal trusses, large transverse ribs, portholes, hatches, armored fort linings and other hull structural facilities, Mao Se rifle bullets, Weiblie revolver bullets, 37mm Hakikkai rapid-fire shells, 47mm Hakikkai shells. In addition, the archaeologists also found 53mm Grusen gun cartridge and 120mm shell primer, both of which are not found in the factory files of Jingyuan Ship. Archaeologists speculate that it should be an emergency weapon and equipment added before the Sino-Japanese War of 1894 to strengthen the firepower of the stern.

　　Archaeologists also found a "canopy pole" used to hang a sunshade. The wood was covered with fire marks and almost carbonized, which confirmed the theory that Jingyuan ship was hit and caught fire in the naval battle. At the bow of the ship, archaeologists found some hookahs, mahjong tiles, mazars, oil lamps, wooden pots, shoes soles and other items. According to reports, this place is the living quarters of junior soldiers.

　　Archaeologists have found many bullets of Mao Se rifles in the bow area of Jingyuan Ship. It is speculated that this may indicate that at the beginning of the naval battle, the soldiers of Jingyuan Ship had plans to board Japanese warships with guns.

　　"The underwater archaeological achievements of the remote ship have extremely important historical and scientific value for the study of the history of the Sino-Japanese War, the history of the navy and the history of ships. The discovery of some investigation objects provides a new understanding for the research work, such as ‘ Jingyuan ’ The nameplate is the nameplate of the Beiyang Navy warship discovered for the first time, and its material, technology and installation method are also clear for the first time. " Zhou Chunshui and others introduced.

　　conversation

　　Archaeologist: The soldiers who passed the distant ship were heroes who fought to the last minute.

　　Yu Haiming, an underwater archaeologist from Dalian Institute of Cultural Relics and Archaeology, participated in the underwater archaeology of the remote ship. On the 28th, he told the Beijing Youth Daily reporter that the most crucial evidence to prove the true identity of the remote ship — — The "Jingyuan" nameplate was discovered before a typhoon, when archaeology had come to an end. "This is the most shocking moment in the whole archaeological process."

　　Beiqing Daily: How did you participate in this underwater archaeology?

　　Yu Haiming: I completed the training of underwater archaeology from May to June this year, because the sunken warship in this investigation was on Zhuanghe side of Dalian, so I was invited by National Cultural Heritage Administration Underwater Cultural Heritage Protection Center to participate in the investigation of the sunken ship passing through the distant ship in this Sino-Japanese War. I came to the archaeological site of Jingyuan Ship in early July and participated in the follow-up archaeological investigation.

　　Beiqing Daily: You said that your views on Beiyang Navy have changed through this archaeological investigation?

　　Yu Haiming: In the past, we might think that Beiyang Navy was influenced by the Qing Dynasty and had many corruption problems, which led to the defeat of Beiyang Navy in the Sino-Japanese War. Many people who participated in the underwater archaeology this time are very familiar with the history of Beiyang Navy. Every day, everyone works and lives together, and the topic of conversation is Beiyang Navy. They will also take out old photos and materials, and analyze each other together. I feel that my previous views may be misunderstood.

　　It can be seen that Beiyang Navy has been affected by corruption, but the officers and men of Beiyang Navy are indeed heroes. Not only did they fight to the last minute after crossing the distant ship, but in some diaries left by the Japanese army, they also admired the spirit of Beiyang Navy in fighting to the end. A large number of Beiyang Navy officers died in battle or committed suicide.

　　Beiqing Daily: What impressed you the most in this survey?

　　Yu Haiming: What impressed me the most was when the word "Jingyuan" was discovered in the later period of archaeology. The typhoon was coming soon that day. At 6 o’clock in the morning, an archaeological teacher went into the water to investigate. He first photographed the word "far" passing by a distant ship. At that time, the wind and waves were already very heavy, so we asked him to get out of the water quickly. Then everyone looked at the instrument and basically confirmed that the sunken ship must have passed by a distant ship. Later, we successfully found the word "Jing" with gold on it, and everyone was very excited. The identity of Jing Yuan Ship was confirmed like this.

　　Beiqing Daily: How was the wooden sign with the word "Jingyuan" discovered?

　　Yu Haiming: The’ re’ was drawn when pumping sand. There are many things like shells in the pumped sand. During sorting, we found this’ re’ in it. Because when the distant ship sinks, it carries a lot of coal, and these cinders will dye some wooden cultural relics black. This’re like this. At first, I couldn’t see what it was, but I could vaguely see the word "Jing". Then I took this’re "and went to the team leader. According to the experience, the team leader judged that it might be the word "Jingyuan". Later, through some processing, the word "Jingyuan" appeared.

　　Beiqing Daily: What impressed you about the cultural relics coming out of the water?

　　Yu Haiming: Some teachers are very familiar with Beiyang Navy. I found a 120 mm shell primer when sorting cultural relics. I don’t know much about this cultural relic, but one teacher was very excited. He said that this kind of shell itself was not recorded in the equipment of Jingyuan Ship, and it was suspected that it was specially added to prepare for the Sino-Japanese War. It can be seen that Beiyang Navy had actively prepared its combat effectiveness before the war. In addition, unlike some previous legends, we found some hookahs in archaeology, but we didn’t find any big hookahs. The hookahs are normal when sailing on the sea, and we know that we need such a pastime when sailing. This is inconsistent with the previous statement that some Beiyang Navy officers smoked opium.

　　memory

　　The distant ship is a distant ship.

　　Jingyuan Ship is one of the important warships of China Beiyang Navy in Qing Dynasty. It was built by German Vulcan Shipyard and launched on January 3, 1887. It has a length of 82.4 meters (waterline), a width of about 12 meters and a speed of 15.5 knots. Its main weapons include Krupp 210 mm, 2 caliber guns, 2 150 mm caliber guns and 4 torpedo tubes.

　　Jing Yuan Ship returned to China at the end of 1887, and at that time, as the current ship of Zhiyuan Ship, he was incorporated into Beiyang Navy. Deng Shichang and Lin Yongsheng, the famous generals, respectively served as the duct tape (captains) of the two ships. On September 17th, 1894, the Sino-Japanese Sino-Japanese Sino-Japanese War of 1894 broke out in Dadonggou in the northern part of the Yellow Sea. The officers and men of Beiyang Navy fought bravely against Japan, and the Qing army lost four warships in this battle, namely Yang Wei, Chaoyong, Zhiyuan and Jingyuan.

　　In the battle, Zhiyuan and Jingyuan, under the leadership of Deng Shichang and Lin Yongsheng, fought bravely to kill the enemy, but unfortunately they sank successively. Among them, the distant ship was besieged by four Japanese ships, namely Yoshino, Takachiho, Akinzhou and Nobukuro. The officers and men of the whole ship, led by Lin Yongsheng, took up the battle bravely and never raised the flag until their death. There are more than 200 officers and men in the whole ship. Except for more than 10 people who swam to the nearby Old Man Stone to survive, most of them sank with the ship.

　　Zhou Chunshui and others wrote that the Sino-Japanese War of 1894-1895 was a landmark historical event in the modern history of East Asia. For the Qing Empire, this war ended the historical process in which Emperor Guangxu, Li Hongzhang and other upper-level rulers in the late Qing Dynasty tried to realize the rich country of Qiang Bing through the Westernization Movement and naval construction, and China slipped into the abyss of being poor and weak and being trampled upon by others. For the Japanese side, it became famous in the world after the decisive battle and World War I, and finally it was possible to re-examine China as a victor, thus fueling its ambition of conquering China and dominating East Asia. This edition/reporter Qu Chang

　　The transformation of cell fate is determined by precise and complex signal regulation and epigenetic regulation, and the study of its molecular mechanism is one of the core problems that need to be solved urgently in the development of cell biology. Studies have shown that mouse pluripotent stem cells have two different states in signal maintenance and function, namely, primitive Epiblast stem cells, EpiSCs) and naive Embryonic stem cells, ESCs). In vitro, these two kinds of pluripotent stem cells can transform each other. Under the stimulation of ActivinA and bFGF signals, naive ESCs can differentiate into primed EpiSCs. On the contrary, by overexpressing a single naive pluripotent gene, such as Esrrb, Klf2, Nr5a2, etc., the initial to naive transition (PNT) can also be realized. Studying the mechanism of cell fate change in mouse PNT process can provide reference for isolating or inducing naive pluripotent stem cells from different species, but the main molecular mechanism of cell fate change in mouse PNT is still unclear.
　　On May 11th, Pei Duanqing’s research group and Liu Jing’s research group of Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences published a research paper entitled BMP4 resets mouse epi blast stem cells to naive proliferation through zbtb7a/b-mediated chromatin remolding online in the journal Nature Cell Biology. In this study, we first found that BMP4 can induce PNT in mice, and established an efficient PNT induction system with clear components. Subsequently, high-throughput sequencing techniques such as ATAC-seq were used to reveal the specific molecular mechanism of mouse PNT process.
　　At first, researchers found that growth factor BMP4 can induce PNT in mice. With the help of visual reporting system and screening of compound library, it was found that EZH2 inhibitor EPZ6438 and DOT1L inhibitor EPZ5676 can significantly improve the induction efficiency, and then a mouse PNT induction system with a clear chemical composition with an induction efficiency of 80% within 8 days was established.
　　On the basis of this platform, researchers combined bioinformatics analysis based on chromatin transposase accessibility sequencing (ATAC-Seq). The dynamic changes of chromatin accessibility in the process of PNT induced by small chemical molecules in mice were described, and it was found that the most critical factor in this system, BMP4, mediated the progress of PNT by regulating chromatin accessibility, on the one hand, inhibiting the opening of differentiation-related sites, on the other hand, promoting the opening of naive pluripotent gene sites. By analyzing the gene sites where BMP4 opens and activates expression, the researchers found that the new downstream targets of BMP4, Zbtb7a and Zbtb7b, regulate the function of PNT by influencing chromatin remodeling. Furthermore, chromatin immunoprecipitation (Chip) proved that Zbtb7a directly binds to and activates the expression of naive pluripotent genes such as Esrrb, Klf2, Nr5a2, thus regulating the occurrence of PNT.
　　To sum up, this study established an efficient technical platform for chemical induction of mouse PNT, revealed the molecular mechanism and found new targets from the perspective of chromatin accessibility, and made new discoveries in the study of cell fate transformation mechanism, which provided a new understanding and breakthrough point for the study of chemical regulation of cell fate transformation, and also provided a very meaningful reference direction for other research systems, such as the acquisition of naive pluripotent stem cells in human system.
　　Researchers Pei Duanqing and Liu Jing are the corresponding authors of this paper. Doctoral students Yu Shengyong and Zhou Chunhua, Ph.D. students Cao Shangtao and He Jiangping are the co-first authors of this paper.
　　Paper link
　　Cell fate transition process, chromatin changes and intervening regulatory proteins

Recently, a group of renderings of M8, which were drawn by a car blogger according to the patent drawings, have a high similarity with the final vehicle products. The front face design of Wenjie M8 adopts a zigzag daytime running light, and the middle decorative plate can be lit at the edge, and the logo stands in it, so the overall shape is simple and atmospheric. The Xinghe design of vehicles is an important symbol to distinguish different levels of vehicles. The higher the level, the brighter the Xinghe. There is no "Xinghe" area in the M7, while the M8 has a full side shape, and the tail design is a reduced version of M9. The size of the light group is reduced, and the license plate frame is moved down. The first model chose the color scheme of "Purple Gas from the East", which added a sense of fantasy.

The front face design of the M8 is different, which is considered as a design strategy to prevent "one loss and one loss" and spread risks. Bloggers predict that the M8 in the world may be positioned at the level of 300,000 yuan, and the price is between M7 and M9. The design and positioning of this model have attracted the attention and discussion of the market.

　　Beijing, January 30th, 2007 (Reporter Chang Yafei of the Central Television Station) Recently, there was a picture circulating on the Internet: the central government required "returning home from a low-risk area with a green code", but in the province, it became "negative proof of nucleic acid test", in the city, it became "home isolation", in the town, it became "nucleic acid proof+centralized isolation+home isolation", and in the village, it became "please leave gracefully". The reporter’s interview and investigation found that although this picture on the Internet has deductive elements, it is also a reflection of the facts at the grassroots level. Especially in some places, the epidemic prevention policy is "overweight" or even "one size fits all".

　　On January 27th, at the press conference of the joint prevention and control mechanism in the State Council, Zhao Chenxin, secretary-general and spokesman of the National Development and Reform Commission, and Zeng Yixin, deputy director of National Health Commission, proposed that all localities should not be allowed and do not want to make "one size fits all" treatment when implementing the relevant policies formulated by the state for returning home for the New Year, and should not block people from traveling and returning home, but should give more protection and convenience to the people. What problems did the "Spring Festival returnees" encounter? Why is the "return home policy" being "overweight" in implementation?

　　National Health Commission recently issued the Notice on Printing and Distributing the Work Plan of COVID-19 Epidemic Prevention and Control in Rural Areas in Winter and Spring (hereinafter referred to as the Notice). The "Notice" clarifies that returnees need to return home with a negative result of effective nucleic acid test within 7 days, and implement home health monitoring for 14 days after returning home, during which they will not gather or flow, and carry out nucleic acid testing every 7 days. On January 14th, Xiao Li returned to a low-risk area in Benxi City, Liaoning Province from nangang district, a low-risk area in Harbin, with a negative report of nucleic acid test. When he returned to the village, he was asked to stay at home for 7 days.

　　Xiao Li told reporters: "Normally, those who return home from low-risk areas and have negative reports of nucleic acid testing can move at home normally without isolation. However, our village said that according to the superior’s opinion, I was still quarantined at home for 7 days. However, after the expiration of 7 days of isolation, no one gave me a nucleic acid test, and there were no measures and guarantees during the isolation process. In fact, it was a mere formality. "

　　Xiao Li said that because of the recurrence of the epidemic in Heilongjiang Province, his colleague Xiao Zhang returned to a low-risk area in his hometown of Hubei for 10 days and was isolated in his hometown. He said: "He had already returned home for about 10 days, and there were sporadic cases in Heilongjiang, so the local government asked them to concentrate on isolation again. From the day he came home, he was not released until 14 days after the quarantine expired. Not all of Hubei is like this, but only some parts of Hubei, such as a certain district or a certain township. This is actually the grassroots blindly pursuing prevention and control effects in the process of prevention and control without considering the actual situation. "

　　Mr. Wang from Shanghai recently returned his high-speed train ticket to his hometown in Jiaozuo, Henan. He said that in mid-January, he paid attention to his hometown’s policy of returning home. He learned from the neighborhood Committee that people returning from low-risk areas only need to provide proof of nucleic acid testing within 7 days and then monitor their health at home. He also took the initiative to declare his trip to the neighborhood Committee. But I didn’t expect that the feedback policy of the neighborhood Committee changed two days later: when he returned from Shanghai, he needed to be isolated at his own expense.

　　Mr. Wang said: "My mother called me and said that people in the community came to tell me that if I went back, I would go to the designated hotel for 14 days at my own expense. There is no point in going back like this, because the annual leave is only seven days. This is a soft way to let you not come back. "

　　Ms. Zhou from Anqing City, Anhui Province told the Voice of China reporter that she had planned to go back from Shanghai to visit her grandmother with a cerebral infarction during the Spring Festival, but because the community where her hometown is located requires that she be isolated at home for 14 days and have a nucleic acid test every seven days. Ms. Zhou calculated that the second nucleic acid test after returning home coincided with the date of the doctoral examination, and the neighborhood Committee stressed that the date of nucleic acid could not be revised, so she had to stay in Shanghai.

　　"Even if the nucleic acid testing, why can’t we reschedule? Wouldn’t it be nice to advance or postpone one day? But the people in the neighborhood Committee kept saying ‘ No ’ . In the process of talking to the staff of the (neighborhood) Committee, I found it hard to accept what she said. She said, ‘ I don’t care if you are low-risk or what kind of risk, as long as you come to us, that’s it. ’” Ms. Zhou said.

　　Requirements of returning home for epidemic prevention and control in Anqing City, Anhui Province

　　The "overweight" epidemic prevention policy has also been corrected in some places.

　　On January 24th, a village in Linxi County, Xingtai, Hebei Province issued a notice forbidding villagers working outside to go home for the New Year. After being reported by the media, the village secretary said that there was something wrong with the statement of the notice, but he just hoped that the villagers outside would try not to go home and had corrected the notice. Some netizens also reported that in Taocheng District, Hengshui City, Hebei Province, residents’ committees or property requirements, if they have to return to Hengshui under special circumstances, need to report to the community residents’ committees for registration in advance. After the personnel arrive, they will be isolated for 14 days at their own expense. After media reports, residents’ committee staff said that they had received orders from their superiors to cancel the notice. At present, the requirement is to carry out nucleic acid testing twice within 3 days after returning home, and to monitor the physical condition at home during this period, and not to go out unless necessary.

　　Regarding the deformation of the policy of returning home during the Spring Festival in some areas, Yang Hongshan, a professor at the School of Public Administration of Renmin University of China, told the Voice of China reporter that this is a manifestation of insufficient refined management in some places. He said: "The relationship between epidemic prevention and control, local resumption of production and normal production and living order is actually a parallel relationship, not a one-way choice relationship. Therefore, we can see that in today’s local epidemic situation, maybe our place needs to take care of all aspects. Simply considering only one factor and pursuing absolute safety or absolute self-exemption may also be a manifestation of insufficient initiative and meticulous management in some places. In the process of operation, the basic top-down epidemic prevention and control policies and related laws and regulations are sometimes ignored by grassroots governments. "

　　Yang Hongshan believes that it is necessary to attract the attention of local governments through media publicity and reports, so as to urge them to take corresponding measures in time to stop the "overweight" epidemic prevention and control behavior. Local governments should adopt differentiated management by regions and levels, and pay more attention to "embroidery" and human feelings.

　　"Today, in the face of big data, there is also a collaborative management mechanism between different regions. It is necessary to take the clues of the epidemic itself as the guide, and adopt refined prevention and control measures for local and sporadic epidemics. In the case of complete control, just for the convenience of one’s own work, regardless of the convenience of the other party, and completely ignoring the interests and rights of the other party, it is actually a bit simple and rude, and it is also a manifestation of not taking measures according to people’s policies in local governance. The more you are in the grass-roots governance, the more you face the vivid reality, and the more you know all kinds of differentiated situations. In fact, in the process of grassroots governance, it is more necessary to consider the human touch. " Yang Hongshan said.

Original Wuyuan Li Na and other SIFIC infection horizons　

Author: Wu Yuan Li Na Jin Wenting Ma Yuyan

Review: Hu Bijie and Pan Jue

First, a brief introduction to medical history

Male, 63 years old, from Shanghai, was admitted to the Infectious Diseases Department of Zhongshan Hospital for the second time on November 23, 2022.

Chief complaint: indwelling catheterization with repeated urine color turbidity for 2 months and then 8 days.

Current medical history:

On September 19, 2022, I went to a hospital in Shanghai for fatigue, anorexia and dysuria. WBC 10.12×10 9/L, N 87.6%, Hb 53g/L, hsCRP 135.22mg/L, ESR 62mm/H, albumin 30.1g/L, Scr 589μmol/L, K 2 were examined. Urine routine: WBC 3892/ul, occult blood 3+/RBC 5579/ul, protein 2+; Chest CT: bilateral pleural effusion, partial atelectasis of lower lobe of both lungs; Abdominal pelvic CT: Bilateral middle and upper ureteral dilatation and renal pelvis and calyceal dilatation, the patch in the right part of calyceal is slightly high density, the bladder wall is thickened, there is a little flocculent blur around the left renal fat sac and ileocecal part, and there is a little effusion in the pelvic cavity. A large amount of turbid urine was drained by indwelling catheter. Urine culture showed that Klebsiella pneumoniae was positive. Considering urinary tract infection, acute kidney injury, hypokalemia and severe anemia, patients were given symptomatic support treatment such as anti-infection, bladder irrigation, antioxidation, potassium supplementation and blood transfusion. The symptoms of patients improved and the urine was slightly clarified. 10-18 Review urine routine: WBC3+, RBC3+, protein 1+, SCR 263 μ mol/L.

I was admitted to our department on October 19, 2022. Blood routine: WBC 5.08X10 9/L, N 66.1%, inflammatory markers: ESR 19mm/H, hsCRP 52.3mg/L, PCT 0.52ng/ml, Scr 257μmol/L, and urine routine: WBC 28493/μ. Urinary color Doppler ultrasound: hydronephrosis, bilateral ureteral dilatation, bladder wall thickening significantly; Abdominal pelvic CT: hydronephrosis of both renal pelvis and ureter, thickening of ureter wall (inflammatory change), inflammatory change of bladder and ureter may be large, the volume of both kidneys increases and the substance is thin. Meropenem 1g q12h is given for empirical anti-infection. Urology consultation considers the acute stage of infection, so it is not suitable to put double J tubes. If necessary, pyelostomy can be done, but it does not improve renal function much. Bladder irrigation is recommended. 10-20 middle-stage urine culture (sampling on October 19): Klebsiella pneumoniae was positive; 10-22 urine culture drug sensitivity: Carbapenem-resistant Klebsiella pneumoniae (CRKP), adjusted to ceftazidime and abamectin 2.5g q12h for anti-infection, and daily bladder irrigation. After treatment, the urine color of the patients gradually became clear, and the urine white blood cell and bacterial count gradually decreased during follow-up. The urine bacterial culture was negative on November 1 and November 4. Check the urine routine on November 09: WBC 28/uL, RBC 4/uL, urine protein+,bacterial count 29/UL;Blood WBC 7.64×10 9/L, N 76.5%, hs-CRP 0.4mg/L, ESR 25mm/H, PCT 0.18ng/mL, Scr 175μmol/L, which were significantly improved compared with those at admission. Stop ceftazidime and abamectin on November 11 and be discharged.

On November 15, 2022, the patient appeared turbid urine again, and there was no fever and other discomfort. On November 23, he was admitted to the hospital for a second diagnosis and treatment.

Past history: In September, 1991, T12-L1 comminuted fracture was treated with internal fixation. After operation, the catheter was retained for half a year due to urinary incontinence, and then the catheter was removed after urination. There was no urinary tract infection during this period. Diabetes for 16 years, insulin therapy, blood sugar control can be; Hypertension for 5 years, oral amlodipine to reduce blood pressure, blood pressure control can be.

Second, the admission examination (admitted on November 23, 2022)

[physical examination]

T: 36.2℃ P: 90 times/min R: 20 times/min BP: 176/105 mmHg.

Stay in bed, feel refreshed and calm, lose weight, and muscle atrophy of lower limbs; Breathing sounds in both lungs are thick, and dry and wet rales are not heard; The rhythm of the heart is regular, the abdomen is soft, without tenderness and rebound pain, without mass, without percussion pain in both kidneys, without tenderness at ureter point and rib and waist point, and the lower abdomen does not touch the enlarged bladder. During indwelling catheterization, the urine in the urine collection bag is turbid and more white flocs are deposited. Limbs are not swollen.

[Laboratory examination]

Blood routine: WBC 7.85×10 9/L, N 81.3%, HB 121g/L, PLT 170×10 9/L.

Urine routine: WBC 2775/μ l; RBC 2/μl, bacterial count: 39879/μl, nitrite positive, leukocyte esterase+++.

Inflammation markers: hs-CRP 17.9mg/L, ESR 68mm/H, PCT 0.12ng/mL.

Biochemistry: ALT/AST 23/21U/L, Alb 47g/L, Scr 199μmol/L, eGFR 30ml/min/1.73m2, na/k 140/5.5mmol/l.

Third, clinical analysis

Characteristics of medical history: middle-aged and elderly male, indwelling catheter, with repeated urinary turbidity and abnormal urine routine. Urine culture showed CRKP one month ago, and it improved after ceftazidime-ababactam treatment, but urine turbidity reappeared three days after drug withdrawal, blood inflammatory index increased, urinary leukocyte and bacterial count increased significantly, and the diagnosis of urinary tract infection was clear. The reasons for short-term recurrence after antibacterial drug treatment improved were considered:

Recurrence of CRKP infection: The patient has been indwelling catheter for 2 months, and there may be biofilm formation of catheter and abnormal urinary tract structure, which makes it difficult to completely eliminate the infection and relapse after stopping taking the drug. Therefore, urine culture and drug sensitivity test can be improved.

New infection: the patient has high risk factors of recurrent urinary tract infection, and the pathogen may be different each time. The patient’s previous CRKP infection treatment was effective, and the possibility of new pathogen infection should be considered in the short term, until the urine culture is perfect and clear.

Multiple infections: patients with abnormal urinary tract structure, indwelling catheter and other risk factors can not be removed, so it is necessary to be alert to the possibility of multiple pathogens including fungi combined with infection, repeat the cultivation of urine bacteria, mycoplasma, fungi and mycobacteria, and improve urine mNGS to help clarify the infected pathogens.

Four, further examination, diagnosis and treatment process and treatment response

On November 23, 2022, the middle urine smear was used to find bacteria: moderate amount of G- bacilli, and continued ceftazidime and abamectin 2.5g q12h ivgtt for anti-infection and bladder irrigation.

On November 26, 2022, the bacterial drug sensitivity of the middle-stage urine culture (sampling on November 23) was CRKP, ≥ 100,000 /ml, and urine mNGS: a large number of Klebsiella pneumoniae (species strict sequence number: 406,866) was detected.

On November 29, 2022, the abdominal and pelvic CT was reexamined: bilateral dilated hydronephrosis accompanied with inflammatory changes of ureter, and the parenchyma of both kidneys was thin, and the inflammatory changes of cystitis might be larger, similar to that of 22-10-20 slices.

November 30, 2022 (sampling on November 29): Enterococcus faecalis was positive. On December 2, according to the drug sensitivity, fosfomycin 3g qod was added orally, and ceftazidime and abamectin were suspended.

Repeated urine cultures on March, April and June, December, 2022: Enterococcus faecalis was positive and CRKP was negative.

On December 8, 2022, the urine WBC was 38738/μ L, and the bacterial count was 43285/μ L; Urine culture: CRKP positive, Enterococcus faecalis negative.

Phage therapy was carried out from the afternoon of December August, 2022: Phage cocktail (composed of 5 strains of Klebsiella pneumoniae phages A103KP172, A106KP176, A121KP192, A49KP106 and A58KP118, 5mL each), injected with 225mL physiological saline (according to the estimated bladder volume), and the total volume was 250mL, and then the catheter was clamped.

Urine routine on the third day of phage treatment on December 11, 2022: white blood cell count: 235/uL, bacterial count: 722/uL；; Urine bacterial culture was negative.

Urine routine on the 5th day of phage therapy on December 13th, 2022: white blood cell count: 279/uL, bacterial count: 92/ul; Urine bacterial culture was negative; Blood WBC 6.35X109/L, N 70%, hs-CRP 0.9mg/L, ESR 26mm/H, and inflammatory index decreased compared with before; Re-examination of urinary color ultrasound showed that bilateral renal pelvis separation and upper ureteral dilatation were better than before (10-20), and the thickness of bladder wall was reduced (12-25mm→13mm).

He was discharged from hospital on December 14, 2022 for follow-up.

V. Final diagnosis and diagnosis basis

Final diagnosis:

Complex urinary tract infection (CRKP, Enterococcus faecalis)

Neurogenic bladder, hydronephrosis and hydroureter (indwelling catheter)

Renal insufficiency

Diagnostic basis:

The patient is a middle-aged and elderly male with neurogenic bladder caused by paraplegia, indwelling catheter, turbid urine with flocs, increased CRP and PCT, significantly increased WBC and bacterial count in urine, repeated CRKP positive in urine culture, positive in enterococcus faecalis, abdominal basin CT: hydronephrosis of renal pelvis and ureter, anti-infection, normal inflammatory markers and urine routine after phage treatment, clear urine and negative urine culture, so complicated urinary tract infection.

The patient suffered from anorexia and dysuria, and the serum creatinine increased obviously. Abdominal CT showed that both kidneys were enlarged, the cortex was thin, and bilateral urinary tract was hydronephrosis. After active treatment such as controlling infection and improving renal function, the serum creatinine decreased, so the diagnosis of renal insufficiency was clear.

Six, experience and experience

Phage is a targeted sterilization virus in nature and a sterilization star in the "pre-antibiotic era". Phage therapy has a history of more than 100 years, but the discovery and application of broad-spectrum antibiotics have gradually marginalized it. With the increasingly serious problem of bacterial drug resistance, phages have once again received attention and become the most promising supplement and alternative therapy for treating superbugs. The clinical application of phage in China is relatively late, but it has developed rapidly in recent years. In 2017, the Shanghai Institute of Phage and Drug Resistance was established, with Professor Hu Bijie as an academic member. Since 2018, the institute has carried out the first clinical trial of phage therapy in China. At present, it has treated nearly 100 patients with drug-resistant bacterial infections from all over the country and accumulated rich clinical experience in phage therapy, which is a leading position in the field of clinical phage therapy in China.

Phage has many advantages, such as host bacteria dependence, targeted specific sterilization, no infection to eukaryotic cells (little influence on normal flora), no influence on bacterial drug resistance, synergy with antibacterial drugs, penetration of biofilm and so on. The cure rate of acute bacterial infection is high, and the therapeutic effect of chronic bacterial infection is no less than that of antibacterial drugs, and the safety of phage treatment is also extremely high. A systematic retrospective study showed that the vast majority of patients who received phage therapy had no or only slight adverse reactions, 86.7% patients’ clinical symptoms improved, and 78.8% patients achieved the eradication of pathogenic bacteria. Our clinical trials also show that more than 70% of patients have achieved good therapeutic effects, and there are no obvious cases of adverse reactions. This patient was repeatedly infected with Klebsiella pneumoniae due to long-term paraplegia, abnormal urinary tract structure, indwelling catheter and other factors. The diagnosis of complicated urinary tract infection was unquestionable, and the choice of antibacterial drugs was limited due to multi-drug resistance and renal insufficiency. Phage therapy is very suitable.

The disadvantages of phage therapy include narrow host spectrum, individualized plan (it is difficult to treat empirically), no unified standard for the best treatment decision, and rapid tolerance. Phage cocktails, combined antibacterial drugs and multiple treatments are usually used in clinic to improve the curative effect. At present, the targeted pathogens of phage therapy in our team mainly include: multi-drug resistant Gram-negative bacteria (Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecalis); Covering respiratory system, urinary system, abdominal cavity, bones and joints, skin and soft tissue and other infected sites; Treatment depends on the site of infection, and intravenous application of phage is still being explored. In this case, the patient didn’t have percutaneous nephrostomy because of the little clinical benefit, so he was treated by transurethral bladder perfusion, and the phage could not cover the whole urinary tract evenly. Although the pathogen turned negative in a short period of time and was well tolerated, its long-term curative effect may not be good, and it needs repeated phage treatment.

Phage therapy has huge clinical demand and broad market. In recent years, our team has focused on the clinical application (treatment and prevention and control of nosocomial infection) and basic research of phage therapy, with a view to becoming a powerful weapon to curb drug-resistant bacteria in the future.

references

[1] Uyttebroek S, Chen B, Onsea J, Ruythooren F, Debaveye Y, Devolder D, Spriet I, Depypere M, Wagemans J, Lavigne R, Pirnay JP, Merabishvili M, De Munter P, Peetermans WE, Dupont L, Van Gerven L, Metsemakers WJ. Safety and efficacy of phage therapy in difficult-to-treat infections: a systematic review. Lancet Infect Dis. 2022 Aug; 22(8):e208-e220.

[2] Chegini Z, Khoshbayan A, Taati Moghadam M, Farahani I, Jazireian P, Shariati A. Bacteriophage therapy against Pseudomonas aeruginosa biofilms: a review. Ann Clin Microbiol Antimicrob. 2020 Sep 30; 19(1):45.

[3] Lusiak-Szelachowska M, Weber-Dabrowska B, Gorski A. Bacteriophages and Lysins in Biofilm Control[J]. Virol Sin, 2020,35(2):125-133.

Every Monday night

The Department of Infectious Diseases of Zhongshan Hospital affiliated to Fudan University in Shanghai will be with you!

Photo: Xiaoxiao

Original title: "Detective Case: The Nemesis of Super Bacteria is Coming"

Read the original text

　　February 4th is the 17th World Cancer Day, and this year’s theme is "WE CAN, I CAN". The member of the Standing Committee of Cancer Radiotherapy Committee of China Anti-Cancer Association and the president of Cancer Hospital said: At present, 70% of cancer patients in our city are in the middle and late stage when they are diagnosed, so it may be a better choice for them to eliminate the fear of cancer and realize coexistence with cancer.

　　70% of cancer patients need to live with tumors.

　　Mr. Luo, who lives in Yubei District, is 55 years old. He is used to working from nine to five every day. If no one tells him, no one will think that he is actually a cancer patient. Five years ago, he suddenly felt that he was always urinating, but he couldn’t urinate. At first, he thought he was getting angry. But a pile of heat-clearing drugs didn’t improve after eating, and the more urgent the urine, the less smooth it was, and sometimes it was accompanied by pain. At this time, he thought about going to the hospital for examination.

　　I didn’t want to be diagnosed with prostate cancer and have bone metastasis. I have lost the best opportunity for surgery and can only use antiandrogen drugs to control my condition. In the face of cancer, he did not intend to give up, but actively cooperated with the treatment. After one year, his condition gradually stabilized, and Mr. Luo began to plan to go to work in the unit.

　　Professor Dean of the Municipal Cancer Hospital said that according to the "2015 China Cancer Statistics" issued by the National Cancer Center, there were 4.3 million new cancer cases in China in 2015, and the number of cancer deaths exceeded 2.8 million; In Chongqing, there were about 80,000 new tumors and more than 50,000 cancer deaths in 2014. Because the incidence of tumor is relatively concealed, more than 70% of cancers are found in the middle and late stages, and the best opportunity for surgical treatment is lost. For them, survival with tumor may be a better choice.

　　Unfortunately, in real life, there are not many patients who can scientifically understand the survival with tumors like Mr. Luo. As soon as many patients heard that they could not operate, their spirits suddenly collapsed and they thought they were hopeless. In fact, surgical treatment is not the only treatment for all tumors; Even if we miss the best opportunity for surgical treatment, it doesn’t mean that there is no cure. At present, tumor treatment advocates comprehensive treatment, which includes surgery, chemotherapy, radiotherapy, endocrine therapy, traditional Chinese medicine treatment and other ways. Experienced specialists will choose the appropriate treatment according to the results of tumor pathological examination, course of disease and development trend.

　　"It is very important for cancer patients and their families to accept" survival with tumor ",which is a more pragmatic method for treating advanced cancer." Dean said that cancer is essentially a genetic disease, and all cancers come from genetic mutation, which is caused by genetic mutation and epigenetic regulation. At present, human beings can’t use drugs to reverse this genetic mutation and "kill all cancer cells" in the body.

　　It is also a pragmatic choice for patients in the middle and late stage to realize long-term "survival with tumor" and "peaceful coexistence" with tumor. Everyone should treat it as a medical disease with disease, and treat tumor as a chronic disease such as hypertension, diabetes and coronary heart disease, which is more conducive to treatment.

　　The misunderstanding of survival with tumor needs to be vigilant

　　There may be many people who don’t understand that living with a tumor is not cured. There is a tumor in the body, and the condition may deteriorate at any time. Can this be safe? Dean Wu Yongzhong said that in fact, survival with tumor is not to let it go, but to choose a suitable treatment model, which is also the core of "individual medicine" developed from "evidence-based medicine" in recent years. First of all, we should recognize the fact that the dream of conquering tumor has not been realized.

　　WHO has regarded tumor as a chronic disease, because its condition has a process of development, which can not be cured and exists for life, just like diabetes, hypertension and coronary heart disease. Secondly, sometimes over-active treatment is also a kind of injury. In clinic, some elderly cancer patients are often encountered. When children hear that they can have surgery and treat at all costs, they have not achieved good results. This is because the elderly, especially those over 80 years old, have degraded their physical functions and cannot tolerate surgery and chemotherapy at all.

　　At this time, you don’t have to think about eliminating the tumor at all. You can choose radiotherapy alone or other treatments, so as to survive with cancer. Advocating survival with tumor again also means waiting for treatment conservatively. If it can be cured by surgical resection, radiotherapy and other treatment methods, tumor patients should still be encouraged to actively treat.

　　Age-related macular degeneration (AMD) mostly occurs in people over the age of 50, and it is one of the main blinding diseases of the elderly in the world. According to statistics in 2010, there are more than 23 million AMD patients worldwide. The patient’s chief complaint is decreased vision, which is characterized by the absence of central visual field (see schematic diagram).

　　Normal visual field (left), central visual field damage caused by AMD (right)

　　Age-related macular degeneration can be divided into Dry AMD and Wet AMD. Dry amd is characterized by no vascular proliferation, while wet amd is characterized by obvious vascular proliferation in macular area. There is almost no treatment for dry age-related macular degeneration, while wet age-related macular degeneration is mainly aimed at vascular proliferation. For vascular proliferation, Genentech’s Ranibizumab (trade name: Lucentis) is a fragment antibody against VEGFA, and it costs two thousand dollars for a shot. However, many places bypass Ranibizumab and choose Avastin (Avastin), which is also anti-VEGF, for only fifty dollars. It can be seen that there are policies and countermeasures, which are available to people at all times and all over the world, but the interests are accelerating. In addition, laser therapy is also aimed at vascular proliferation. Although there is symptomatic treatment for vascular hyperplasia, it is also a temporary solution, because macular degeneration itself has not improved.

　　A core problem of macular degeneration is degeneration of retinal pigment epithelial cells (RPE). These cells are close to the interlayer between Choroid and optic nerve cells in retina, and are responsible for bringing blood nutrition to optic nerve cells. If this layer of cells degenerates, the optic nerve cells will not get nutrition, so the vision will decrease. There’s an old saying in China, what can I do without fur? Is the image explanation of this disease.

　　A remarkable pathological feature of macular degeneration is yellow sediment distributed on the retina, which is a mixture of protein and lipid, but its source is unknown, and it may be an inflammatory product, and its pathological function is to destroy retinal pigment epithelial cells (RPE). See the figure below.

　　Since it is a degenerative disease, the research and development of drugs lacks molecular targets, which are a bit like Alzheimer’s disease and neurodegeneration, and there are not many effective targets. In contrast, the stem cell technology that surfaced in the past ten years is an ideal choice. Stem cells are induced to differentiate into retinal pigment epithelial cells (RPE), which provides a feasible and effective method for the treatment of macular degeneration.

　　Can normal retina replace diseased retina? A few decades ago, someone replaced the diseased retina with the baby’s retina (of course, the source was the baby who died in a car accident under two years old), and the success rate was very low, because the source of newborn retina was difficult, the protection was difficult, and the operation was difficult, which were all restrictive factors. However, some people have gained some vision (such as light perception and figure) through retinal replacement. This scheme can at least prove that infant retinal replacement is a direction that can be improved. However, it is not successful to replace the bad eye retina with the good eye retina of the same adult, which shows that the physiological age of retina is an important reason. Nowadays, retinal pigment epithelial cells (RPE) can be produced from stem cells, whether from embryonic sources (hESC) or from self-induced sources (iPSC), and they can be made into Sheet, which is beneficial to surgical implantation. Of course, there are many technical problems, mainly the problem of eye surgery and the problem of ensuring the survival of cells after implantation. A positive factor is that the eye is an immune escape, so don’t use immunosuppressants, immune rejection should be small, which is conducive to survival.

　　Regenerative medicine is a new field, and big pharmaceutical companies are unwilling to take this risk. Seven years ago, the author worked in the world’s largest ophthalmic pharmaceutical company (Allergan) and once recommended this project, but the decision makers are interested in Miu Miu. At present, several small companies have pushed the application of regenerative medicine in senile macular degeneration into the clinical stage. Although I dare not predict when it will be approved by the FDA, it is still expected as a promising direction. After all, there is no other way at present. Although the experiment of regenerative medicine is still in the "primary stage of socialism", the AMD market is very large, and there are still some large and medium-sized pharmaceutical companies to follow up. Not long ago, Astra, the second largest pharmaceutical company in Japan, bought Ocata Therapeutics LLC to jointly develop this method for treating AMD, which mainly focuses on hESC inducing retinal pigment epithelial cells (RPE).

　　Regenerative medicine is not only dedicated to age-related degenerative macular degeneration (AMD), but also can be used to treat another cause of blindness, Retinal pigmentosa. It also damages retinal pigment epithelial cells (RPE), but retinal pigment degeneration damages peripheral visual field, and other eye diseases such as glaucoma and corneal burn. In order to give you a big picture of regenerative medicine in treating ophthalmic diseases, the author summarizes the general situation of some companies entering clinical trials at present. I sincerely hope that these companies can succeed in regenerative medicine and bring good news to patients with ophthalmic diseases.

　　Table 1. Summary of Clinical Trials of Regenerative Medicine in Treating Ophthalmic Diseases

In 2024, AITO will launch a brand-new model, the M8, with its positioning between M7 and M9, and its estimated price is about 350,000 yuan.

Taking the asking M9 as a reference, it is expected that the asking M8 will also be equipped with technologies such as Huawei Turing intelligent chassis, megapixel intelligent projection headlights, integrated triple screen, 75-inch AR-HUD and 800v fast charging, and provide two power versions of extended range and pure electricity.

In terms of price, at present, the starting price of Wenjie M7 is 249,800 yuan, and the starting price of Wenjie M9 is 469,800 yuan. It is estimated that the starting price of Wenjie M8 will be somewhere in between, with a high probability of about 350,000 yuan, and it will mainly compete with the ideal L8 after listing in the future.

In terms of intelligent driving, Wenjie M8 is expected to be equipped with HUAWEI ADS 2.0 intelligent driving system like M9, including 1 192-line laser radar, 3 millimeter-wave radars, 12 ultrasonic radars and 11 high-definition cameras. With the integration of sensing BEV, it can identify all kinds of abnormal obstacles and realize the functions of high speed+urban pilot-assisted driving and parking service. In terms of intelligent cockpit, HarmonyOS 4.0 system will also be installed.

In terms of chassis, Wenjie M8 will also adopt Huawei Turing intelligent chassis, including all-aluminum alloy material, air suspension, CDC variable damping shock absorber and other configurations.

With the launch of the M8, it will form a more comprehensive competitive relationship with L series models. At the same time, we will join hands to seize the market of traditional luxury brand BBA.

　　[car home Technology] On December 21st, FAW Toyota/GAC Toyota announced that there were quality problems in the hydraulic torque converter in CVT gearbox of (|)/C-HR model, and the oil circulation blade of the hydraulic torque converter was riveted badly. When the vehicle was subjected to repeated rapid acceleration and other operations, the blade might fall off, causing damage to the torque converter. In extreme cases, it might lead to power interruption while the vehicle was driving, posing a safety hazard. FAW Toyota/GAC Toyota will replace the qualified hydraulic torque converter and continuously variable transmission assembly for vehicles within the scope of recall free of charge to eliminate potential safety hazards.

"Screenshot of the recall announcement of the State Administration of Market Supervision"

"GAC Toyota C-HR/ FAW Toyota Yize IZOA』"

　　FAW Toyota will recall 10,442 IZOA models produced from September 14, 2018 to November 27, 2018; GAC Toyota will recall 9,454 C-HR models produced between September 13, 2018 and November 14, 2018. Since the CVT gearbox is standard in all the Izawa IZOA/C-HR models, all the Izawa IZOA/C-HR models produced within the above time are within the recall scope.

● Go straight to the place where the problem occurs.

　　According to the recall announcement, the problem is the hydraulic torque converter of CVT gearbox. Hydraulic torque converter exists in both AT and CVT gearboxes, and its function is to realize the soft connection between the engine output shaft and the gearbox input shaft, allowing the speed difference between the two shafts, realizing the semi-linkage state similar to that in manual gearboxes, and facilitating the gearbox to automatically shift gears.

More exciting videos are all on the car home video platform.
"Video of technical explanation of hydraulic torque converter"

　　The transmission of hydraulic torque converter depends on the internal blades. If the blades on the pump wheel, guide wheel or turbine fall off, the power from the engine will not be transmitted to the gearbox, which will cause the vehicle to lose power.

● TNGA-based Direct Shift CVT gearbox is so delicate?

　　The CVT gearbox mounted on Izawa IZOA/C-HR is the Direct Shift CVT gearbox under the Toyota TNGA architecture. There are some big differences between this gearbox and the general CVT gearbox in structure.

　　The gear ratio range of CVT gearbox mounted on Yize IZOA/C-HR reaches 7.5, which is higher than 7.0 of other CVT gearboxes with similar torque capacity. A higher transmission ratio range is beneficial to better balance the vehicle’s low-speed speed-up performance and fuel economy during high-speed cruising.

　　From a technical point of view, the design of this Direct Shift CVT gearbox to broaden the transmission range of the gearbox by increasing the starting gear transmission is quite innovative. According to Toyota’s development system, CVT gearboxes will be mass-produced. In the development stage and mass production stage, all kinds of rigorous durability tests are essential. The problem of this recall is more likely that the quality of parts suppliers is not up to requirements. At present, the CVT gearbox used by Yize IZOA/C-HR is imported from Japan, and we have not been able to obtain the information of the CVT gearbox hydraulic torque converter parts supplier. We will publish more information on the website as soon as possible.

● What will happen to the car when it breaks down?

　　The recall information simply describes the problem, but does not specify the phenomenon when the fault occurs. I checked the posts of netizens on car home Yize IZOA Forum. On December 16th, a netizen reported that the engine stopped immediately after Yize IZOA was parked in D gear, and the vehicle could not start, and the vehicle could not reverse when it was parked in R gear. Later, the netizen’s car was tested in a 4S shop, and the gearbox needed to be replaced, but it took one month for the gearbox to adjust the goods (click to view the forum post).

　　When the CVT gearbox of Yize IZOA breaks down, the torque converter loses its power transmission ability, and the vehicle will lose power. If the vehicle breaks down at the start, the vehicle can’t start, which generally has little impact on the safety of users. The trailer can be handled at the 4S shop. It is much more complicated if the internal blades of the hydraulic torque converter break in the CVT gearbox during the start-up of Yize IZOA. However, because the gearbox is equipped with input shaft speed sensor and output shaft speed sensor, and the engine is equipped with crankshaft speed sensor, when the transmission of hydraulic torque converter fails, ECU can recognize it by the above speed signal, and at this time, some protective measures will be taken. I guess the system will put the gearbox into neutral and the vehicle will lose power to slide. At this time, the user can stop the vehicle by hitting the direction and braking the pedal, and then can call the trailer to be towed back to the 4S shop for treatment.

● I am the owner of Izawa IZOA/C-HR. What should I do?

　　Since the manufacturer only started to recall from February 22, 2019, this means that there are still 2 months. What should I do as the owner of Izawa IZOA/C-HR?

　　If the gearbox of your vehicle has been damaged and the vehicle loses power, then you can only ask the trailer to tow the car back to the 4S shop for repair. Therefore, the problem of this recall caused the vehicle to break down, and the user was not responsible for the trailer fee.According to the information we have obtained at present, it takes about 10 hours to replace the gearbox, during which the manufacturer will provide a scooter or transportation subsidy.

● The gearbox with problems is not specially supplied by China.

　　This CVT gearbox matched with Toyota 2.0L naturally aspirated engine is not the only problem in China. The CVT gearbox of the new Corolla 2.0L model listed in North America, Oceania and Taiwan, China has also been recalled. In the recall announcement, it is stated that only the models with the specified production batch need to be recalled, and the remaining models have not been included in the recall list yet. Considering that the gearbox of Yize IZOA/C-HR is imported, this type of gearbox recalled by Toyota in the world is likely to come from the same faulty production line or use the same batch of faulty hydraulic torque converter parts.

● Summary:

　　According to the posts of users in car home Yize IZOA/C-HR Forum, there is no large-scale gearbox damage in these two cars, and consumers who have bought these two models need not panic excessively. The practice of recalling without large-scale failure reflects from one aspect that FAW Toyota/GAC Toyota are more responsible and sincere towards consumers. We also hope that manufacturers can nip potential problems in the bud through recall. We will continue to pay attention to the subsequent recall of Yize IZOA/C-HR. Please continue to pay attention to the relevant reports in car home. (Photo/Text/car home Chang Qinglin)

At the press conference of the State Administration of Taxation

Rong Hai building:Good morning, media reporters and friends! I am Rong Hailou, director of the Tax Publicity Center of the State Administration of Taxation, deputy director of the general office and spokesperson. Today, we invited Mr. Cai Zili, Director of the Revenue Planning and Accounting Department of the State Administration of Taxation, to attend the conference, introduce relevant information and answer your questions. We noticed that the major media were interpreting the economic and social development of China in 2020 and the 13th Five-Year Plan period through figures at the beginning of the year. In order to help you better understand China’s tax economy in 2020, we have specially combed 10 groups of data from the tax big data. Let’s invite Director Cai to give a detailed introduction.

Cai Zili, Director of Revenue Planning and Accounting Department of State Administration of Taxation

Cai Zili:Good morning, journalists and friends! In the past 2020, it was an extraordinary year. Facing the complicated and severe domestic and international situation and the severe impact of the COVID-19 epidemic, under the strong leadership of the CPC Central Committee with the Supreme Leader as the core, China coordinated the prevention and control of the epidemic and economic and social development, and handed over an answer that was satisfactory to the people, attracted worldwide attention and could go down in history. Taxation is often called the "barometer" of the economy. We fully tap the advantages of tax big data and systematically sort out ten sets of data to help you better understand the tax economy of China in 2020.

The first set of data: the annual tax revenue decreased by 2.6%, and the tax revenue target arranged in the fiscal budget was successfully completed.In 2020, the tax revenue (excluding export tax rebate) organized by the national tax authorities reached 13,678 billion yuan, down 2.6% year-on-year, and the tax revenue target arranged in the fiscal budget was successfully completed. From the trend of the whole year,The growth rate of tax revenue has rebounded for nine consecutive months since "bottoming out" in March.It reflects the good momentum of China’s economic recovery, but due to the epidemic situation and the implementation of tax reduction and fee reduction, the annual tax revenue decreased by 2.6%. During the "Thirteenth Five-Year Plan" period, the national tax revenue reached 65.7 trillion yuan, an increase of 18.5 trillion yuan over the "Twelfth Five-Year Plan" period, which provided a solid financial guarantee for economic and social development.

The second set of data: the proportion of tax revenue organized by tax authorities in fiscal revenue was 75.5%, an increase of 1.7 percentage points over 2019.In 2020, the tax revenue organized by the tax authorities will account for 75.5% of the general public budget revenue, an increase of 1.7 percentage points over 2019. Compared with 2015 at the end of the Twelfth Five-Year Plan, the proportion of tax revenue in fiscal revenue increased by 2.9 percentage points in 2020, which shows that the function of tax revenue in gathering wealth for the country continued to increase during the Thirteenth Five-Year Plan period.

The third set of data: the social security fee income collected by the tax authorities in the whole year was 3.8 trillion yuan, which provided a guarantee for the development of people’s livelihood.In 2020, the tax authorities will conscientiously implement the phased policy of reducing and exempting enterprise social insurance premiums and effectively reduce the burden on enterprises. Since November 2020, all social insurance premiums have been collected by the tax authorities. While maintaining the stability of the collection method, the tax authorities at all levels have continuously optimized the payment service, providing the majority of payers with various payment channels such as "online, handheld and self-help" to facilitate the payers to declare their payment. In 2020, the national tax authorities organized social insurance premium income of 3.8 trillion yuan.

The fourth set of data: the annual new tax reduction and fee reduction is expected to exceed 2.5 trillion yuan, successfully fulfilling the target of reducing the burden for enterprises as determined in the government work report.In 2020, the CPC Central Committee and the State Council will continue to increase tax reduction and fee reduction, and the tax authorities will implement it to the letter. In the first 11 months, the accumulated tax reduction and fee reduction will be 2,367.3 billion yuan, and it is expected to exceed 2.5 trillion yuan for the whole year, which can successfully complete the annual target of reducing the burden on enterprises as set in the 2020 government work report. During the "Thirteenth Five-Year Plan" period, the national new tax reduction and fee reduction is expected to exceed 7.6 trillion yuan. A series of practical tax reduction and fee reduction policies have effectively reduced the tax burden of enterprises, enhanced their sense of acquisition and stimulated the vitality of market players.

The fifth set of data: the proportion of tax revenue to GDP decreased by about 0.82 percentage points, and the tax burden of enterprises was further reduced.In 2020, with the implementation of tax reduction policies to support epidemic prevention and control and economic and social development, the proportion of tax revenue in China’s general public budget revenue is expected to drop to about 15.2%, which is about 0.82 percentage points lower than that in 2019.

The sixth set of data: the sales revenue of enterprises nationwide increased by 6%, and the production and operation of enterprises improved step by step.According to the VAT invoice data, in 2020, the sales revenue of national enterprises increased by 6% year-on-year. On a quarterly basis, it rebounded quarter by quarter, with a year-on-year decline of 17.6% in the first quarter, a 9% increase from negative to positive in the second quarter, a 12.4% increase in the third quarter and a further 15.7% increase in the fourth quarter. 29 of the 31 provinces achieved positive growth in sales revenue. The production and operation of enterprises are improving steadily. China is the first major economy in the world to control the epidemic, take the lead in resuming production and achieve positive economic growth. It is expected to become the only major economy in the world to achieve positive economic growth.

The seventh set of data: the sales revenue of high-tech industries increased by 14.7%, and the development potential of new kinetic energy was accelerated.In 2020, the national high-tech industry maintained a rapid growth trend, with sales revenue increasing by 14.7% year-on-year, which was 8.7 percentage points faster than the national average. Among them, the high-tech service industry represented by information services and e-commerce has increased by more than 20% year-on-year for nine consecutive months since April, with a cumulative increase of 23.6% for the whole year, indicating that the development potential of new kinetic energy has been accelerated and the new economy has continued to grow sturdily.

The eighth set of data: the R&D expenditure of key tax source enterprises increased by 13.1%, and the innovation and development situation continued to improve.In 2020, benefiting from preferential tax policies such as R&D expenses plus deduction, the R&D expenditure of key tax source enterprises in China is expected to increase by 13.1% year-on-year, of which the manufacturing industry will increase by 9.6% and the software and information technology service industry will increase by 25.3%, all of which maintain a good momentum of innovation and development. The amount of high-tech equipment and high-tech services purchased by 330,000 enterprises enjoying the policy of R&D expenses plus deduction increased by 15.8% year-on-year. During the "Thirteenth Five-Year Plan" period, the R&D expenditure of key tax source enterprises maintained a rapid growth rate of more than double digits, which added a strong stamina for the high-quality development of China’s economy.

The ninth set of data: 11.44 million tax-related market entities were newly established in the whole year, which was higher than the previous two years, and the market vitality was steadily enhanced.In 2020, the number of newly established tax-related market entities in the country reached 11.44 million, an increase of 10.1% over 2019, indicating that the state’s policies and measures to support market entities to solve problems and develop healthily have been effective and the market vitality has recovered rapidly. During the "Thirteenth Five-Year Plan" period, the total number of tax-related market entities newly established in China reached 57.45 million, of which the number of new offices in 2020 was significantly higher than that in 2018 and 2019.

The tenth set of data: the export tax rebate was 1,454.9 billion yuan in the whole year, which strongly supported the steady foreign trade.In 2020, the tax authorities implemented convenient measures such as paperless, "non-contact" and "tolerance handling" to speed up the progress of export tax rebate. The average time for processing normal tax rebate business was 20% faster than that in 2019, and the export tax rebate was 1,454.9 billion yuan in the whole year, which effectively eased the financial pressure on enterprises and played an important supporting role for the stable recovery of foreign trade. During the "Thirteenth Five-Year Plan" period, the country handled a total of 7,073.6 billion yuan of export tax rebates, an increase of 1,645.3 billion yuan over the "Twelfth Five-Year Plan" period, which effectively promoted the steady growth of foreign trade exports.

Around the above ten groups of data, we specially made vivid charts and sent them to you after the meeting, so that you can better understand and report.

Rong Hai Building: OK, thank you for your introduction. Let’s enter the question session.

The reporter from the Central Taiwan Broadcasting Station asked questions.

1. Reporter Yang Guang: Hello, Director Rong. Just now, Director Cai released ten sets of tax data, which gave a panoramic display of the tax economy operation last year and during the Thirteenth Five-Year Plan period. Could you please briefly introduce the tax department’s deepening of the application of tax big data?

Rong Hailou, Director of the Tax Publicity Center of the State Administration of Taxation, Deputy Director of the General Office and Spokesman

Rong Hai building:Thank you for your question. Tax big data has the advantages of strong timeliness, wide coverage and fine granularity, which records the production and operation status of market players and can reflect the economic operation more quickly, comprehensively, accurately and objectively. In recent years, the tax authorities have conscientiously implemented the decision-making arrangements of the CPC Central Committee and the State Council on using big data to improve the modernization level of national governance, and carried out in-depth construction and application of tax big data. Especially in 2020, in the face of the sudden COVID-19 epidemic, the Party Committee of the State Administration of Taxation put forward the requirement of "data service should be strengthened", gave full play to the advantages of tax big data, fully supported the overall prevention and control of epidemic situation and economic and social development, and made beneficial explorations in helping market players to solve problems, implementing tax reduction and fee reduction policies, and serving macroeconomic decision-making.

First, play the role of data bridge to support enterprises to resume work and production.Using the advantage of connecting the upstream and downstream of the industrial chain with VAT invoice data, we can accurately locate key enterprises and their main business related parties that are affected by the epidemic situation, promote the docking of supply and demand sides according to the principle of marketization, smooth the supply chain cycle of the industrial chain, carry out targeted assistance and support the development of enterprises.

The second is to accurately locate demand and promote tax reduction and fee reduction.Relying on tax big data, we will accurately screen eligible taxpayers, take the initiative to publicize and coach, and track and monitor in real time to ensure that policy dividends reach market players with the fastest speed and the most accurate accuracy. Just now, Secretary Cai introduced that the new tax reduction and fee reduction last year is expected to exceed 2.5 trillion yuan, and big data has played an important role in it.

The third is to objectively reflect the economic operation and make service decisions.Tax big data can not only timely monitor the process of resuming work and production, but also objectively reflect the macroeconomic operation and assist economic decision-making.

Tax big data has great potential. In the next step, the tax authorities will continue to deepen data sharing, improve data algorithms, and give full play to the advantages of tax big data, focusing on accurately grasping the new development stage, thoroughly implementing the new development concept, accelerating the construction of a new development pattern, selecting and analyzing topics, digging deep into the economic laws and characteristics reflected by the data, and continuously creating authoritative and reliable tax economic analysis products to better support the development of market players and better serve macroeconomic decision-making.

People’s Daily reporter asked questions.

2. People’s Daily reporter: Just now, Secretary Cai introduced that in order to support epidemic prevention and control and economic and social development, in 2020, China expects to increase taxes and reduce fees by more than 2.5 trillion yuan. Could you please ask Director Cai to introduce the implementation effect of tax reduction and fee reduction in 2020?

Cai Zili:In 2020, the tax authorities resolutely implemented the decision-making arrangements of the CPC Central Committee and the State Council, and adopted a series of practical and effective measures to ensure that the "real money" of tax reduction and fee reduction accurately reached market players. It is estimated that the annual tax reduction and fee reduction will exceed 2.5 trillion yuan, successfully fulfilling the annual burden reduction target set in the 2020 government work report, and exceeding the scale of larger tax reduction and fee reduction in 2019. The main achievements are as follows:

First, the tax burden of Chinese enterprises continues to decline.Since the "Thirteenth Five-Year Plan", with the implementation of a series of large-scale tax reduction and fee reduction policies and measures, from 2016 to 2019, the proportion of tax revenue in China’s general public budget revenue to GDP was 17.47%, 17.35%, 17.01% and 16.02% respectively, and it is expected to further drop to about 15.2% in 2020, which is about 0.2% lower than that in 2019. Accordingly, the tax burden of Chinese enterprises has been reduced year by year. The tax burden rate of sales revenue of 100,000 key tax source enterprises monitored by the State Administration of Taxation (that is, the proportion of tax and social security fees paid by enterprises in sales revenue) is expected to decrease by 8% year-on-year in 2020, and it has decreased by 18.1% since the Thirteenth Five-Year Plan.

Second, the real economy and the private economy benefit the most.In 2020, tax reduction and fee reduction will focus on helping market players to solve problems and promote economic recovery growth. Among them, the new tax reduction and fee reduction in manufacturing and related links is expected to account for about 35%, which is the industry that benefits the most; The new tax reduction and fee reduction in the private economy is expected to account for about 70%, with the most obvious benefits. Thanks to the tax reduction and fee reduction policy, in 2020, the tax burden rate of sales revenue of key tax source manufacturing and private enterprises in 2020 decreased by 8.8% and 9.5% respectively.

Third, the development confidence and entrepreneurial vitality of market players have been significantly enhanced.According to the questionnaire on the prosperity of key tax source enterprises, 90.6% of key tax source enterprises expect the production and operation situation to be "improved" or "stable" in the first quarter of 2021, which is 1.2 percentage points higher than that in the fourth quarter of 2020, and has maintained a rising trend for three consecutive quarters.

The confidence of market participants continued to increase, and the vitality of innovation and entrepreneurship recovered rapidly. The number of new market participants who went to the tax authorities to handle tax-related matters has achieved positive growth year-on-year since May. The growth rates in the first three quarters and the whole year were 5.9% and 10.1% respectively, showing a trend of rising quarter by quarter; At the same time, market players have accelerated their growth. At the end of 2020, there were 11.193 million national general VAT taxpayers with annual sales income above 5 million, an increase of 10.2% compared with the end of 2019 and an increase of 86.2% compared with taxpayers of the same scale at the end of the Twelfth Five-Year Plan. thank you

National business daily reporter asked questions.

3. Reporter national business daily: In 2020, the tax authorities will use big tax data such as VAT invoices to continuously track and reflect the sales of enterprises and the national economic operation. I would like to ask, from the perspective of tax big data, what is the overall situation of economic development in 2020?

Cai Zili:Thank you for your question. In 2020, with the implementation of the policy of coordinating epidemic prevention and control and economic and social development, the national economic operation will recover steadily. According to the data of VAT invoice, in 2020, the sales revenue of national enterprises increased by 6% year-on-year, 4.2 percentage points higher than that of the previous three quarters. Among them, the growth rate in the fourth quarter was 15.7%, 3.3 percentage points higher than that in the third quarter, reflecting the rapid release of the vitality and development potential of China’s economic market. Mainly presents the following six characteristics:

First, the sales of industrial enterprises rose steadily, and the supporting role of equipment manufacturing industry was enhanced.Industry is an important foundation of the national economy and the main battlefield for deepening the structural reform of the supply side. In 2020, the sales revenue of industrial enterprises increased by 2.7% year-on-year, and continued to rise steadily after the cumulative growth rate turned positive in October. In the fourth quarter, it increased by 11.1%, 1.9 percentage points higher than that in the third quarter. Of the 41 major categories of industry, 26 achieved positive growth. The manufacturing industry recovered rapidly, with the annual sales revenue increasing by 3.2% year-on-year, especially the supporting role of equipment manufacturing industry continued to increase, increasing by 7.1% year-on-year.

Second, commodity consumption recovered quickly and online consumption maintained rapid growth.Consumption is the main focus of expanding domestic demand and plays a fundamental role in economic development. In 2020, the sales revenue of the wholesale and retail industry increased by 5% year-on-year, including 15.4% in the fourth quarter, 4.1 percentage points higher than that in the third quarter. The epidemic situation changed the consumption pattern of residents, the "non-contact" consumption developed rapidly, the integration of online and offline platforms accelerated, and the Internet retail and take-away food delivery services increased by 29.2% and 31.6% respectively.

Third, investment-related industries grew rapidly, and the development of new infrastructure accelerated.Investment plays a key role in optimizing the supply structure. In 2020, the sales revenue of civil engineering construction related to infrastructure investment increased by 19.7% year-on-year. In particular, investment in new infrastructure areas such as 5G base stations, UHV, urban rail transit and environmental protection grew rapidly, driving the sales revenue of communication and power transmission facilities projects, urban rail transit projects and energy-saving projects to increase by 10%, 13.4% and 20.8% respectively.

Fourth, the transportation and logistics industry has recovered steadily, and road freight transportation has grown rapidly.Transportation and logistics industry is an important support to smooth the domestic circulation. In 2020, the sales revenue of transportation and logistics industry increased by 9.6% year-on-year, which was 3.6 percentage points higher than the national overall level, including 22.8% in the fourth quarter and 10.3 percentage points higher than that in the third quarter. In particular, the sales revenue of road freight transportation, warehousing and postal logistics increased by 9.9%, 16.5% and 23.1% respectively.

Fifth, the energy structure was gradually optimized, and the development of environmental protection-related industries was accelerated.In 2020, the sales revenue of new energy power generation industries such as hydropower, nuclear power and wind power accounted for 37.9% of the total power generation industry, an increase of 3 percentage points over 2019. Among them, the sales revenue of solar power generation and wind power generation increased by 16.5% and 14.1% respectively. The sales revenue of comprehensive utilization of resources, ecological protection and environmental management increased by 17.8% and 15% respectively year-on-year, reflecting that the environmental protection industry continued to accelerate development and the green concept was more deeply rooted in people’s hearts.

Sixth, the leading advantage of private economy is obvious, and private enterprises are growing rapidly.Private economy is an important subject to promote high-quality development. In 2020, the sales revenue of private economy increased by 8% year-on-year, 2 percentage points higher than the overall level of enterprises in China, including an increase of 18% in the fourth quarter and an increase of 3.2 percentage points over the third quarter. In particular, the sales revenue of private enterprises increased by 9.6% year-on-year, which was 1.6 percentage points higher than the overall level of private economy. thank you

CCTV reporter at the reception desk asked questions.

4. CCTV reporter: Hello, Director Cai, just now you mentioned that the high-tech industry in China will achieve double-digit rapid growth in 2020. Excuse me, what are the specific highlights?

Cai Zili:Thank you for your question. According to the big tax data, in 2020, the high-tech industry showed a good development trend, with a year-on-year growth of 14.7%, which was 8.7 percentage points higher than the overall level of enterprises in China. Since it turned positive in April, it has maintained rapid growth, playing a leading role and becoming a new kinetic energy to promote the high-quality development of China’s economy. Specifically, it mainly presents the following four highlights:

First, investment in research and development has increased.R&D is the source of innovation and an important strategic support for China’s scientific and technological self-reliance. In 2020, the invoice sales revenue of R&D and design services increased by 17.3% year-on-year, among which medical research, agricultural scientific research and design services increased by 41.5%, 26% and 16.6% respectively. In 2020, the R&D expenditure of national key tax source enterprises is expected to increase by 13.1% year-on-year, among which the software and information technology service industry will increase by 25.3%.

Second, the transformation of scientific and technological research and development achievements has been accelerated.This is the key link to build a strong innovation system in China. In 2020, the sales revenue of service invoices for the transformation of scientific and technological achievements increased by 45.1% year-on-year, among which technology promotion services, science and technology intermediary services and intellectual property services increased by 45.4%, 33.2% and 27.4% year-on-year, respectively, reflecting the accelerated transformation of scientific and technological achievements into real productivity.

Third, the rapid growth of high-tech enterprises.Enterprise is the main body of innovation. In 2020, China’s high-tech enterprises are expected to reach 275,000, which is 3.5 times that of 2015 at the end of the Twelfth Five-Year Plan. Among them, the sales revenue of industrial control computer systems and information security equipment manufacturing invoices related to high-end equipment manufacturing increased by 20.1% and 17.2% respectively. The manufacturing of smart consumer equipment related to consumption upgrading increased by 24% year-on-year.

Fourth, new formats and new models are booming.In 2020, industries related to the digital economy grew rapidly, and the invoice sales revenue of seven related industries such as computer equipment manufacturing and Internet increased by 12.1% year-on-year, which was 6.1 percentage points higher than the national overall level. Online platform transactions have developed rapidly. Sales revenue of e-commerce credit service, Internet platform and information technology service increased by 45.7%, 29.4% and 24.5% respectively.

It is particularly noteworthy that the integration of the Internet, big data and artificial intelligence is further enhanced. In 2020, the purchase of information services by manufacturing industry increased by 18% year-on-year, which was 10.4 percentage points higher than the national average, and promoted the digital transformation and upgrading of China’s manufacturing industry. thank you

Rong Hai building:Because of the time, the question session is here.

2021 is a year of historic significance. China will solemnly celebrate the centenary of the founding of the Communist Party of China (CPC) and start a new journey of building a socialist modern country in an all-round way. The national taxation system will adhere to the guidance of Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era, conscientiously implement the decision-making arrangements of the CPC Central Committee and the State Council, promote the modernization of taxation in the new development stage with high quality, give full play to the basic, pillar and supportive role of taxation in state governance, and contribute to maintaining the economic operation in a reasonable range and achieving a good start in the Tenth Five-Year Plan.

Special feature of 1905 film network　First, the most crowded May 1st file in history, waiting for 13 new films to be released together.

　

After the "involution", 520 also released a number of films, quietly forming a new schedule.

　

"520" and "521" as advertising language make May 20th and 21st a festival about love. With festivals, there is also a movie schedule. The 520 files can be traced back to 2018. On May 20th, that week, it won over 100 million box office, which was the highest achievement in the single-day box office of the film. In the end, the cumulative box office of the film won 900 million.

However, this schedule has not formed a stable situation, and it has been in a gap for two years after 18 years.

　

This year’s 520 stalls were originally set up by the joint leadership of My Love on May 20th and May 21st. The overall tonality of My Love is in line with the atmosphere of "520", but "Fast 9" is coming, and many people in the industry speculate that My Love’s film is also the first to plan to release it on May 1 due to various competitive considerations.

　

When My Love left 520, he made room for other films.

　

Up to now, except Fast & Furious 9, a total of six new films will be released in 520 files: Chasing the Ball, The Love I haven’t finished talking about, and all of them are love movies.

This year’s sunset on May 20th and 21st is in the film release period on Thursday and Friday, and it is the first time that many new love films have been released in this festival. Will there be any breakthrough in the 520th movie? At the same time, looking at the Valentine’s Day schedule throughout the year, what new atmosphere can we find?

01　

The 520 schedule has taken shape.

Among the 520 romantic films, the number of people who want to see the platform of Cat’s Eye, Taobao Film and Douban is currently ranked comprehensively, and "Deep Love" and "I want us to be together" rank in the top two.

　

What these two films have in common is that they are adapted from online literature, and the original works have a certain popularity and audience base.

　

"Deep Love" is adapted from Tianya literature’s popular work "Shenzhen, I don’t have the courage to say love again". This article ranks first in the click-through rate of Tianya emotional column in 2014, telling the "deep drift" love story between young men and female executives in Shenzhen; "I want us to be together" is adapted from the 2013 Douban long post "My girlfriend who has been running for ten years with me will get married tomorrow". The bumpy love story of the protagonists Lu Qinyang and Ling Yiyao since high school has caused heated discussion among netizens.

The director of "I want us to be together" once directed the youth love online drama "Hello, Old Times", which was adapted from the original work of Chang ‘an with the same name in August, and the Douban score was as high as 8.7. This time, I once again took the same type of theme, from the screen to the big screen, and the production scale has also been upgraded.

　

The film is produced by the industrial film industry, produced jointly by Alibaba Pictures and Tencent Pictures, and acted as the producer. Desert was also selected as the "Bad Monkey 72 Movie Project" initiated with,, and others. The industry has been expecting the quality of this new love film, but as a new director and actor, it is also necessary to keep a wait-and-see attitude.

In contrast, other incoming romantic films are relatively weak in terms of production volume and the strength of the main lineup. From the perspective of theme selection, Deep Love can be compared with the last film focusing on the group of "drifters". After the film was released in early April, the box office and word-of-mouth performance were not good, and Deep Love hit again this time.

　

In addition, "A little tempted" starring directors, actors and actresses comes from the classic song of the same name. Since 2014, the mode of adapting songs into movies has been continuous, and 2019 can be called a big year. There are three films in a row, and there will be three films in 2020. However, the reputation of these films has dropped almost all the way, so the prospect of "A little tempted" is inevitable.

Judging from the current situation, it is estimated that these romantic films are difficult to have a particularly large performance in the market, and there are no signs of explosion, unless there is a dark horse of word of mouth, or as last year, they break through with marketing and publicity strategies to win.

02　

Fast & Furious 9 assists the one-day box office

There is no doubt that Fast & Furious 9 is definitely the main force of the 520th gear this year. And this festival will definitely add value to the market, and the box office results on May 20th are worthy of attention.

Under the joint promotion of "Living Together in Time and Space", 520 in 2018 coincides with a weekend holiday, with a comprehensive box office of 300 million. In 2019, May 20th is a relatively deserted Monday working day, with no new films released. With the help of the fading popularity, the box office in a single day reached 80 million.

　

In 2020, due to the shutdown of the cinema, 520 became vacant, but this year, with the strong blessing of Fast & Furious 9, the industry also expects that the joint assistance of many domestic romantic films and the zero-point field of Fast 9 on that day will make the single-day box office harvest of this working day exceed 100 million.

This goal may not be difficult to achieve. In 2017, the zero-point box office in China mainland was about 58 million, which broke the zero-point box office record of Fast 7 two years ago. It is very likely that Fast 9 will surpass the figure of 58 million this time. In addition, the festive atmosphere of that day will help boost the box office, so it should not be a problem to break 100 million on the same day in 520.

03　

The Space Potential of Valentine’s Day Schedule

Count the love festivals throughout the year. Apart from 520, there are also Valentine’s Day on February 14th and Chinese Valentine’s Day. The film schedules formed under these festivals are also very different.

　

Because February 14 is generally near the Spring Festival, there are often changes. For example, 2018 falls on the day before New Year’s Eve, and it is impossible to form an effective schedule. This year is just on the third day of the New Year’s Eve, heating up the box office for the Spring Festival. In 2019, after the end of the Spring Festival, four romantic films were released that day.

At that time, "seal it with a kiss" ranked in the top three in terms of first-day screening and box office, followed by leading and waiting for the Spring Festival blockbuster. The final box office of the film was 173 million, of which the first day box office was about 91 million, accounting for about 50%. It can be seen how much Valentine’s Day helps a love movie at the box office.

　

However, the word-of-mouth of "seal it with a kiss" declined the next day due to the reduction in the number of films, and the box office in a single day decreased to more than 15 million, and then gradually declined. The performance of high opening and low walking proves that the key to winning the market for romantic films is still excellent quality and gaining audience recognition.

　

This year’s 520-slot, judging from the overall configuration of romantic films, may not be a big climate, and top foreign films are needed to support the market, but this slot has begun to take shape. The most stable file is still Tanabata. Last year, the box office on Tanabata was as high as 527 million, which set a new record in history and also promoted the resumption of the cinema.

　

On that day, three romantic films landed in the cinema, and "I am waiting for you at the end of time" surpassed 50% of the films, and won 277 million single-day box office, becoming the first box office in the history of Tanabata and the top ten films in the first day of domestic film history.

Tanabata is often in August, which is included in the popular summer file, so the volume level of the films released is relatively large. The formation of the Tanabata market originated in 2015, and the starring actor was released on the day of Tanabata, which set a box office of about 92 million on the first day, more than half of the film’s total box office of 173 million. This data is also very close to seal it with a kiss many years later.

The first day performance of "The Bride Fight" raised the box office on Tanabata Day to 234 million. Since then, the comprehensive box office figures of Tanabata have been 200 million+,and continue to rise.

In 18 years, due to the release of seven new films, the box office climbed to 440 million that day. Although only one new film was released on Tanabata Day in 19 years, it was supported by popularity, which raised the box office of Tanabata to 525 million in one fell swoop.

　

It is worth noting that most of the new films released on Tanabata in recent years are not love movies, and it was not until last year that they changed and ushered in the "Tanabata Special Offer". Although there are still nearly four months before this year’s Tanabata file, there are already love movies customized for Tanabata, so we can look forward to it.

　

The first to grab the spot is the youth film starring the director, the actor and the actress. At the shooting stage, the official announcement was aimed at the release of Tanabata. At present, the movie starring Zifeng Zhang has exceeded 800 million box office, and the main lineup of "Summer Future" is also quite interesting. Can we continue to increase the outbreak of "Zifeng Zhang Year"?

　

In addition, the team’s recent success, this can be a romantic film with the theme of cute pets starring,, and so on. According to sources, the film also plans to join the summer file war, and Tanabata is an option.

The spark of collision between schedule and type should not be underestimated. The 520 files that have become a pattern need to be continuously developed, and the market potential of traditional Qixi files is still great. Especially since this year, the domestic pure love movies that meet the audience in the cinema are not ideal.

　

There is no doubt that the public is eager for love masterpieces. After all, no one wants to see a bad love movie on Valentine’s Day.