1905 movie network news The launching ceremony of Native Crime was held in Malaysia. This 24-episode drama is the second time that godfather producer Han Sanping has cooperated with iQiyi as a producer after Crime Without a Certificate, and it is also the first time that film director Ye Weimin has touched the net. In addition, director Xu Hongyu is the editing director and the action director is Wai Leung Wong, and the cast matching the top production team is also luxurious: Zhai Tianlin and Yin Zhengling, who have just gained great popularity in The Birth of Actors, starred in the original title.
"Native Crime" is the second cooperation between iQiyi and Wannian Film after the 2017 annual phenomenal online drama "Crime without a license", and it is also the second time that Han Sanping has served as the producer of iQiyi’s self-made drama. When talking about the second collaboration, all three parties said that after the publication of "Crime without a license", word-of-mouth and clicks have achieved good results, which also enabled the three parties to establish a strong tacit understanding and trust, hoping to take another big step on the road of online drama quality. Han Sanping said at the launching ceremony, "Before the Crime of Undocumented, there were actually quite a few filmmakers who had some reservations about online drama, but the Crime of Undocumented showed everyone that there is no boundary or type about creation and quality, and we are more confident to refine the experience of the Crime of Undocumented into the Crime of Primitive Nature." Ying Dai, vice president of Aiqiyi and general manager of the self-made drama development center, said that the investment scale of "Native Crime" has also reached a higher level, and the top-level investment combined with the whole overseas shooting will make a qualitative leap in the story background and visual presentation. Re-cooperation with the team of He Junyi of Wannian Film Industry is also the determination of iQiyi to impress the market and audience with its works, and jointly seek new sparks and breakthroughs in story and production. Director Ye Weimin has directed many word-of-mouth films, and he is especially good at outlining characters and creating environmental atmosphere. Under its film and television lens, every detail is rigorously polished and strives to create fine products. Ye Dao’s joining has made Aiqiyi more confident in this drama and more looking forward to the wonderful performances of Zhai Tianlin and Andrew.
Ye Weimin, a famous film director whose representative works are warlords, A Man on a Embarrassed Road and No.81 Capital, is the director of Native Crime this time. When talking about touching the net for the first time, Ye Dao said, first of all, two characters who were strongly attracted by the script and seemed to be black and white were bound together to solve the case because of the strangulation of fate, and each case was related to the human exploration of ordinary people. Malaysia was chosen as the shooting location because "there is a heavy rain almost every day in Malaysia, and the rain in the hot environment soaks the reflective ground, as well as the wet feeling on the surface of people’s skin, which is particularly in line with the temperament of this drama.
"Native Crime" tells the story of a lawyer who was imprisoned after he was released from prison, and an honorary student of the police academy who repeatedly broke major cases after joining the police station. However, due to the heavy moral burden of his family, they were woven together by an invisible hand, from opposing each other to being brothers and sisters, and finally died together … Zhai Tianlin incarnates as a lawyer in the play, and cooperates with detective police officer played by Andrew to stage interlocking suspense reasoning. For their respective roles, Zhai Tianlin described them as "the contradiction between justice and morality" and Yin Zhengzheng described them as "half sunny and half rainy".
In addition, Bai Bing, the goddess of ancient costume, made a strong return to Native Crime, and gathered many new generations of actors, including Yan Zhuoling, who was nominated for the Golden Horse and the Golden Horse and the Golden Academy Award, and Li Ruoning, a "new idol power school".
"Native Crime" is expected to be broadcast on iQiyi in the fourth quarter of 2018.
Cctv newsAt 8 o’clock every day, CCTV will sort out the big and small things that happened around us within 24 hours.
The Central Committee of the Communist Party of China the State Council sent a congratulatory message to the China sports delegation of the 16th Paralympic Games.
The Overall Plan for the Construction of Hengqin Guangdong-Macao Deep Cooperation Zone was released, and Guangdong Provincial Governor and Macao Chief Executive jointly served as the directors of Hengqin Guangdong-Macao Deep Cooperation Zone.
Feedback was completed during the seventh round of inspections by the 19th Central Committee, and the risks of integrity in school-run enterprises and other fields were more prominent.
Vaccination in COVID-19 has exceeded 2.1 billion doses nationwide, and the plan of strengthening replanting with the third dose of Sinopharm has been submitted for approval.
The State Council inspection team made an unannounced visit: Shizuishan in Ningxia is now the "exclusive agent" for safety and liability insurance, and the emergency department is suspected of monopoly.
Xiamen plans to set up an exemption list for more than 50 minor illegal acts such as mobile vendors occupying the road.
The yield per mu of Yuan Longping Super Rice Mengzi Base has exceeded 1,100 kg for four consecutive years.
Brazil found cases of mad cow disease and suspended beef exports to China.
Afghan refugees bask in the US military base: only a few pieces of chicken and fruit have to wait 12 hours for the next meal.
IUCN: More than 38,000 species are threatened with extinction.
Flat support for 9 hours, 30 minutes and 1 second! A man in Australia broke the world record of flat support.
A pickup truck fell into a ravine in Taihu County, Anhui Province, killing 12 people and injuring 2 others.
A woman died in Sichuan after being vaccinated with COVID-19 vaccine. Officially, the woman went to see a doctor because of abnormal liver function. After the doctor injected the drug, the patient died after suffering from symptoms such as loss of consciousness and cardiac arrest. The incident has nothing to do with vaccination.
Online celebrity officially apologizes for bread pastoral: it exceeded the standard because gluten was added to the formula. Previously, WeChat official account, the official WeChat of Shanghai Consumer Protection Committee, issued two articles saying that many nutritional components of pastoral were inconsistent with the actual measurement.
The military training performance of freshmen in Guang ‘an No.1 Middle School in Sichuan was held in the rain, and the school leaders were not absent. The school responded: Because parents wanted to see the results of military training, they insisted on finishing the performance. The school tried to shorten the time as much as possible, and the school canteen also prepared ginger soup. At present, no students have been unwell.
A cinema in Wuzhou City, Guangxi Zhuang Autonomous Region was fined 5000 yuan for misleading consumers to buy 3D glasses by misleading propaganda.
Plastic brotherhood! A man in Bozhou, Anhui Province was reported drunk by a drinking friend at the same table, and his driver’s license was revoked, and he could not obtain a driver’s license for 5 years.
Like it! The 9-year-old girl invited around 200 sanitation workers, disabled people and lonely old people to have a love breakfast on her birthday: helping others is really happy.
Respect is the best gift.
— — Beijing Evening News commented that "Shenzhen No.1 Middle School Scholars Committee mobilized all classes to buy gifts for Teacher’s Day"
On September 4th, the staff displayed the digital RMB "hard wallet" at the booth of China Bank in the exhibition area of the National Convention Center.
Hainan gibbon, an extremely endangered species, likes to add two babies.
Xing Yifan, a freshman with gradual freezing disease weighing 18kg, reported to Beihang University: 645 points in the college entrance examination, determined to be "Hawking" in China.
On December 25th, the inaugural meeting of the "Giant Panda" Cultural Tourism Development Alliance was held in Chengdu, and the Declaration of the "Giant Panda" Cultural Tourism Development Alliance was issued.
The "Declaration of the Giant Panda" Cultural Tourism Development Alliance proposes to promote the operation mechanism of "Giant Panda" resource sharing, brand co-creation, customer promotion, market co-governance, talent co-education, basic co-construction and regional co-governance. The alliance will focus on establishing the brand service standard system of "Giant Panda" cultural tourism, the reciprocal mechanism of regional tourism market, the resource sharing platform and sharing mechanism.
The brand building concept of "Giant Panda" cultural tourism released at the meeting shows that the brand of "Giant Panda" cultural tourism relies on the Giant Panda National Park and surrounding radiation areas to form a development pattern of "one park, one circle, one capital, one city", establish a brand image of "exploring the panda home and enjoying the life of Sichuan people", and focus on "panda science popularization", "panda paradise", "panda hometown" and "panda"
In April this year, the Provincial Party Committee and the provincial government issued the Opinions on Vigorously Developing the Cultural Tourism Economy and Accelerating the Construction of a Strong Cultural Province and a Strong Tourism Province, demanding the construction of "Top Ten" well-known cultural tourism products. The establishment of the "Giant Panda" cultural tourism development alliance will further promote the construction of Sichuan’s "Top Ten" cultural tourism brands.
Vice Governor Yang Xingping attended the inaugural meeting.(Reporter   Lei qi)
1905 movie network news Six years after becoming an army, the bad monkey film industry, which has been intensively cultivated, once again gathered at the Shanghai International Film Festival. This time they brought a summer movie and launched a new director, Muye Wen; As well as the finalist of the Asian Newcomer Award at the film festival, the new director Zeng Zeng was introduced; Ning Hao, artistic director of Bad Monkey Film, served as the chairman of the jury of the Jin Jue short film unit of this film festival; In the venture capital unit of the last film festival, Bad Monkey Film awarded "The Queen Mother and I" the special attention award. At the same time, the "Bad Monkeys" are still working hard to promote the "Bad Monkeys 72 Change Movie Plan" signed by 14 directors.
The plan has been launched for three years, and it will take a year and a half for it to be officially announced. Before the formal meeting with the audience, there was director Lu Yang. According to Ning Hao, artistic director of Bad Monkey Film, no matter how limited the production capacity is at present, it must be a "slow process". During the film festival, Ning Hao appeared as a producer at the press conference of the film Dying to Survive, and was interviewed to mention the future plan of the bad monkey film industry. Ning Hao said half jokingly: "I originally wanted to hold a press conference and release (the film list)." Immediately, he said seriously: "Forget it at last. It is enough to make a few good films in a down-to-earth manner." Ning Hao’s partner, Wang Yibing, CEO of Bad Monkey Film, also thinks: "Everyone tends to be calm. Compared with the release of hundreds of new films during the previous film festival, this year is more calm and calm. You need to cultivate intensively according to the law. "
The word "support" is often used in the industry when it comes to the "Bad Monkey 72 Change Movie Plan". In this regard, Ning Hao thinks: "We can’t talk about support. We just want to find like-minded people to make movies together. Later, we found that our favorite directors are all local and innovative. " And what are the specific criteria for bad monkeys to choose new works? Ning Hao once again mentioned "local": "As long as it is characteristic enough, has the characteristics of the author, has an innovative level, is related to the local, and is local enough, it will be fine." Wang Yibing said: "It should be innovative and local. The film is the recorder of the times. I hope that young directors can tell the stories of their own experiences and their own times. "
"Struggle" with Time
Native, contemporary, interesting, innovative and individual — — It is the consistent value of the bad monkey film industry. They try to find at least one or two points in every work of the bad monkey. During the six years since its establishment, CEO Wang Yibing’s function is strategic, while Ning Hao’s function is creative. Only when two people walk on two legs can the whole brand of bad monkeys be formed. As the most important creator of Bad Monkey Film, Ning Hao should not only promote his own projects, such as,, and, but also be the producer of the new director’s works of "Bad Monkey 72 Change Film Project". In this process, he claimed to be responsible for playing a "mirror": "I often have to communicate with them (the new director) and keep asking why you want to make this film? Let them see themselves. Have you combed your hair? Aren’t the shoes in a different color? Just look at it clearly. "
As a producer, Ning Hao’s work often starts from the front end, including the development of scripts. Both he and Wang Yibing believe that this process must be a "long polishing process". Take Dying to Survive, which will be released on July 6th, for example, producer Ning Hao asked director Muye Wen to polish the script for "two years at a time". Ning Hao said: "It’s normal to write a script for two years. That’s how movies are made. As long as the director in the middle goes to shoot advertisements again, it will wait. I used to shoot a movie when I was filming an MV, but I just couldn’t get out and I couldn’t do it at once. Now, why did I go four years after "Let Love Walk"? It is the next movie ("Crazy Alien"), the script, and the meeting. "
Wang Yibing, on the other hand, thinks that it is impossible for a bad monkey to shoot a complete script in the face of a new director. "The normal project cycle should be around 18 months, and some will be extended to two years. This is a carefully polished work. For example, Wen Shipei, the director we selected last year, has reached the stage of complete script when he started venture capital. However, because there are many factors to consider from the script to a complete work, it has been polished for a year and will be launched in Guangzhou on the 25 th of next month. " Wang Yibing said.
Make a dignified movie
This "struggle" between bad monkeys and time has achieved good results. Ning Hao mentioned "making several good films in a down-to-earth manner", which also fulfilled his promise. On June 19th, Dying to Survive’s screening of thousands of people in Shanghai Studios fully proved this point. As a film with a scarce realistic theme of "paying attention to the present", Dying to Survive focuses on the story of little people’s metamorphosis due to "medicine", conveying tenacious life force, and with the burst group acting of powerful actors such as Xú Zhēng, Zhou Yiwei, Eric Wang, Tan Zhuo and Zhang Yu, Dying to Survive has broken through the existing types of domestic films and presented a rare new texture. In the process of watching movies, the audience applauded three times, and the main creative and audience choked several times in the post-screening interaction. After Weibo’s circle of friends exploded that day, there were voices that Dying to Survive was the conscience of the 2018 China film, and "booked the top ten movies of the year in advance". There are also a large number of voices who admire and see the light of social progress and human nature.
Debut at the film Dying to Survive conference.
In the face of Dying to Survive’s strong reputation that has not been officially released, Ning Hao and Wang Yibing mentioned the word "dignity" in unison. Ning Hao said in an interview: "When I was a child, I listened to Zhao Chuan’s songs, and there was a lyric,’ Which is more important, the pressure of life or the dignity of life’. Dying to Survive is a film about the dignity of life. It is a powerful, powerful, very moving and dignified film, and it has also achieved dignity. " Wang Yibing thinks that the film "finds the dignity and makes the dignity of the film!"
The Bad Monkey pursues contemporary and local values, which is in perfect agreement with Dying to Survive’s realism. Ning Hao even confided that he wanted to direct this work himself. "I was interested in realistic themes, and later I thought it would be better to have a newer director. If I shoot, the distance will be far away, and I won’t be so close to the characters. The film Muye Wen is a character. " Ning Hao said. Adhering to the "Bad Monkey 72 Change Movie Plan", young directors are the original intention of the future, and Ning Hao chose to escort Muye Wen with more realistic portrayal ability.
Localized "aliens"
The project to make Ning Hao "give up what he loves" in Dying to Survive is the sci-fi comedy film Crazy Alien, which will be released on the first day of 2019, directed by Ning Hao and starring Bo Huang and Shen Teng. This film is not only the "return" of Ning Hao’s "Crazy" series after ten years, but also the first director’s work of Ning Hao’s official Spring Festival campaign. Although the theme of the film seems to be "out of tune" with the realistic theme pursued by the bad monkey, Ning Hao, who is busy with the later stage of the film, still thinks that how to localize the film is the most important point. He said: "The biggest question is, what is China’s science fiction film? I guarantee that they (foreigners) can’t make Crazy Alien, and all American movies can’t be applied. Our core problem is localization, and this difference will lead to great changes in stories and types. "
"Crazy Alien" is a brand-new attempt by Bad Monkey Film and Ning Hao. They believe that although the film industry in China has developed rapidly, the infrastructure has not been completed. "It takes more than ten years to take the road of the United States for a hundred years." Ning Hao believes that the level of special effects management of China’s films is still very backward, and there is no ability to make sci-fi blockbusters. The working method and technical process of Crazy Alien are different from before, and a large number of early and late special effects of the film make Ning Hao fall into a "technical rut". He declared: "the special effects film only shoots this one, and there is no next one." It’ s too difficult in the later stage! " On the other hand, he gritted his teeth and insisted, "The key is that I, a perfectionist, can’t overspend over time."
"Crazy Alien" is adapted from the works of China science fiction writer Liu Cixin. Ning Hao said: "His works make people feel a lot — — There are classical, romantic, heroic, absurd and naive parts. The absurd part can be combined with us. " Excavating the absurdity from Liu Cixin’s works and combining it with the bad monkey’s values, we can imagine that Crazy Alien still adheres to the bad monkey’s concern about localization, China’s cultural ontology and the stories of little people, and finds innovation and interest from it. Talking about his expectations for this new work, Ning Hao said: "I like the common pleasure of the left and right brain, and only the stimulation of the right brain is almost exciting for me. It is interesting to have a good balance between the two sides. "
Future boundary expansion
In addition to Dying to Survive in the summer and Crazy Alien in the Spring Festival, Bad Monkey Film also released a unique work during the film festival, that is, Cloud Water, which was produced by Ning Hao and Amanda, starring Amanda and directed by young female directors Zeng Zeng. The film was shortlisted for the best cinematography in the Asian Newcomer Award of the Shanghai Film Festival. It was officially shown for the first time in China on June 22, and the trailer of "All Life Crossing" was released for the first time. This film, which focuses on reincarnation and redemption, once again shows the bad monkey’s pursuit of refusing vulgarity and expanding "width" and "thickness" for the film theme. Zeng Zeng, the film director, also said in the interactive session after the screening: "It is a great honor to participate in the Bad Monkey 72 Movie Project. The word’ cloud water’ is the so-called’ cloud water monk’ in the Buddhist scriptures, that is, the ascetic monk who travels in all directions."
At the Asian Newcomer Award Ceremony, Ning Hao, who served as the chairman of the jury of the Jin Jue short film unit of this film festival, also appeared and joined hands.Nansun ShiAward the best film award. He also expressed the gratitude of the "Asian New Award" to him: "13 years ago, my filmHe won the most popular film award in the 8th Asian Newcomer Award. The Asian New Award has made me known to the outside world and the industry, and more importantly, it has spared no effort in incubating and supporting young filmmakers. "
Bad monkey film industry has been in the army for six years. In addition to focusing on the theme of "focusing on the present" and "happening", it has been constantly exploring localization. Facing the future, they have also opened a new cross-border strategic layout. The "Bad Monkey 72 Change Movie Plan" introduced two new strategic partners, Youku Movie and Cat’s Eye. Youku Film will rely on its powerful online communication platform, and Cat’s Eye will jointly promote the works of young directors under the program with its superior resources in distribution and ticketing, so that more outstanding film works can be presented to the market and audience. The bad monkey, who has been deeply involved in the venture capital unit of Shanghai Film Festival for three consecutive years, has also been awarded the "Queen Mother and I" special attention award. Whether this is another "turning the stone into gold" project is unknown, but the bad monkey has shown many possibilities and efforts in planning, taste and action. Wang Yibing said frankly: "The bad monkey has higher requirements for the script, and hopes that the first work of the new director will be successful. But it does not mean pure commercial success, but ontological success, including artistic, ornamental and commercial success. "
Ning Hao, on the other hand, said that what he wanted to do was to keep investors from losing money. He revealed that in the future, the bad monkey mainly plans to be a new director, and there are still explorations on cartoons. What is even more exciting is to "help Liu Cixin put his works on the screen, focusing on science fiction." As for the expectation for the future of the bad monkey, Ning Hao hopes to hold his horses and polish every work: "We have signed three new directors, and each new director is a huge attempt, and the probability of failure is not low. How many directors do you think have been produced over the years? In the past ten years, there have been only a few films taken by one department. Of course, I hope that all (new directors) will be successful, and I also hope that our new director will not make money, and the lower part will be flat, and then the lower part will earn back. We have 14 directors, more than ten years! Why Worry? Take your time. "
Hubei Daily News (Reporter Yang Nianming) On June 11, Wang Zhonglin, deputy secretary of the provincial party committee and governor, presided over the executive meeting of the provincial government to convey the spirit of the important speech delivered by the General Secretary of the Supreme Leader at the meeting of academicians of Politburo meeting of the Chinese Communist Party and the two academies and the tenth National Congress of China Association for Science and Technology on May 31, and to study and implement measures according to the deployment of the provincial party committee; Study and adjust the relevant social security standards, and deploy safety production and social stability.
The meeting stressed that it is necessary to effectively unify thoughts and actions with the important speech of the Supreme Leader General Secretary and the spirit of Politburo meeting of the Chinese Communist Party, clearly understand the population development situation in our province, and do a good job in optimizing the birth policy in light of the actual situation; Effectively improve the policy system, refine supporting policies and measures such as fertility, parenting, education, taxation, housing, pension, social security, increase the construction of public service facilities, and solve the problem of "one old and one small"; Effectively strengthen organizational leadership, pay close attention to the formulation of the population development plan of the province during the 14 th Five-Year Plan, strengthen overall planning, policy coordination and work implementation, promote the supporting connection between the birth policy and related economic and social policies, and promote the long-term balanced development of the population in our province.
The meeting demanded that we should improve our political stance, fully understand the extreme importance of scientific and technological innovation from a strategic and overall perspective, and make greater efforts to promote the construction of a strong province of science and technology in accordance with the work requirements of the provincial party Committee. We should pay close attention to key tasks and implement them, speed up the construction of Optics Valley Science and Technology Corridor with East Lake Science City as the core, promote the operation of Hubei laboratory entities, lay out and build a number of scientific apparatus, pay close attention to the introduction of a series of policies and measures such as talent incentives, taxation and finance, and land security, increase investment in science and technology, and strive to build a scientific and technological innovation highland. It is necessary to focus on the transformation of scientific and technological achievements, deepen the reform of system and mechanism, fully mobilize the enthusiasm of scientific researchers, build an innovative ecological chain of "R&D+transformation+industry", implement inclusive and prudent supervision, actively create conditions for the development of new technologies, new formats and new models, and get through the channel from strong science and technology to strong industry and economy, so as to provide strong scientific and technological support for the high-quality development of our province.
The meeting stressed that it is necessary to bear in mind that making people’s lives happy is "the country’s greatest", do a solid job in social security and assistance, and firmly grasp the bottom line of people’s livelihood. Based on the reality of Hubei, we should do our best and do what we can, scientifically determine the relevant social security standards, improve the linkage mechanism between social assistance and security standards and price increases, and let the people enjoy more fruits of reform and development. It is necessary to promote the implementation of the policy of benefiting the people and the people with heart and affection, increase the propaganda and interpretation of policies, strengthen supervision and supervision, and do good things well and do practical things.
The meeting demanded that we should accurately grasp the current situation, strengthen ideological understanding, strengthen the resolution of contradictions, strengthen the investigation of hidden dangers, strengthen the prevention and control services, strengthen the implementation of responsibilities, comprehensively carry out the investigation and rectification of potential risks in various industries and fields, promptly solve the problems and demands reflected by the masses, strengthen emergency response to emergencies, do a good job in safety production and social stability, fully protect the lives and property of the people, and create a peaceful, harmonious and stable social environment for celebrating the 100th anniversary of the founding of the Party.
Author: Ni Wan, vice president, professor and doctoral supervisor, School of Journalism and Communication, Shandong University
Since the party’s symposium on news and public opinion work was held in 2016, marked by a series of important speeches by the Supreme Leader General Secretary, our understanding of news and public opinion work has entered a new stage. At present, the ecology of public opinion, the pattern of media and the mode of communication have undergone profound changes, and the work of news public opinion is facing new challenges. In 2020, the epidemic in COVID-19 made us deeply realize the importance of the news and public opinion front. At the deployment meeting of coordinating the prevention and control of epidemic situation and economic and social development in COVID-19, the General Secretary of the Supreme Leader particularly emphasized that it is necessary to "improve the effectiveness of news and public opinion work", which is also the inevitable path for China to realize the modernization of national governance capacity in the field of public opinion. In the all-media era, the whole process of news gathering, production, distribution, reception and feedback has undergone tremendous changes. Generally speaking, improving the effectiveness of news public opinion work should meet ten basic requirements.
One of the requirements: effectively judge the information environment.
In the era of all-media, new features have emerged in China’s information environment. First, in terms of international information environment, western media, represented by the United States, still have a monopoly position in the international public opinion field, and they do everything they can to strengthen the leading position of information technology and stabilize the monopoly of information field. Second, in terms of social and ideological environment, it is facing a great change that has never happened in a hundred years. The ecology of public opinion and the ideological situation of the public in China are more complicated and changeable, and the collision of ideas is more intense. There are different social ideological trends behind it, and capital forces representing different positions are involved in different degrees. At the same time, with the in-depth application of emerging media, the opinions of netizens show a typical trend of group polarization. Thirdly, in the aspect of media application environment, media application shows the core characteristics of socialization, mobility, intelligence and data, media content presents the mainstream expression of audio-visual, and media forms converge into a platform operation mode.
To effectively judge the international information environment, we must fully understand the ideological struggle behind the information environment and the long-term and difficult struggle for international discourse power; To effectively judge the social ideological environment, we must fully understand the characteristics and influence of the changes in China’s social ideological trend in the new era, and lay an ideological and cognitive foundation for the modernization of the national governance system and governance capacity; To effectively judge the media application environment, it is necessary to have a deep understanding and control of the ecology of information content production and dissemination under the background of high-speed iteration of media technology.
Requirement 2: Grasp the communication opportunity effectively.
Time effect is the yardstick to test the work level of news public opinion. Whether it is theme propaganda, typical propaganda, achievement propaganda, or emergency reporting, hot spot guidance, and public opinion supervision, we must focus on time and efficiency and reflect the requirements of time and efficiency.
First, effectively grasp the opportunity from the law of news and public opinion communication. Grasping the opportunity is an inevitable requirement to follow the law of news public opinion dissemination, which depends on the different attributes of different events: some need to speak out immediately and be tit for tat; Some need to release public opinion and gradually guide; Some need to plan as a whole and move at the right time.
The second is to effectively use the opportunity from the operation law of the communication platform. From a global perspective, a diversified head platform matrix with obvious advantages has been formed, and the operating characteristics of each head platform are different, forming different communication characteristics and laws. The systematic use of cross-platform communication chain is an important guarantee for effectively grasping the communication opportunity.
The third is to effectively grasp the opportunity from the time law of user behavior. As far as the media resources used by all kinds of users are concerned, there are significant differences in the distribution of usage time, duration and type among different user groups, and at the same time, it also shows obvious regularity. Grasping the law of users’ use time is the practical basis for effectively grasping the communication opportunity.
The third requirement: effectively plan communication strategies.
How to plan the communication strategy effectively? We should seize the opportunity, grasp the rhythm, pay attention to strategies, be good at setting topics, and let the hot heat up and the cold cool down through the continuous supply of high-quality content.
First, the timing is accurate and the information is true. In the era of all-media, the network information from major media platforms is complex and has strong communication, but the content is inevitably biased and difficult to trace and verify. On the one hand, news media workers are required to pay more attention to the timeliness, authenticity and accuracy of information dissemination; on the other hand, higher requirements are put forward for the construction of the guiding force of new mainstream media: we should not only grasp the communication opportunity, but also always uphold the principle that authenticity is the life of news.
The second is to reflect the overall situation and grasp the rhythm. "What to report, what not to report, what to publicize more and what to publicize less must proceed from the overall situation and reflect the requirements of the overall situation." In the dialectical relationship between quantitative change and qualitative change, we should set topics, grasp the rhythm, and stress the systematic and effective balance between national reports and local reports, first reports and follow-up reports, news reports and in-depth reports.
The third is to enrich the content and respond to concerns. For the principles and policies of the party and the government and the issues that the people are concerned about, we should not stop at the simple presentation of information, but fully consider the people’s understanding ability and concern when formulating communication strategies, and fully interpret the major policies and specific policies of the party and the government.
Requirement 4: Effectively construct internal and external relations.
From the perspective of organizational communication, building a new mainstream media and shaping an all-media communication system requires the effective construction of a coordinated internal relationship among all components within the organization and a benign interaction with the external environment, which is the organizational guarantee for improving the effectiveness of news and public opinion work.
In terms of internal relations construction, the new mainstream media, as a special social organization, adheres to the party’s leadership over news and public opinion work, which is the premise for the operation of this news and public opinion organization. In specific work links, it is necessary to have an effective internal work coordination operation mechanism, an effective upper and lower communication management control mechanism, and an effective emergency management decision-making mechanism.
In terms of the construction of external relations, the media, as an integral part of the social system, is bound to face the problem of dealing with the external environment. Specifically, it is necessary to effectively coordinate the relationship with party and government organs, enterprises and institutions, social organizations, the general public and other media.
As General Secretary of the Supreme Leader requested, "We should establish the concept of propaganda, mobilize all fronts and departments to do it together, and more closely integrate propaganda and ideological work with administrative management, industry management and social management in various fields." The coordination of internal and external relations is the basis for completing this requirement.
Requirement 5: Effective production of media content
Under the background of all media, we should adhere to the advanced technology as the support and content construction as the foundation, and implement the requirements of the Supreme Leader General Secretary "to build a socialist ideology with strong cohesion and leading force, so that all the people can be closely United in ideals, beliefs, values and moral concepts".
Facing the new development situation at home and abroad, the effective production of media content should be presented strategically on the basis of implementing the "four self-confidences". For content production, we should be especially good at expressing, and the profound truth should impress and convince people by telling stories.
In terms of domestic communication, keeping integrity and innovation is the core of telling a good story. Keeping the right is to consolidate the foundation and cultivate the yuan, and always keep the direction, position, root vein and bottom line; Innovation means pioneering and innovating, and solving new problems with new ideas, ideas, methods and means. This requires news media workers to change their style of writing, bend down, calm down, examine the truth, tell the truth, move the truth, and strive to create works with thought, temperature and quality.
In terms of international communication, storytelling is the best way of international communication. We should make great efforts to strengthen the construction of international communication ability, including building a foreign discourse system and consolidating the semantic foundation of telling China’s story; Integrate new concepts, new categories and new expressions at home and abroad to lay a pragmatic foundation for telling China’s story well; Promote media integration, create key media for external publicity, and build a channel foundation for telling the story of China, so as to accelerate the promotion of the international influence of China’s discourse, so that the whole world can hear and hear China’s voice clearly.
Requirement 6: Effective use of communication skills.
In order to make the policy of giving priority to positive publicity achieve good results, we must effectively improve communication skills. A condescending, empty and tasteless news report with blunt language and rigid form can’t really touch people’s hearts, even if the content is no matter how good. Good ideas, concepts and contents should be expressed through vivid forms and various means in order to achieve the best publicity effect. It is necessary to adopt more popular forms, constantly enhance the vividness and visibility of news propaganda, and strive to improve the quality and level of news propaganda.
First, under the requirements of the in-depth development of media integration, with the help of the opportunity of all-media development, we should give full play to the advantages and characteristics of emerging media such as "two micro and one shake", various news clients, websites and forums.
Second, news, summary, sidelights, editorials, comments, charts, diagrams, short videos, H5, cartoons and other forms should be comprehensively used to enrich news language and creative skills.
The third is to improve interactivity, especially to innovate discourse forms and enhance the user stickiness of new mainstream media while ensuring positive publicity, so as to enhance the publicity effect.
The fourth is to be good at creating and exploring hot spots, while not blindly chasing hot spots. We should not only pay attention to the hot spots that netizens pay attention to, but also keep the seriousness, accuracy and politics of mainstream media.
Requirement 7: Effectively analyze user data.
With the continuous development of media technologies such as 5G, big data, cloud computing, Internet of Things, artificial intelligence, etc., mobile media with socialization, intelligence and data as the main line has entered an accelerated development stage. From audience to netizens to users, every individual on the Internet can be accurately digitally portrayed.
Effective user data analysis is of great practical significance to the development of news public opinion work. By analyzing the data, we can not only know user attributes, user preferences and user influence, but also modify the communication strategies of media organizations according to the analysis results, and predict user behavior and guard against a series of ideological risks.
In recent years, domestic journalism has paid more and more attention to the measurement and use of user data. The data analysis function of byte system platform can capture real-time hot spots and predict possible hot spots in the future based on massive behavior data and article data of user groups, and provide data analysis of hot events for media organizations. It does not collect news in the real sense, but through the capture and analysis of data such as user attributes and reading behaviors, it re-integrates and finds users’ concerns in the massive content published on the platform, so as to reproduce news.
Requirement 8: Effectively distribute accurate information.
At present, cross-platform and intelligent information distribution mechanism is gradually taking the lead. First, multi-platform linkage communication: under the trend of platformization, the same news event and the same content material are distributed on different media platforms after processing, resulting in linkage resonance effect. Second, intelligent distribution: personalized content push led by algorithms has become the mainstream of news distribution, especially artificial intelligence technology including robot writing is changing all aspects of news topic planning, information collection, content generation and product distribution, leading to increasingly blurred boundaries between news production, distribution and consumption.
Accurate distribution of information is not only a problem of technology and market, but also a guidance and control problem that needs to be effectively solved in news and public opinion work. Therefore, the General Secretary of the Supreme Leader specifically pointed out that "it is necessary to explore the application of artificial intelligence in news gathering, production, distribution, reception and feedback, and comprehensively improve the ability of public opinion guidance" and control the "algorithm" with mainstream value orientation.
Requirement 9: Effectively evaluate the communication effect.
For news opinion workers, the pursuit of effect and actual effect should be the starting point and the end result of public opinion guidance, so as to effectively enhance the ability of public opinion guidance.
The evaluation of communication effect plays an important role in improving the effectiveness of news public opinion work. Its premise is to judge from the ideological level whether the news and public opinion work has adhered to guiding people with correct public opinion, and that all work is conducive to upholding the Communist Party of China (CPC)’s leadership and China’s socialist system, promoting reform and development, enhancing the unity of people of all ethnic groups throughout the country, and maintaining social harmony and stability. From a practical point of view, on the one hand, an effective evaluation of communication effect should be able to directly reflect the concrete results of news public opinion work at home and abroad, society and individuals, organizations and groups from three overlapping dimensions of cognition, attitude and behavior; On the other hand, through the evaluation of communication effect, we can effectively sum up the experience and lessons of news public opinion work and better guide future work.
Requirement 10: effectively shape the ecology of public opinion
To effectively improve the communication, guidance, influence and credibility of news public opinion is to effectively shape a good public opinion ecology.
First, there must be a scientific top-level design. It is necessary to adapt to the trend of differentiated communication and accelerate the construction of a new pattern of public opinion guidance. Since the 18th National Congress of the Communist Party of China, the central government has rearranged the ecological pattern of public opinion in China from a strategic perspective, and now it has achieved remarkable results.
Second, we must grasp the relationship between online and offline. Nowadays, more and more people are used to expressing their demands and opinions through the Internet. The General Secretary of the Supreme Leader stressed that it is necessary to "respond to social concerns, especially the concentrated demands of the masses in a timely manner, not avoid contradictions, and actively promote problem solving", and listen carefully to well-intentioned criticisms, opinions and suggestions. To do a good job in online public opinion monitoring, we should accurately grasp and effectively respond to people’s concerns and demands expressed through the Internet, properly solve the problems reflected as soon as possible, and realize the benign interaction between online and offline.
Third, we must run on the track of the rule of law. Effective news public opinion work should not only stimulate positive energy and promote truth, goodness and beauty in the whole society, but also resolutely crack down on malicious spreading of false information and creating panic, so as to ensure that a good public opinion ecology runs on the track of the rule of law.
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Visualization of Original Ugly Sister’s Patent Analysis
Dogs are our friends and family members. As dogs get older, many dogs will develop tumors like people. At present, domestic pet hospitals can provide very few treatment schemes for pet tumors, only surgery and chemotherapy, and radiotherapy for small animals is still prohibited in our country.
In recent years, there have been many breakthroughs in the treatment of human tumors, such as PD-1, CAR-T cell immunotherapy, etc. These methods have shown good therapeutic effects on tumors, and some can even be completely cured.
Therefore, when the dog who has been with us for more than ten years is old and has a tumor, and it can’t be operated and the chemotherapy effect is not good, of course we can’t just give up. Try to find out whether there is a tumor immunotherapy program suitable for dogs, inhibit tumors, let them live with cancer, and be happy and healthy to accompany us for a few more years.
Today, this article introduces the current scheme that can be used for pet tumor treatment by analyzing related patents.
PART 1 retrieval strategy
Technical scope of patent search: This search is mainly aimed at the technology of tumor immunotherapy involving pets. Therefore, the key words include: dog, cat, pet, cancer and tumor, and the IPC classification numbers involved are C12N (bio-related) and A61K or A61P (drug-related).
Geographical scope of patent search: the current search is to provide domestic pet owners with a treatment plan in China, and the technical feasibility in places too far away like the United States and Europe is not high. Therefore, the applicant’s address is limited to Chinese mainland and Japan (considering that Japan’s medical technology is developed and close to us, many Chinese patients go to Japan for treatment of cancer).
Manual reading and screening: after the number of patent documents is limited to the range that can be read manually through the above retrieval, manual reading is started to screen useful information. The basic requirement of the standard of artificial screening is to make it clear that it can be used for tumor treatment in dogs, and more preferably, it can give experimental data in the examples to confirm that it does have anti-tumor effect in dogs.
PART 2 analysis results
Through analysis, the treatment schemes that can be tried in domestic tumor immunotherapy for pets are sorted out as follows:
1. Beijing Weijiexin Biotechnology Co., Ltd
CN110590959A, recombinant canine PD-1 fusion protein, its preparation method and application, filed on September 19, 2019.
This patent application provides a recombinant canine PD-1 fusion protein, and in its example, it shows that this treatment scheme has been used in pet cats and dogs. It should be the second half of 2019 in a pet hospital in Beijing for clinical trials.
Therapeutic effect: The overall objective remission rate is 20%-30%.
The inventor of this patent application, Dr. Luo Haoshu, is an associate professor and master/doctoral supervisor of the School of Biology, China Agricultural University.
2. Beijing Conoco Fu Biotechnology Co., Ltd.
WO2019149039A1, an anti-tumor protein composition and its application, filed on January 9, 2019.
The patent application relates to an anti-tumor method using cytokine fusion protein, which comprises an anti-tumor composition, including proteins IL12, GMCSF and IL2, and achieves the technical effect of good inhibition on tumors at all stages and slight adverse reactions.
This cytokine fusion protein is a broad-spectrum anti-tumor drug. The protein anti-tumor drug is directly injected into the tumor to adjust the immune environment inside the tumor and realize the inhibition of the tumor. Experiments on sarcoma, oral melanoma and breast cancer in dogs and cats have been done in the examples, and the data show that most tumors have been suppressed, even shrunk and subsided.
Further search found that Conoco Clothing Company and the inventor of this patent, Zhang Jinyu, also applied for two other patents and published a paper in The Lancet’s sub-journal EBioMedicine. Although these two patents and journals did not explicitly say that they were used to treat Wang Wang tumor, their technical contents were very relevant to this application:
WO2018184484A1, cytokine combination, with the earliest priority date of April 6, 2017, relates to a cytokine combination, which comprises at least three cytokines, and the cytokines are selected from the following groups: IL12, GMCSF, FLT3L, IL2, IL15 and IL21；;
WO2020024922A1, protein heterodimer and its use, the earliest priority date is July 30, 2018, and it relates to a protein heterodimer, which comprises a first polypeptide chain and a second polypeptide chain, wherein the first polypeptide chain comprises IL12a and a first factor fused with IL12a, and the second polypeptide chain comprises IL12b and a second factor fused with IL12b, and the first factor and the second factor are selected from IL2 and GMCSF.
The paper "In Situ Administration of Cytokine Combinations Induces Tumour Regression in Mice" also involves the treatment of tumors with IL-12+GMCSF+IL-2.
Through reading the above patents, Xiao Bian understands that they use the cytokine composition to treat tumors (WO2018184484A1), then use protein heterodimer (WO2020024922A1) to make these cytokines into a cytokine fusion protein, and then use this cytokine fusion protein to treat tumors (WO2019149039A1), and treat tumors in dogs.
The applicant should think that this technology is more important and has better effect, so all the applications are PCT patent applications. Because they have been applied in recent two years, they have not seen the published texts of other countries.
3. Japan Quanyao Industry Co., Ltd.
Japan Quanyao Industrial Co., Ltd. has two patent applications in pet tumor immunotherapy.
Patent application 1: cn110603056a, a method for inhibiting the infiltration of regulatory T cells based on CCR4 blockade and a method for treating tumor diseases in dogs, filed on April 26th, 2018.
Patent application 2: wo2016006241a1, anti-canine -PD-1 antibody or anti-canine-PD-L1 antibody. The earliest priority date is July 9, 2014. This patent has been granted in Europe, Japan and the United States.
Founded in 1946, Japan Quanyao Industry Co., Ltd. is a research and development enterprise engaged in animal medicines. Its current animal drugs include some conventional veterinary drugs, such as anti-inflammatory, analgesic, fever-reducing, anthelmintic and so on.
However, judging from the above two patents, Japanese Quanyao should be engaged in the research and development of animal antitumor drugs. I continue to check the inventors of these two patents. They are not researchers of Quanyao in Japan, but researchers of Tokyo University and Yamaguchi University in Japan. This shows that Quanyao Industrial Co., Ltd. is cooperating with Japanese universities to develop animal antitumor drugs.
Continuing to search with the inventors of the above two patent applications, I found two Japanese scientific research institutions specializing in the treatment and research of Wang Wang tumor.
4. Laboratory of Veterinary Clinical Pathology, University of Tokyo, Japan
CN110603056A, a method for inhibiting the infiltration of regulatory T cells based on CCR4 blockade and a method for treating tumor diseases in dogs, by former Tian Zhen Wu.
The patent application relates to a pharmaceutical composition for treating canine tumors, which contains a compound that blocks the combination of canine CCL17 and canine CCR4 as an active ingredient. The pharmaceutical composition is a broad-spectrum antineoplastic agent, and can be used for treating transitional epithelial carcinoma, prostate cancer, breast cancer, malignant melanoma, squamous cell carcinoma and lung adenocarcinoma.
Before treatment, it is necessary to analyze the Treg (Regulatory T Cell) infiltration analysis in the tumor tissue of dogs and confirm the CCR4 expression in the tumor infiltration Treg. (Xiao Bian’s understanding: First of all, we should do pathological examination to see if the tumor of the dog has Treg infiltration and CCR4 expression. If so, the treatment with the pharmaceutical composition of this application may be effective. Just like treatment with PD-1, tumor cells need to express PD-1. Xiaobian is not in the biological field, please pat it if it is wrong)
Then, in the example of this patent application, the therapeutic effect data of pet dogs are given, which proves that the anti-CCR4 antibody (Mojiamuzumab) in this patent application is an effective therapeutic drug with less side effects on various tumors in dogs.
The inventor of this patent application is former Tian Zhen Wu of the Veterinary Clinical Pathology Laboratory of the University of Tokyo.
This Maeda teacher should be a very caring and enthusiastic person, and even found his personal website, which specifically introduces his veterinary clinical pathology laboratory at the University of Tokyo.
Moreover, their laboratory is currently recruiting clinical evaluation of anti-regulatory T cells (CLEAR), which is the anti-Treg treatment scheme related to the above patent.
The recruitment copy says:
がんをぅたちのためにののををぅぅさにのの12357
For Wang Wang who has cancer, for the shovel officer who thinks of his beloved Wang Wang, and for those who have cancer, it will be a great honor if this project can make a little contribution.
I hope this project can be successful and I can come to China in the future to give Wang Wang, who has cancer, more hope.
5. Laboratory of Veterinary Molecular Diagnosis and Therapy, Faculty of Common Veterinary Medicine, Yamaguchi University, Japan
WO2016006241A1, anti-canine -PD-1 antibody or anti-canine-PD-L1 antibody, inventor: Nobuya Mizuno.
This patent has been authorized in Europe, Japan and the United States. His inventor, Takuya Mizuno, is also a professor in the Laboratory of Veterinary Molecular Diagnosis and Therapy, Faculty of Common Veterinary Medicine, Yamaguchi University, Japan.
The research currently being carried out in the Laboratory of Veterinary Molecular Diagnostics and Therapeutics, where Professor Mizuno Toyo is located, includes:
Wang Wang oncolytic virus therapy, a kind of therapy that specifically infects cancer and destroys cancer cells. It has been proved that it can kill cancer cells in dogs to fight against various cancers.
Wang Wang PD-1 antibody drugs, including therapeutic methods for immunomodulation purposes, such as molecular suppression of immune checkpoints, and cytotoxic antibodies using antibodies against cancer cell surface molecules. This technology should be the PD-1 technology that was searched above and developed in cooperation with Japan Quanyao.
Wang Wang CAR-T immune cell therapy, which uses immune cells collected from dogs with cancer to prepare genetically modified immune cell CAR-T cells in vitro, is a very popular research direction of tumor treatment at present.
CN109452229A, preparation method and application of canine PD-1 genetically modified animal model, filed on November 19th, 2018.
The patent application provides an sgRNA capable of specifically targeting Pd-1 gene, a canine-derived animal model of PD-1 gene, a method for preparing an sgRNA vector of the canine-derived animal model, a preparation method of the canine-derived animal model and related applications, and a genetically modified canine-derived mouse is prepared, which can normally express PD-1 protein containing the functional domain of the canine PD-1 protein. The example of this patent provides relevant experimental data on tumor inhibition in mice, but there is no relevant patent on clinical experimental data of tumor in dogs.
Beijing Baiao Saitu Gene Biotechnology Co., Ltd. is a gene biotechnology company located in Daxing, Beijing, and its management team is all doctors in the field of biomedicine. At present, 84 patents have been applied, most of which are related to humanized genetic modification technology. This company mainly develops human antibody drugs, and only the above patent involves PD-1 in dogs.
It is also found in the Eye of the Sky that Beijing Baiao Saitu has registered a Maple Leaf Pet Hospital (Beijing) Co., Ltd. in March this year, and it should start to enter the field of immunotherapy for pet tumors. But I haven’t seen them start business yet. I hope to get up and start business quickly and give the dogs more hope.
7. Beijing Xinuogu Biotechnology Co., Ltd.
CN110194799A, an anti-canine PD-1 antibody that binds to canine PD-1, filed on Jun. 3, 2019.
The patent relates to an anti-canine PD-1 antibody and a preparation method thereof, and the canine PD-1 antibody can be combined with canine PD-1 for application in drugs for treating canine cancer. The patent only discloses the experimental data of mice, but there is no clinical experimental data of dogs.
Xiao Bian has an impression on Sinovalley Biotechnology Company because they specialize in cloning cats and dogs, cloning 380,000 dogs.
Summary of analysis results of PART 3
At present, there are not many options to treat small animal tumors in China. After analysis, it is found that the following three are more reliable in terms of technical strength and experimental effect:
The cytokine fusion protein of Beijing Conoco Fu Biotechnology Co., Ltd. has been used in more than 300 cases of pets, most of which have achieved the effect of inhibiting tumor growth, and some of them have been completely relieved, and it is a broad-spectrum anti-tumor drug that can be tried;
Beijing Baiao Saitu Gene Biotechnology Co., Ltd., with strong technical strength, has 84 patent applications. It hopes to be used as a human medicine and also for the treatment of Wang Wang tumor. From the perspective of patent technology, it mainly involves PD-1 antibody, and their Maple Leaf Pet Hospital has just been established. It is expected that it will not start clinical trials for dogs until September this year, which is also a treatment plan worth looking forward to.
Japan Quanyao Industrial Co., Ltd., and its two scientific research institutions, the Laboratory of Veterinary Clinical Pathology of Tokyo University and the Laboratory of Veterinary Molecular Diagnosis and Therapeutics of the Faculty of Veterinary Medicine of Yamaguchi University, have entered the clinical trial stage. One is a regulatory T cell infiltration inhibition method based on CCR4 blockade, and the other is PD-1, which should be reliable, but it is not convenient to be applied in China at present, and it is recommended to Japanese shovel officials.
PART 4 Application of Patent Analysis Results
Ugly sister wanted to do this research because my ugly sister had been sneezing and running nose since the end of last year. At first, she thought it was rhinitis, but she didn’t get better after treatment for a long time. As a result, she went to the hospital for CT at the beginning of March this year and was highly suspected of being a nasal tumor.
An ugly younger sister with a runny nose when she sleeps.
The doctor said that if you have an operation, you should open your head, and it will recur soon. Ugly sister is 16 years old and can’t bear such a big operation. Chemotherapy is not effective for nasal cavity tumors. People who get nasal cavity tumors are usually treated with radiotherapy, but there is no place to treat small animals with radiotherapy in China at present.
Don’t you just let the tumor grow up? Now there are so many new methods for the treatment of human tumors, and our ugly sister can give it a try.
How can I know where I can give my dog tumor immunotherapy? So Ugly Sister analyzed all the patents about immunotherapy of dog tumors at present and found the above companies that are doing research in this field. After so many years of patent analysis, I finally feel useful.
Then, according to our actual situation, we can select the treatment options.
First of all, it is not convenient to go to Japan, so we ruled out two scientific research institutions in Japan first, but we are still looking forward to the related drugs of Japan Quanyao Industrial Co., Ltd. to achieve good results and successfully pass clinical trials.
Secondly, because the ugly sister is 16 years old, the ugly mother’s request is not to do any examination that requires general anesthesia, that is, not to do CT (dogs need general anesthesia when doing CT) and not to do pathological examination (because the tumor is in the nasal cavity, if you want to do pathological examination, you need to take samples with nasal endoscope under general anesthesia). Without biopsy, we don’t know what kind of tumor it is, and we don’t know if PD-1 is expressed.
So, in the end, we chose the cytokine fusion protein of Conoco. Because Conoco’s mature treatment plan is to inject drugs directly into the tumor, but our ugly sister’s nasal cavity tumor is in a bad position, so if she wants to inject it, she must be under general anesthesia, and ugly mother doesn’t agree. So we tried a new anti-tumor drug from Conoco Clothing Company, which was treated by intravenous injection, so that there was no need for anesthesia. So we ugly became the first Wang Wang in Chengdu to try this therapy.
On March 29th, Ugly Mommy took Ugly to the hospital to take venous blood, and the staff of Conoco Service Company took the blood sample away and sent it to their company’s laboratory. Then send it back after an operation in the laboratory.
On April 5th, Ugly received the first intravenous treatment.
Ugly receives the first treatment.
After treatment, I thought I would have a fever, but I didn’t have a fever at all.
I was going to have a second treatment the next week. As a result, just two days before preparing for the second treatment, Ugly suddenly had stomach cramps, pulled blood and vomited. The doctor diagnosed it as upper gastrointestinal bleeding, and quickly treated it. It took several days to stop bleeding and stop vomiting.
Because Ugly Ugly had digestive tract problems ten days before treatment, we don’t know whether this sudden upper gastrointestinal bleeding was caused by the poor digestive tract, the side effects of treatment, or the presence of lesions in the digestive tract.
However, Ugly Mom was afraid that Ugly would bleed if she was treated again, so she didn’t want to give Ugly a second treatment. We also want to get it in shape first.
Then Ugly Mom atomizes Ugly three times a day, and then drops some eye drops to stimulate it, so that it can sneeze hard to beat out the secretions inside.
Zhong Ugly does atomization three times a day.
On May 15, more than a month after the treatment, one day Ugly sneezed and sneezed a lot of secretions.
Ugly sneezing secretions from the nose.
Ugly mom said that the whole dog looks happier since it hit such a big lump, and it has to grind its teeth, which means that its nose doesn’t hurt.
On May 21st, I sneezed again and produced a lot of secretions.
Ugly sneezing secretions from the nose.
Then ugly mom said that ugly’s left nostril was open, and two points of water vapor could be seen when atomizing. In the past, the left nostril was blocked because of a tumor.
When atomizing, you can see the water vapor produced by the exhalation of two nostrils.
Now Ugly Ugly has completely stopped sneezing and running nose, and the previous symptoms have completely disappeared.
The staff of Conoco Clothing told us that it was a course of treatment for three times, but Ugly Mom saw the effect after the first treatment, and she was afraid that she would have stomach bleeding again, so she was hesitant to do it again.
Because ugly mom doesn’t want to take ugly to do CT, so we don’t know what the effect of tumor treatment is this time, just consider it effective. Ugly sister boldly guessed that the tumor might have shrunk, the nostril passage became larger, and all the secretions deposited in it were typed out, and then it was easy.
In a word, under the careful care of Ugly Mommy, the symptoms of Ugly Nose are gone now, and my mental state is good. Besides being clumsy when I am old, I can occasionally fight.
Ugly just celebrated her 17th birthday a few days ago. I hope she will always be healthy and happy.
postscript
Thanks for the technical support given by Lihua, Youhe and Teacher Mao, the small partners in the biological field, during the search for related patents; I would also like to thank Zhan Xing and Xin Rui for helping to contact the inventors. Thanks to the scientists and staff of Conoco Service, we can live a healthy life now.
Writing this article, I hope I can give you some information. If your master has a tumor, don’t give up. It would be a great honor if this article could make a little contribution.
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Original title: How to Save Your Dog’s Life with Patent Analysis
