In recent years, under the protection of policies and the support of real estate market demand, the whole decoration market has achieved rapid development. According to the data of the real estate home research of Zhongzhi Holdings, in 2020, the total amount of fully renovated residential development reached 3.913 million sets. In this context, on the basis of in-depth research on the whole decoration market, Zhongzhi Holdings Real Estate Home has released the list of the whole decoration market and the list of parts brands. Strictly record the development and pattern evolution of the industry, and provide reference for judging the industry trend.

In the fine decoration market in 2020, the development scale of fine decoration houses in 30 cities is 2.562 million sets, mainly concentrated in major cities in East China, South China and Central China, with Wuhan as the representative in East China. The top ten cities have more than 100,000 sets, among which Wuhan ranks more than 200,000 sets. In terms of the number of projects, the number of fine decoration projects in 30 cities in the fine decoration market is 2309, and the number of projects in the top eight cities exceeds 100, among which Hangzhou ranks more than 150.

In 2020, the total development scale of 30 cities in the rough market is 4.674 million sets, and the development scale and the number of projects in Wuhan are 0. The top 18 cities have more than 100,000 sets, including more than 400,000 sets in Wuhan and Changsha, more than 300,000 sets in Chongqing and Huizhou, and more than 200,000 sets in Zhengzhou and Chengdu. Judging from the number of projects, there are 2,802 in total, with more than 100 in the top ten cities, including more than 200 in Wuhan, Chongqing and Changsha.

* In 2020, the number of fully renovated projects in China and the number of projects in the list of 30 cities are based on the statistics of fully renovated buildings during the period from January 1 to December 31, 2020, mainly based on the parts data of CREIS; This index list is for reference only.

When everyone is avoiding embarrassment, the variety "Fifty Kilometers of Peach Blossom House" will"embarrassed"As his own signboard.

In the first season, the word-of-mouth was very unsatisfactory, and even the second season was released.

The program puts "embarrassment" on the table in a careless way, and presents all kinds of uncomfortable behaviors such as rubbing hands and scratching ears of guests in front of the audience.

Be proud of embarrassment and make embarrassment a selling point.The guests in front of the camera are in a dilemma, and I am in the throat outside the screen. What is this variety show playing?

Let’s take a look at the original intention of the program self-report:

"Explore the various faces of social life in contemporary society under the changes of different social distances, and write new answers to the beautiful social life."

What kind of presentation?

Invite 15 guests with different ages and personalities to get together and live together for 21 days. The 15 guests came from all walks of life, including actors, models, athletes, talk shows and piano players, as well as online celebrity and singers …

It’s more like a social experiment than a variety show.

The essence of variety shows is to entertain the public, but it is obviously difficult for this program with a "social experiment style" to be associated with "entertainment".

Why don’t you just find another way for the program group, and then create a topic with "embarrassment".This gives the audience a kind of pleasure like "watching the excitement", which can also be regarded as entertaining the public in a certain sense?

Because of the variety tone of entertaining the public, the program group must find ways to make the guests collide with sparks, instead of really leaving people in front of the camera like social experiments.

Chatting together, eating together, even sleeping together will be a big shop, which can be described in four words:There is nothing to hide.

In this way, the first impression of the program becomes chaos.

Fifteen people live in one room, which is extremely crowded objectively and quite messy subjectively. In a word, it makes people feel bad.

This is the audience’s point of view, and from the guest’s point of view, it is even more speechless.

Everyone is flocking to do anything. Just talking about washing dishes, it is clear that one or two people can solve the problem, but a group of people can be surrounded.

Don’t they know that they are actually embarrassed to stand there? Of course I know, but I can’t help it.

The camera is there, others are washing dishes, and it’s embarrassing to sit by yourself. Standing next to it is also a sense of participation, seeking a little comfort for the heart.

The embarrassment caused by too many guests is still secondary. The program regards embarrassment as the first color, so it is really uncomfortable to be ashamed and proud.

There is also a game in which two guests who are most embarrassed with each other dance a tango, and they can get contribution value.

What’s the use of contribution value? It’s about all their expenses here.

In other words, they must be embarrassed to dance a passionate tango with the most unfamiliar and "unsuitable" people in order to "live".

If you don’t jump, you won’t have food. Will you jump? Personality self-publicity, such as Eric Wang, has to be obedient.

Such hegemony is not only embarrassing, but also terrible.

In the first phase of the program, I always emphasize one thing:At present, everyone is unfamiliar.

The subtext is that the social embarrassment caused by strangeness will be alleviated in the next few issues.

Why is it so sure?

The program will bring 15 people together to live in groups, and the last thing is that everyone will blend in as in the poster.

I don’t care what your original personality is, and I don’t care whether you like socializing or whether you prefer being alone. All this is pushing you and forcing you to get rid of "social fear" and become a "social cow".

This is the biggest problem of the program "Fifty Kilometers of Peach Blossom House 2".

The social roles of the guests in the program can be completely ignored. For example, Silence Wang is no longer regarded as a singer, Eric Wang is no longer an actor, and Wu Muye is no longer a pianist. We just need to regard them as 15 amateurs with different personalities.

Among the 15 guests, the people who took the most shots and spoke the most were several Northeasters.

In many people’s inherent impression, most people in Northeast China are extroverted, familiar and sociable. They in the program, and indeed so. It can be said that the atmosphere of the whole program is supported by a few of them.

We envy the extroverted people who can talk with the stranger Kan Kan, and we like to watch them chat with each other.

On the other hand, should introverts and inarticulate people be discriminated against?

Some people like to socialize, while others prefer to be alone.

Some people tend to fight side by side with their teammates, while others prefer to fight alone.

Some people enjoy singing in front of everyone, while others prefer to whisper silently in the middle of the night when no one is around.

······

The world is wonderful because there are all kinds of people.

But "Fifty Kilometers of Peach Blossom House 2" doesn’t seem to allow the latter to exist. At the beginning of the program, the tune is "good social life".

Is social life necessarily beautiful? Small groups of three or two people are still fighting in secret, and a large group of 15 people must be like family? What kind of fairy collective is that?

Especially at the end of the program, Song Dandan asked everyone to save a bonfire party, and everyone would come out to perform their talents.

If the whole program is like a "group building" organized by the company, then the party proposed by Song Dandan is undoubtedly an "annual meeting" of the company. Older elders with high status have made demands. Even if the younger generation is reluctant, are they really embarrassed to say it? The purpose of socializing is actually communication, but the differences in ideas between generations and the different status in the circle will undoubtedly make communication very difficult. Song Dandan certainly meant well, but when her proposal was heard by young people, it became a source of embarrassment.

To tell the truth, such a performance party is not even as good as the annual meeting of the company. At least you can win an award at the annual meeting, but in the program, you get nothing.

The way Song Dandan lets everyone put on the show looks like a child being dragged out by his parents to perform in front of his relatives.

The extroverted child has a calm face, and the introverted child can’t wait to get into the crack.

Originally, they only had different personalities, but the latter was denied and scolded by adults, and was defined as "worthless". "Fifty Kilometers of Peach Blossom House 2" gives people the feeling that it is so absurd.

Cecilia Boey’s discomfort:

Jesuli Chen’s embarrassment:

Wu Muye at a loss:

Eric Wang’s resistance:

······

Some people are naturally unsociable. Is it wrong?

The program group even regards "solitude" as a punishment, and the person with the lowest contribution will be "exiled" to live alone on the island for one night.

After the first program was broadcast, Song Dandan became the target of public criticism. The audience thought that she was leaning on the old and selling the old, forcing everyone to hold a party and give a program, and supporting Eric Wang, thinking that he was right and cool.

It can be seen that everyone is surprisingly disgusted with this kind of social binding.

The perspective can be expanded. Isn’t the whole Fifty Kilometers Peach Blossom Noon 2 a Song Dandan?

Forcing 15 people to live a beautiful group life together, those who don’t "fit in" will be exiled, and the punishment is "one night alone". I really can’t laugh at this magic.

Looking back, it is really disgraceful to watch the program group clip out the embarrassment of social phobia and present it on the screen as a gimmick for the audience’s entertainment.

The pictures in this article are from the Internet. If there is any infringement, please contact and delete.

Finally, back to the initial question, what is this variety show broadcasting, or what is the point of view?

Is it an embarrassing moment of social fear? Or the peace and love of 15 people from strangers to family?

It takes 21 days to try to reverse the character formed by their 20 or 30 years’ experience, which is probably the only joke in Fifty Kilometers of Peach Blossom House 2.

Ha ha ha ha, I smiled, you are free.

　　International Online Car Channel News: On January 20, FAW Toyota’s 2022 masterpiece, the much-anticipated "preferred, multi-functional urban SUV" Corolla Ruifang officially debuted. The new car launched a total of 5 models, priced 129,800 yuan – 169,800 yuan. In order to meet the individual needs of users, the new car also provides 7 monochromes plus 4 contrasting colors to choose from, and is accompanied by four happiness gifts. With all-round strength and excellent quality that exceed expectations, Corolla Ruifang will accompany the majority of users to go to the shining happy time and create a better and more exciting life.

Corolla sharp release

　　In particular, it is worth mentioning that under the name of "determined to live, beautiful bloom", FAW Toyota has used leading digital technology and realistic real scenes to build a warm and cordial "Corolla Sharp Home", inviting surprise guests from different generations and different fields to reminisce about classic melodies and witness the new life of legends. This is a "slow variety show" that travels through time and space and is full of affection, and it is also a "new innovation" that has accumulated and paid tribute to users. It not only cleverly realizes the mutual brilliance of products and atmospheres, but also deeply reaches the emotional resonance of users and brands, which can be called another cross-border immersive marketing innovation for new cars.

Hu Shaohang, Secretary of the Party Committee and General Manager of FAW Toyota Motor Sales Co., Ltd., delivered a speech

　　Inheriting Corolla’s classic genes, Corolla is as sharp as her original intention

　　Classic, is a time-honored aging, is a beautiful jade carved by time. After 56 years of precipitation, sold in more than 150 countries, China’s sales 4.50 million, global sales exceeded 50 million, Corolla meets the different needs of users in different eras and regions with the super high product charm that keeps pace with the times, wins the love of consumers all over the world, and establishes the unshakable status of the king of sedan cars.

　　In the 1960s, the Corolla shouldered the mission of "allowing ordinary people to enjoy cars", enabling families to realize the dream of owning a car with revolutionary affordable prices and high quality, and pioneering the core concept of "80 + α". In the 1970s, the third-generation Corolla swept the world car market with better safety and comfort performance, winning the honor of "Best Selling Model in the World". In the 1980s, the fifth-generation Corolla further consolidated its dominance as the world’s best-selling car, and gave birth to the later famous AE86. The guests on the scene said: "Love is deep, and the guest Zhong Zhentao performed" As long as you live better than me "on the spot. Time seems to freeze and memories are quietly reborn.

Corolla Rui released the guests at the press conference

　　In 2004, Corolla entered China. After 18 years of deep cultivation in the sedan market, the 12th generation of Corolla under the TNGA architecture has achieved a complete innovation from R & D, design to procurement and manufacturing, and has formed a family camp with a variety of dynamics and versions to fully meet the diverse needs of users. The scene once again sounded a song "Friends" "Never met, began to approach, and silently treated people with sincerity", just like the most sincere and profound emotional sustenance between users and Corolla.

　　With three major hard powers, Corolla is reborn

　　Create a leapfrog space and enjoy a comfortable experience. Based on users’ attention to large space and practicality, Corolla Ruifang has a large-size body design that surpasses the same level, with a wheelbase of 2640mm, creating a wide and comfortable riding space and strong storage capacity. Abundant head space, wide driving views from front and rear windows, even for a long time, you can enjoy comfort. The exclusive design of the high door frame allows parents and elders to easily enter the back row when holding a sleeping baby, improving the convenience of getting on and off the bus. 438L large-capacity luggage space, easy to fit the whole family’s luggage. The optimized ground height, with a kick-type electric tailgate, makes it easier for female users to carry and put items.

　　Enjoy safe escort and travel with peace of mind and convenience. Corolla Ruifang has leading and rich active and passive safety configurations. The whole system is equipped with a new generation of TSS Zhixing safety system as standard, which actively avoids unexpected risks and reduces the probability of accidents. Up to 9 SRS air bags are equipped, combined with high rigidity and lightweight body structure, to give drivers and passengers all-round safety protection. In addition, Corolla Ruifang also has a series of high-tech configurations, including PVM panoramic monitoring system, Toyota Zhixing interconnection system, automatic speech recognition system, etc., to bring users a convenient and comfortable travel experience and convey happiness with intelligent technology.

　　Smart driving empowers, and the control moves with the heart. The Corolla Sharp is equipped with the power combination of 2.0L Dynamic Force Engine engine and Direct Shift-CVT transmission. The maximum engine power is 126kW, the maximum torque is 205N · m, and the fuel consumption is 5.9L per hundred kilometers. At the same time, the TNGA architecture gives the Corolla Sharp excellent low center of gravity, wide body, and high rigidity body design. With the minimum turning radius of 5.2m in the same class, it makes turning and turning more convenient. At the same time, it also brings the driver easy control fun.

　　Feeding beauty, Corolla Rui Fang helps FAW Toyota reach millions

　　Accompanied by live music notes, a musical about happiness and family slowly kicked off. Guest Zhang Jie sang "A Letter to His Daughter" in public for the first time, telling all the guests his sincere love for his family, and once again moved all the guests. Today’s new generation is always committed to creating a better life for their families and themselves. The new generation is full of confidence and continuous progress. It not only pays attention to hard work in the workplace, but also cares more about enjoying life with family and friends. The new generation is an optimistic and positive life home, and a "new generation" who pursues happiness. Carola Ruifang’s mission is to be the perfect partner of the new generation and accompany the new generation "until the end of the world".

group photo on site

　　Ambitious users have created a brand that has overcome obstacles. Looking back on 2021, FAW Toyota has launched a number of blockbuster new cars in the face of challenges such as epidemic reversal, intensified competition, and supply chain risks, and finally harvested 860,000 sales. The performance of 108% year-on-year ushered in a milestone moment of cumulative sales breaking through 9 million vehicles.

　　At the same time, FAW Toyota’s consistently excellent quality and service experience has also been widely recognized by the industry and consumers. It has won the "Toyota Global Service Commendation Gold Award" for 6 consecutive years and 7 times, and won the championship of sales and after-sales satisfaction in the China Automotive Industry User Satisfaction Index (CACSI). FAW Toyota, which is flying against the wind, has delivered a wonderful answer of making progress while maintaining stability and improving both quantity and quality.

　　In 2022, FAW Toyota will anchor the grand goal of "annual sales of one million, customers exceeding 10 million, and revenue of 100 billion yuan", accelerate the transformation of digital intelligence, build a three-dimensional brand, and further realize brand value leadership and value transcendence, bringing users an excellent experience in the whole life cycle. As the first blockbuster product in the beginning of the year, with the listing of Corolla Sharp, FAW Toyota has shown its ambition and pride over one million. There will be more blockbuster products and brand activities in the future, and the engine will bloom and be wonderful. FAW Toyota will join hands with every user who aspires to a better life, and work together for a Shared Future. (Image source: FAW Toyota)

On May 18th, the State Council Press Office held a routine briefing on the State Council policy, introducing the situation of supporting SMEs to solve difficulties and develop healthily, and answering reporters’ questions. At the meeting, Xu Xiaolan, vice minister of the Ministry of Industry and Information Technology, said that since the beginning of this year, the economic operation of small and medium-sized enterprises has started smoothly. Statistics from the Bureau of Statistics show that the operating income and profits of small and medium-sized industrial enterprises above designated size increased by 14.1% and 6.5% respectively in the first quarter, which fully reflected the resilience and vitality of small and medium-sized enterprises. However, at present, the complexity and uncertainty of the domestic and international environment have obviously increased. We also see that many small and medium-sized enterprises like the service industry and those at the end of the industrial chain have some operational difficulties. Small and medium-sized enterprises generally report that it is difficult to find orders, reduce costs, collect accounts, finance, people and logistics, and make normal production and operation difficult.

Xu Xiaolan said that the new round of epidemic has brought a great impact on the economic operation of small and medium-sized enterprises, but we must see that the long-term fundamentals of China’s economy have not changed. In this regard, the Ministry of Industry and Information Technology, in conjunction with relevant departments and localities, fully implemented the decision-making arrangements of the CPC Central Committee and the State Council, focused on the practical difficulties and needs of SMEs, and implemented detailed policies through horizontal coordination of departments, vertical linkage of ministries and provinces, and demonstration and guidance, and went all out to support SMEs to solve problems and develop healthily.

　　BEIJING, Beijing, June 24 (Xinhua) The kick-off meeting of "Health Education and Screening Ability Improvement Project for High-risk People with Diabetes" was held online recently. This year, the coverage of the project will be further expanded to eight provinces (autonomous regions and municipalities directly under the Central Government) to help early screening, early diagnosis and early treatment of diabetes.

　　The project is sponsored by the Center for Capacity Building and Continuing Education of the National Health and Wellness Committee, with academic support from the School of Medicine and Public Health of Peking Union Medical College, and joint support from Beijing Great Medical Foundation and Novo Nordisk China.

　　Huang Lei, director of the Basic Public Health Department of National Health Commission Grass-roots Department, said that at present, the situation of prevention and control of chronic diseases in China is still very grim. As one of the most common chronic diseases, diabetes has become a major public health problem that seriously threatens the country’s economic and social development. In 2022, National Health Commission Center for Capacity Building and Continuing Education, based on the good results of the previous project, further implemented the new era health and wellness policy of "focusing on grass-roots units and giving priority to prevention", pushed the project to more areas of the country, covered more people, promoted the popularization of diabetes health knowledge at grass-roots units, and improved the awareness rate of diseases, which was of great significance for continuously improving the service capacity of grass-roots units and the level of prevention and treatment of chronic diseases, and making early prevention and control of fine diabetes.

　　Yang Aiping, director of the Center for Capacity Building and Continuing Education in National Health Commission, pointed out that the grass-roots level is the main position of diabetes prevention and treatment. As the "national team" of continuing medical education, the center has taken root in the grass-roots level in recent years under the guidance and support of the National Health Commission Department of Primary Health and Health, and has improved the comprehensive management ability of diabetes among primary medical and health personnel in many aspects, and promoted the implementation of the graded diagnosis and treatment system in primary medical institutions across the country.

　　It is reported that since 2021, the "Project of Improving Health Education and Screening Ability of Diabetes High-risk Groups" has been carried out in five provinces (autonomous regions and municipalities directly under the Central Government) such as Tianjin, Shandong and Xinjiang, with a total of 310,000 screening of high-risk groups, which has played an important role in timely detection of diabetes and early intervention management. In 2022, the coverage of the project will be further expanded to eight provinces (autonomous regions and municipalities directly under the Central Government), which will help promote early screening, early diagnosis and early treatment of diabetes and benefit more grassroots doctors and the masses.

On August 23rd, many media reported that Xu Zifa, the chairman of Hebei Xinxing Gree Electric Sales Co., Ltd., the general distributor of Gree in Hebei Province, said in a recent event that he would no longer sell Gree products and turn to Philips. Gree Electric has recently stopped supplying Hebei dealers, and this news has been confirmed by many Gree dealers.

The above news was once on Sina Weibo Hot Search List.

Where is Xu Zifa, a rising star in Hebei?

Gree official website shows that the marketing company in Hebei is Hebei Shengshi Xinxing Gree Trading Co., Ltd. (hereinafter referred to as Hebei Shengshi Xinxing). It is understood that Xu Zifa, the party who defected, has been a core distributor of Gree for many years, and has also been on the board of directors of Gree Electric, and even been called an important "clique" of Dong Mingzhu by some insiders.

Hebei Xinxing, established in 2002, is a member of Hebei Guoao Investment Group, located in Shijiazhuang City, Hebei Province. It is a wholesale-oriented enterprise with a registered capital of 10 million yuan and its legal representative is Xu Zifa.

According to Zhongxin Jingwei, on June 24th this year, Gree Electric announced that Jinghai Internet Technology Development Co., Ltd. (hereinafter referred to as Jinghai Internet) reduced its shareholding by 110 million shares on the same day through block trading, accounting for 1.86% of Gree Electric’s total share capital, with a cash-out scale of nearly 3.5 billion yuan. After this reduction, Jinghai Interconnect holds 6.47% of Gree Electric shares, with a cumulative change ratio of 2.43%.

According to Gree Electric’s financial report, Jinghai Internet is its third largest shareholder, and its full name is Jinghai Internet Technology Development Co., Ltd., which was established on August 18, 2006. The shareholders of Jinghai Internet are 10 regional distributors in Gree Electric, including Hebei Gree Electric Marketing Co., Ltd. (hereinafter referred to as Hebei Gree), the protagonist of this incident, which holds the highest proportion of Jinghai Internet, accounting for 28%.

Tianyancha APP shows that Hebei Gree and Hebei emerging controlling shareholders are both Hebei Guoao Investment Group Co., Ltd.

Although Xu Zifa has a deep relationship with Gree Electric, the relationship between them is also drifting away. Some media reporters found out that Xu Zifa attended many Philips air-conditioning activities as a shareholder representative.

It’s all the live broadcast?

Gree, which has entered its 30 th year, coincides with the "eventful autumn" This is the 30th year of Gree’s establishment, and it is also the 10th year that Dong Mingzhu took charge of Gree as the chairman and president.

In the last two years, Gree has been making efforts to reform online channels, and Dong Mingzhu has personally left the market to bring goods to Gree air conditioners.

Dong Mingzhu is keen on live broadcast, and has also tasted the sweetness from it. According to the data, from 2020 to 2021, Dong Mingzhu’s nationwide live tour brought goods, and its cumulative sales exceeded 50 billion yuan. During the "618" period this year, the sales of Gree Tik Tok Live Matrix exceeded 40 million yuan. On June 18th, Dong Mingzhu continued to broadcast live until 12 o’clock in the evening. At present, the cumulative number of fans of three Tik Tok accounts, namely Pearl Feather Select, Pearl Feather Air Conditioning Live Room and Pearl Feather Ice Washing Live Room, has reached nearly 3 million.

In fact, a small live broadcast room also reflects the changes in the product layout and marketing channels of an enterprise.

Because online initiatives such as live delivery have caused dissatisfaction among Gree dealers. According to media reports, Dong Mingzhu once sold Gree Pinyue series air conditioners for only 1999 yuan on a live broadcast in JD.COM, and the agent’s delivery price was 2199 yuan, and the purchase price of last year even started from 3000 yuan.

Gree Electric’s 2021 annual report shows that Gree’s "New Retail" is based on 27 sales companies, more than 70 online dealer stores, more than 30,000 offline specialty stores, and the official flagship store of the third-party e-commerce platform, establishing a two-line sales network covering the whole country.

At the 2021 Annual General Meeting of Shareholders held in Gree Electric on June 7, Dong Mingzhu said: "In 1997, the home appliance market was engaged in a price war, and I created Gree’s marketing model. There has been little change for more than 20 years, but now the epidemic has accelerated the development of online model. Under this background, Gree’s marketing model needs reform."

"I have been doing live broadcasts for the past two years. The live broadcast is not that I want to do this market, but that I want to experience this market." Dong Mingzhu said. She also said that in 2021, the company’s sales changes did not meet expectations, and channel change was one of the influencing factors. "But the impact is not great, because in this process, it is more important to let everyone know. Dealers must gradually open physical stores and engage in live broadcasts. "

The controversial Gree Diversification

Diversification is Dong Mingzhu’s choice for Gree Electric.

In the past 30 years, Gree has become the leader of air conditioning, and the slogan of "Good air conditioning is made by Gree" and "Gree grasps the core technology" is well known. In the next 30 years, Dong Mingzhu said that she hoped that the public would remember "Good Electrical Appliances Made by Gree".

She predicted at a forum five years ago: "In the future, everyone will blow Gree’s air conditioners, use Gree’s mobile phones, eat rice cooked by Gree rice cookers and drive Yinlong (now it should be Gree Titanium) electric cars. This is the future."

In 2016, Gree officially announced the opening of diversification strategy and the transformation to a global industrial group. Today, Gree’s products are exported to more than 180 countries and regions, covering air conditioners, refrigerators, washing machines, water heaters, kitchen appliances and environmental appliances. The industrial field covers high-end equipment, precision molds, refrigeration equipment, motors, compressors, etc. The new energy field covers new energy vehicles, lithium batteries and industrial energy storage.

At the China Refrigeration Exhibition held in early August, Gree unveiled a variety of new products, from air conditioners to water purifiers and air purifiers, from intelligent equipment to new energy automobile parts, which attracted many exhibitors to stop for consultation, reflecting the diversified business development to some extent.

However, the controversy surrounding specialization or diversification always comes along, especially in the context that peers have begun to shrink non-core businesses and the proportion of business income other than Gree Air Conditioning has not increased significantly.

In Dong Mingzhu’s view, those businesses that seem unprofitable now have reasons to do it.

For example, the controversial Gree mobile phone, which Dong Mingzhu will use to broadcast live every day, is a product that she must adhere to in her diversified layout. "This is based on the planning of Gree’s entire home appliance layout, and the interconnection of home appliances is realized through Gree mobile phones."

Who will take over from Dong Mingzhu?

According to the Securities Times, not surprisingly, Gree Electric’s "Dong Mingzhu era" will continue for at least three years.

So, who will be Gree’s successor after Dong Mingzhu?

Gree’s trademark "Pearl Feather Boy" was successfully registered this month. However, many people found that Meng Yutong, a young secretary who once praised Dong Mingzhu, recently began to fade out of the Gree live room in a "low-key" way.

Earlier, Dong Mingzhu publicly stated that Meng Yutong should be "cultivated into the second Dong Mingzhu in the future", so that the latter’s popularity soared and he was labeled as "Dong Mingzhu’s successor".

However, recently, the Tik Tok account of Gree’s "Pearl Feather Boy Selection" was exploded to change its avatar, and the photo of Dong Mingzhu and Meng Yutong was removed and replaced with a single photo of Dong Mingzhu. Meng Yutong was suspected to have faded out of the live broadcast room.

(Tik Tok screenshot)

According to the analysis of insiders, from the actual situation, Meng Yutong, the "successor", is more like the "online celebrity with Goods" created by Dong Mingzhu to cooperate with the company’s online channel reform. Li Guoqing once commented that Dong Mingzhu pushed Meng Yutong, "the purpose is to bring goods for live broadcast, and to incubate online celebrity by himself". To take over Dong Mingzhu’s big stick, I’m afraid my ability is far from enough.

After all, the training of successors does not happen overnight. Huang Hui, the former second-in-command of Gree, trained in Gree for nearly 29 years, and Dong Mingzhu also worked in Gree for nearly 22 years before becoming the "number one". After all,Gree’s top-level handover is not only a simple personnel turnover, but also involves the inheritance of the whole enterprise in terms of system, organization and culture.

In 2022, Gree’s first quarterly report showed that Gree Electric achieved a total operating income of 35.26 billion yuan, a year-on-year increase of 6.24%; The net profit attributable to shareholders of listed companies was 4.003 billion yuan, a year-on-year increase of 16.28%. Compared with last year’s annual report, the performance in the first quarter obviously exceeded expectations.

Now that the company’s semi-annual report is disclosed soon, the market is quite concerned about Gree’s performance in the first half of the year.

Gree, 30 years old, is it a "middle-aged crisis" or another "thirty-year-old"? Dong Mingzhu, 68, will show Gree how to tell new stories, and time will tell.

Upstream news synthesis

　　Sohu Entertainment News Compared with movies, the scale of TV dramas that are watched by horrible people will naturally converge a lot. Among many TV stations in the United States, except Showtime, which is paid for, and HBO, which is quite deep, most TV dramas broadcast by other TV stations are secretive and dare not show more than half an inch of skin. I am used to seeing the characters wrapped tightly on the screen every day. Occasionally, a fragrant lens will make my pupils dilate. I want to press the pause button immediately and remember this unforgettable sexy moment.

　　Double-faced female spy Alias

　The female spy played by Jennifer Garner is absolutely generous. She often takes off her blouse and makes a sexy appearance. This has also become one of the successful elements for the drama to win a large number of fans. In Jenny Buddhism, you know that "good things should be shared with everyone".

　　Lost

　Sawyer always exudes a wild smell when he wears clothes on weekdays. When he walks out of the sea naked, which woman will not scream?

　　Grey’s Anatomy

　Although the pictures of the three female doctors taking a bath together received all kinds of bad comments, it did become a major attraction at that time, not to mention that after reading it, you can’t forget it. In contrast, Dr. "McSteamy"’ s bathing picture is a hundred times better, and how can the looming thigh lines not be reverie?

　　Beach guard Baywatch

　This TV series has a long history, but it is safe to say that the audience may not remember what was played in it at all, but you will never forget Pamela Anderson running on the beach in a high-heeled bathing suit.

　　Friday Night Lights

　As long as there is a picture of Tim Riggins, we can see those eight abdominal muscles waving to us, which makes people want to tip him.

Editor: Li Ming

　　Photo courtesy of vision china

　　Gene therapy can "correct" the mutant genes that cause diseases, thus bringing hope for the patients suffering from congenital genetic diseases. But recently, in a clinical trial of gene therapy conducted by a biotechnology company in the United States, two children who participated in the trial died unfortunately.

　　After decades of twists and turns, gene therapy has brought new hope for the treatment of major human diseases, especially many genetic defects. However, gene therapy has recently suffered setbacks.

　　Recently, an American biotechnology company (Audentes Therapeutics) issued a letter saying that among the 17 children with neuromuscular rare diseases who participated in the company’s "AT132" gene therapy, two children died after receiving high-dose gene therapy.

　　The key research of this gene therapy began in 2017, aiming at treating a fatal disease caused by a single gene mutation — — X chromosome linked myotubular myopathy. The treatment was originally intended to be submitted this year and expected to be approved by the US Food and Drug Administration by the end of the year, but the plan has now been shelved.

　　Some children died while receiving gene therapy 20 years ago. What are the differences between the gene therapy at that time and this gene therapy? After decades of development, what improvements have been made in gene therapy and what problems are still facing? In this regard, the Science and Technology Daily reporter interviewed relevant experts.

　　"What is missing makes up for what is missing" and "corrects" mutated genes.

　　In human body, there is a gene named "MTM1", which is used for the development and maintenance of muscle cells by expressing a protein called "Myocardin". X chromosome linked myotubular myopathy is caused by the mutation of "MTM1" gene.

　　X chromosome linked myotubular myopathy mainly affects skeletal muscle, and its symptoms are muscle weakness and hypotonia. Muscle lesions will damage the patient’s ability to sit, stand and walk, even cause difficulty in eating and breathing, and may also lead to ophthalmoplegia, facial muscle weakness and muscle reflex disappearance.

　　At present, the main treatments for the disease include physical therapy and the use of support equipment such as ventilators. Studies have shown that the chemical drug "pyridostigmine" may be beneficial to improve clinical symptoms, but no formal clinical trial has been carried out. Generally speaking, there is no effective treatment for this disease at present.

　　To this end, researchers began to explore the use of gene therapy to "correct" mutated genes. "Based on ‘ What is missing is what is needed ’ The gene therapy uses adeno-associated virus (AAV) as a vector to transfer normal ‘ MTM1’ Genes are introduced into muscle cells to produce myotubes with normal function, thus repairing the function of damaged muscle cells. " Qiu Zilong, a researcher at the Center for Excellence and Innovation in Brain Intelligence of China Academy of Sciences, said that this is a "permanent cure" treatment method, and under ideal conditions, it can even achieve "one treatment and lifelong benefit".

　　How to realize this "correction" process? "The whole process and ‘ Drip ’ Very similar. " Qiu Zilong pointed out that the researchers injected the adeno-associated virus loaded with normal "MTM1" gene into the patient’s blood, delivered the adeno-associated virus vector to muscle cells through blood circulation, and produced "myosin protein" with normal function in it.

　　Before these children participated in clinical trials, the gene therapy had been pre-clinical studied, including verifying the safety and effectiveness of the therapy in cell and mouse disease models cultured in vitro, and the therapy was generally safe.

　　But in order to improve the therapeutic effect, the researchers tested a higher dose of gene therapy. "High doses are particularly important for neuromuscular diseases, because more copies of genes are needed to reach the targeted tissues through blood circulation." Dr. Cheng Cheng, from the School of Bioengineering, East China University of Science and Technology, said that the dose used in this gene research is the highest dose in gene therapy: 300 trillion copies of genome per kilogram of body weight.

　　The upgraded transmission carrier is safer.

　　In recent years, gene therapy has developed rapidly. The event that the "brake button" was also pressed occurred in 1999. An 18-year-old American patient named Jesse Kissinger died in a clinical trial of gene therapy with adenovirus as the carrier.

　　At that time, researchers used adenovirus as a vector to insert genes into patients’ cells to replace those parts that were lost or dysfunctional and caused diseases. A few days later, Jesse died of multiple organ failure due to severe immune response, which poured cold water on those who were initially optimistic about gene therapy.

　　After the tragedy of Jesse Kissinger’s death due to gene therapy, the researchers reduced the size of the laboratory and focused on finding safer virus vectors. Finally, they discovered and promoted the use of adeno-associated viruses.

　　Adeno-associated virus (AAV) is a kind of single-stranded DNA deficient virus with the simplest structure found at present. Adeno-associated virus gene therapy uses adeno-associated virus as a carrier to deliver therapeutic genes to specific tissues and organs, and these therapeutic genes stably exist and express in the form of free bodies in these non-splinter cell, thus effectively treating monogenic genetic diseases.

　　At present, adeno-associated virus (AAV) is the mainstream carrier platform for gene therapy, and there are also adenovirus and lentivirus gene therapy. Qiu Zilong pointed out that compared with adenovirus, adeno-associated virus vector has the advantages of high safety, low immunogenicity, longer curative effect and easy modification, and the newly discovered adeno-associated viruses such as AAV8 and AAV9 are 10-mdash stronger than adenovirus in transferring genes into cells. A hundred times. Lentiviruses, on the other hand, have the characteristics of randomly integrating genomes, and there is a potential risk of destroying normal gene functions.

　　In addition to the rare diseases caused by single gene mutation reported in this report, gene therapy is also used to treat Parkinson’s disease, Alzheimer’s disease, cancer and other complex diseases at home and abroad. At present, about 42 companies and nearly 100 drug research and development projects use adeno-associated virus vectors for gene therapy. In this fatal accident, the carrier used by researchers for gene therapy was AAV8.

　　Too high dose is easy to produce toxic and side effects.

　　Regarding the insecurity of gene therapy, Cheng Cheng believes that in the case of "AT132" gene therapy, the cause of children’s death may be that they received an excessive dose of adeno-associated virus intravenous injection, which produced a large number of antibodies against adeno-associated virus. The combination of virus and antibody can further activate complement pathway or innate immune response, thus causing strong toxic and side effects.

　　"Another kind of insecurity is the dislocation expression of normal genes." Cheng Cheng took the gene therapy of spinal muscular atrophy "Zolgensma" as an example, saying that intravenous injection would lead to excessive accumulation of normal genes carried by "Zolgensma" in the liver, but this gene did not play a role in the liver, which triggered a common hepatotoxicity after treatment, which was manifested by the increase of transaminase.

　　As early as a few years ago, james wilson, an American scientist who was a pioneer in gene therapy and one of the developers of adeno-associated virus, expressed concern about the high-dose vector used in gene therapy. In February 2018, the Wilson team published a paper saying that after high-dose injection of adeno-associated virus, it caused serious toxic reactions in rhesus monkeys and piglets, and one rhesus monkey had to be euthanized due to liver failure. To this end, Wilson called on researchers to carefully monitor similar toxic effects during gene therapy.

　　Wilson’s collaborator, Professor Gao Guangping of the Massachusetts Institute of Technology, once expressed similar views. In an interview in 2019, he expressed concern that the rapid development of this field would make people less cautious and might make Jesse Kissinger happen again.

　　"Scientific and technological progress will experience setbacks." Qiu Zilong said that although this high-dose gene therapy caused the death of the patient, the effectiveness of gene therapy cannot be denied. In the face of the lack of effective treatment for rare diseases with single gene, gene therapy has indeed brought hope to many patients and their families. At present, there are still many shortcomings in gene therapy, which needs continuous improvement and perfection by experts and scholars in the field to make it safer and more effective, and should not be abandoned because of choking.

　　In promoting the development of gene therapy, Qiu Zilong suggested that it is necessary to constantly transform to obtain new types of adeno-associated viruses with special tissue affinity, reduce the immune response of the human body after injection, achieve more accurate delivery of normal genes, and further reduce toxic and side effects; At the same time, research and develop better gene regulatory elements, so that normal genes delivered to patients can produce functional proteins in a timely and appropriate way.

　　Cheng Cheng also suggested that the production and purification process of adeno-associated virus can be further optimized to reduce impurities in the virus and improve its purity. Choose a better carrier delivery mode, such as intrathecal injection or intraventricular injection for diseases of nervous system.

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